James N Martin

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Standardized Mississippi Protocol treatment of 190 patients with HELLP syndrome: slowing disease progression and preventing new major maternal morbidity
    James N Martin
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and the Biostatistics Center, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertens Pregnancy 31:79-90. 2012
  2. ncbi request reprint Postpartum plasma exchange as adjunctive therapy for severe acute fatty liver of pregnancy
    James N Martin
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Clin Apher 23:138-43. 2008
  3. doi request reprint HELLP syndrome with and without eclampsia
    Sharon D Keiser
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Am J Perinatol 28:187-94. 2011
  4. pmc IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy
    Pushpinder Dhillion
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, Jackson, Mississippi, USA
    Am J Physiol Regul Integr Comp Physiol 303:R353-8. 2012
  5. pmc Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy
    Justin Brewer
    Department of Pharmacology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216
    Hypertension 62:886-92. 2013
  6. pmc Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats
    Sarah Richards Novotny
    Department of Obstetricsand Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1197-201. 2012
  7. pmc Effects of 17-hydroxyprogesterone on tumor necrosis factor-alpha-induced hypertension during pregnancy
    Sharon D Keiser
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 22:1120-5. 2009
  8. pmc Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 system
    Kedra Wallace
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 303:R144-9. 2012
  9. doi request reprint Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension
    Marc R Parrish
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 24:835-40. 2011
  10. doi request reprint Seeking the mechanism(s) of action for corticosteroids in HELLP syndrome: SMASH study
    Kedra Wallace
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Obstet Gynecol 208:380.e1-8. 2013

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Standardized Mississippi Protocol treatment of 190 patients with HELLP syndrome: slowing disease progression and preventing new major maternal morbidity
    James N Martin
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and the Biostatistics Center, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertens Pregnancy 31:79-90. 2012
    ..To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome...
  2. ncbi request reprint Postpartum plasma exchange as adjunctive therapy for severe acute fatty liver of pregnancy
    James N Martin
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    J Clin Apher 23:138-43. 2008
    ..Further study appears to be indicated to validate a role for PPEX as supportive therapy for puerperal patients with AFLP suffering multiorgan failure...
  3. doi request reprint HELLP syndrome with and without eclampsia
    Sharon D Keiser
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Am J Perinatol 28:187-94. 2011
    ..In our experience, eclampsia does not appear to contribute a significant adverse impact upon the course or outcome of HELLP syndrome pregnancies...
  4. pmc IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy
    Pushpinder Dhillion
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, Jackson, Mississippi, USA
    Am J Physiol Regul Integr Comp Physiol 303:R353-8. 2012
    ..These data indicate that IL-17 causes placental oxidative stress, which serves as stimulus modulating AT1-AAs that may play an important role in mediating IL-17-induced hypertension during pregnancy...
  5. pmc Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy
    Justin Brewer
    Department of Pharmacology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216
    Hypertension 62:886-92. 2013
    ....
  6. pmc Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats
    Sarah Richards Novotny
    Department of Obstetricsand Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1197-201. 2012
    ..Therefore, we conclude that one mechanism of hypertension in response to CD4(+) T lymphocytes activated during placental ischemia is via AT1 receptor activation, potentially via AT1-AA during pregnancy...
  7. pmc Effects of 17-hydroxyprogesterone on tumor necrosis factor-alpha-induced hypertension during pregnancy
    Sharon D Keiser
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 22:1120-5. 2009
    ..We examined the effect of 17-hydroxyprogesterone caproate (17-OHP) on TNF-alpha-stimulated endothelin (ET) production and hypertension during pregnancy...
  8. pmc Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 system
    Kedra Wallace
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 303:R144-9. 2012
    ..These data indicate the importance of endothelin-1 activation to cause hypertension via chronic exposure to activated CD4(+) T cells in response to placental ischemia...
  9. doi request reprint Hypertension in response to AT1-AA: role of reactive oxygen species in pregnancy-induced hypertension
    Marc R Parrish
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 24:835-40. 2011
    ..The objective of this study was to determine the role of AT1-AA to stimulate placental oxidative stress in vivo and role ROS in mediating hypertension in response to AT1-AA during pregnancy...
