Eden Martin

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Reconstructing the population genetic history of the Caribbean
    Andres Moreno-Estrada
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 9:e1003925. 2013
  2. pmc Reconsidering association testing methods using single-variant test statistics as alternatives to pooling tests for sequence data with rare variants
    Daniel D Kinnamon
    Dr John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 7:e30238. 2012
  3. pmc A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
    John P Hussman
    John P, Hussman Institute for Human Genomics, University of Miami, 1501 NW 10th Avenue, Miami, FL 33136, USA
    Mol Autism 2:1. 2011
  4. pmc Visualizing genotype x phenotype relationships in the GAW15 simulated data
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Proc 1:S132. 2007
  5. pmc Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies
    Mike Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Proc 1:S138. 2007
  6. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
  7. pmc CAPL: an efficient association software package using family and case-control data and accounting for population stratification
    Ren Hua Chung
    Center for Genetic Epidemiology and Statistical Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA
    BMC Bioinformatics 12:201. 2011
  8. pmc The future is now - will the real disease gene please stand up?
    E R Martin
    Center for Genetic Epidemiology and Statistical Genetics, Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Hered 66:127-35. 2008
  9. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011
  10. pmc SeqEM: an adaptive genotype-calling approach for next-generation sequencing studies
    E R Martin
    John P Hussman Institute for Human Genomics and the Dr John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Bioinformatics 26:2803-10. 2010

Research Grants

  1. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2002
  2. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2003
  3. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2004
  4. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2005
  5. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2006
  6. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2006
  7. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2005
  8. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2006
  9. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2007

