Research Topics
Genomes and Genes
| Jamey D MarthSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesisRyan S Green
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Immunity 27:308-20. 2007..Thus, mammalian N-glycan branching safeguards against the formation of an endogenous immunologic signal of nonself that can provoke a sterile inflammatory response in the pathogenesis of autoimmune disease...
Mammalian glycosylation in immunityJamey D Marth
Department of Cellular and Molecular Medicine, The Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA
Nat Rev Immunol 8:874-87. 2008..This Review focuses on the emerging immunological roles of the mammalian glycome...- Glycosyltransferase function in core 2-type protein O glycosylationErica L Stone
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Mol Cell Biol 29:3770-82. 2009..Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes... - Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunityMari Tenno
Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell Biol 27:8783-96. 2007..These findings reveal that the initiation of protein O glycosylation by ppGalNAcT-1 provides a distinctive repertoire of advantageous functions that support vascular responses and humoral immunity... - Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiationSeung Ho Lee
Glycobiology Unit, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
J Biol Chem 285:37683-92. 2010..These studies are the first to clearly identify functional mucin-type O-glycan structures modulating cell surface expression of SI and DPP-IV during the intestinal cell differentiation... - Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitmentJunya Mitoma
Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
Nat Immunol 8:409-18. 2007..Our results demonstrate the critical function of N-glycan-linked 6-sulfo sialyl Lewis X in L-selectin-dependent lymphocyte homing and recruitment... - Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain developmentKiyohiko Angata
Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Mol Cell Biol 27:6659-68. 2007..These results indicate that polysialic acid regulates cell migration and differentiation of neural precursors crucial for brain development... - ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signalingPrabhjit K Grewal
Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, 9500 Gilman Drive MC0625, University of California San Diego, La Jolla, CA 92093, USA
Mol Cell Biol 26:4970-81. 2006.... - Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosisSteven J Van Dyken
Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0625, USA
Mol Cell Biol 27:1096-111. 2007..We propose that an endogenous lectin activates an apoptotic pathway constructed in CD8+ T cells following TCR stimulation and enables contraction upon attenuation of immune signaling... - The Ashwell receptor mitigates the lethal coagulopathy of sepsisPrabhjit K Grewal
The Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine University of California, San Diego, La Jolla, California 92093, USA
Nat Med 14:648-55. 2008..Hemostatic adaptation by the Ashwell receptor moderates the onset and severity of disseminated intravascular coagulation during sepsis and improves the probability of host survival... - Glycosylation in cellular mechanisms of health and diseaseKazuaki Ohtsubo
Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive-MC0625, University of California, San Diego, La Jolla, CA 92093, USA
Cell 126:855-67. 2006..This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease... - Cellular and molecular analysis of neural development of glycosyltransferase gene knockout miceKiyohiko Angata
Glycobiology Program, Cancer Center, Burnham Institute for Medical Research, La Jolla, California, USA
Methods Enzymol 417:25-37. 2006..In this chapter, we discuss methods used to analyze polysialyltransferase knockout mice using immunohistochemistry of brain and primary cultures of neurons... - A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteinsSALLY L ORR
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0687, USA
Glycobiology 23:363-80. 2013.... - Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in miceTomoya O Akama
Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:8983-8. 2006..Thus, either MII or MX can biochemically compensate for the deficiency of the other in vivo, and either of two is required for late embryonic and early postnatal development... - Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behaviorKiyohiko Angata
Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
J Biol Chem 279:32603-13. 2004..This genetic partitioning of PSA formation engenders discrete neurological processes and reveals that this post-translational modification forms the predominant basis for the multiple functions attributed to the NCAM glycoprotein... - Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamicsBin Zheng
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
Proc Natl Acad Sci U S A 103:16776-81. 2006..Taken together, our findings demonstrate an essential role for RGS-PX1/SNX13 in mouse development and provide previously undescribed insights into its cellular function in the regulation of endocytosis dynamics... - N-glycan branching requirement in neuronal and postnatal viabilityZhengyi Ye
