Research Topics
Species | J N MartinSummaryAffiliation: University of California Country: USA Publications
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Publications
Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009Elvin H Geng
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA, USA
J Int AIDS Soc 14:46. 2011..Regionally representative socio-demographic, laboratory and clinical characteristics of patients accessing ART over time and across sites have not been well described...- CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?Keri N Althoff
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
AIDS Res Ther 7:45. 2010..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed... 
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcomaJ N Martin
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Adv Dent Res 23:76-8. 2011..KSHV has special importance to the dental profession because saliva is the body fluid that harbors it most commonly, although exactly in which ways saliva spreads the virus are not known...
A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus diseaseJ N Martin
Center for AIDS Prevention Studies, AIDS Research Institute, and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
J Infect Dis 180:896-9. 1999..Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication...- Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodiesJ N Martin
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94105, USA
J Clin Microbiol 38:696-701. 2000.... - Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS eraJ N Martin
Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
J Infect Dis 180:1809-18. 1999..A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance... - Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer riskJ N Martin
Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
Curr Opin Oncol 11:508-15. 1999..Spread via renal allograft appears to occur, and in endemic areas of Europe and Africa, nonsexual horizontal and perhaps vertical spread are the dominant modes of transmission... - Feasibility of postexposure prophylaxis (PEP) against human immunodeficiency virus infection after sexual or injection drug use exposure: the San Francisco PEP StudyJ O Kahn
Positive Health Program, Dept of Medicine, University of California San Francisco, at San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 183:707-14. 2001..PEP, after nonoccupational HIV exposure, is feasible for persons at risk for HIV infection... - Immunologic and virologic evolution during periods of intermittent and persistent low-level viremiaAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
AIDS 18:981-9. 2004..It is likely that higher viremia and stronger immune activation act synergistically to accelerate the development of systemic drug resistance... - Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatmentBrinda Emu
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
J Virol 79:14169-78. 2005.... - Decline in HIV infectivity following the introduction of highly active antiretroviral therapyTravis C Porco
San Francisco Department of Public Health, Community Health and Epidemiology Section, San Francisco, CA, USA
AIDS 18:81-8. 2004..048 after the widespread use of HAART- a decline of 60% (P=0.028). CONCLUSIONS: Use of HAART by infected persons in a community appears to reduce their infectiousness and therefore may provide an important HIV prevention tool... - HIV-induced changes in T cell signaling pathwaysMarc Schweneker
Division of Experimental Medicine, University of California, San Francisco, CA 94110, USA
J Immunol 180:6490-500. 2008.... - Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 17:1907-15. 2003..The immune system's capacity for CD4 T lymphocyte restoration is not limited by low pre-therapy CD4 counts... - Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adultsJason D Barbour
Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, California, USA
J Virol 76:11104-12. 2002.... - History-adjusted marginal structural models for estimating time-varying effect modificationMaya L Petersen
Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA
Am J Epidemiol 166:985-93. 2007.... - Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapyBarbara Schmidt
Division Hematology/Oncology, Department of Medicine, University of California, San Francisco, California 94143-1270, USA
J Clin Immunol 26:55-64. 2006..Circulating plasmacytoid dendritic cells may provide important additional information about immune function in HIV-infected subjects receiving or not receiving antiretroviral therapy... - Continued evolution in gp41 after interruption of enfuvirtide in subjects with advanced HIV type 1 diseaseChristina M R Kitchen
Department of Biostatistics, University of California, Los Angeles, Los Angeles, California 90095, Section of Retroviral Therapeutics, Brigham and Women s Hospital, Boston, MA 02115, USA
AIDS Res Hum Retroviruses 22:1260-6. 2006..In contrast to observations when all drugs are interrupted, loss of resistance during enfuvirtide interruption is most likely due to ongoing viral evolution (and back-mutation), rather than emergence of an archived virus... - Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV diseaseDavid M Naeger
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e8886. 2010..The impact of untreated and treated HIV infection on the frequency of these cells remains undefined... - Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infectionS G Deeks
University of California, San Francisco, AIDS Program, San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 181:946-53. 2000..These observations suggest that transient or partial declines in plasma HIV RNA levels can have sustained effects on CD4+ T cell levels... - Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosisPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, San Francisco, California 94110, USA
AIDS 23:1059-67. 2009.... - Use of saliva as a lubricant in anal sexual practices among homosexual menLisa M Butler
From the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
J Acquir Immune Defic Syndr 50:162-7. 2009..Because one common element between these organisms is their presence in saliva, we evaluated saliva exposure among MSM in a heretofore relatively unrecognized route-via use of saliva as a lubricant in anal sex... - Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyHiroyu Hatano
