KELSEY MARTIN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Local protein synthesis and its role in synapse-specific plasticity
    K C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Gonda Center, University of California, Los Angeles, 695 Charles Young Drive South, CA 90095 1761, USA
    Curr Opin Neurobiol 10:587-92. 2000
  2. pmc mRNA localization: gene expression in the spatial dimension
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 1737, USA
    Cell 136:719-30. 2009
  3. ncbi request reprint RNA trafficking and local protein synthesis in dendrites: an overview
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 1761, USA
    J Neurosci 26:7131-4. 2006
  4. pmc Anchoring local translation in neurons
    Kelsey C Martin
    Department of Biological Chemistry, University of California, Los Angeles, BSRB 390B, 615 Charles E Young Drive South, Los Angeles, CA 90095 1737, USA
    Cell 141:566-8. 2010
  5. ncbi request reprint Local protein synthesis during axon guidance and synaptic plasticity
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Curr Opin Neurobiol 14:305-10. 2004
  6. ncbi request reprint Synaptic tagging during synapse-specific long-term facilitation of Aplysia sensory-motor neurons
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Mental Retardation Research Center, University of Caliornia at Los Angeles, 90095 1761, USA
    Neurobiol Learn Mem 78:489-97. 2002
  7. ncbi request reprint Arc mRNA dynamics: return to sender--the NMDA receptor provides the targeting address for Arc mRNA
    K C Martin
    Dept of Psychiatry, UCLA Brain Research Institute, Gonda Building Rm 3506C, 695 Charles Young Dr Street, Los Angeles, CA 90095 1761, USA
    Trends Neurosci 24:621-3. 2001
  8. ncbi request reprint Synaptic tagging -- who's it?
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Nat Rev Neurosci 3:813-20. 2002
  9. ncbi request reprint Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitation
    Yali Zhao
    Department of Psychiatry and Biobehavioral Science, University of California at Los Angeles, Los Angeles, California 90095 1606, USA
    J Neurosci 26:8847-56. 2006
  10. ncbi request reprint An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs
    Robert Moccia
    Brain Research Institute Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 23:9409-17. 2003

Collaborators

  • Anne Ephrussi
  • E R Kandel
  • Kenneth S Kosik
  • Ashok N Hegde
  • S G N Grant
  • Wayne S Sossin
  • Daniel Geschwind
  • Yali Zhao
  • Kimberly R Thompson
  • Klara Olofsdotter Otis
  • Vlasta Lyles
  • Jary Y Delgado
  • Michael M Poon
  • THOMAS J O'DELL
  • Jake Ormond
  • Robert Moccia
  • Carrie L Heusner
  • Erin E Gray
  • Christopher N G Anderson
  • Marcelo Coba
  • Christina A M Jamieson
  • Karina Leal
  • Carole Abi-Farah
  • Sang Hyun Choi
  • Marc Klein
  • John R Dyer
  • Francois Vaillaincourt
  • Neil Webb
  • Phil Barker
  • Dillon Y Chen
  • Jonathan Hislop
  • Gino Ferraro
  • Dillon Chen
  • Joachim Frank
  • Sergey Kalachikov
  • Estreya Kapuya
  • Christian M T Spahn
  • Yaping E
  • Mark Barad

