S L Martin

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein
    Sandra L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 E 17th Ave, Aurora, CO 80045, USA
    J Mol Biol 348:549-61. 2005
  2. ncbi Spatial assembly and RNA binding stoichiometry of a LINE-1 protein essential for retrotransposition
    Solomon Basame
    Molecular Machines Laboratory, Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
    J Mol Biol 357:351-7. 2006
  3. ncbi Mammalian hibernation: a naturally reversible model for insulin resistance in man?
    Sandra L Martin
    University of Colorado School of Medicine, Department of Cell and Developmental Biology and Program in Molecular Biology, 12801 E 17th Ave Aurora, CO 80045, USA
    Diab Vasc Dis Res 5:76-81. 2008
  4. ncbi The structures of mouse and human L1 elements reflect their insertion mechanism
    S L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Denver, CO 80045, USA
    Cytogenet Genome Res 110:223-8. 2005
  5. ncbi Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine
    Sandra L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Physiol Regul Integr Comp Physiol 295:R316-28. 2008
  6. ncbi Trimeric structure for an essential protein in L1 retrotransposition
    Sandra L Martin
    Department of Cell and Developmental Biology and Program in Molecular Biology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:13815-20. 2003
  7. ncbi Survival strategies for transposons and genomes
    Sandra L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Box B111, 4200 E, Ninth Avenue, Denver, CO 80262, USA
    Genome Biol 4:313. 2003
  8. ncbi Mutation frequency and type during ageing in mouse seminiferous tubules
    S L Martin
    Department of Cellular and Structural Biology, B111, University of Colorado School of Medicine, 4200 E Ninth Ave, Denver, CO 80262, USA
    Mech Ageing Dev 122:1321-31. 2001
  9. ncbi Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Mol Cell Biol 21:467-75. 2001
  10. ncbi Deletion analysis defines distinct functional domains for protein-protein and nucleic acid interactions in the ORF1 protein of mouse LINE-1
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Mol Biol 304:11-20. 2000

