Wallace Marshall

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii
    Ivan Zamora
    Dept of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    BMC Biol 3:15. 2005
  2. ncbi request reprint Gene expression and nuclear architecture during development and differentiation
    Wallace F Marshall
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mech Dev 120:1217-30. 2003
  3. pmc Modeling recursive RNA interference
    Wallace F Marshall
    Department of Biochemistry and Biophysics, Integrative Program in Quantitative Biology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 4:e1000183. 2008
  4. ncbi request reprint Cilia: tuning in to the cell's antenna
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
    Curr Biol 16:R604-14. 2006
  5. pmc Cilia orientation and the fluid mechanics of development
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Fransciso, CA 94158, USA
    Curr Opin Cell Biol 20:48-52. 2008
  6. doi request reprint Engineering design principles for organelle size control systems
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, United States
    Semin Cell Dev Biol 19:520-4. 2008
  7. ncbi request reprint What is the function of centrioles?
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    J Cell Biochem 100:916-22. 2007
  8. pmc Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance
    Wallace F Marshall
    Department of Biochemistry and Biophysics and Integrative Program in Quantitative Biology, University of California, San Francisco, CA, USA
    Biophys J 93:1818-33. 2007
  9. pmc Don'T blink: observing the ultra-fast contraction of spasmonemes
    Wallace F Marshall
    Department of Biochemistry and Biophysics Integrative Program in Quantitative Biology, University of California at San Francisco, San Francisco, California 94158, USA
    Biophys J 94:4-5. 2008
  10. ncbi request reprint Centriole assembly: the origin of nine-ness
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    Curr Biol 17:R1057-9. 2007

Research Grants

  1. Centriole Orientation During Left/Right Symmetry Breaking in the Mouse
    Wallace Marshall; Fiscal Year: 2007
  2. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007

