Doug S Martin

Summary

Affiliation: University of South Dakota
Country: USA

Publications

  1. pmc Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats
    Shuai Li
    Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States of America
    PLoS ONE 8:e78564. 2013
  2. doi request reprint Regional differences in sexually dimorphic protein expression in the spontaneously hypertensive rat (SHR)
    Douglas S Martin
    Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 5760 2390, USA
    Mol Cell Biochem 362:103-14. 2012
  3. doi request reprint Effect of ovariectomy on blood pressure and venous tone in female spontaneously hypertensive rats
    Douglas S Martin
    Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA
    Am J Hypertens 21:983-8. 2008
  4. ncbi request reprint Adrenergic nerves mediate the venoconstrictor response to PVN stimulation
    D S Martin
    Basic Biomedical Sciences, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
    Brain Res 1076:93-100. 2006
  5. ncbi request reprint Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats
    D S Martin
    Division of Basic Biomedical Sciences, School of Medicine University of South Dakota, Vermillion, SD 57069, USA
    Am J Physiol Regul Integr Comp Physiol 281:R553-60. 2001
  6. ncbi request reprint Castration reduces blood pressure and autonomic venous tone in male spontaneously hypertensive rats
    Doug S Martin
    Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota, USA
    J Hypertens 23:2229-36. 2005
  7. ncbi request reprint Pressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats
    Douglas S Martin
    Hypertension Unit, Systems Physiology and Structural Biology Research Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 East Clark St, Vermillion, SD 57069, USA
    Can J Physiol Pharmacol 80:1180-6. 2002
  8. ncbi request reprint Vascular ECE-1 mRNA expression decreases in response to estrogens
    Manoj C Rodrigo
    Hypertension Unit, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    Life Sci 73:2973-83. 2003
  9. ncbi request reprint Teaching human cardiovascular and respiratory physiology with the station method
    Barbara E Goodman
    Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA
    Adv Physiol Educ 26:50-6. 2002
  10. pmc The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries
    Kathleen M Eyster
    Division of Basic Biomedical Science, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Vascul Pharmacol 47:238-47. 2007