Collaborators

Detail Information

Publications30

  1. ncbi LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein
    Sandra L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 E 17th Ave, Aurora, CO 80045, USA
    J Mol Biol 348:549-61. 2005
    ..These findings establish the importance of the nucleic acid chaperone activity of ORF1p to successful L1 retrotransposition, and provide insight into the essential properties of nucleic acid chaperones...
  2. ncbi Spatial assembly and RNA binding stoichiometry of a LINE-1 protein essential for retrotransposition
    Solomon Basame
    Molecular Machines Laboratory, Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
    J Mol Biol 357:351-7. 2006
    ..Furthermore, these in vitro L1 ribonucleoprotein particles provide insight into the structure of the L1 retrotransposition intermediate...
  3. ncbi Mammalian hibernation: a naturally reversible model for insulin resistance in man?
    Sandra L Martin
    University of Colorado School of Medicine, Department of Cell and Developmental Biology and Program in Molecular Biology, 12801 E 17th Ave Aurora, CO 80045, USA
    Diab Vasc Dis Res 5:76-81. 2008
    ....
  4. ncbi The structures of mouse and human L1 elements reflect their insertion mechanism
    S L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Denver, CO 80045, USA
    Cytogenet Genome Res 110:223-8. 2005
    ..5' truncation may be a successful evolutionary strategy that is exploited by L1 as a means to escape host suppression of transposition...
  5. ncbi Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine
    Sandra L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Physiol Regul Integr Comp Physiol 295:R316-28. 2008
    ..It also reveals the importance of enterocyte maturation in defining the hibernating gut proteome and the role of changing cell populations for the differences between sham and I/R-treated summer animals...
  6. ncbi Trimeric structure for an essential protein in L1 retrotransposition
    Sandra L Martin
    Department of Cell and Developmental Biology and Program in Molecular Biology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:13815-20. 2003
    ..These structural features are compatible with the nucleic acid binding and chaperone activities of L1 ORF1p and offer further insight into the functions of this unique protein during LINE-1 retrotransposition...
  7. ncbi Survival strategies for transposons and genomes
    Sandra L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Box B111, 4200 E, Ninth Avenue, Denver, CO 80262, USA
    Genome Biol 4:313. 2003
    ..A report on the Keystone Symposium "Transposition and other genome rearrangements", Santa Fe, USA, 8-14 February 2003...
  8. ncbi Mutation frequency and type during ageing in mouse seminiferous tubules
    S L Martin
    Department of Cellular and Structural Biology, B111, University of Colorado School of Medicine, 4200 E Ninth Ave, Denver, CO 80262, USA
    Mech Ageing Dev 122:1321-31. 2001
    ..73x10(-8). This is significantly less than the known frequency of approximately 7% of all spontaneous mutations in the mouse being due to retrotransposition of these elements...
  9. ncbi Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Mol Cell Biol 21:467-75. 2001
    ..These findings suggest a role for L1 ORF1p in mediating nucleic acid strand transfer steps during L1 reverse transcription...
  10. ncbi Deletion analysis defines distinct functional domains for protein-protein and nucleic acid interactions in the ORF1 protein of mouse LINE-1
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Mol Biol 304:11-20. 2000
    ..Separation of these activities into different domains of ORF1p will facilitate detailed biochemical analyses of the structure and function of this protein and understanding of its role during L1 retrotransposition...
  11. ncbi Reversible depression of oxygen consumption in isolated liver mitochondria during hibernation
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Physiol Biochem Zool 72:255-64. 1999
    ....
  12. ncbi Functional reverse transcriptases encoded by A-type mouse LINE-1: defining the minimal domain by deletion analysis
    S L Martin
    University of Colorado School of Medicine, Department of Cellular, Structural Biology, Program in Molecular Biology, 4200 E Ninth Avenue, Box B111, Denver, CO 80262, USA
    Gene 215:69-75. 1998
    ....
  13. ncbi Translational initiation is uncoupled from elongation at 18 degrees C during mammalian hibernation
    F van Breukelen
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, Colorado 80262-B111, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1374-9. 2001
    ..These data indicate a role for both passive and active depression of translation during torpor and are consistent with a requirement for new protein biosynthesis during each interbout arousal...
  14. ncbi Quantitative assessment of ground squirrel mRNA levels in multiple stages of hibernation
    L Elaine Epperson
    Program in Molecular Biology, Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Physiol Genomics 10:93-102. 2002
    ..None of the 12 mRNAs increased during torpor. The implications for these newly recognized upregulated mRNAs for hibernation as well as more global issues of maintaining steady-state levels of mRNA during torpor are discussed...
  15. ncbi Quantitative analysis of liver protein expression during hibernation in the golden-mantled ground squirrel
    L Elaine Epperson
    Program in Molecular Biology, Department of Cell and Developmental Biology, University of Colorado School of Medicine, P.O. Box 6511, Mail Stop 8108, Aurora, CO 80045, USA
    Mol Cell Proteomics 3:920-33. 2004
    ..Functional roles are proposed to explain the changes seen in protein levels and their potential influence on the phenotype of hibernation...
  16. ncbi Seasonal protein changes support rapid energy production in hibernator brainstem
    L Elaine Epperson
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, P O Box 6511, Mail Stop 8108, Aurora, CO 80045, USA
    J Comp Physiol B 180:599-617. 2010
    ....
  17. ncbi Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR
    Natalie J Serkova
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado 80238, USA
    Physiol Genomics 31:15-24. 2007
    ..The torpor-arousal switch is characterized by the accumulation of metabolites of nitrogen (glutamine) and phospholipid (betaine) catabolism in LT with the capacity to act as protective osmolytes...
  18. ncbi Seasonal proteomic changes reveal molecular adaptations to preserve and replenish liver proteins during ground squirrel hibernation
    L Elaine Epperson
    Dept of Cell and Developmental Biology, Univ of Colorado School of Medicine, PO Box 6511, MS 8108, Aurora, CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 298:R329-40. 2010
    ....
  19. ncbi High-affinity, non-sequence-specific RNA binding by the open reading frame 1 (ORF1) protein from long interspersed nuclear element 1 (LINE-1)
    Vladimir O Kolosha
    Department of Cellular and Structural Biology and Program in Molecular Biology, University of Colorado School of Medicine, Denver 80262, USA
    J Biol Chem 278:8112-7. 2003
    ..The results of both types of assay unambiguously support the conclusion that purified ORF1p from mouse L1 is a high-affinity, non-sequence-specific RNA binding protein...
  20. ncbi A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity
    Sandra L Martin
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Nucleic Acids Res 36:5845-54. 2008
    ....
  21. ncbi Reversible depression of transcription during hibernation
    F van Breukelen
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262-B111, USA
    J Comp Physiol [B] 172:355-61. 2002
    ..Restoration of euthermic body temperatures during the interbout arousals reverses this transcriptional depression and permits gene expression...
  22. ncbi Characterization of a LINE-1 cDNA that originated from RNA present in ribonucleoprotein particles: implications for the structure of an active mouse LINE-1
    S L Martin
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver 80262
    Gene 153:261-6. 1995
    ..The structure of this element suggests a revision of the predicted sequence of an active mouse L1 and provides a tag that can be used to isolate its locus in the genome...
  23. ncbi The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition
    Patrick Wai-Lun Li
    Cell and Developmental Biology, University of Colorado School of Medicine, 12801 E. 17th Avenue, Aurora, CO 80010, USA
    Nucleic Acids Res 34:853-64. 2006
    ..In addition, translational regulation may provide an additional layer of control on L1 retrotransposition efficiency, thereby protecting the integrity of the genome...
  24. ncbi Invited review: molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?
    Frank van Breukelen
    Department of Cellular and Structural Biology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Appl Physiol 92:2640-7. 2002
    ..These capabilities are likely due to novel regulation of biochemical pathways shared by all mammals, including humans...
  25. ncbi Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1
    Kurt Januszyk
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 282:24893-904. 2007
    ..A similar structure and mechanism of RNA binding is expected for all vertebrate long interspersed nuclear element-1 elements, since residues encoding the middle, protease-sensitive segment, and CTD are highly conserved...
  26. ncbi Seasonally hibernating phenotype assessed through transcript screening
    Daryl R Williams
    School of Biological Sciences, University of Liverpool, United Kingdom
    Physiol Genomics 24:13-22. 2005
    ....
  27. ncbi Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis
    Sarah F C Soper
    Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA
    Dev Cell 15:285-97. 2008
    ..This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of TEs and identifies the initiation of meiosis as an important step in TE control in the male germline...
  28. ncbi Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor
    Frank van Breukelen
    Department of Biological Sciences, University of Nevada, Las Vegas, Nevada 89154-4004, USA
    Am J Physiol Regul Integr Comp Physiol 287:R349-53. 2004
    ..The regulation of cap-dependent initiation of translation may allow for the differential expression of proteins directed toward enhancing survivorship...
  29. ncbi The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity
    Sara R Heras
    , , CSIC, Avda del Conocimiento s/n, 18100 Granada, Spain
    Mol Cell Biol 25:9209-20. 2005
    ..Thus, a short basic polypeptide containing the two C(2)H(2) motifs promotes formation of the most stable duplex DNA at a concentration only three times higher than that required for C2-L1Tc...
  30. ncbi Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature
    Hannah V Carey
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Physiol Rev 83:1153-81. 2003
    ....