Collaborators

Detail Information

Publications59

  1. pmc Reconstructing the population genetic history of the Caribbean
    Andres Moreno-Estrada
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 9:e1003925. 2013
    ....
  2. pmc Reconsidering association testing methods using single-variant test statistics as alternatives to pooling tests for sequence data with rare variants
    Daniel D Kinnamon
    Dr John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 7:e30238. 2012
    ..We conclude that efficient locus-wide inference using single-variant test statistics should be reconsidered as a useful framework for devising powerful association tests in sequence data with rare variants...
  3. pmc A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
    John P Hussman
    John P, Hussman Institute for Human Genomics, University of Miami, 1501 NW 10th Avenue, Miami, FL 33136, USA
    Mol Autism 2:1. 2011
    ..abstract:..
  4. pmc Visualizing genotype x phenotype relationships in the GAW15 simulated data
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Proc 1:S132. 2007
    ..The generated plots provide information about genetic models for the simulated continuous covariates and may help identify the single-nucleotide polymorphisms associated with the underlying quantitative trait loci...
  5. pmc Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies
    Mike Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Proc 1:S138. 2007
    ..The quantitative trait loci analysis performed well in identifying these loci, and the power to identify disease-associated alleles was increased by using ordered-subset analysis as a case selection tool...
  6. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
    ..Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships...
  7. pmc CAPL: an efficient association software package using family and case-control data and accounting for population stratification
    Ren Hua Chung
    Center for Genetic Epidemiology and Statistical Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA
    BMC Bioinformatics 12:201. 2011
    ..Because computationally intensive algorithms are used in CAPL, implementing CAPL with efficient parallel algorithms is essential...
  8. pmc The future is now - will the real disease gene please stand up?
    E R Martin
    Center for Genetic Epidemiology and Statistical Genetics, Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Hered 66:127-35. 2008
    ..In conclusion, our results suggest that TDT is an effective screening tool for WGA studies, especially in multiplex families...
  9. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011
    ..abstract:..
  10. pmc SeqEM: an adaptive genotype-calling approach for next-generation sequencing studies
    E R Martin
    John P Hussman Institute for Human Genomics and the Dr John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Bioinformatics 26:2803-10. 2010
    ..Other genotype-calling methods, such as MAQ and SOAPsnp, are implementations of Bayes classifiers in that they classify genotypes using posterior genotype probabilities...
  11. pmc Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era
    Nadine Norton
    Cardiovascular Division, Department of Medicine and the Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 5:167-74. 2012
    ..Now broadly applied, exome sequencing data sets provide a novel opportunity to evaluate the allele frequencies of previously published pathogenic rare variants...
  12. doi request reprint A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms
    Xiaoyi Gao
    Center for Genetic Epidemiology and Statistical Genetics, Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Genet Epidemiol 32:361-9. 2008
    ..The efficiency and accuracy of the proposed method make it an attractive choice for multiple testing adjustment when there is high intermarker LD in the SNP data set...
  13. pmc Resolving the relationship between ApolipoproteinE and depression
    Michael A Slifer
    Miami Institute for Human Genomics, University of Miami, Miami, FL 33136, USA
    Neurosci Lett 455:116-9. 2009
    ..003) but not among those with Alzheimer disease. Additionally, individuals with Alzheimer disease and depression had a significantly younger age of onset for their Alzheimer disease than those without depression (p=0.017)...
  14. pmc APOE is not associated with Alzheimer disease: a cautionary tale of genotype imputation
    Gary W Beecham
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Ann Hum Genet 74:189-94. 2010
    ..This shows that joint analyses of imputed genotypes, particularly failure to replicate strong signals, should be considered critically and examined on a case-by-case basis...
  15. pmc Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
    Gary W Beecham
    Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Am J Hum Genet 84:35-43. 2009
    ..These results help to further define the genetic architecture of LOAD...
  16. pmc Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136 1015, USA
    Am J Hum Genet 88:273-82. 2011
    ..Knockdown of bag3 in a zebrafish model recapitulated DCM and heart failure. We conclude that new comprehensive genomic approaches have identified rare variants in BAG3 as causative of DCM...
  17. pmc Exome sequencing of a multigenerational human pedigree
    Dale J Hedges
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 4:e8232. 2009
    ....
  18. pmc Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18
    Xiaoyi Gao
    Dr John T Macdonald Foundation, Department of Human Genetics and Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Hum Genet 84:499-504. 2009
    ..The finding of two loci (one highly statistically significant) suggests that additional PD susceptibility genes might be identified through targeted candidate gene studies in these regions...
  19. pmc A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test
    Todd L Edwards
    Center for Genetic Epidemiology and Statistical Genetics, Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Florida, USA
    Genet Epidemiol 34:194-9. 2010
    ..We report that the CV procedure is valid with the permutation test, MDR-PDT performs similarly with 5- and 10-fold CV, and that the MOR is more powerful than PE as the fitness metric for MDR-PDT...
  20. pmc Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    Todd L Edwards
    John P Hussman Institute for Human Genomics, University of Miami, FL 33136, USA
    Ann Hum Genet 74:97-109. 2010
    ..79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD...
  21. pmc Common susceptibility variants examined for association with dilated cardiomyopathy
    Evadnie Rampersaud
    Hussman Institute for Human Genomics, Department of Human Genetics, University of Miami, Miami, FL, USA
    Ann Hum Genet 74:110-6. 2010
    ..Our results suggest that examination of common genetic variants may be warranted in future studies of DCM and other Mendelian-like disorders...
  22. pmc A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
    Deqiong Ma
    Miami Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA
    Ann Hum Genet 73:263-73. 2009
    ..24E-04 to 3.40E-06) than in either dataset alone. Our findings demonstrate that in addition to multiple rare variations, part of the complex genetic architecture of autism involves common variation...
  23. ncbi request reprint The APL test: extension to general nuclear families and haplotypes and examination of its robustness
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, N C, USA
    Hum Hered 61:189-99. 2006
    ..Furthermore, the robustness of APL in practice has not been examined. Here we present a generalization of the APL model and examination of its robustness under a variety of non-standard scenarios...
  24. pmc Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis
    Tricia A Thornton-Wells
    Biobehavioral Intervention Training Program, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University Institute for Imaging Science, Vanderbilt University, Nashville, Tennessee 37203, USA
    Genet Epidemiol 32:187-203. 2008
    ..Further studies are needed to replicate these statistical findings and to elucidate possible biological interaction mechanisms between LRRTM3 and these genes...
  25. doi request reprint X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design
    Li Zhang
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
    Genet Epidemiol 32:370-80. 2008
    ..In addition, estimation of disease-related marker relative risks provides a measure of the magnitude of X-linked genetic effects on complex disorders...
  26. doi request reprint Disease associations and family-based tests
    Warren J Ewens
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Protoc Hum Genet . 2003
    ..The unit includes the Sib TDT (S-TDT) method, which allows application of the principle of the TDT to sibships without parental data. This extension of TDT is potentially valuable for studying late onset diseases...
  27. doi request reprint Disease associations and family-based tests
    Warren J Ewens
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Protoc Hum Genet . 2008
    ..The unit includes the Sib TDT (S-TDT) method, which allows application of the principle of the TDT to sibships without parental data, and several related tests...
  28. ncbi request reprint Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Genet Epidemiol 31:883-93. 2007
    ..g., population stratification) and the interpretation of its OR estimates...