San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Virol 83:329-35. 2009..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy... - HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus controlBrinda Emu
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
J Virol 82:5398-407. 2008..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication... - Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 197:126-33. 2008.... - Comparison of an interferon-gamma release assay with tuberculin skin testing in HIV-infected individualsAnnie F Luetkemeyer
HIV AIDS Division, San Francisco General Hospital, University of California at San Fracisco, San Francisco, Box 0874, Building 80, 995 Potrero Avenue, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 175:737-42. 2007..Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection... - Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertensionPriscilla Y Hsue
Divisions of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
AIDS 22:825-33. 2008.... - Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patientsMark A Jacobson
Positive Health Program, Department of Medicine, University of California San Francisco and The Medical Service, San Francisco General Hospital, San Francisco, CA, USA
PLoS ONE 4:e5277. 2009.... - Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmissionLisa M Butler
University of California, San Francisco, 50 Beale St, Suite 120, San Francisco, California 94105, USA
J Infect Dis 200:430-8. 2009..However, few studies have directly examined children, particularly in locations where KS is not commonly endemic... - Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patientsPriscilla Y Hsue
Division of Cardiology, Positive Health Program of the Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
AIDS 23:2021-7. 2009..As endothelial dysfunction is central to the pathogenesis of atherosclerosis, we tested the hypothesis that current treatment with abacavir is associated with impaired endothelial function... - HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responsesApril L Ferre
Department of Medical Microbiology and Immunology, School of Medicine, University of California, 3327 Tupper Hall, 1 Shields Ave, Davis, CA 95616, USA
J Virol 84:11020-9. 2010..43, P=0.005), suggesting that increased CD4+ T-cell "help" may be important in maintaining strong CD8+ T-cell responses in the gut of HIV controllers... - Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in UgandaJudith A Hahn
University of California, San Francisco, CA 94143 0811, USA
AIDS Behav 14:1265-8. 2010..These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes... - Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllersApril L Ferre
Dept of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
J Virol 84:10354-65. 2010.... - Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individualsHiroyu Hatano
Department of Medicine, University of California, San Francisco, California, USA
AIDS 24:2535-9. 2010..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear... - Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseDavid Favre
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Sci Transl Med 2:32ra36. 2010..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease... - Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapyHiroyu Hatano
University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 54:389-93. 2010..Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined... - Impact of HIV infection on diastolic function and left ventricular massPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, San Francisco, CA 94110, USA
Circ Heart Fail 3:132-9. 2010..These results suggest that contemporary asymptomatic patients with HIV manifest mild functional and morphological cardiac abnormalities, which are independently associated with HIV infection... - Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in AfricaElvin H Geng
Division of HIV AIDS, Department of Medicine, San Francisco General Hospital, San Francisco, CA, USA
Trop Med Int Health 15:63-9. 2010..Losses to follow-up, however, are high in these settings and may lead to bias in understanding the determinants of mortality... - Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North AmericaSteven G Deeks
University of California San Francisco, San Francisco, San Diego, CA 94110, USA
Clin Infect Dis 49:1582-90. 2009.... - Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approachElvin H Geng
Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, Building 80, San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 53:405-11. 2010..We sought to characterize, through a sampling-based approach, reasons for and outcomes of patients who become lost to follow-up... - HIV-infected persons continue to lose kidney function despite successful antiretroviral therapyAndy I Choi
Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
AIDS 23:2143-9. 2009..To identify risk factors associated with kidney function decline in a contemporary cohort of treated and untreated HIV-infected patients... - Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responsesKeith E Garrison
Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA
Clin Vaccine Immunol 16:1369-71. 2009..T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects... - Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directionsElvin H Geng
Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
Curr HIV/AIDS Rep 7:234-44. 2010..Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework... - Interruption of enfuvirtide in HIV-1 infected adults with incomplete viral suppression on an enfuvirtide-based regimenSteven G Deeks
University of California, San Francisco, San Francisco, CA 94110, USA
J Infect Dis 195:387-91. 2007..Although enfuvirtide resistance mutations are associated with significant fitness defects in vivo, the clinical significance of these mutations remains undefined... - Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responsesSteven G Deeks
Department of Medicine, University of California at San Francisco, San Francisco General Hospital, CA 94110, USA
