Research Topics
Species | James N MartinSummaryAffiliation: University of Mississippi Medical Center Country: USA Publications
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Detail Information
Publications
Standardized Mississippi Protocol treatment of 190 patients with HELLP syndrome: slowing disease progression and preventing new major maternal morbidityJames N Martin
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and the Biostatistics Center, University of Mississippi Medical Center, Jackson, MS 39216, USA
Hypertens Pregnancy 31:79-90. 2012..To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome...- Postpartum plasma exchange as adjunctive therapy for severe acute fatty liver of pregnancyJames N Martin
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
J Clin Apher 23:138-43. 2008..Further study appears to be indicated to validate a role for PPEX as supportive therapy for puerperal patients with AFLP suffering multiorgan failure... - HELLP syndrome with and without eclampsiaSharon D Keiser
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
Am J Perinatol 28:187-94. 2011..In our experience, eclampsia does not appear to contribute a significant adverse impact upon the course or outcome of HELLP syndrome pregnancies... 
IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancyPushpinder Dhillion
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, Jackson, Mississippi, USA
Am J Physiol Regul Integr Comp Physiol 303:R353-8. 2012..These data indicate that IL-17 causes placental oxidative stress, which serves as stimulus modulating AT1-AAs that may play an important role in mediating IL-17-induced hypertension during pregnancy...- Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic ratsSarah Richards Novotny
Department of Obstetricsand Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Am J Physiol Regul Integr Comp Physiol 302:R1197-201. 2012..Therefore, we conclude that one mechanism of hypertension in response to CD4(+) T lymphocytes activated during placental ischemia is via AT1 receptor activation, potentially via AT1-AA during pregnancy... - Effects of 17-hydroxyprogesterone on tumor necrosis factor-alpha-induced hypertension during pregnancySharon D Keiser
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
Am J Hypertens 22:1120-5. 2009..We examined the effect of 17-hydroxyprogesterone caproate (17-OHP) on TNF-alpha-stimulated endothelin (ET) production and hypertension during pregnancy... - Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 systemKedra Wallace
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
Am J Physiol Regul Integr Comp Physiol 303:R144-9. 2012..These data indicate the importance of endothelin-1 activation to cause hypertension via chronic exposure to activated CD4(+) T cells in response to placental ischemia... - Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertensionMarc R Parrish
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA
Am J Hypertens 24:835-40. 2011..The objective of this study was to determine the role of AT1-AA to stimulate placental oxidative stress in vivo and role ROS in mediating hypertension in response to AT1-AA during pregnancy... - Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistanceKiran B Tam Tam
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Am J Obstet Gynecol 204:330.e1-4. 2011.... 
Obstetric implications of antepartum corticosteroid therapy for HELLP syndromeCarl H Rose
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Obstet Gynecol 104:1011-4. 2004..We reviewed the impact of intravenous high-dose corticosteroid administration for preterm hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome on vaginal delivery rate and degree of clinically significant thrombocytopenia...- Hypertension in response to placental ischemia during pregnancy: role of B lymphocytesBabbette LaMarca
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
Hypertension 57:865-71. 2011..These data demonstrate the important roles that B-lymphocyte activation and agonistic autoantibodies to the angiotensin II type I receptors play in the pathophysiology of hypertension in response to placental ischemia... - The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancyMarc R Parrish
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
Am J Hypertens 23:911-6. 2010..Recent studies have also demonstrated that an imbalance of angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1), and sEndoglin, exists in preeclampsia; however, the mechanisms that initiate their overproduction are unclear... - Thrombotic thrombocytopenic purpura in 166 pregnancies: 1955-2006James N Martin
Department of Obstetrics and Gynecology, Divisions of Maternal Fetal Medicine and Women s Health, University of Mississippi Medical Center, Jackson, MS, USA
Am J Obstet Gynecol 199:98-104. 2008..Rapid and readily available laboratory testing to quickly diagnose TTP and HELLP syndrome/preeclampsia is desperately needed to improve care... - Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressureJames N Martin
