Otoniel Martinez-Maza

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
  2. pmc CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11448. 2010
  3. pmc Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, CA 90095 1740, USA
    AIDS Res Treat 2010:164586. 2010
  4. pmc Overexpression of microRNAs from the miR-17-92 paralog clusters in AIDS-related non-Hodgkin's lymphomas
    Dharma R Thapa
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e20781. 2011
  5. ncbi request reprint B-cell activation and lymphoma in patients with HIV
    Otoniel Martinez-Maza
    Department of Microbiology, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    Curr Opin Oncol 14:528-32. 2002
  6. ncbi request reprint Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Public Health, Los Angeles, California 90095, USA
    AIDS 21:2265-70. 2007
  7. pmc Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation
    Deborah L Regidor
    Department of Epidemiology, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California, USA
    AIDS 25:303-14. 2011
  8. pmc A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    BMC Cancer 13:195. 2013
  9. pmc Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 25:149-56. 2009
  10. ncbi request reprint Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1740, USA
    Tumour Biol 27:187-94. 2006

Research Grants

  1. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2006
  2. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2006
  3. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2000
  4. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1993
  5. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
  6. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1999
  7. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2005
  8. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2009
  9. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
  10. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2007

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
    ....
  2. pmc CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11448. 2010
    ..These findings are consistent with a role for HIV in the direct stimulation of B cells, potentially leading to the accumulation of molecular lesions that have the potential to contribute to the development of NHL...
  3. pmc Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, CA 90095 1740, USA
    AIDS Res Treat 2010:164586. 2010
    ..AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL...
  4. pmc Overexpression of microRNAs from the miR-17-92 paralog clusters in AIDS-related non-Hodgkin's lymphomas
    Dharma R Thapa
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e20781. 2011
    ..Several miRNAs, including those encoded by the miR-17-92 polycistron, have been shown to play significant roles in B cell tumorigenesis. However, the role of miRNAs in NHL in the setting of HIV infection has not been defined...
  5. ncbi request reprint B-cell activation and lymphoma in patients with HIV
    Otoniel Martinez-Maza
    Department of Microbiology, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    Curr Opin Oncol 14:528-32. 2002
    ....
  6. ncbi request reprint Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Public Health, Los Angeles, California 90095, USA
    AIDS 21:2265-70. 2007
    ..Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma...
  7. pmc Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation
    Deborah L Regidor
    Department of Epidemiology, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California, USA
    AIDS 25:303-14. 2011
    ....
  8. pmc A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    BMC Cancer 13:195. 2013
    ..47 as a potential therapy for PCa. Our goal was to take advantage of the unique properties of IgE in order to trigger immune activation against PCa...
  9. pmc Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 25:149-56. 2009
    ..46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men...
  10. ncbi request reprint Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1740, USA
    Tumour Biol 27:187-94. 2006
    ....
  11. pmc Serum Levels of Cytokines and Biomarkers for Inflammation and Immune Activation, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk
    Elena Vendrame
    Authors Affiliations University of California Los Angeles UCLA AIDS Institute, Jonsson Comprehensive Cancer Center at UCLA, Departments of Obstetrics and Gynecology, Psychiatry and Biobehavioral Sciences, and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California Departments of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois and Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
    Cancer Epidemiol Biomarkers Prev 23:343-9. 2014
    ..HIV infection is associated with a marked increase in risk for non-Hodgkin lymphoma (AIDS-NHL). However, the mechanisms that promote the development of AIDS-NHL are not fully understood...
  12. pmc Acute HIV-1 seroconversion with an unusual plasma biomarker profile
    Najib Aziz
    Department of Epidemiology, Fielding School of Public Health, University of California in Los Angeles, Los Angeles, California, USA
    Clin Vaccine Immunol 20:1774-7. 2013
    ..Numerous serum cytokine concentrations were elevated during HIV-1 seroconversion. ..
  13. pmc Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells
    Jose A Rodriguez
    Molecular Biology Institute, David Geff en School of Medicine, University of California, Los Angeles, CA 90095 1782, USA
    Leuk Lymphoma 52:2169-78. 2011
    ..These findings are expected to facilitate the rational design and clinical use of therapeutic agents targeting iron import via TfR1 in hematopoietic malignancies...
