Otoniel Martinez-Maza

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
  2. ncbi request reprint B-cell activation and lymphoma in patients with HIV
    Otoniel Martinez-Maza
    Department of Microbiology, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    Curr Opin Oncol 14:528-32. 2002
  3. ncbi request reprint Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Public Health, Los Angeles, California 90095, USA
    AIDS 21:2265-70. 2007
  4. ncbi request reprint Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1740, USA
    Tumour Biol 27:187-94. 2006
  5. ncbi request reprint Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1740, USA
    Curr Opin Oncol 18:444-8. 2006
  6. pmc A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    BMC Cancer 13:195. 2013
  7. doi request reprint Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles
    Irene Souter
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Fertil Steril 91:2012-9. 2009
  8. ncbi request reprint Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1740, USA
    Mol Immunol 44:934-42. 2007
  9. ncbi request reprint Expression and function of CD28 on Epstein-Barr virus-positive B cell lines and AIDS-associated non-Hodgkin's lymphoma cell lines
    Daniel Widney
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, 90095 1747, USA
    Tumour Biol 24:82-93. 2003
  10. pmc Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 90095 1782, USA
    Cancer Immunol Immunother 61:991-1003. 2012

Research Grants

  1. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
  2. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2007
  3. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
  4. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2009
  5. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2009
  6. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
  7. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1993
  8. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2000
  9. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
    ....
  2. ncbi request reprint B-cell activation and lymphoma in patients with HIV
    Otoniel Martinez-Maza
    Department of Microbiology, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    Curr Opin Oncol 14:528-32. 2002
    ....
  3. ncbi request reprint Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Public Health, Los Angeles, California 90095, USA
    AIDS 21:2265-70. 2007
    ..Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma...
  4. ncbi request reprint Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1740, USA
    Tumour Biol 27:187-94. 2006
    ....
  5. ncbi request reprint Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1740, USA
    Curr Opin Oncol 18:444-8. 2006
    ..We discuss recently published studies that elucidate the pathogenesis of AIDS-associated lymphoma...
  6. pmc A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    BMC Cancer 13:195. 2013
    ..47 as a potential therapy for PCa. Our goal was to take advantage of the unique properties of IgE in order to trigger immune activation against PCa...
  7. doi request reprint Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles
    Irene Souter
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Fertil Steril 91:2012-9. 2009
    ..To assess whether gonadotropin-induced changes in E(2) alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines...
  8. ncbi request reprint Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1740, USA
    Mol Immunol 44:934-42. 2007
    ..These findings indicate that EBV induced AID and pol-eta expression, and that this was associated with oncogene mutation, providing a novel means by which EBV infection of B cells may contribute to lymphomagenesis...
  9. ncbi request reprint Expression and function of CD28 on Epstein-Barr virus-positive B cell lines and AIDS-associated non-Hodgkin's lymphoma cell lines
    Daniel Widney
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, 90095 1747, USA
    Tumour Biol 24:82-93. 2003
    ..Overall, these results suggest a role for CD28 and its ligands, B7-1 and B7-2, in homotypic interactions in EBV+ B cell lines, which may mediate cellular activation and/or viability...
  10. pmc Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 90095 1782, USA
    Cancer Immunol Immunother 61:991-1003. 2012
    ..In summary, our results suggest that this IgE should be further explored as a potential therapeutic against HER2/neu overexpressing tumors, such as breast and ovarian cancers...
  11. pmc An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunother 34:500-8. 2011
    ..Our results suggest that ch128.1Av and ch128.1 may be effective in the therapy of human multiple myeloma and potentially other hematopoietic malignancies...
  12. pmc Animal models for IgE-meditated cancer immunotherapy
    Tracy R Daniels
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, CHS 54 140, Box 951782, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 61:1535-46. 2012
    ..This article describes the advantages and disadvantages of these models and their use in evaluating the in vivo properties of IgE antibodies for cancer therapy...
  13. pmc B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas
    Dharma R Thapa
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095 7365, USA
    AIDS 26:1177-80. 2012
    ....
  14. pmc HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma
    Marta Epeldegui