  10. doi request reprint Seeking the mechanism(s) of action for corticosteroids in HELLP syndrome: SMASH study
    Kedra Wallace
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Obstet Gynecol 208:380.e1-8. 2013
    ..However, the pathophysiological mechanisms involved with this intervention remain unclear...
  11. pmc Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes
    Babbette LaMarca
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 57:865-71. 2011
    ..These data demonstrate the important roles that B-lymphocyte activation and agonistic autoantibodies to the angiotensin II type I receptors play in the pathophysiology of hypertension in response to placental ischemia...
  12. pmc Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance
    Kiran B Tam Tam
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Obstet Gynecol 204:330.e1-4. 2011
    ....
  13. ncbi request reprint Obstetric implications of antepartum corticosteroid therapy for HELLP syndrome
    Carl H Rose
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Obstet Gynecol 104:1011-4. 2004
    ..We reviewed the impact of intravenous high-dose corticosteroid administration for preterm hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome on vaginal delivery rate and degree of clinically significant thrombocytopenia...
  14. doi request reprint Maternal hemodynamics by thoracic impedance cardiography for normal pregnancy and the postpartum period
    Rachael Morris
    Divisions of Maternal Fetal Medicine and Biostatistics, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi The Division of Maternal Fetal Medicine in the Department of OBGYN at the University of Mississippi Medical Center funded this study
    Obstet Gynecol 123:318-24. 2014
    ..To establish normative impedance cardiography values for the second half of pregnancy and up to 48 hours postpartum after either vaginal or cesarean delivery...
  15. pmc The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy
    Marc R Parrish
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
    Am J Hypertens 23:911-6. 2010
    ..Recent studies have also demonstrated that an imbalance of angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1), and sEndoglin, exists in preeclampsia; however, the mechanisms that initiate their overproduction are unclear...
  16. ncbi request reprint Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure
    James N Martin
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Obstet Gynecol 105:246-54. 2005
    ..To identify important clinical correlates of stroke in patients with preeclampsia and eclampsia...
  17. ncbi request reprint Thrombotic thrombocytopenic purpura in 166 pregnancies: 1955-2006
    James N Martin
    Department of Obstetrics and Gynecology, Divisions of Maternal Fetal Medicine and Women s Health, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Obstet Gynecol 199:98-104. 2008
    ..Rapid and readily available laboratory testing to quickly diagnose TTP and HELLP syndrome/preeclampsia is desperately needed to improve care...
  18. ncbi request reprint Postpartum thrombotic microangiopathic syndrome
    Michelle Y Owens
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, United States
    Transfus Apher Sci 48:51-7. 2013
    ..RETROSPECTIVE STUDY DESIGN: Patients who underwent postpartum plasma-exchange (PPEX) for preeclampsia-related, and microangiopathy/coagulopathy illnesses unresponsive to medical therapy between 1994 and 2008 in our center and elsewhere...
  19. doi request reprint Hellp syndrome and composite major maternal morbidity: importance of Mississippi classification system
    James N Martin
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Matern Fetal Neonatal Med 26:1201-6. 2013
    ..We explored the prevalence of Composite Major Maternal Morbidity (CMMM) for patients with severe preeclampsia (SPRE) and each class or category of HELLP syndrome...
  20. ncbi request reprint Thrombotic thrombocytopenic purpura masquerading as hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in late pregnancy
    Jonathan F Rehberg
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Obstet Gynecol 108:817-20. 2006
    ..This report describes the clinical course of a patient considered to have hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome but later determined to have thrombotic thrombocytopenic purpura...
  21. pmc CD4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancy
    Kedra Wallace
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 57:949-55. 2011
    ..These data support the hypothesis that RUPP-induced CD4(+) T cells play an important role in the pathophysiology of hypertension in response to placental ischemia...
  22. ncbi request reprint Using case reports to determine when liver bleeding occurs during disease progression in HELLP syndrome
    Marie Darby
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA Electronic address
    Int J Gynaecol Obstet 123:7-9. 2013
    ..Hepatic hemorrhage occurs in less than 5% of patients with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome but it is a profound cause of maternal/perinatal morbidity and mortality...