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Obstet Gynecol 105:246-54. 2005..To identify important clinical correlates of stroke in patients with preeclampsia and eclampsia... - Thrombotic thrombocytopenic purpura masquerading as hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in late pregnancyJonathan F Rehberg
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA
Obstet Gynecol 108:817-20. 2006..Lack of response to dexamethasone within 12-24 hours and atypical relationships among laboratory values are two clues that thrombotic thrombocytopenic purpura may be the underlying pathology and that plasma exchange is emergently needed... - CD4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancyKedra Wallace
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
Hypertension 57:949-55. 2011..These data support the hypothesis that RUPP-induced CD4(+) T cells play an important role in the pathophysiology of hypertension in response to placental ischemia... - A high LDH to AST ratio helps to differentiate pregnancy-associated thrombotic thrombocytopenic purpura (TTP) from HELLP syndromeSharon D Keiser
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
J Matern Fetal Neonatal Med 25:1059-63. 2012..We review our institutional experience with pregnancy-associated TTP and determine if the ratio of LDH to AST reliably distinguishes patients with TTP from those with HELLP syndrome... - Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1Babbette LaMarca
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Hypertension 54:905-9. 2009..Collectively, these data support the hypothesis that one potential pathway whereby AT1-AAs increase blood pressure during pregnancy is by an ET-1-dependent mechanism... - Septic pelvic thrombophlebitis and preeclampsia are related disordersChristy M Isler
Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA
Hypertens Pregnancy 23:121-7. 2004..To elicit factors associated with the postpartum development of septic pelvic thrombophlebitis in a single large referral tertiary patient population... - Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant ratsKiran B Tam Tam
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
Am J Hypertens 24:110-3. 2011..Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat... - Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunctionMarc R Parrish
Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Gend Med 8:184-8. 2011..AT1-AA induced hypertension was attenuated by the AT1 receptor and/or endothelin-1 type A receptor antagonists... - Impedance cardiography facilitates differentiation of severe and superimposed preeclampsia from other hypertensive disordersMarc R Parrish
Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Hypertens Pregnancy 31:327-40. 2012..To determine if hemodynamic profiling using noninvasive impedance cardiography (ICG) reliably identifies the patient with severe (SPRE) or superimposed (SuPRE) preeclampsia... - Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and childJames N Martin
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA
Am J Obstet Gynecol 195:914-34. 2006.... - Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsiaMarc Parrish
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
J Matern Fetal Neonatal Med 23:1451-5. 2010.... - Postpartum preeclampsia management with furosemide: a randomized clinical trialMarian H Ascarelli
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
Obstet Gynecol 105:29-33. 2005..Shortening of hospitalization and reduction of delayed postpartum complications were not benefitted... - Postpartum intravenous dexamethasone for severely preeclamptic patients without hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome: a randomized trialP Scott Barrilleaux
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA
Obstet Gynecol 105:843-8. 2005..CONCLUSION: Adjunctive use of intravenous dexamethasone for postpartum patients with severe preeclampsia does not reduce disease severity or duration. LEVEL OF EVIDENCE: I... - Lymphocytic myocarditis presenting as nausea, vomiting, and hepatic dysfunction in the first trimester of pregnancyRobert Clifton Moore
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA
Obstet Gynecol 108:815-7. 2006..Intrinsic cardiac disease with secondary hepatic compromise is a rare cause of gastrointestinal symptomatology early in pregnancy... - Maternal benefit of high-dose intravenous corticosteroid therapy for HELLP syndromeJames N Martin
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
Am J Obstet Gynecol 189:830-4. 2003..001). CONCLUSION: Routine early initiation of high-dose intravenous corticosteroids for patients with HELLP syndrome significantly lessened maternal disease, reduced maternal morbidity, and expedited recovery... - 17-Hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant ratsEdward W Veillon
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
Am J Obstet Gynecol 201:324.e1-6. 2009.... - The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndromeChristy M Isler
Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina 27858 4354, USA
Hypertens Pregnancy 22:287-94. 2003..To determine if the rate of major morbidity from severe preeclampsia with/without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome differs by parity...