  14. pmc Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Toxicol In Vitro 27:220-31. 2013
    ..1Av/b-SO6 is not toxic to normal human hematopoietic stem cells suggesting that this critical cell population would be preserved in therapeutic interventions using this immunotoxin...
  15. ncbi request reprint Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL
    Dharma R Thapa
    University of California, Los Angeles, AIDS Institute, Los Angeles, CA Departments of Obstetrics and Gynecology Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA Department of Epidemiology, University of California, Los Angeles, Fielding School of Public Health, Los Angeles, CA Departments of Epidemiology Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL and Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA
    J Acquir Immune Defic Syndr 66:229-37. 2014
    ..To determine if changes in levels of serum microRNAs (miRNAs) were seen preceding the diagnosis of AIDS-related non-Hodgkin lymphoma (AIDS-NHL)...
  16. ncbi request reprint Interleukin-6 (IL-6) expression and natural killer (NK) cell dysfunction and anergy in heart failure
    Donna L Vredevoe
    UCLA School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Cardiol 93:1007-11. 2004
    ..These results support a model of cytokine-induced anergy in conditions that result in high systemic levels of IL-6...
  17. ncbi request reprint Expression and function of CD28 on Epstein-Barr virus-positive B cell lines and AIDS-associated non-Hodgkin's lymphoma cell lines
    Daniel Widney
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, 90095 1747, USA
    Tumour Biol 24:82-93. 2003
    ..Overall, these results suggest a role for CD28 and its ligands, B7-1 and B7-2, in homotypic interactions in EBV+ B cell lines, which may mediate cellular activation and/or viability...
  18. ncbi request reprint Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1740, USA
    Curr Opin Oncol 18:444-8. 2006
    ..We discuss recently published studies that elucidate the pathogenesis of AIDS-associated lymphoma...
  19. pmc Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 90095 1782, USA
    Cancer Immunol Immunother 61:991-1003. 2012
    ..In summary, our results suggest that this IgE should be further explored as a potential therapeutic against HER2/neu overexpressing tumors, such as breast and ovarian cancers...
  20. pmc Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk
    Shehnaz K Hussain
    Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Cancer Epidemiol Biomarkers Prev 22:295-307. 2013
    ....
  21. pmc TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis
    Yu Guo
    UCLA AIDS Institute, Los Angeles, CA The Institution of Viral disease Control and Prevention, CDC, Beijing, China Departments of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, Los Angeles, CA and Jonsson Comprehensive Cancer Center, Los Angeles, CA
    J Acquir Immune Defic Syndr 64:204-10. 2013
    ....
  22. pmc Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e72414. 2013
    ..This mouse model may be useful for future studies on the interactions of the innate immune system and AIDS-BL tumor cells, as well as for the assessment of potential tumor biomarkers for this disease. ..
  23. ncbi request reprint Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1740, USA
    Mol Immunol 44:934-42. 2007
    ..These findings indicate that EBV induced AID and pol-eta expression, and that this was associated with oncogene mutation, providing a novel means by which EBV infection of B cells may contribute to lymphomagenesis...
  24. doi request reprint Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles
    Irene Souter
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Fertil Steril 91:2012-9. 2009
    ..To assess whether gonadotropin-induced changes in E(2) alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines...
  25. pmc When grief makes you sick: bereavement induced systemic inflammation is a question of genotype
    Christian R Schultze-Florey
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Brain Behav Immun 26:1066-71. 2012
    ..For these patients, clinical interventions for bereavement-related stressor reduction might be crucial for overall health...
  26. pmc B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas
    Dharma R Thapa
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095 7365, USA
    AIDS 26:1177-80. 2012
    ....
  27. pmc Multisite comparison of high-sensitivity multiplex cytokine assays
    Elizabeth Crabb Breen
    UCLA Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7076, USA
    Clin Vaccine Immunol 18:1229-42. 2011
    ....
  28. pmc B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma
    Elizabeth Crabb Breen
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7076, USA
    Cancer Epidemiol Biomarkers Prev 20:1303-14. 2011
    ..The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL)...