    Department of Microbiology, Immunology and Molecular Genetics, UCLA AIDS Institute, Los Angeles, CA, USA
    Immunol Res 48:72-83. 2010
    ..In this review, we discuss recent reports that further support the importance of these factors, and we highlight emerging evidence of different mechanisms that potentially drive lymphomagenesis in HIV-infected individuals...
  15. ncbi request reprint Pain-related activation of leukocyte cellular adhesion molecules: preliminary findings
    Charles A Griffis
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 1702, USA
    Neuroimmunomodulation 14:224-8. 2007
    ..This study examined the effects of acute experimental pain on catecholamine and cortisol levels and leukocyte expression of cellular adhesion molecules...
  16. pmc Relation of depression, natural killer cell function, and infections after coronary artery bypass in women
    Lynn V Doering
    UCLA School of Nursing, Los Angeles, CA 90095 6918, United States
    Eur J Cardiovasc Nurs 7:52-8. 2008
    ..Background: After hospital discharge for coronary artery bypass grafting (CABG), infection is a common cause of morbidity. Although depression has been associated with immune dysfunction, its role in post-CABG infection is unknown...
  17. pmc IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
    Milan Fiala
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
    J Neuroinflammation 7:76. 2010
    ..Immune modulation of chronic inflammation may be a new approach to sALS...
  18. pmc Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
    Tracy R Daniels-Wells
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Toxicol In Vitro 27:220-31. 2013
    ..1Av/b-SO6 is not toxic to normal human hematopoietic stem cells suggesting that this critical cell population would be preserved in therapeutic interventions using this immunotoxin...
  19. pmc Levels of Murine, but Not Human, CXCL13 Are Greatly Elevated in NOD-SCID Mice Bearing the AIDS-Associated Burkitt Lymphoma Cell Line, 2F7
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America UCLA AIDS Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e72414. 2013
    ..This mouse model may be useful for future studies on the interactions of the innate immune system and AIDS-BL tumor cells, as well as for the assessment of potential tumor biomarkers for this disease. ..
  20. doi request reprint The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs
    Mario I Vega
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095 1747, USA
    Leuk Lymphoma 49:1982-94. 2008
    ..These findings offer novel potential therapeutic applications in the reversal of rituximab/drug resistant AIDS-derived B-NHL...
  21. pmc Sleep loss activates cellular inflammatory signaling
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
    Biol Psychiatry 64:538-40. 2008
    ..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade...
  22. pmc Multisite comparison of high-sensitivity multiplex cytokine assays
    Elizabeth Crabb Breen
    UCLA Cousins Center for Psychoneuroimmunology, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7076, USA
    Clin Vaccine Immunol 18:1229-42. 2011
    ....
  23. ncbi request reprint Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:119-29. 2003
    ..009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma...
  24. ncbi request reprint Serum levels of soluble vascular cell adhesion molecule-1 are decreased in women receiving oral contraceptives compared with normally menstruating women: implications in atherosclerosis
    Irene Souter
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Fertil Steril 83:1480-8. 2005
    ..The secondary objective was to assess the association, if any, between inflammatory cytokines and expression of sVCAM-1...
  25. doi request reprint Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry
    Gustavo Helguera
    Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Immunol Methods 368:54-63. 2011
    ....

Research Grants29

  1. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  2. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..These studies should provide valuable insight on the role of immune dysfunction and/or loss of immunoregulatory control of EBV infection on the development of B cell NHL. ..
  3. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2007
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  4. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2009
    ..These studies should provide valuable insight on the role of immune dysfunction and/or loss of immunoregulatory control of EBV infection on the development of B cell NHL. ..
  5. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2009
    ..The accomplishment of these aims will provide valuable information on HIV-induced immune dysfunction and the development of ARL. ..
  6. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
    ....
  7. IMMUNE DYSFUNCTION AND AIDS-ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 1993
    ..Finally, the results of these studies may indicate if AZT therapy contributes directly to the development of AIDS-BCL...
  8. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2000
    ..The accomplishment of these specific aims will add valuable new information to our understanding of the molecular epidemiology of AIDS-lymphoma, as well as the role of immune dysfunction in the generation and growth of this cancer. ..
  9. IMMUNE DYSFUNCTION AND AIDS ASSOCIATED B CELL LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2001
    ....