  23. ncbi request reprint Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia
    Justin Brewer
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Obstet Gynecol 208:468.e1-6. 2013
    ..We sought to investigate the concurrence of posterior reversible encephalopathy syndrome (PRES) with eclampsia and to describe the obstetric, radiological, and critical care correlates...
  24. doi request reprint A high LDH to AST ratio helps to differentiate pregnancy-associated thrombotic thrombocytopenic purpura (TTP) from HELLP syndrome
    Sharon D Keiser
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    J Matern Fetal Neonatal Med 25:1059-63. 2012
    ..We review our institutional experience with pregnancy-associated TTP and determine if the ratio of LDH to AST reliably distinguishes patients with TTP from those with HELLP syndrome...
  25. ncbi request reprint Septic pelvic thrombophlebitis and preeclampsia are related disorders
    Christy M Isler
    Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA
    Hypertens Pregnancy 23:121-7. 2004
    ..To elicit factors associated with the postpartum development of septic pelvic thrombophlebitis in a single large referral tertiary patient population...
  26. pmc Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1
    Babbette LaMarca
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Hypertension 54:905-9. 2009
    ..Collectively, these data support the hypothesis that one potential pathway whereby AT1-AAs increase blood pressure during pregnancy is by an ET-1-dependent mechanism...
  27. pmc Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunction
    Marc R Parrish
    Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Gend Med 8:184-8. 2011
    ..AT1-AA induced hypertension was attenuated by the AT1 receptor and/or endothelin-1 type A receptor antagonists...
  28. pmc Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats
    Kiran B Tam Tam
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
    Am J Hypertens 24:110-3. 2011
    ..Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat...
  29. ncbi request reprint Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy
    Lorena M Amaral
    Department of Pharmacology, University of Mississippi Medical Center, Jackson, MS
    Am J Obstet Gynecol 211:158.e1-6. 2014
    ..Hypertension in response to elevated interleukin (IL)-6 during pregnancy occurs with increased renin activity and AT1-AA, and reduced kidney function...
  30. ncbi request reprint Impedance cardiography facilitates differentiation of severe and superimposed preeclampsia from other hypertensive disorders
    Marc R Parrish
    Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertens Pregnancy 31:327-40. 2012
    ..To determine if hemodynamic profiling using noninvasive impedance cardiography (ICG) reliably identifies the patient with severe (SPRE) or superimposed (SuPRE) preeclampsia...
  31. ncbi request reprint Postpartum preeclampsia management with furosemide: a randomized clinical trial
    Marian H Ascarelli
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Obstet Gynecol 105:29-33. 2005
    ....
  32. ncbi request reprint Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child
    James N Martin
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Obstet Gynecol 195:914-34. 2006
    ....
  33. ncbi request reprint Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia
    Marc Parrish
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    J Matern Fetal Neonatal Med 23:1451-5. 2010
    ....
  34. ncbi request reprint Lymphocytic myocarditis presenting as nausea, vomiting, and hepatic dysfunction in the first trimester of pregnancy
    Robert Clifton Moore
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Obstet Gynecol 108:815-7. 2006
    ..Lymphocytic myocarditis, an immune disorder of left ventricular dysfunction with sometimes confounding clinical presentations, occurs rarely during pregnancy...
  35. ncbi request reprint Postpartum intravenous dexamethasone for severely preeclamptic patients without hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome: a randomized trial
    P Scott Barrilleaux
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Obstet Gynecol 105:843-8. 2005
    ..We compared maternal outcomes for patients with severe preeclampsia who were managed postpartum with or without adjunctive intravenous dexamethasone...
  36. ncbi request reprint Maternal benefit of high-dose intravenous corticosteroid therapy for HELLP syndrome
    James N Martin
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
    Am J Obstet Gynecol 189:830-4. 2003
    ..We compared maternal outcomes for patients with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome treated with or without high-dose corticosteroids to ameliorate maternal disease...
  37. pmc 17-Hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats
    Edward W Veillon
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Obstet Gynecol 201:324.e1-6. 2009
    ....
  38. ncbi request reprint The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome
    Christy M Isler
    Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina 27858 4354, USA
    Hypertens Pregnancy 22:287-94. 2003
    ..To determine if the rate of major morbidity from severe preeclampsia with/without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome differs by parity...