Detail Information

Publications44

  1. pmc A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii
    Ivan Zamora
    Dept of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    BMC Biol 3:15. 2005
    ..The role of centrioles in mitotic spindle function remains unclear. One approach to investigate mitotic centriole function is to ask whether mutation of centriole-associated proteins can cause genomic instability...
  2. ncbi request reprint Gene expression and nuclear architecture during development and differentiation
    Wallace F Marshall
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mech Dev 120:1217-30. 2003
    ..The remainder of the review will examine developmental processes from the point of view of the nucleus...
  3. pmc Modeling recursive RNA interference
    Wallace F Marshall
    Department of Biochemistry and Biophysics, Integrative Program in Quantitative Biology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 4:e1000183. 2008
    ..The model suggests potential ways to optimize the effectiveness of recursive RNAi both for screening of RNAi components as well as for improved temporal control of gene expression in switch off-switch on experiments...
  4. ncbi request reprint Cilia: tuning in to the cell's antenna
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
    Curr Biol 16:R604-14. 2006
    ..While these diseases highlight the pivotal roles of cilia in physiology and development, the mechanistic link between cilia, physiology, and disease remains unclear...
  5. pmc Cilia orientation and the fluid mechanics of development
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Fransciso, CA 94158, USA
    Curr Opin Cell Biol 20:48-52. 2008
    ..Errors in cilia orientation have been observed in human ciliary disease patients, suggesting that orientation defects may constitute a novel class of ciliopathies with a distinct etiology at the cell biological level...
  6. doi request reprint Engineering design principles for organelle size control systems
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, United States
    Semin Cell Dev Biol 19:520-4. 2008
    ..Each class represents a design principle by which artificial size controllers could be developed for synthetic biology applications...
  7. ncbi request reprint What is the function of centrioles?
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    J Cell Biochem 100:916-22. 2007
    ....
  8. pmc Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance
    Wallace F Marshall
    Department of Biochemistry and Biophysics and Integrative Program in Quantitative Biology, University of California, San Francisco, CA, USA
    Biophys J 93:1818-33. 2007
    ....
  9. pmc Don'T blink: observing the ultra-fast contraction of spasmonemes
    Wallace F Marshall
    Department of Biochemistry and Biophysics Integrative Program in Quantitative Biology, University of California at San Francisco, San Francisco, California 94158, USA
    Biophys J 94:4-5. 2008
  10. ncbi request reprint Centriole assembly: the origin of nine-ness
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    Curr Biol 17:R1057-9. 2007
    ..Recent studies of the Chlamydomonas bld10 mutant have revealed that the ninefold symmetry of the centriole is set by the length of the cartwheel spokes, which fixes the diameter, and thereby the circumference, of the centriole...
  11. pmc Centriole evolution
    Wallace F Marshall
    Dept of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    Curr Opin Cell Biol 21:14-9. 2009
    ..Far from being irreducibly complex, centrioles appear to be based on a rather minimal underlying core structure requiring only a handful of genes to construct...
  12. pmc The cell biological basis of ciliary disease
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 180:17-21. 2008
    ..The clinical complexity of the ciliopathies can therefore only be understood in light of the basic cell biology of the cilia themselves, which I will discuss from the viewpoint of cell biological studies in model organisms...
  13. pmc Flagellar length control system: testing a simple model based on intraflagellar transport and turnover
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:270-8. 2005
    ..These results are consistent with the balance-point model for length control. The three strategies used here are not limited to flagella and can in principle be adapted to probe size control systems for any organelle...
  14. ncbi request reprint Cellular length control systems
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Annu Rev Cell Dev Biol 20:677-93. 2004
    ..The lessons learned from size control in linear structures should be applicable to organelles with more complex three-dimensional structures...
  15. pmc The mother centriole plays an instructive role in defining cell geometry
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 5:e149. 2007
    ..The genes documented here that are required for proper centriole positioning may represent a new class of ciliary disease genes, defects in which would be expected to cause disorganized ciliary position and impaired function...
  16. ncbi request reprint Size control in dynamic organelles
    Wallace Marshall
    Dept Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Ave, New Haven, CT, USA
    Trends Cell Biol 12:414-9. 2002
    ..This model of the flagellum might represent a general scheme for organelle size control that could apply to any organelle whose maintenance involves continuous assembly balanced by disassembly...
  17. doi request reprint A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    Cytoskeleton (Hoboken) 68:188-203. 2011
    ....
  18. pmc Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Methods Cell Biol 93:157-77. 2009
    ..This chapter also reviews current IFT insights gleaned from TIRF microscopy of Chlamydomonas and provides an outlook on the future of the technique, with particular emphasis on combining TIRF with other emerging imaging technologies...
  19. doi request reprint Isolation and proteomic analysis of Chlamydomonas centrioles
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Methods Mol Biol 432:289-300. 2008
    ..Isolated centrioles can be used in combination with a wide variety of biochemical assays in addition to being utilized as a source for proteomic analysis...
  20. doi request reprint Building the cell: design principles of cellular architecture
    Susanne M Rafelski
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 9:593-602. 2008
