J N Martin

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcoma
    J N Martin
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Adv Dent Res 23:76-8. 2011
  2. pmc Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009
    Elvin H Geng
    Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA, USA
    J Int AIDS Soc 14:46. 2011
  3. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
  4. ncbi request reprint A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease
    J N Martin
    Center for AIDS Prevention Studies, AIDS Research Institute, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    J Infect Dis 180:896-9. 1999
  5. pmc Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies
    J N Martin
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94105, USA
    J Clin Microbiol 38:696-701. 2000
  6. ncbi request reprint Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era
    J N Martin
    Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    J Infect Dis 180:1809-18. 1999
  7. ncbi request reprint Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk
    J N Martin
    Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
    Curr Opin Oncol 11:508-15. 1999
  8. ncbi request reprint Feasibility of postexposure prophylaxis (PEP) against human immunodeficiency virus infection after sexual or injection drug use exposure: the San Francisco PEP Study
    J O Kahn
    Positive Health Program, Dept of Medicine, University of California San Francisco, at San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 183:707-14. 2001
  9. ncbi request reprint Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    AIDS 18:981-9. 2004
  10. pmc Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    Brinda Emu
    Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
    J Virol 79:14169-78. 2005

Detail Information

Publications84

  1. doi request reprint Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcoma
    J N Martin
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Adv Dent Res 23:76-8. 2011
    ..KSHV has special importance to the dental profession because saliva is the body fluid that harbors it most commonly, although exactly in which ways saliva spreads the virus are not known...
  2. pmc Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009
    Elvin H Geng
    Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA, USA
    J Int AIDS Soc 14:46. 2011
    ..Regionally representative socio-demographic, laboratory and clinical characteristics of patients accessing ART over time and across sites have not been well described...
  3. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
    ..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...
  4. ncbi request reprint A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease
    J N Martin
    Center for AIDS Prevention Studies, AIDS Research Institute, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    J Infect Dis 180:896-9. 1999
    ..Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication...
  5. pmc Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies
    J N Martin
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94105, USA
    J Clin Microbiol 38:696-701. 2000
    ....
  6. ncbi request reprint Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era
    J N Martin
    Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    J Infect Dis 180:1809-18. 1999
    ..A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance...
  7. ncbi request reprint Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk
    J N Martin
    Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
    Curr Opin Oncol 11:508-15. 1999
    ..Spread via renal allograft appears to occur, and in endemic areas of Europe and Africa, nonsexual horizontal and perhaps vertical spread are the dominant modes of transmission...
  8. ncbi request reprint Feasibility of postexposure prophylaxis (PEP) against human immunodeficiency virus infection after sexual or injection drug use exposure: the San Francisco PEP Study
    J O Kahn
    Positive Health Program, Dept of Medicine, University of California San Francisco, at San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 183:707-14. 2001
    ..PEP, after nonoccupational HIV exposure, is feasible for persons at risk for HIV infection...
  9. ncbi request reprint Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    AIDS 18:981-9. 2004
    ..The interaction of these factors is not well understood, particularly in the setting of antiretroviral therapy...
  10. pmc Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    Brinda Emu
    Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
    J Virol 79:14169-78. 2005
    ....
  11. pmc Decline in HIV infectivity following the introduction of highly active antiretroviral therapy
    Travis C Porco
    San Francisco Department of Public Health, Community Health and Epidemiology Section, San Francisco, CA, USA
    AIDS 18:81-8. 2004
    ..We estimated the degree to which the probability of HIV infection from an infected partner (the infectivity) declined following the introduction of highly active antiretroviral therapy (HAART) in San Francisco...
  12. pmc HIV-induced changes in T cell signaling pathways
    Marc Schweneker
    Division of Experimental Medicine, University of California, San Francisco, CA 94110, USA
    J Immunol 180:6490-500. 2008
    ....
  13. ncbi request reprint Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 17:1907-15. 2003
    ..To determine the extent to which HIV-infected patients, including those with advanced immunodeficiency, can reverse peripheral CD4 T-cell depletion while maintaining long-term viral suppression on highly active antiretroviral therapy...
  14. pmc Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California, USA
    J Virol 76:11104-12. 2002
    ....
  15. pmc History-adjusted marginal structural models for estimating time-varying effect modification
    Maya L Petersen
    Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA
    Am J Epidemiol 166:985-93. 2007
    ....
