George Martin

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons
    Bethany H Cool
    Department of Pathology, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e10351. 2010
  2. pmc SOD2 polymorphisms: unmasking the effect of polymorphism on splicing
    Jing Shao
    Department of Pathology, University of Washington, Seattle, Washington, USA
    BMC Med Genet 8:7. 2007
  3. ncbi request reprint Introduction: genetic determinants of mid- and late-life dementias
    G M Martin
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Cell Mol Life Sci 54:895-6. 1998
  4. ncbi request reprint Help wanted: physiologists for research on aging
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Sci Aging Knowledge Environ 2002:vp2. 2002
  5. pmc The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 128:9-12. 2007
  6. ncbi request reprint New opportunities for genetic approaches to aging research using Roy Walford's favorite animal
    George M Martin
    Department of Pathology, Health Sciences Building, University of Washington, 1959 N E Pacific Street, Box 357470, Seattle, WA 98195 7470, USA
    Exp Gerontol 39:913-6. 2004
  7. ncbi request reprint Keynote lecture: an update on the what, why and how questions of ageing
    George M Martin
    University of Washington, Room K543 Health Sciences, 1959 NE Pacific Street, Seattle, WA 98195 7470, USA
    Exp Gerontol 41:460-3. 2006
  8. ncbi request reprint Genetic engineering of mice to test the oxidative damage theory of aging
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Ann N Y Acad Sci 1055:26-34. 2005
  9. ncbi request reprint Genetic modulation of senescent phenotypes in Homo sapiens
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Cell 120:523-32. 2005
  10. ncbi request reprint Modalities of gene action predicted by the classical evolutionary biological theory of aging
    George M Martin
    Departments of Pathology and Genome Sciences, P O Box 357470, University of Washington, Seattle, WA 98195 7470, USA
    Ann N Y Acad Sci 1100:14-20. 2007

Research Grants

  1. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2005
  2. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2001
  3. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2002
  4. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2003
  5. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2004
  6. International Registry of Werner Syndrome
    George Martin; Fiscal Year: 2007
  7. Seeking the Biomarkers of Aging and Diseases of Aging conference
    George Martin; Fiscal Year: 2007