J Virol 80:6155-64. 2006..These observations also suggest that the neutralizing antibody response may contribute to the long-term control of HIV in some patients while protecting against HIV superinfection in most patients... - The independent effect of drug resistance on T cell activation in HIV infectionPeter W Hunt
Positive Health Program, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
AIDS 20:691-9. 2006.... - High-risk sexual behavior in adults with genotypically proven antiretroviral-resistant HIV infectionPeter V Chin-Hong
Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA, USA
J Acquir Immune Defic Syndr 40:463-71. 2005..Although there is an increasing emphasis on understanding high-risk behavior among HIV-infected patients, little work has focused on those with drug-resistant virus... - Seroconversion following nonoccupational postexposure prophylaxis against HIVMichelle E Roland
Positive Health Program at San Francisco General Hospital, California, USA
Clin Infect Dis 41:1507-13. 2005..We sought to describe the occurrence and circumstances of HIV seroconversion following nonoccupational PEP... - T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Infect Dis 187:1534-43. 2003..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy... - Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infectionSteven G Deeks
University of California, San Francisco, and San Francisco General Hospital, San Francisco 94110, USA
J Infect Dis 192:1537-44. 2005..We hypothesized that the use of simplified regimens could maintain treatment benefit while preventing viral evolution and reducing drug-related toxicity and costs... - Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease geneAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
J Virol 77:6743-52. 2003..Our results indicate that both HIV type 1-specific CD8(+) T cells and antiretroviral drugs provide complex pressures on the same amino acid sequence of the HIV protease gene and, thus, can influence viral sequence evolution... - Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cellsAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California San Francisco, P O Box 419100, San Francisco, CA 94141 9100, USA
J Immunol Methods 283:141-53. 2003..In contrast, the CFC has a greater dynamic range and allows for phenotypic discrimination of responding cells, making it the assay of choice for most other applications... - HIV RNA testing in the context of nonoccupational postexposure prophylaxisMichelle E Roland
Positive Health Program at San Francisco General Hospital, Department of Medicine, University of California, San Francisco, CA 94110, USA
J Infect Dis 190:598-604. 2004..The specificity and positive predictive value of human immunodeficiency virus (HIV) RNA assays have not been evaluated in the setting of postexposure prophylaxis (PEP)... - Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadSteven G Deeks
San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
Blood 104:942-7. 2004..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time... - Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infectionPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco, CA 94110, USA
Circulation 109:1603-8. 2004..In HIV patients, carotid IMT is associated with classic coronary risk factors and with nadir CD4 count < or =200, suggesting that immunodeficiency and traditional coronary risk factors may contribute to atherosclerosis... - Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte functionMark A Jacobson
Positive Health Program, Department of Medicine, University of California San Francisco, 995 Potrero, San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 31:472-7. 2002..This study provides the longest reported observation to date of the effect of HAART on HIV-induced abnormal antibody-mediated immunity. Larger and longer-term studies of HAART effect on B-cell reconstitution are needed... - Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1Steven G Deeks
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
J Infect Dis 189:312-21. 2004..Collectively, these data suggest that the selection of drug-resistance mutations may reduce the pathogenic potential of HIV, which leads to a balanced state of enhanced cellular immunity and low-level viremia... - Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremiaSteven G Deeks
UCSF AIDS Program, University of California and San Francisco General Hospital, San Francisco, California 94110, USA
AIDS 16:201-7. 2002..Sustained elevations in CD4 cell counts commonly occur despite incomplete viral suppression with protease inhibitor-based antiretroviral therapy... - Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemicDennis H Osmond
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
JAMA 287:221-5. 2002.... - Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremiaPeter W Hunt
Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 194:926-30. 2006..CCR5 inhibitors may thus be best strategically used before salvage therapy and before significant CD4 + T cell depletion... - Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responsesPriscilla Y Hsue
Divisions of Cardiology, San Francisco General Hospital, University of California, San Francisco, USA
AIDS 20:2275-83. 2006.... - Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimenHiroyu Hatano
University of California San Francisco, San Francisco, CA, USA
Clin Infect Dis 43:1329-36. 2006..Resistance mutations vary over time, which suggests that the results of any single resistance test may not be representative of all mutations selected by a given treatment regimen... - HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllersPeter W Hunt
Department of Medicine, University of California, San Francisco, California, USA
Clin Infect Dis 52:681-7. 2011..Despite robust immune responses, these individuals never eradicate HIV infection. We hypothesized that HIV-specific CD4(+) T cells might serve as target cells for HIV, contributing to viral persistence in this setting... - A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell responseHiroyu Hatano
University of California, San Francisco, USA
J Infect Dis 203:960-8. 2011..We conducted an intensification study to assess whether residual viral replication contributes to replenishment of the latent reservoir and whether mucosal HIV-specific T cell responses limit the reservoir size... - A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllersPeter W Hunt
Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e15924. 2011..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion... - Use of postexposure prophylaxis against HIV infection following sexual exposure does not lead to increases in high-risk behaviorJeffrey N Martin
Department of Epidemiology and Biostatistics, the Center for AIDS Prevention Studies, and San Francisco, California 94105, USA
AIDS 18:787-92. 2004..Coupled with prior safety and feasibility data, this lack of behavioral disinhibition suggests that use of PEP should be routinely considered following high-risk sexual exposures... - Awareness of Kaposi's sarcoma-associated herpesvirus among men who have sex with menAbigail M Phillips
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
Sex Transm Dis 35:1011-4. 2008..This is particularly the case for men who have sex with men (MSM), the group at greatest risk for infection... - Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-AmericansL Seu
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94110, USA
Genes Immun 13:258-67. 2012..04). These data demonstrate that the HO-1 GT(n) microsatellite polymorphism is associated with higher levels of HO-1 expression and that this pathway may have important effects on the association between inflammation and HIV replication... - Postexposure prophylaxis for human immunodeficiency virus infection after sexual or injection drug use exposure: identification and characterization of the source of exposureM E Roland
University of California at San Francisco, Div of AIDS, Dept of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
J Infect Dis 184:1608-12. 2001..The treatment history, particularly nonuse of a class of antiretroviral drugs, can be used to predict drug resistance... - Use of antiretroviral therapies among HIV-infected men who have sex with men: a household-based sample of 4 major American citiesR Stall
Center for AIDS Prevention Studies, AIDS Research Institute, University of California, San Francisco, USA
Am J Public Health 91:767-73. 2001..This study sought to determine the prevalence and determinants of use of recommended antiretroviral regimens among urban seropositive men who have sex with men (MSM)... - A population-based study of how children are exposed to saliva in KwaZulu-Natal Province, South Africa: implications for the spread of saliva-borne pathogens to childrenL M Butler
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Trop Med Int Health 15:442-53. 2010..We endeavoured to identify the range and determinants of acts by which African children are exposed to saliva... - The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infectionJoan C Lo
Department of Medicine, University of California San Francisco, CA, USA
Clin Infect Dis 41:1335-40. 2005..We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance... - Diagnosis and epidemiology of human herpesvirus 8 infectionJeffrey N Martin
Department of Epidemiology, University of California, San Francisco, CA 94105, USA
Semin Hematol 40:133-42. 2003..While saliva is the likely conduit for transmission in highly endemic areas, the precise mechanism for person-to-person spread-and whether this is preventable-is not understood... - Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from Gag to PolA C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
J Virol 81:11543-8. 2007..The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy... - Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimenJohn Friend
AIDS 18:1965-6. 2004 - Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1Maureen P Martin
Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
Nat Genet 39:733-40. 2007.... - Moving toward clarity on 2 fronts in the epidemiology of Kaposi sarcoma-associated herpesvirus infectionJeffrey N Martin
J Infect Dis 196:173-5. 2007 - Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection... - Oral candidiasis as a marker of HIV disease progression among Zimbabwean womenMidion M Chidzonga
Department of Dentistry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
J Acquir Immune Defic Syndr 47:579-84. 2008..To estimate oral disease prevalence among Zimbabwean women by HIV serostatus and CD4 cell count and to assess accuracy of oral disease diagnoses made by nurses as compared with an oral surgeon... - Rapid emergence of enfuvirtide resistance in HIV-1-infected patients: results of a clonal analysisJing Lu
Section of Retroviral Therapeutics, Brigham and Women's Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 43:60-4. 2006.... - Cost-effectiveness of HIV postexposure prophylaxis following sexual or injection drug exposure in 96 metropolitan areas in the United StatesSteven D Pinkerton
Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53202, USA
AIDS 18:2065-73. 2004..To evaluate the cost-effectiveness of HIV postexposure prophylaxis (PEP) following sexual or injection-related exposures in 96 metropolitan statistical areas in the United States (MSA)... - Cost-effectiveness of postexposure prophylaxis after sexual or injection-drug exposure to human immunodeficiency virusSteven D Pinkerton
Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI 53202, USA
Arch Intern Med 164:46-54. 2004..CONCLUSIONS: For this study population, HIV PEP was cost-effective by conventional standards and cost-saving for persons seeking PEP after male-male receptive anal intercourse... - Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitorsNeelanjana Ray
Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, Philadelphia, PA 19104, USA
J Virol 81:3240-50. 2007.... - Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)Stephen J Gange
NA-ACCORD Coordinating Center, Baltimore, MD 21287, USA
Int J Epidemiol 36:294-301. 2007 - Sampling-based approach to determining outcomes of patients lost to follow-up in antiretroviral therapy scale-up programs in AfricaElvin H Geng
JAMA 300:506-7. 2008
Research Grants
- Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in AfricaJeffrey Martin; Fiscal Year: 2007..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
- Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in AfricaJeffrey Martin; Fiscal Year: 2009..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..