  16. ncbi request reprint Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy
    Barbara Schmidt
    Division Hematology Oncology, Department of Medicine, University of California, San Francisco, California 94143 1270, USA
    J Clin Immunol 26:55-64. 2006
    ..Circulating plasmacytoid dendritic cells may provide important additional information about immune function in HIV-infected subjects receiving or not receiving antiretroviral therapy...
  17. ncbi request reprint Continued evolution in gp41 after interruption of enfuvirtide in subjects with advanced HIV type 1 disease
    Christina M R Kitchen
    Department of Biostatistics, University of California, Los Angeles, Los Angeles, California 90095, Section of Retroviral Therapeutics, Brigham and Women s Hospital, Boston, MA 02115, USA
    AIDS Res Hum Retroviruses 22:1260-6. 2006
    ..In contrast to observations when all drugs are interrupted, loss of resistance during enfuvirtide interruption is most likely due to ongoing viral evolution (and back-mutation), rather than emergence of an archived virus...
  18. pmc Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease
    David M Naeger
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8886. 2010
    ..The impact of untreated and treated HIV infection on the frequency of these cells remains undefined...
  19. ncbi request reprint Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection
    S G Deeks
    University of California, San Francisco, AIDS Program, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 181:946-53. 2000
    ..These observations suggest that transient or partial declines in plasma HIV RNA levels can have sustained effects on CD4+ T cell levels...
  20. pmc Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
    Priscilla Y Hsue
    Division of Cardiology, San Francisco General Hospital, San Francisco, California 94110, USA
    AIDS 23:1059-67. 2009
    ....
  21. doi request reprint Use of saliva as a lubricant in anal sexual practices among homosexual men
    Lisa M Butler
    From the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    J Acquir Immune Defic Syndr 50:162-7. 2009
    ..Because one common element between these organisms is their presence in saliva, we evaluated saliva exposure among MSM in a heretofore relatively unrecognized route-via use of saliva as a lubricant in anal sex...
  22. pmc Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    Hiroyu Hatano
    San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 83:329-35. 2009
    ..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
  23. pmc HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control
    Brinda Emu
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    J Virol 82:5398-407. 2008
    ..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication...
  24. pmc Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 197:126-33. 2008
    ....
  25. pmc Comparison of an interferon-gamma release assay with tuberculin skin testing in HIV-infected individuals
    Annie F Luetkemeyer
    HIV AIDS Division, San Francisco General Hospital, University of California at San Fracisco, San Francisco, Box 0874, Building 80, 995 Potrero Avenue, San Francisco, CA 94110, USA
    Am J Respir Crit Care Med 175:737-42. 2007
    ..Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection...
  26. pmc Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension
    Priscilla Y Hsue
    Divisions of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
    AIDS 22:825-33. 2008
    ....
  27. pmc Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients
    Mark A Jacobson
    Positive Health Program, Department of Medicine, University of California San Francisco and The Medical Service, San Francisco General Hospital, San Francisco, CA, USA
    PLoS ONE 4:e5277. 2009
    ....
  28. doi request reprint Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission
    Lisa M Butler
    University of California, San Francisco, 50 Beale St, Suite 120, San Francisco, California 94105, USA
    J Infect Dis 200:430-8. 2009
    ..However, few studies have directly examined children, particularly in locations where KS is not commonly endemic...
  29. pmc Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients
    Priscilla Y Hsue
    Division of Cardiology, Positive Health Program of the Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    AIDS 23:2021-7. 2009
    ..As endothelial dysfunction is central to the pathogenesis of atherosclerosis, we tested the hypothesis that current treatment with abacavir is associated with impaired endothelial function...
  30. pmc HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses
    April L Ferre
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, 3327 Tupper Hall, 1 Shields Ave, Davis, CA 95616, USA
    J Virol 84:11020-9. 2010
    ..43, P=0.005), suggesting that increased CD4+ T-cell "help" may be important in maintaining strong CD8+ T-cell responses in the gut of HIV controllers...
  31. pmc Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda
    Judith A Hahn
    University of California, San Francisco, CA 94143 0811, USA
    AIDS Behav 14:1265-8. 2010
    ..These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes...
  32. pmc Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers
    April L Ferre
    Dept of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
    J Virol 84:10354-65. 2010
    ....
  33. pmc Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals
    Hiroyu Hatano
    Department of Medicine, University of California, San Francisco, California, USA
    AIDS 24:2535-9. 2010
    ..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear...