Collaborators

Detail Information

Publications53

  1. pmc A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons
    Bethany H Cool
    Department of Pathology, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e10351. 2010
    ..We previously generated p97FE65 isoform-specific knockout mice that showed learning/memory deficits. In this study, we further characterized the 97FE65 null mice using cDNA microarray and RT-PCR analyses...
  2. pmc SOD2 polymorphisms: unmasking the effect of polymorphism on splicing
    Jing Shao
    Department of Pathology, University of Washington, Seattle, Washington, USA
    BMC Med Genet 8:7. 2007
    ..The SOD2 gene encodes an antioxidant enzyme, mitochondrial superoxide dismutase. SOD2 polymorphisms are of interest because of their potential roles in the modulation of free radical-mediated macromolecular damage during aging...
  3. ncbi request reprint Introduction: genetic determinants of mid- and late-life dementias
    G M Martin
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Cell Mol Life Sci 54:895-6. 1998
    ..The most important such modulation so far discovered involves polymorphic forms of the APOE locus...
  4. ncbi request reprint Help wanted: physiologists for research on aging
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Sci Aging Knowledge Environ 2002:vp2. 2002
  5. pmc The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 128:9-12. 2007
    ..Alternatively, such background "noise" in transcription and translation may simply reflect a type of informational entropy...
  6. ncbi request reprint New opportunities for genetic approaches to aging research using Roy Walford's favorite animal
    George M Martin
    Department of Pathology, Health Sciences Building, University of Washington, 1959 N E Pacific Street, Box 357470, Seattle, WA 98195 7470, USA
    Exp Gerontol 39:913-6. 2004
  7. ncbi request reprint Keynote lecture: an update on the what, why and how questions of ageing
    George M Martin
    University of Washington, Room K543 Health Sciences, 1959 NE Pacific Street, Seattle, WA 98195 7470, USA
    Exp Gerontol 41:460-3. 2006
    ..How does it happen? To gain insight into fundamental mechanisms of ageing, we have focused upon classes of gene actions that, according to the evolutionary theory, can escape the forces of natural selection...
  8. ncbi request reprint Genetic engineering of mice to test the oxidative damage theory of aging
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Ann N Y Acad Sci 1055:26-34. 2005
    ....
  9. ncbi request reprint Genetic modulation of senescent phenotypes in Homo sapiens
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Cell 120:523-32. 2005
    ..They thus support the importance of the maintenance of proper protein processing and folding as a partial antidote to aging...
  10. ncbi request reprint Modalities of gene action predicted by the classical evolutionary biological theory of aging
    George M Martin
    Departments of Pathology and Genome Sciences, P O Box 357470, University of Washington, Seattle, WA 98195 7470, USA
    Ann N Y Acad Sci 1100:14-20. 2007
    ..This contrasts with the dominant factor in the determination of interspecific variations in longevity-the constitutional genome, most likely based upon variations in regulatory loci...
  11. pmc Genetic determinants of human health span and life span: progress and new opportunities
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e125. 2007
    ..We can conclude that there are great opportunities for research on the genetics of human aging, particularly given the huge fund of information on human biology and pathobiology, and the rapidly developing knowledge of the human genome...
  12. ncbi request reprint Some new directions for research on the biology of aging
    G M Martin
    Department of Pathology and Genetics, University of Washington, Seattle 98195, USA
    Ann N Y Acad Sci 908:1-13. 2000
    ..Finally, our community should investigate the impact of environmental "gerontogens," agents that accelerate specific processes of aging and specific senescent phenotypes...
  13. ncbi request reprint Molecular mechanisms of late life dementias
    G M Martin
    Departments of Pathology and Genetics, University of Washington, WA 98195, Seattle, USA
    Exp Gerontol 35:439-43. 2000
    ..Aberrations in the metabolism of this protein (which is found in Lewy body fibrillar material) may therefore be of importance to the genesis of some LBD cases...
  14. pmc Epigenetic drift in aging identical twins
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:10413-4. 2005
  15. doi request reprint The 2008 American Federation For Aging Annual Research Conference: aging and cancer: two sides of the same coin?
    George M Martin
    American Federation for Aging Research, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 64:615-7. 2009
    ..Griffith). Overview presentations were given by John W. Rowe and Harvey Jay Cohen. The conference closed with a roundtable discussion with representatives of industry in an effort to enhance communications with academicians...
  16. ncbi request reprint Clonal attenuation of somatic cells in aging mammals: a review of supportive evidence and its biomedical significance
    George M Martin
    Department of Pathology Box 357470, Room K543 Health Sciences Building, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 7470, USA
    Ann N Y Acad Sci 1119:1-8. 2007
    ..For the case of neoplasia, an argument can be made that such failures precede what is increasingly regarded as the most critical step in carcinogenesis-the evolution of a mutator phenotype...
  17. ncbi request reprint Isoform-specific knockout of FE65 leads to impaired learning and memory