    ..By examining how these parameters are controlled in specific cell biological examples we can identify a handful of simple design principles that seem to underlie cellular architecture and assembly...
  21. doi request reprint Cilia self-organize in response to planar cell polarity and flow
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, USA
    Nat Cell Biol 12:314-5. 2010
    ..We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow...
  22. ncbi request reprint Centrioles: bad to be bald?
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Curr Biol 14:R659-60. 2004
    ..In the alga Chlamydomonas, mutation of the gene encoding the novel centriolar component Bld10p results in seemingly acentriolar cells. Remarkably, bld10 cells are viable, highlighting the question of whether or not centrioles are essential...
  23. pmc De novo formation of left-right asymmetry by posterior tilt of nodal cilia
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, Japan
    PLoS Biol 3:e268. 2005
    ....
  24. pmc ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Biol 19:1238-43. 2009
    ..The defects in centriole number control, centriole positioning, and spindle orientation appear to arise from perturbation of centriole linkage mediated by Tbccd1/Asq2p...
  25. pmc Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:1150-66. 2009
    ..Together, these data suggest that POC1 is involved in early steps of centriole duplication as well as in the later steps of centriole length control...
  26. doi request reprint Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA
    J Biomol Screen 14:133-41. 2009
    ..The 2 assays have different advantages in terms of speed and sensitivity to small reductions in motility and may be most efficiently used in combination...
  27. ncbi request reprint Flagellar length control in chlamydomonas--paradigm for organelle size regulation
    Kimberly A Wemmer
    Department of Biochemistry, University of California, San Francisco, California 94158, USA
    Int Rev Cytol 260:175-212. 2007
    ..Studies in this organism using genetics, biochemistry, imaging, and mathematical modeling have revealed many genes involved in length control of cilia and flagella, and have suggested several testable models for length regulation...
  28. doi request reprint Ciliary secretion: switching the cellular antenna to 'transmit'
    Prachee Avasthi
    Department of Biochemistry and Biophysics, UCSF Mission Bay, San Francisco, CA 94143 2200, USA
    Curr Biol 23:R471-3. 2013
    ..New work in Chlamydomonas demonstrates that cilia can also act as secretory organelles by budding enzyme-containing vesicles from the flagellar membrane for post-mitotic hatching of daughters from the mother cell wall...
  29. ncbi request reprint Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord
    Timothy E Kennedy
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:8866-74. 2006
    ..The detection of a gradient of netrin-1 protein supports the operation of long-range chemotropic mechanisms in the developing nervous system...
  30. ncbi request reprint Order and disorder in the nucleus
    Wallace F Marshall
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Curr Biol 12:R185-92. 2002
    ....
  31. pmc Influence of centriole number on mitotic spindle length and symmetry
    Lani C Keller
    Department of Biochemistry and Biophysics, UCSF, San Francisco, California 94158, USA
    Cytoskeleton (Hoboken) 67:504-18. 2010
    ....
  32. ncbi request reprint Tubulin superfamily: giving birth to triplets
    Wallace F Marshall
    Molecular, Cellular, and Developmental Biology Department, Yale University, 06520, New Haven, CT, USA
    Curr Biol 13:R55-6. 2003
    ..The function of these triplets, and the precise role of e tubulin in triplet formation, remains unclear...
  33. pmc Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:81-9. 2009
    ....
  34. doi request reprint Basal bodies platforms for building cilia
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA
    Curr Top Dev Biol 85:1-22. 2008
    ..The "parts list" of basal body proteins and genes is rapidly being completed, opening the way to more mechanistic studies in the future...
  35. ncbi request reprint Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Biol 15:1090-8. 2005
    ..Centrioles also act as basal bodies during interphase to nucleate the assembly of cilia and flagella. There are currently only a handful of known centriole proteins...
  36. ncbi request reprint Flagellar motility: all pull together
    Kimberly A Wemmer
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, USA
    Curr Biol 14:R992-3. 2004
    ..Eukaryotic flagella produce a swimming force by coordinating thousands of dynein motor proteins. Recent work provides new clues into how this coordination is achieved...
  37. doi request reprint Use of transcriptomic data to support organelle proteomic analysis
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Methods Mol Biol 432:403-14. 2008
    ..Such an approach can be used to narrow down a preliminary proteomic data set and help us to focus on a smaller sub-set of proteins that are supported by transcriptomic cross-validation...
  38. ncbi request reprint Quantitative modeling in cell biology: what is it good for?
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, 95616, USA
    Dev Cell 11:279-87. 2006
    ....
  39. ncbi request reprint PCR-based assay for mating type and diploidy in Chlamydomonas
    Ivan Zamora
    University of California, San Francisco, CA 94143, USA
    Biotechniques 37:534-6. 2004
  40. ncbi request reprint Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin
    Wallace F Marshall
    Curr Biol 14:R913-4. 2004
  41. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....
  42. pmc Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes
    Viktor Stolc
    Genome Research Facility, National Aeronautic and Space Administration, Ames Research Center, Moffett Field, CA 94035, USA
    Proc Natl Acad Sci U S A 102:3703-7. 2005
    ....
  43. ncbi request reprint Loss of checkpoint proteins: an occupational hazard
    Wallace F Marshall
    Trends Cell Biol 12:160. 2002
  44. ncbi request reprint Polar wind left flapping in the breeze?
    Wallace F Marshall
    Trends Cell Biol 12:9. 2002

Research Grants2

  1. Centriole Orientation During Left/Right Symmetry Breaking in the Mouse
    Wallace Marshall; Fiscal Year: 2007
    ....
  2. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007
    ....