Luis Martinez-Sobrido

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013
  2. pmc The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
    J Transl Med 9:127. 2011
  3. pmc Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals
    Margaret J Wortman
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W, Olney Road, Norfolk, VA 23507, USA
    BMC Mol Biol 11:81. 2010
  4. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
  5. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
  6. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
  7. doi request reprint Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 88:878-89. 2014
  8. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
  9. pmc Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:1684-95. 2011
  10. doi request reprint Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
    Zhihua Kou
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 410:240-7. 2011

Collaborators

  • Emilio Ortiz-Riaño
  • Juan C de la Torre
  • Aravinda de Silva
  • Megan L Shaw
  • Xia Jin
  • Stefan Kunz
  • W W Shanaka I Rodrigo
  • Hayk Davtyan
  • Zhihua Kou
  • Adolfo Garcia-Sastre
  • Margaret J Wortman
  • Christelle Pythoud
  • Richard Cadagan
  • Shengyong Liu
  • Michael G Agadjanyan
  • Huiyuan Chen
  • Joanne Y H Lim
  • Matthew Quinn
  • Irina Petrushina
  • Dmitriy Zamarin
  • Michael S Diamond
  • Nina Movsesyan
  • Luis Martnez-Sobrido
  • Federica Sallusto
  • Anahit Ghochikyan
  • Jacob J Schlesinger
  • Randy A Albrecht
  • Shengyo Ng Liu
  • Martina Beltramello
  • Ann E Campbell
  • Laura K Hanson
  • Jonas A Nance
  • Edward M Johnson

Detail Information

Publications10

  1. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013
    ..Moreover, we show the feasibility of using these novel strategies for efficient rescue of recombinant tri-segmented both LCMV and Candid#1...
  2. pmc The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
    J Transl Med 9:127. 2011
    ..We hypothesized that in elderly people with pre-existing memory Th cells specific to influenza this dual vaccine will simultaneously boost anti-influenza immunity and induce production of therapeutically active anti-Aβ antibodies...
  3. pmc Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals
    Margaret J Wortman
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W, Olney Road, Norfolk, VA 23507, USA
    BMC Mol Biol 11:81. 2010
    ..The distinct but related roles of Purα suggest a need for expression regulated differently depending on intracellular and external signals...
  4. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
    ..Additionally, we also document the dominant negative effect of D471G mutation on viral infection, suggesting that NP self-association is an excellent target for the development of new antivirals against arenaviruses...
  5. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
    ..Altogether, our findings demonstrate that arenavirus infection inhibits NF-κB-dependent innate immune and inflammatory responses, possibly playing a key role in the pathogenesis and virulence of arenavirus...
  6. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
    ....
  7. doi request reprint Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 88:878-89. 2014
    ..We document an additive antiarenavirus effect of A3 and ribavirin, supporting the potential combination therapy of ribavirin and pyrimidine biosynthesis inhibitors for the treatment of arenavirus infections. ..
  8. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
    ..In addition, this NP-Z interaction represents a potential target for the development of antiviral drugs to combat human-pathogenic arenaviruses...
  9. pmc Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:1684-95. 2011
    ..Using GP-pseudotyped rLCMVΔGP/GFP, we have also obtained evidence supporting the feasibility of this approach to identify and evaluate candidate antiviral drugs against HF arenaviruses without the need of BSL-4 laboratories...
  10. doi request reprint Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
    Zhihua Kou
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 410:240-7. 2011
    ..These results demonstrate that the regulation of virus production in ADE infection of primary human monocytes is more complex than previously appreciated...