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats
    Shuai Li
    Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States of America
    PLoS ONE 8:e78564. 2013
    ..This study tested the hypothesis that the proteasome inhibitor, bortezomib, would attenuate AngII-induced hypertension and its sequelae such as aortic remodeling in rats...
  2. doi request reprint Regional differences in sexually dimorphic protein expression in the spontaneously hypertensive rat (SHR)
    Douglas S Martin
    Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 5760 2390, USA
    Mol Cell Biochem 362:103-14. 2012
    ..These data suggest that broad spectrum inhibition or stimulation of these systems may not be the best approach for hypertension treatment. Instead regionally targeted manipulation of these systems should be investigated...
  3. doi request reprint Effect of ovariectomy on blood pressure and venous tone in female spontaneously hypertensive rats
    Douglas S Martin
    Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, USA
    Am J Hypertens 21:983-8. 2008
    ..A number of reports have suggested an effect of estrogen on venous function. This study tested the hypothesis that ovariectomy would increase venous tone in the female spontaneously hypertensive rat (SHR) via autonomic mechanisms...
  4. ncbi request reprint Adrenergic nerves mediate the venoconstrictor response to PVN stimulation
    D S Martin
    Basic Biomedical Sciences, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
    Brain Res 1076:93-100. 2006
    ..These data indicate that adrenomedullary catecholamines are not necessary for full expression of the venoconstrictor response to PVN stimulation...
  5. ncbi request reprint Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats
    D S Martin
    Division of Basic Biomedical Sciences, School of Medicine University of South Dakota, Vermillion, SD 57069, USA
    Am J Physiol Regul Integr Comp Physiol 281:R553-60. 2001
    ..These findings indicate that dietary soy exerts an antihypertensive effect in OVX SHR. This effect does not involve the nitric oxide system but may be related to an as yet undefined interaction with the autonomic nervous system...
  6. ncbi request reprint Castration reduces blood pressure and autonomic venous tone in male spontaneously hypertensive rats
    Doug S Martin
    Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota, USA
    J Hypertens 23:2229-36. 2005
    ..Venous tone is elevated in the spontaneously hypertensive rat model of hypertension. This study tested the hypothesis that endogenous androgens exacerbate venous tone in the developmental stages of spontaneous hypertension...
  7. ncbi request reprint Pressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats
    Douglas S Martin
    Hypertension Unit, Systems Physiology and Structural Biology Research Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 East Clark St, Vermillion, SD 57069, USA
    Can J Physiol Pharmacol 80:1180-6. 2002
    ..We conclude that ACE inhibition does not account for the antihypertensive effect of dietary soy in mature SHR...
  8. ncbi request reprint Vascular ECE-1 mRNA expression decreases in response to estrogens
    Manoj C Rodrigo
    Hypertension Unit, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    Life Sci 73:2973-83. 2003
    ..Moreover, the data suggest that genistein and daidzein inhibit ECE-1 expression by an estrogen receptor-mediated mechanism...
  9. ncbi request reprint Teaching human cardiovascular and respiratory physiology with the station method
    Barbara E Goodman
    Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA
    Adv Physiol Educ 26:50-6. 2002
    ..Although we neglected to formally assess the impact on students of changes in laboratory design, students appeared to respond enthusiastically to the laboratory and prepared knowledgeable laboratory reports...
  10. pmc The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries
    Kathleen M Eyster
    Division of Basic Biomedical Science, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Vascul Pharmacol 47:238-47. 2007
    ..Aryl hydrocarbon nuclear translocator-like gene was reduced by testosterone. These data identify genes not previously known to be responsive to estrogen and testosterone in the vasculature...
  11. ncbi request reprint Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats
    Jin Song
    Basic Biomedical Sciences, University of South Dakota, Vermillion SD 57069, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1608-15. 2006
    ..Collectively, these data suggest that androgens modulate renal and systemic vascular responsiveness to ANG II, which may contribute to androgen-induced facilitation of NZGH rat hypertension...
  12. ncbi request reprint Fructose feeding and intermittent hypoxia affect ventilatory responsiveness to hypoxia and hypercapnia in rats
    Evelyn H Schlenker
    Basic Biomedical Sciences, Univ of South Dakota School of Medicine, Vermillion, SD 57069, USA
    J Appl Physiol (1985) 97:1387-94. 2004
    ..Intermittent hypoxia interacted with FF to increase insulin levels and depress ventilatory responses to acute hypoxia that remained depressed during washout...
  13. ncbi request reprint Estrogen decreases biglycan mRNA expression in resistance blood vessels
    Manoj C Rodrigo
    University of South Dakota School of Medicine, Vermillion, SD 57069, USA
    Am J Physiol Regul Integr Comp Physiol 285:R754-61. 2003
    ..Biglycan protein was localized to the media of the mesenteric arteries by immunohistochemistry. Collectively, these data suggest that biglycan is a vascular protein regulated at the genomic level by estrogens...
  14. ncbi request reprint Effects of estrogens and selective estrogen receptor modulators on vascular reactivity in the perfused mesenteric vascular bed
    Connie J Mark
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1969-75. 2007
    ..However, the three formulations of estrogen did not produce equivalent effects, and the effects of the SERMs were different from those of the estrogens...
  15. ncbi request reprint Rho kinase contributes to androgen amplification of renal vasoconstrictor responses in the spontaneously hypertensive rat
    Jin Song
    Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    J Cardiovasc Pharmacol 48:103-9. 2006
    ..Collectively, these findings indicate that androgen modulation of hypertension development in the SHR involves a fasudil-sensitive pathway and suggest that further study is warranted in this area...
  16. ncbi request reprint Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway
    Jin Song
    Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
    Cardiovasc Res 72:456-63. 2006
    ..This study assessed whether the Rho kinase signaling pathway contributes to androgenic amplification of angiotensin II (Ang II) induced pressor and renal constrictor responses...
  17. ncbi request reprint A method for the extraction of high-quality RNA and protein from single small samples of arteries and veins preserved in RNAlater
    Manoj C Rodrigo
    Hypertension Unit, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 East Clark Street, Vermillion, SD 57069, USA
    J Pharmacol Toxicol Methods 47:87-92. 2002
    ..However, the limited quantity of tissue available and the activity of RNases and proteases during dissection of the vessels make it difficult to study gene and protein expression in this tissue...
  18. ncbi request reprint Dietary protein and hypertension: where do we stand?
    Douglas S Martin
    Nutrition 19:385-6. 2003

Research Grants2

  1. Equipment Support for USD Laboratory Animal Services
    Douglas Martin; Fiscal Year: 2005
    ..The long-term goal is to achieve AAALAC accreditation. It is expected that AAALAC review for accreditation will be requested within 18 months of completion and occupancy of the new LAS. ..
  2. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..