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, Glycobiology Research and Training Center, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093, USA
Glycobiology 14:547-58. 2004..Structural features associated with hybrid N-glycan branching comprise a requisite posttranslational modification to neuronal glycoproteins that permits normal cellular function and viability... - Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetesKazuaki Ohtsubo
Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093, USA
Cell 123:1307-21. 2005..We infer that beta cell glucose-transporter glycosylation mediates a link between diet and insulin production that typically suppresses the pathogenesis of type 2 diabetes... - Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viabilityNiall O'Donnell
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093 0625, USA
Mol Cell Biol 24:1680-90. 2004..We find that O-GlcNAc modulates protein phosphorylation and expression among essential and conserved cell signaling pathways... - Symbol nomenclature for glycan representationAjit Varki
Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093 0687, USA
Proteomics 9:5398-9. 2009..We also note that >200 illustrations in the second edition have already been published using our nomenclature and are available for download at PubMed... - Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contactBrian E Collins
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:6104-9. 2004..The combined results suggest that equilibrium binding to cis ligands does not preclude binding of CD22 to ligands in trans, and allows for its redistribution to sites of contact between lymphocytes... - Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIaYan Wang
Howard Hughes Medical Institute, the Glycobiology Research and Training Center, and the Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
Biochim Biophys Acta 1573:301-11. 2002..Pre-natal defects appear in a significant number of embryos, and likely reflect a limited window of time in which a future therapeutic approach might effectively operate... - Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homingNobuyoshi Hiraoka
Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 279:3058-67. 2004.... - Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylationLaura T Martin
Glycobiology Research and Training Center, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
J Biol Chem 277:32930-8. 2002..These data demonstrate selective regulation of sialylation and 9-O-acetylation, point to cell types with potential physiological defects in null animals, and show in vivo evidence for competition between Golgi enzymes... - T-cell activation results in microheterogeneous changes in glycosylation of CD45Joseph D Hernandez
Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Int Immunol 19:847-56. 2007..Thus, changes in glycan structure during T-cell activation are microheterogeneous and unique to individual glycans on specific glycoproteins, implying that these glycans have precise functions in T-cell biology... - Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion moleculeBirgit Weinhold
Zelluläre Chemie, Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
J Biol Chem 280:42971-7. 2005.... - Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implantShaolin Shi
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, New York, NY 10461, USA
Mol Cell Biol 24:9920-9. 2004..5. Therefore, complex or hybrid N-glycans are required at some stage of oogenesis for the generation of a developmentally competent oocyte, but fertilization, blastogenesis, and implantation may proceed in their absence... - A genetic approach to Mammalian glycan functionJohn B Lowe
Department of Pathology and Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Annu Rev Biochem 72:643-91. 2003..T. Hager: Force of Nature (1).. - Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interactionAnne Marie Moody
Laboratory of Immunobiology, Department of Cancer Immunology and AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:7240-6. 2003..These results suggest how sialylation in a discrete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental switch that affects ligand binding... - Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigenYan Zhang
Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
J Biol Chem 278:573-84. 2003..pp-GalNAc-T13 would be a major enzyme responsible for the synthesis of O-glycan and specifically the Tn antigen epitope in neurons... - Unusual N-glycan structures in alpha-mannosidase II/IIx double null embryos identified by a systematic glycomics approach based on two-dimensional LC mapping and matrix-dependent selective fragmentation method in MALDI-TOF/TOF mass spectrometryMegumi Hato
Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, N21, W11, Sapporo 001-0021, Japan
Mol Cell Proteomics 5:2146-57. 2006..The present study demonstrated that use of the versatile matrix-dependent selective fragmentation method in MALDI-TOF/TOF MS greatly accelerates detailed structural analysis of a trace amount of N-glycans...