  29. pmc Factors affecting the prevalence of strongly and weakly carcinogenic and lower-risk human papillomaviruses in anal specimens in a cohort of men who have sex with men (MSM)
    Dorothy J Wiley
    School of Nursing, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e79492. 2013
    ..HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs)...
  30. ncbi request reprint Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure
    Julia R Gage
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
    Neuroimmunomodulation 11:173-80. 2004
    ..To examine the potential impact of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors, medications which modulate beta-adrenergic signaling, on immune function in patients with chronic heart failure (HF)...
  31. pmc Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Drug Alcohol Depend 94:165-71. 2008
    ..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...
  32. pmc HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, Los Angeles, CA, USA
    Immunol Res 48:72-83. 2010
    ..In this review, we discuss recent reports that further support the importance of these factors, and we highlight emerging evidence of different mechanisms that potentially drive lymphomagenesis in HIV-infected individuals...
  33. pmc An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunother 34:500-8. 2011
    ..Our results suggest that ch128.1Av and ch128.1 may be effective in the therapy of human multiple myeloma and potentially other hematopoietic malignancies...
  34. pmc Transcriptome analysis of HIV-infected peripheral blood monocytes: gene transcripts and networks associated with neurocognitive functioning
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine, University of California, Los Angeles, United States Electronic address
    J Neuroimmunol 265:96-105. 2013
    ..We hypothesized that transcriptome changes in peripheral blood monocytes relate to neurocognitive functioning in HIV+ individuals, and that such alterations could be useful as biomarkers of worsening HAND...
  35. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  36. pmc Assessment of pre-diagnosis biomarkers of immune activation and inflammation: insights on the etiology of lymphoma
    Elena Vendrame
    Departments of Obstetrics and Gynecology and Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, California, USA
    J Proteome Res 10:113-9. 2011
    ..The availability of prediagnosis serum/plasma from cohort studies provides unique opportunities for proteomic approaches to identify novel prediagnosis etiologic biomarkers for NHL...
  37. pmc Temporal stability of serum concentrations of cytokines and soluble receptors measured across two years in low-risk HIV-seronegative men
    Mara M Epstein
    Authors Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts UCLA AIDS Institute, and Departments of Psychiatry and Biobehavioral Sciences and Obstetrics and Gynecology, David Geffen School of Medicine at UCLA Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Medicine Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois Departments of Molecular Microbiology and Immunology and Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Department of Microbiology, Immunology and Molecular Genetics, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California
    Cancer Epidemiol Biomarkers Prev 22:2009-15. 2013
    ..Estimates of the within-person temporal stability of serum markers partly assess the utility of single biomarker measurements and may have important implications for the design of prospective studies of chronic disease risk...
  38. pmc Animal models for IgE-meditated cancer immunotherapy
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, CHS 54 140, Box 951782, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 61:1535-46. 2012
    ..This article describes the advantages and disadvantages of these models and their use in evaluating the in vivo properties of IgE antibodies for cancer therapy...
  39. pmc Relation of depression, natural killer cell function, and infections after coronary artery bypass in women
    Lynn V Doering
    UCLA School of Nursing, Los Angeles, CA 90095 6918, United States
    Eur J Cardiovasc Nurs 7:52-8. 2008
    ..Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown...
  40. pmc IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
    Milan Fiala
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
    J Neuroinflammation 7:76. 2010
    ..Immune modulation of chronic inflammation may be a new approach to sALS...
  41. ncbi request reprint C-reactive protein in nipple aspirate fluid associated with Gail model factors
    Diana Lithgow
    College of Graduate Nursing at Western University of Health Sciences, Pomona, California, USA
    Biol Res Nurs 9:108-16. 2007
    ..This study ascertained CRP's presence in NAF and evaluated if risk factors, as identified by the Gail model, were associated with NAF CRP levels among healthy women...
  42. doi request reprint The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs
    Mario I Vega
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095 1747, USA
    Leuk Lymphoma 49:1982-94. 2008
    ..These findings offer novel potential therapeutic applications in the reversal of rituximab/drug resistant AIDS-derived B-NHL...