  29. ncbi request reprint Interpreting analyses of continuous covariates in affected sibling pair linkage studies
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 31:541-52. 2007
    ..They suggest that the side-by-side evaluation of OSA and QTL results may provide important information about the relationship of measured covariates with either disease risk or linkage heterogeneity...
  30. pmc Accounting for linkage in family-based tests of association with missing parental genotypes
    Eden R Martin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 73:1016-26. 2003
    ..As an example, we compare the performance of the tests in a candidate-gene study in families with Parkinson disease...
  31. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  32. ncbi request reprint Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
    Sofia A Oliveira
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurogenetics 5:147-55. 2004
    ..02). These results define the genes and regulatory regions included in this region of LD, containing an important susceptibility allele contributing to increased risk of neurodegeneration...
  33. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
    ..Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies...
  34. ncbi request reprint Lack of association between autism and SLC25A12
    Raquel Rabionet
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, 595 LaSalle St, Durham, NC 27710, USA
    Am J Psychiatry 163:929-31. 2006
    ..This study aimed to test for association in SLC25A12 in an independent data set of 327 families with autistic offspring...
  35. ncbi request reprint Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:409-22. 2006
    ....
  36. ncbi request reprint Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis
    Ping I Lin
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:157-65. 2006
    ..0026). These results suggest that subset and covariate analyses may be one approach to help identify novel susceptibility genes on chromosome 12q for LOAD...
  37. ncbi request reprint Interpretation of simultaneous linkage and family-based association tests in genome screens
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27710, USA
    Genet Epidemiol 31:134-42. 2007
    ..We concluded that when linkage and association tests are applied in the same data, the type I error rate of neither test will be affected and that power can be increased by applying tests conditionally...
  38. pmc No gene is an island: the flip-flop phenomenon
    Ping I Lin
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Am J Hum Genet 80:531-8. 2007
    ....
  39. ncbi request reprint Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease
    Xueying Liang
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
    Hum Mutat 28:1065-73. 2007
    ..However, the candidate gene and linkage analysis results did not converge, suggesting that there is more extensive heterogeneity on chromosome 10 than previously appreciated...
  40. ncbi request reprint Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease
    Kristin K Nicodemus
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurogenetics 5:201-8. 2004
    ..In conclusion, SNPs +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small...
  41. ncbi request reprint Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
    ..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE...
  42. pmc Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 74:1121-7. 2004
    ..0003), whereas a second haplotype (A-G-G-G-C) was found to be negatively associated with risk of PD (P=.0009). Our results strongly support FGF20 as a risk factor for PD...
  43. pmc Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
    ....
  44. ncbi request reprint Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk
    Allison E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Snyderman Genomic Sciences Building, Durham, NC 27710, USA
    Psychiatr Genet 17:221-6. 2007
    ..RELN shares a common biological pathway with APOE, and Persico et al. have observed transmission distortion of the APOE-2 allele in autism families...
  45. ncbi request reprint The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  46. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  47. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  48. pmc Increased efficiency of case-control association analysis by using allele-sharing and covariate information
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 65:154-65. 2008
    ....
  49. ncbi request reprint Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes
    Raquel Rabionet
    Department of Medicine, Center for Human Genetics, 595 LaSalle St, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 372:209-14. 2004
    ....
  50. ncbi request reprint NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006
    ..NOS2A is a candidate gene for Parkinson's disease (PD) that potentially interacts with cigarette smoking. We examined NOS2A for association with PD risk and age at onset (AAO) and for interaction with smoking...
  51. pmc Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
    Ann L Collins
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:167-74. 2006
    ..0253). These results confirmed our earlier findings, indicating GABRA4 and GABRB1 as genes contributing to autism susceptibility, extending the effect to multiple ethnic groups and suggesting seizures as a stratifying phenotype...
  52. ncbi request reprint Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease
    Sun J Kang
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mov Disord 21:2175-80. 2006
    ..02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women...
  53. pmc Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    Gaofeng Wang
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 82:283-9. 2008
    ..We propose this is likely to be a common mechanism of genetic modulation of individual susceptibility to complex disease...
  54. ncbi request reprint Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring
    Andrew S Allen
    Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:248-58. 2006
    ..The power and efficacy of the approach is illustrated through a series of simulation experiments in which the approach is compared to existing methods...
  55. pmc X-APL: an improved family-based test of association in the presence of linkage for the X chromosome
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA
    Am J Hum Genet 80:59-68. 2007
    ..To show its utility and to discuss interpretation in real-data analysis, we also applied the X-APL to candidate-gene data in a sample of families with Parkinson disease...
  56. ncbi request reprint Maternal lineages and Alzheimer disease risk in the Old Order Amish
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 118:115-22. 2005
    ..Therefore, we suggest that the genetic effect responsible for AD dementia in the affected Amish pedigrees is unlikely to be of mitochondrial origin and may be caused by nuclear genetic factors...
  57. ncbi request reprint The ubiquilin 1 gene and Alzheimer's disease
    Michael A Slifer
    N Engl J Med 352:2752-3; author reply 2752-3. 2005
  58. pmc Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases
    Yi Ju Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurobiol Aging 27:1087-93. 2006
    ..These findings suggest the presence of genetic heterogeneity for GSTO1h's effect on AAO, and support GSTO1h's role in modifying AAO in these two disorders...
  59. pmc Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis
    Silke Schmidt
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:708-17. 2002
    ..03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02)...

Research Grants9

  1. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2002
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  2. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2003
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  3. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2004
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  4. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2005
    ..Thus, the statistical methods and software developed through this grant will have an immediate application in gene mapping studies, and will help researchers identify and localize these important X-linked genes. ..
  5. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2006
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  6. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2006
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  7. Revealing Epistasis in Alzheimer Disease
    Eden Martin; Fiscal Year: 2005
    ..Further, knowledge gained from the proposed research will be invaluable for public health efforts to prevent and treat the initiation, progression, and severity of Alzheimer disease. ..
  8. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2006
    ..Thus, the statistical methods and software developed through this grant will have an immediate application in gene mapping studies, and will help researchers identify and localize these important X-linked genes. ..
  9. Statistical tests for association with X-linked genes
    Eden Martin; Fiscal Year: 2007
    ..Thus, the statistical methods and software developed through this grant will have an immediate application in gene mapping studies, and will help researchers identify and localize these important X-linked genes. ..