Research Topics
| KELSEY MARTINSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Local protein synthesis and its role in synapse-specific plasticityK C Martin
Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Gonda Center, University of California, Los Angeles, 695 Charles Young Drive South, CA 90095 1761, USA
Curr Opin Neurobiol 10:587-92. 2000..The cellular and molecular mechanisms underlying RNA localization and regulated translation in neurons are just beginning to be delineated, and appear to be similar to those used in asymmetric non-neuronal cells...
mRNA localization: gene expression in the spatial dimensionKelsey C Martin
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 1737, USA
Cell 136:719-30. 2009..In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell...- RNA trafficking and local protein synthesis in dendrites: an overviewKelsey C Martin
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 1761, USA
J Neurosci 26:7131-4. 2006.... - Anchoring local translation in neuronsKelsey C Martin
Department of Biological Chemistry, University of California, Los Angeles, BSRB 390B, 615 Charles E Young Drive South, Los Angeles, CA 90095 1737, USA
Cell 141:566-8. 2010..Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis... - Local protein synthesis during axon guidance and synaptic plasticityKelsey C Martin
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
Curr Opin Neurobiol 14:305-10. 2004..Several powerful new tools have recently been developed to visualize each of these processes... - Arc mRNA dynamics: return to sender--the NMDA receptor provides the targeting address for Arc mRNAK C Martin
Dept of Psychiatry, UCLA Brain Research Institute, Gonda Building Rm 3506C, 695 Charles Young Dr Street, Los Angeles, CA 90095 1761, USA
Trends Neurosci 24:621-3. 2001..This specific localization has now been shown to depend on local signaling through the NMDA receptor... - Synaptic tagging -- who's it?Kelsey C Martin
Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
Nat Rev Neurosci 3:813-20. 2002 - Synaptic tagging during synapse-specific long-term facilitation of Aplysia sensory-motor neuronsKelsey C Martin
Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Mental Retardation Research Center, University of Caliornia at Los Angeles, 90095 1761, USA
Neurobiol Learn Mem 78:489-97. 2002..In this review, I describe our studies of synapse-specific, transcription-dependent facilitation of cultured Aplysia sensory-motor synapse in the context of the synaptic tagging hypothesis... - An unbiased cDNA library prepared from isolated Aplysia sensory neuron processes is enriched for cytoskeletal and translational mRNAsRobert Moccia
Brain Research Institute Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
J Neurosci 23:9409-17. 2003..Our finding of mRNAs encoding components of the translational machinery suggests that local protein synthesis serves to increase the translational capacity of synapses... - Isoform specificity of PKC translocation in living Aplysia sensory neurons and a role for Ca2+-dependent PKC APL I in the induction of intermediate-term facilitationYali Zhao
Department of Psychiatry and Biobehavioral Science, University of California at Los Angeles, Los Angeles, California 90095-1606, USA
J Neurosci 26:8847-56. 2006.... - Synapse to nucleus signaling during long-term synaptic plasticity; a role for the classical active nuclear import pathwayKimberly R Thompson
Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095, USA
Neuron 44:997-1009. 2004.... - Synapse formation and mRNA localization in cultured Aplysia neuronsVlasta Lyles
Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095, USA
Neuron 49:349-56. 2006..They further suggest that translation of a specific localized mRNA, encoding the neuropeptide sensorin, is required for synapse formation between sensory and motor neurons... - ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neuronsJake Ormond
Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada
Neuron 44:715-28. 2004..Thus, transactivation of the receptor tyrosine kinase ApTrkl by serotonin is an essential step in the biochemical events leading to long-term facilitation in Aplysia... - The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengtheningYali Zhao
Department of Physiological Sciences and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Curr Biol 13:887-98. 2003.... - To learn better, keep the HAT onKelsey C Martin
Department of Psychiatry and Beiobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles 90095, USA
Neuron 42:879-81. 2004..and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein (CBP) in long-term memory and plasticity... - Identification of process-localized mRNAs from cultured rodent hippocampal neuronsMichael M Poon
Interdepartmental Program in Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 26:13390-9. 2006..These findings indicate that there is a rich repertoire of mRNAs whose translation can be locally regulated and support the emerging idea that local protein synthesis serves to boost the translational capacity of synapses... - NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840Jary Y Delgado
Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
J Neurosci 27:13210-21. 2007..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD... - Importin-mediated nuclear transport in neuronsKlara Olofsdotter Otis
University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, CA 90095-1761, USA
Curr Opin Neurobiol 16:329-35. 2006..In neurons, importins might serve an additional function by carrying signals from distal sites to the soma...
Research Grants
- Importin-mediated signaling from synapse to nucleus during neuronal plasticityKelsey C Martin; Fiscal Year: 2010....
- Importin-mediated signaling from synapse to nucleus during neuronal plasticityKELSEY MARTIN; Fiscal Year: 2007....
- Developing RNA Interference for Gene Specific Silencing in Aplysia NeuronsKELSEY MARTIN; Fiscal Year: 2007..Such diseases include mental retardation, age-related memory loss, Alzheimer's disease, drug addiction as well as many neuropsychiatric diseases. ..
- Localized mRNAs in Synaptic PlasticityKELSEY MARTIN; Fiscal Year: 2006..abstract_text> ..
- The Ubiquitin Proteasome Pathway & Synaptic PlasticityKELSEY MARTIN; Fiscal Year: 2005..abstract_text> ..
- CDNA LIBRARIES PREPARED FROM PURE NEURONAL PROCESSESKELSEY MARTIN; Fiscal Year: 2001..Develop methodologies to test the representation and localized accumulation of transcripts in unstimulated and stimulated neuronal processes. ..
- Localized mRNAs in Synaptic PlasticityKelsey C Martin; Fiscal Year: 2010..Such diseases include Fragile X Mental Retardation, Spinal Muscular Atrophy, and Alzheimer's disease, epilepsy, drug addiction and many neuropsychiatric disorders. ..