  34. pmc Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    David Favre
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Sci Transl Med 2:32ra36. 2010
    ..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease...
  35. pmc Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy
    Hiroyu Hatano
    University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 54:389-93. 2010
    ..Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined...
  36. pmc Impact of HIV infection on diastolic function and left ventricular mass
    Priscilla Y Hsue
    Division of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
    Circ Heart Fail 3:132-9. 2010
    ..After adjustment for age and traditional risk factors, patients with HIV had a 2.4 greater odds of having diastolic dysfunction as compared with controls (P=0.019)...
  37. pmc Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in Africa
    Elvin H Geng
    Division of HIV AIDS, Department of Medicine, San Francisco General Hospital, San Francisco, CA, USA
    Trop Med Int Health 15:63-9. 2010
    ..Losses to follow-up, however, are high in these settings and may lead to bias in understanding the determinants of mortality...
  38. pmc Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America
    Steven G Deeks
    University of California San Francisco, San Francisco, San Diego, CA 94110, USA
    Clin Infect Dis 49:1582-90. 2009
    ....
  39. pmc Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach
    Elvin H Geng
    Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, Building 80, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 53:405-11. 2010
    ..We sought to characterize, through a sampling-based approach, reasons for and outcomes of patients who become lost to follow-up...
  40. pmc HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy
    Andy I Choi
    Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    AIDS 23:2143-9. 2009
    ..To identify risk factors associated with kidney function decline in a contemporary cohort of treated and untreated HIV-infected patients...
  41. pmc Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses
    Keith E Garrison
    Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA
    Clin Vaccine Immunol 16:1369-71. 2009
    ..T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects...
  42. pmc Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions
    Elvin H Geng
    Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
    Curr HIV/AIDS Rep 7:234-44. 2010
    ..Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework...
  43. ncbi request reprint Interruption of enfuvirtide in HIV-1 infected adults with incomplete viral suppression on an enfuvirtide-based regimen
    Steven G Deeks
    University of California, San Francisco, San Francisco, CA 94110, USA
    J Infect Dis 195:387-91. 2007
    ..Although enfuvirtide resistance mutations are associated with significant fitness defects in vivo, the clinical significance of these mutations remains undefined...
  44. pmc Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses
    Steven G Deeks
    Department of Medicine, University of California at San Francisco, San Francisco General Hospital, CA 94110, USA
    J Virol 80:6155-64. 2006
    ..These observations also suggest that the neutralizing antibody response may contribute to the long-term control of HIV in some patients while protecting against HIV superinfection in most patients...
  45. ncbi request reprint The independent effect of drug resistance on T cell activation in HIV infection
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    AIDS 20:691-9. 2006
    ....
  46. ncbi request reprint High-risk sexual behavior in adults with genotypically proven antiretroviral-resistant HIV infection
    Peter V Chin-Hong
    Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 40:463-71. 2005
    ..Although there is an increasing emphasis on understanding high-risk behavior among HIV-infected patients, little work has focused on those with drug-resistant virus...
  47. ncbi request reprint Seroconversion following nonoccupational postexposure prophylaxis against HIV
    Michelle E Roland
    Positive Health Program at San Francisco General Hospital, California, USA
    Clin Infect Dis 41:1507-13. 2005
    ..We sought to describe the occurrence and circumstances of HIV seroconversion following nonoccupational PEP...
  48. ncbi request reprint T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Infect Dis 187:1534-43. 2003
    ..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy...
  49. ncbi request reprint Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    Steven G Deeks
    University of California, San Francisco, and San Francisco General Hospital, San Francisco 94110, USA
    J Infect Dis 192:1537-44. 2005
    ..We hypothesized that the use of simplified regimens could maintain treatment benefit while preventing viral evolution and reducing drug-related toxicity and costs...
  50. pmc Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 77:6743-52. 2003
    ..Our results indicate that both HIV type 1-specific CD8(+) T cells and antiretroviral drugs provide complex pressures on the same amino acid sequence of the HIV protease gene and, thus, can influence viral sequence evolution...
  51. ncbi request reprint Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California San Francisco, P O Box 419100, San Francisco, CA 94141 9100, USA
    J Immunol Methods 283:141-53. 2003
    ..In contrast, the CFC has a greater dynamic range and allows for phenotypic discrimination of responding cells, making it the assay of choice for most other applications...