    Baiping Wang
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci Res 75:12-24. 2004
    ..Reduced secretion of Abeta peptides was observed in primary neuronal cultures of hybrids of p97FE65(-/-)/betaPP transgenic (Tg2576) mice. These studies suggest an important and novel function of FE65 in learning and memory...
  18. ncbi request reprint Extension of murine life span by overexpression of catalase targeted to mitochondria
    Samuel E Schriner
    Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
    Science 308:1909-11. 2005
    ..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals...
  19. ncbi request reprint The aging factor in health and disease: the promise of basic research on aging
    Robert N Butler
    International Longevity Center USA, Alliance for Health and the Future, and Department of Geriatrics, Mount Sinai Medical Center, New York, NY 10028, USA
    Aging Clin Exp Res 16:104-11; discussion 111-2. 2004
  20. pmc Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice
    Bethany H Cool
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Neurochem 112:410-9. 2010
    ..These results are consistent with earlier evidence from our laboratory that reduced FE65 nuclear signaling may contribute, in part, to the phenotypes observed in p97FE65 knockout mice...
  21. pmc Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
    Dao Fu Dai
    Department of Pathology, University of Washington, Seattle, 98195, USA
    Circulation 119:2789-97. 2009
    ..We have previously shown that overexpression of catalase targeted to mitochondria (mCAT) prolongs murine median lifespan by 17% to 21%...
  22. pmc Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A
    Shurong Huang
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Exp Cell Res 314:82-91. 2008
    ....
  23. ncbi request reprint Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria
    Piper M Treuting
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195 7190, USA
    J Gerontol A Biol Sci Med Sci 63:813-22. 2008
    ..The variability of the MCAT effect across tissues, however, illustrates the importance of developing semiquantitative histopathology for assessment of comorbidity in life-span studies...
  24. ncbi request reprint Localizations of endogenous APP/APP-proteolytic products are consistent with microtubular transport
    Galynn Zitnik
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    J Mol Neurosci 31:59-68. 2007
    ....
  25. pmc The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
    Lawrence A Loeb
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:18769-70. 2005
  26. ncbi request reprint Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence
    Norman Wolf
    Department of Pathology, University of Washington School of Medicine, Box 3557470, University of Washington, Seattle, WA 98195 7470, USA
    Exp Eye Res 81:276-85. 2005
    ..The exception, the partial deletion of SOD2 in the hemizygous KO model, probably did not represent a sufficiently severe deprivation of anti-oxidant protection to produce pathologic changes in the lens...
  27. ncbi request reprint Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates
    Qubai Hu
    Department of Pathology, University of Washington, Seattle, Washington, 98195, USA
    J Biol Chem 280:12548-58. 2005
    ..Strong p65FE65-APP binding is required for the suppression. The results suggest that p65FE65 may be an intracellular mediator in a signaling cascade regulating alpha-secretion of APP, particularly in primates...
  28. ncbi request reprint Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death
    Lee Way Jin
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    J Mol Neurosci 19:57-61. 2002
    ..Lead compounds will now be selected for their abilities to ameliorate A beta/CTF-mediated pathology in transgenic mice. Our hope is that these compounds may eventually prove beneficial for the prevention and treatment of AD...
  29. ncbi request reprint A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type
    Qubai Hu
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 11:465-75. 2002
    ..That allele may contribute to very late onset form of Alzheimer disease when we are aged...
  30. ncbi request reprint Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Pathol Int 52:551-4. 2002
    ..These findings suggest that PS1 mutations may, in part, contribute to the development of DAT via altered expression of chaperone proteins...
  31. ncbi request reprint An information extraction and representation system for rapid review of the biomedical literature
    Debra Revere
    Telemakus Research Program, Division of Biomedical and Health Informatics, University of Washington, Seattle, WA 98195 7155, USA
    Stud Health Technol Inform 107:788-92. 2004
    ..This system is an innovative approach to creating useful and precise document surrogates and may re-conceptualize the way we currently represent, retrieve, and assimilate research findings from the published literature...
  32. ncbi request reprint Keynote: mechanisms of senescence--complificationists versus simplificationists
    George M Martin
    Department of Pathology, University of Washington, Box 357470, Room K543, Health Sciences Building, 1959 N E Pacific Street, Seattle, WA 98195 7470, USA
    Mech Ageing Dev 123:65-73; discussion 75-9. 2002
    ..Where does the truth lie? Perhaps the truth lies somewhere between these two extremes and is largely dependent upon the organisms and the range of environments being investigated...
  33. ncbi request reprint Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference
    Shurong Huang
    Department of Pathology, University of Washington, Box 357470, HSB K 543, 1959 NE Pacific Ave, Seattle, WA, 98195 7470, USA