  43. doi request reprint 17. Serum free testosterone levels associated with anal human papillomavirus types 16/18 in a cohort of men who have sex with men
    Hilary Hsu
    UCLA School of Nursing, Los Angeles, CA, USA
    Sex Health 10:578. 2013
    ..The mechanisms underlying this association remain unclear and warrant further study. ..
  44. ncbi request reprint Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:119-29. 2003
    ..009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma...
  45. doi request reprint Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry
    Gustavo Helguera
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Immunol Methods 368:54-63. 2011
    ....
  46. ncbi request reprint Investigation of epstein-barr virus as a potential cause of B-cell non-Hodgkin lymphoma in a prospective cohort
    Anneclaire J De Roos
    Authors Affiliations Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania Division of Public Health Sciences and Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center Department of Epidemiology, School of Public Health and Department of Laboratory Medicine, University of Washington, Seattle, Washington Departments of Obstetrics and Gynecology, and Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA Jonsson Comprehensive Cancer Center UCLA AIDS Institute and Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California
    Cancer Epidemiol Biomarkers Prev 22:1747-55. 2013
    ..We hypothesized that poor control of Epstein-Barr virus (EBV) infection, leading to reactivation of the virus, increases the risk of non-Hodgkin lymphoma (NHL) in the general population of primarily immunocompetent persons...
  47. pmc Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling
    Mathew T Mizwicki
    Department of Surgery, David Geffen School of Medicine at UCLA 650 Charles E Young Dr South, Los Angeles, CA 90095 1735, USA
    Am J Neurodegener Dis 1:305-15. 2012
    ..This pilot study demonstrates that in vitro tocilizumab suppresses many factors that drive inflammation in sALS patients, with possible increased efficacy in Group 1 ALS patients...
  48. ncbi request reprint Pain-related activation of leukocyte cellular adhesion molecules: preliminary findings
    Charles A Griffis
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 1702, USA
    Neuroimmunomodulation 14:224-8. 2007
    ..This study examined the effects of acute experimental pain on catecholamine and cortisol levels and leukocyte expression of cellular adhesion molecules...
  49. pmc Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma
    Chun Chao
    Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles Ave, 2nd Floor, Los Angeles, CA 91101, USA
    Clin Cancer Res 18:4702-12. 2012
    ..We investigated the hypothesis that EBV infection is associated with expression of specific B-cell oncogenic markers in HIV-related diffuse large B-cell lymphoma (DLBCL) and examined the prognostic use of detecting EBV infection...
  50. pmc Sleep loss activates cellular inflammatory signaling
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
    Biol Psychiatry 64:538-40. 2008
    ..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade...
  51. ncbi request reprint Serum levels of soluble vascular cell adhesion molecule-1 are decreased in women receiving oral contraceptives compared with normally menstruating women: implications in atherosclerosis
    Irene Souter
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Fertil Steril 83:1480-8. 2005
    ..The secondary objective was to assess the association, if any, between inflammatory cytokines and expression of sVCAM-1...

Research Grants29

  1. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2006
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  2. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2006
    ..These studies should provide valuable insight on the role of immune dysfunction and/or loss of immunoregulatory control of EBV infection on the development of B cell NHL. ..
  3. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2000
    ....
  4. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1993
    ..Finally, the results of these studies may indicate if AZT therapy contributes directly to the development of AIDS-BCL...
  5. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  6. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1999
    ....
  7. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2005
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  8. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2009
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  9. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  10. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..These studies should provide valuable insight on the role of immune dysfunction and/or loss of immunoregulatory control of EBV infection on the development of B cell NHL. ..
  11. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2009
    ..These studies should provide valuable insight on the role of immune dysfunction and/or loss of immunoregulatory control of EBV infection on the development of B cell NHL. ..
  12. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2003
    ....
  13. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1999
    ..The accomplishment of these specific aims will add valuable new information to our understanding of the molecular epidemiology of AIDS-lymphoma, as well as the role of immune dysfunction in the generation and growth of this cancer. ..
  14. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2000
    ..The accomplishment of these specific aims will add valuable new information to our understanding of the molecular epidemiology of AIDS-lymphoma, as well as the role of immune dysfunction in the generation and growth of this cancer. ..
  15. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2001
    ....
  16. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2002
    ....
  17. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2003
    ....
  18. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
    ....