  52. ncbi request reprint HIV RNA testing in the context of nonoccupational postexposure prophylaxis
    Michelle E Roland
    Positive Health Program at San Francisco General Hospital, Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Infect Dis 190:598-604. 2004
    ..The specificity and positive predictive value of human immunodeficiency virus (HIV) RNA assays have not been evaluated in the setting of postexposure prophylaxis (PEP)...
  53. ncbi request reprint Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
    ..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
  54. ncbi request reprint Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection
    Priscilla Y Hsue
    Division of Cardiology, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco, CA 94110, USA
    Circulation 109:1603-8. 2004
    ..HIV-infected patients may be at increased risk for coronary events. The purpose of this study was to identify predictors of carotid intima-media thickness (IMT) in HIV patients at baseline and to measure IMT progression over 1 year...
  55. ncbi request reprint Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function
    Mark A Jacobson
    Positive Health Program, Department of Medicine, University of California San Francisco, 995 Potrero, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 31:472-7. 2002
    ..This study provides the longest reported observation to date of the effect of HAART on HIV-induced abnormal antibody-mediated immunity. Larger and longer-term studies of HAART effect on B-cell reconstitution are needed...
  56. ncbi request reprint Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1
    Steven G Deeks
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 189:312-21. 2004
    ..Collectively, these data suggest that the selection of drug-resistance mutations may reduce the pathogenic potential of HIV, which leads to a balanced state of enhanced cellular immunity and low-level viremia...
  57. ncbi request reprint Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia
    Steven G Deeks
    UCSF AIDS Program, University of California and San Francisco General Hospital, San Francisco, California 94110, USA
    AIDS 16:201-7. 2002
    ..Sustained elevations in CD4 cell counts commonly occur despite incomplete viral suppression with protease inhibitor-based antiretroviral therapy...
  58. ncbi request reprint Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic
    Dennis H Osmond
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    JAMA 287:221-5. 2002
    ....
  59. ncbi request reprint Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 194:926-30. 2006
    ..CCR5 inhibitors may thus be best strategically used before salvage therapy and before significant CD4 + T cell depletion...
  60. ncbi request reprint Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses
    Priscilla Y Hsue
    Divisions of Cardiology, San Francisco General Hospital, University of California, San Francisco, USA
    AIDS 20:2275-83. 2006
    ....
  61. ncbi request reprint Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimen
    Hiroyu Hatano
    University of California San Francisco, San Francisco, CA, USA
    Clin Infect Dis 43:1329-36. 2006
    ..The major risk of this approach is ongoing viral evolution and the loss of future drug options...
  62. pmc HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers
    Peter W Hunt
    Department of Medicine, University of California, San Francisco, California, USA
    Clin Infect Dis 52:681-7. 2011
    ..Despite robust immune responses, these individuals never eradicate HIV infection. We hypothesized that HIV-specific CD4(+) T cells might serve as target cells for HIV, contributing to viral persistence in this setting...
  63. pmc A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response
    Hiroyu Hatano
    University of California, San Francisco, USA
    J Infect Dis 203:960-8. 2011
    ..We conducted an intensification study to assess whether residual viral replication contributes to replenishment of the latent reservoir and whether mucosal HIV-specific T cell responses limit the reservoir size...
  64. pmc A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    Peter W Hunt
    Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e15924. 2011
    ..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion...
  65. ncbi request reprint Use of postexposure prophylaxis against HIV infection following sexual exposure does not lead to increases in high-risk behavior
    Jeffrey N Martin
    Department of Epidemiology and Biostatistics, the Center for AIDS Prevention Studies, and San Francisco, California 94105, USA
    AIDS 18:787-92. 2004
    ..The effectiveness of postexposure prophylaxis (PEP) following occupational exposure to HIV has prompted advocacy for PEP following sexual or drug-use exposures...
  66. pmc Awareness of Kaposi's sarcoma-associated herpesvirus among men who have sex with men
    Abigail M Phillips
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    Sex Transm Dis 35:1011-4. 2008
    ..This is particularly the case for men who have sex with men (MSM), the group at greatest risk for infection...
  67. pmc Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans
    L Seu
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94110, USA
    Genes Immun 13:258-67. 2012
    ..04). These data demonstrate that the HO-1 GT(n) microsatellite polymorphism is associated with higher levels of HO-1 expression and that this pathway may have important effects on the association between inflammation and HIV replication...