    Hum Genet 118:444-50. 2005
    ..These findings provide a rationale for potential gene therapy...
  34. ncbi request reprint Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurochem 91:1312-21. 2004
    ....
  35. ncbi request reprint A dominant role for FE65 (APBB1) in nuclear signaling
    Zheng Yang
    Department of Pathology, The University of Washington, Seattle, 98195, USA
    J Biol Chem 281:4207-14. 2006
    ..Although APP may have modest stimulating effects, apparently there is no absolute requirement for that molecule for the nuclear signaling pathway...
  36. ncbi request reprint Age-related decline in neurogenesis: old cells or old environment?
    Galynn Zitnik
    Department of Pathology, University of Washington, Seattle, Washington 98995, USA
    J Neurosci Res 70:258-63. 2002
  37. ncbi request reprint Gene action in the aging brain: an evolutionary biological perspective
    George M Martin
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Neurobiol Aging 23:647-54. 2002
    ..I here suggest a more comprehensive classification of such gene actions and give possible examples of their potential relevance to brain aging...
  38. doi request reprint Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging
    George M Martin
    Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Aging Cell 8:761-4. 2009
    ..I offer experimental approaches, however, to search for the elusive epigenetic gambler(s)...
  39. pmc Leukocyte telomere length is associated with disability in older u.s. Population
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Am Geriatr Soc 58:1289-98. 2010
    ..To determine whether mean leukocyte telomere length (LTL) serves as a biomarker of disability assessed according to activities of daily living (ADLs) and what factors may modify this relationship...
  40. ncbi request reprint LMNA mutations in atypical Werner's syndrome
    Lishan Chen
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Lancet 362:440-5. 2003
    ..Some features of this disorder are also present in laminopathies caused by mutant LMNA encoding nuclear lamin A/C. Because of this similarity, we sequenced LMNA in individuals with atypical Werner's syndrome (wild-type WRN)...
  41. pmc The spectrum of WRN mutations in Werner syndrome patients
    Shurong Huang
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    Hum Mutat 27:558-67. 2006
    ..These, as well as inducible and complemented hTERT (catalytic subunit of human telomerase) immortalized skin fibroblast cell lines are available to qualified investigators...
  42. pmc Collagen expression in fibroblasts with a novel LMNA mutation
    Desiree Nguyen
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 352:603-8. 2007
    ....
  43. pmc New model of health promotion and disease prevention for the 21st century
    Robert N Butler
    International Longevity Center, New York, USA
    BMJ 337:a399. 2008
  44. ncbi request reprint A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes
    Izumi Maezawa
    MIND Institute and Department of Pathology, University of California Davis, Sacramento, California, USA
    J Neurochem 98:57-67. 2006
    ..CP2 analogs represent a new class of promising compounds for the amelioration of Abeta toxicities within both intracellular and extracellular sites...
  45. ncbi request reprint Research on aging: the end of the beginning
    George M Martin
    Science 299:1339-41. 2003
  46. pmc Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Durham, NC 27708, USA
    Age Ageing 37:288-93. 2008
    ..early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability...
  47. pmc Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Trent Drive, Box 90408, Durham, NC 27708, USA
    J Am Geriatr Soc 56:478-83. 2008
    ....
  48. ncbi request reprint Ageing: mice and mitochondria
    George M Martin
    Nature 429:357-9. 2004
  49. ncbi request reprint The evolutionary substrate of aging
    George M Martin
    Arch Neurol 59:1702-5. 2002
  50. ncbi request reprint SAGE lessons
    George M Martin
    Science 313:17. 2006
  51. ncbi request reprint Genes, rates of aging, and duration of human life
    George M Martin
    Am J Med 117:882-3. 2004
  52. ncbi request reprint Functional evidence for a metastasis suppressor gene for rat prostate cancer within a 60-kilobase region on human chromosome 8p21-p12
    Naoki Nihei
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:367-70. 2002
    ..3 cells. Frequent loss of heterozygosity of this region is detected in human prostate cancer, which suggests that our target metastasis suppressor gene may also play an important role in the progression of human prostate cancer...
  53. ncbi request reprint Longevity determinant genes: what is the evidence? What's the importance? Panel discussion
    Richard Cutler
    Ann N Y Acad Sci 1055:58-63. 2005

Research Grants8

  1. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2005
    ..abstract_text> ..
  2. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2001
    ..abstract_text> ..
  3. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2002
    ..abstract_text> ..
  4. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2003
    ..abstract_text> ..
  5. dementias of the Alzheimer's Type
    George Martin; Fiscal Year: 2004
    ..abstract_text> ..
  6. International Registry of Werner Syndrome
    George Martin; Fiscal Year: 2007
    ....
  7. Seeking the Biomarkers of Aging and Diseases of Aging conference
    George Martin; Fiscal Year: 2007
    ..The goals of this conference are to assess the existing biomarkers available and explore the kinds of biomarkers needed to provide improvements to the human condition by alleviating disease and extending healthy lifespan. ..