Detail Information

Publications19

  1. ncbi request reprint Local protein synthesis and its role in synapse-specific plasticity
    K C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Gonda Center, University of California, Los Angeles, 695 Charles Young Drive South, CA 90095 1761, USA
    Curr Opin Neurobiol 10:587-92. 2000
    ..The cellular and molecular mechanisms underlying RNA localization and regulated translation in neurons are just beginning to be delineated, and appear to be similar to those used in asymmetric non-neuronal cells...
  2. pmc mRNA localization: gene expression in the spatial dimension
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 1737, USA
    Cell 136:719-30. 2009
    ..In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell...
  3. ncbi request reprint RNA trafficking and local protein synthesis in dendrites: an overview
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 1761, USA
    J Neurosci 26:7131-4. 2006
    ....
  4. pmc Anchoring local translation in neurons
    Kelsey C Martin
    Department of Biological Chemistry, University of California, Los Angeles, BSRB 390B, 615 Charles E Young Drive South, Los Angeles, CA 90095 1737, USA
    Cell 141:566-8. 2010
    ..Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis...
  5. ncbi request reprint Local protein synthesis during axon guidance and synaptic plasticity
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Curr Opin Neurobiol 14:305-10. 2004
    ..Several powerful new tools have recently been developed to visualize each of these processes...
  6. ncbi request reprint Synaptic tagging during synapse-specific long-term facilitation of Aplysia sensory-motor neurons
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Mental Retardation Research Center, University of Caliornia at Los Angeles, 90095 1761, USA
    Neurobiol Learn Mem 78:489-97. 2002
    ..In this review, I describe our studies of synapse-specific, transcription-dependent facilitation of cultured Aplysia sensory-motor synapse in the context of the synaptic tagging hypothesis...
  7. ncbi request reprint Arc mRNA dynamics: return to sender--the NMDA receptor provides the targeting address for Arc mRNA
    K C Martin
    Dept of Psychiatry, UCLA Brain Research Institute, Gonda Building Rm 3506C, 695 Charles Young Dr Street, Los Angeles, CA 90095 1761, USA
    Trends Neurosci 24:621-3. 2001
    ..This specific localization has now been shown to depend on local signaling through the NMDA receptor...
  8. ncbi request reprint Synaptic tagging -- who's it?
    Kelsey C Martin
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Nat Rev Neurosci 3:813-20. 2002
  9. ncbi request reprint Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitation
    Yali Zhao
    Department of Psychiatry and Biobehavioral Science, University of California at Los Angeles, Los Angeles, California 90095 1606, USA
    J Neurosci 26:8847-56. 2006
    ....
  10. ncbi request reprint An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAs
    Robert Moccia
    Brain Research Institute Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 23:9409-17. 2003
    ..Our finding of mRNAs encoding components of the translational machinery suggests that local protein synthesis serves to increase the translational capacity of synapses...
  11. ncbi request reprint Synapse formation and mRNA localization in cultured Aplysia neurons
    Vlasta Lyles
    Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095, USA
    Neuron 49:349-56. 2006
    ..They further suggest that translation of a specific localized mRNA, encoding the neuropeptide sensorin, is required for synapse formation between sensory and motor neurons...
  12. ncbi request reprint The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengthening
    Yali Zhao
    Department of Physiological Sciences and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Curr Biol 13:887-98. 2003
    ....
  13. ncbi request reprint ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons
    Jake Ormond
    Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada
    Neuron 44:715-28. 2004
    ..Thus, transactivation of the receptor tyrosine kinase ApTrkl by serotonin is an essential step in the biochemical events leading to long-term facilitation in Aplysia...
  14. ncbi request reprint Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathway
    Kimberly R Thompson
    Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095, USA
    Neuron 44:997-1009. 2004
    ....
  15. ncbi request reprint Importin-mediated nuclear transport in neurons
    Klara Olofsdotter Otis
    University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
    Curr Opin Neurobiol 16:329-35. 2006
    ..In neurons, importins might serve an additional function by carrying signals from distal sites to the soma...
  16. ncbi request reprint Identification of process-localized mRNAs from cultured rodent hippocampal neurons
    Michael M Poon
    Interdepartmental Program in Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:13390-9. 2006
    ..These findings indicate that there is a rich repertoire of mRNAs whose translation can be locally regulated and support the emerging idea that local protein synthesis serves to boost the translational capacity of synapses...
  17. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
  18. ncbi request reprint To learn better, keep the HAT on
    Kelsey C Martin
    Department of Psychiatry and Beiobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles 90095, USA
    Neuron 42:879-81. 2004
    ..and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein (CBP) in long-term memory and plasticity...

Research Grants16

  1. Importin-mediated signaling from synapse to nucleus during neuronal plasticity
    Kelsey C Martin; Fiscal Year: 2010
    ....
  2. Importin-mediated signaling from synapse to nucleus during neuronal plasticity
    KELSEY MARTIN; Fiscal Year: 2007
    ....
  3. Developing RNA Interference for Gene Specific Silencing in Aplysia Neurons
    KELSEY MARTIN; Fiscal Year: 2007
    ..Such diseases include mental retardation, age-related memory loss, Alzheimer's disease, drug addiction as well as many neuropsychiatric diseases. ..
  4. Localized mRNAs in Synaptic Plasticity
    KELSEY MARTIN; Fiscal Year: 2006
    ..abstract_text> ..
  5. The Ubiquitin Proteasome Pathway & Synaptic Plasticity
    KELSEY MARTIN; Fiscal Year: 2005
    ..abstract_text> ..
  6. CDNA LIBRARIES PREPARED FROM PURE NEURONAL PROCESSES
    KELSEY MARTIN; Fiscal Year: 2001
    ..Develop methodologies to test the representation and localized accumulation of transcripts in unstimulated and stimulated neuronal processes. ..
  7. Localized mRNAs in Synaptic Plasticity
    Kelsey C Martin; Fiscal Year: 2010
    ..Such diseases include Fragile X Mental Retardation, Spinal Muscular Atrophy, and Alzheimer's disease, epilepsy, drug addiction and many neuropsychiatric disorders. ..