  68. ncbi request reprint Postexposure prophylaxis for human immunodeficiency virus infection after sexual or injection drug use exposure: identification and characterization of the source of exposure
    M E Roland
    University of California at San Francisco, Div of AIDS, Dept of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 184:1608-12. 2001
    ..The treatment history, particularly nonuse of a class of antiretroviral drugs, can be used to predict drug resistance...
  69. pmc Use of antiretroviral therapies among HIV-infected men who have sex with men: a household-based sample of 4 major American cities
    R Stall
    Center for AIDS Prevention Studies, AIDS Research Institute, University of California, San Francisco, USA
    Am J Public Health 91:767-73. 2001
    ..This study sought to determine the prevalence and determinants of use of recommended antiretroviral regimens among urban seropositive men who have sex with men (MSM)...
  70. doi request reprint A population-based study of how children are exposed to saliva in KwaZulu-Natal Province, South Africa: implications for the spread of saliva-borne pathogens to children
    L M Butler
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Trop Med Int Health 15:442-53. 2010
    ..We endeavoured to identify the range and determinants of acts by which African children are exposed to saliva...
  71. ncbi request reprint The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infection
    Joan C Lo
    Department of Medicine, University of California San Francisco, CA, USA
    Clin Infect Dis 41:1335-40. 2005
    ..We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance...
  72. ncbi request reprint Diagnosis and epidemiology of human herpesvirus 8 infection
    Jeffrey N Martin
    Department of Epidemiology, University of California, San Francisco, CA 94105, USA
    Semin Hematol 40:133-42. 2003
    ..While saliva is the likely conduit for transmission in highly endemic areas, the precise mechanism for person-to-person spread-and whether this is preventable-is not understood...
  73. pmc Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from Gag to Pol
    A C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 81:11543-8. 2007
    ..The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy...
  74. ncbi request reprint Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen
    John Friend
    AIDS 18:1965-6. 2004
  75. ncbi request reprint Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    Maureen P Martin
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
    Nat Genet 39:733-40. 2007
    ....
  76. ncbi request reprint Moving toward clarity on 2 fronts in the epidemiology of Kaposi sarcoma-associated herpesvirus infection
    Jeffrey N Martin
    J Infect Dis 196:173-5. 2007
  77. ncbi request reprint Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  78. doi request reprint Oral candidiasis as a marker of HIV disease progression among Zimbabwean women
    Midion M Chidzonga
    Department of Dentistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
    J Acquir Immune Defic Syndr 47:579-84. 2008
    ..To estimate oral disease prevalence among Zimbabwean women by HIV serostatus and CD4 cell count and to assess accuracy of oral disease diagnoses made by nurses as compared with an oral surgeon...
  79. ncbi request reprint Rapid emergence of enfuvirtide resistance in HIV-1-infected patients: results of a clonal analysis
    Jing Lu
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 43:60-4. 2006
    ..To study the dynamics of enfuvirtide (T-20) resistance development in HIV-1-infected subjects...
  80. ncbi request reprint Cost-effectiveness of HIV postexposure prophylaxis following sexual or injection drug exposure in 96 metropolitan areas in the United States
    Steven D Pinkerton
    Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53202, USA
    AIDS 18:2065-73. 2004
    ..To evaluate the cost-effectiveness of HIV postexposure prophylaxis (PEP) following sexual or injection-related exposures in 96 metropolitan statistical areas in the United States (MSA)...
  81. ncbi request reprint Cost-effectiveness of postexposure prophylaxis after sexual or injection-drug exposure to human immunodeficiency virus
    Steven D Pinkerton
    Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI 53202, USA
    Arch Intern Med 164:46-54. 2004
    ....
  82. pmc Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors
    Neelanjana Ray
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, Philadelphia, PA 19104, USA
    J Virol 81:3240-50. 2007
    ....
  83. pmc Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)
    Stephen J Gange
    NA ACCORD Coordinating Center, Baltimore, MD 21287, USA
    Int J Epidemiol 36:294-301. 2007
  84. pmc Sampling-based approach to determining outcomes of patients lost to follow-up in antiretroviral therapy scale-up programs in Africa
    Elvin H Geng
    JAMA 300:506-7. 2008

Research Grants5

  1. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2007
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  2. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..