Wallace Marshall

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Centrosome size: scaling without measuring
    Wallace F Marshall
    Dept of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    Curr Biol 21:R594-6. 2011
  2. ncbi request reprint The Golgi is a measuring cup
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Dev Cell 29:259-60. 2014
  3. pmc The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 199:151-67. 2012
  4. doi request reprint Differential geometry meets the cell
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Cell 154:265-6. 2013
  5. pmc Centriole asymmetry determines algal cell geometry
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, United States
    Curr Opin Plant Biol 15:632-7. 2012
  6. pmc Organelle size control systems: From cell geometry to organelle-directed medicine
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Bioessays 34:721-4. 2012
  7. doi request reprint Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA
    J Biomol Screen 14:133-41. 2009
  8. doi request reprint Cilia self-organize in response to planar cell polarity and flow
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, USA
    Nat Cell Biol 12:314-5. 2010
  9. pmc Origins of cellular geometry
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    BMC Biol 9:57. 2011
  10. pmc The mother centriole plays an instructive role in defining cell geometry
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 5:e149. 2007

Research Grants

  1. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2006
  2. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2007
  3. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2009
  4. Pattern formation & regeneration in a single cell
    Wallace Marshall; Fiscal Year: 2009
  5. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2010
  6. Pattern formation & regeneration in a single cell
    Wallace Marshall; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Centrosome size: scaling without measuring
    Wallace F Marshall
    Dept of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    Curr Biol 21:R594-6. 2011
    ..This simple scheme explains size control and scaling of centrosomes relative to cell volume...
  2. ncbi request reprint The Golgi is a measuring cup
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Dev Cell 29:259-60. 2014
    ..Reporting in this issue of Developmental Cell, Ferraro et al. (2014) show that the size and topology of the Golgi apparatus determines the size and functionality of a medically important secretory granule...
  3. pmc The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 199:151-67. 2012
    ..Proteomic analysis of dhc1b-3 flagella revealed distinct classes of proteins that change in abundance when retrograde IFT is inhibited...
  4. doi request reprint Differential geometry meets the cell
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Cell 154:265-6. 2013
    ....
  5. pmc Centriole asymmetry determines algal cell geometry
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, United States
    Curr Opin Plant Biol 15:632-7. 2012
    ..Thus to understand cell organization, it will be critical to understand how the different triplets of the centriole come to have distinct molecular identities...
  6. pmc Organelle size control systems: From cell geometry to organelle-directed medicine
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Bioessays 34:721-4. 2012
    ..Organelle size is tuned to metabolic needs, hence reprogramming organelle size could be a novel therapeutic strategy as well as a new tool for metabolic engineering...
  7. doi request reprint Quantitative high-throughput assays for flagella-based motility in chlamydomonas using plate-well image analysis and transmission correlation spectroscopy
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA
    J Biomol Screen 14:133-41. 2009
    ..The 2 assays have different advantages in terms of speed and sensitivity to small reductions in motility and may be most efficiently used in combination...
  8. doi request reprint Cilia self-organize in response to planar cell polarity and flow
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Francisco, CA 94158, USA
    Nat Cell Biol 12:314-5. 2010
    ..We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow...
  9. pmc Origins of cellular geometry
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    BMC Biol 9:57. 2011
    ....
  10. pmc The mother centriole plays an instructive role in defining cell geometry
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 5:e149. 2007
    ..The genes documented here that are required for proper centriole positioning may represent a new class of ciliary disease genes, defects in which would be expected to cause disorganized ciliary position and impaired function...
  11. pmc Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Methods Cell Biol 93:157-77. 2009
    ..This chapter also reviews current IFT insights gleaned from TIRF microscopy of Chlamydomonas and provides an outlook on the future of the technique, with particular emphasis on combining TIRF with other emerging imaging technologies...
  12. doi request reprint Building the cell: design principles of cellular architecture
    Susanne M Rafelski
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 9:593-602. 2008
    ..By examining how these parameters are controlled in specific cell biological examples we can identify a handful of simple design principles that seem to underlie cellular architecture and assembly...
  13. doi request reprint Engineering design principles for organelle size control systems
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, United States
    Semin Cell Dev Biol 19:520-4. 2008
    ..Each class represents a design principle by which artificial size controllers could be developed for synthetic biology applications...
  14. pmc Modeling recursive RNA interference
    Wallace F Marshall
    Department of Biochemistry and Biophysics, Integrative Program in Quantitative Biology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 4:e1000183. 2008
    ..The model suggests potential ways to optimize the effectiveness of recursive RNAi both for screening of RNAi components as well as for improved temporal control of gene expression in switch off-switch on experiments...
  15. pmc Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:1150-66. 2009
    ..Together, these data suggest that POC1 is involved in early steps of centriole duplication as well as in the later steps of centriole length control...
  16. pmc Centriole evolution
    Wallace F Marshall
    Dept of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    Curr Opin Cell Biol 21:14-9. 2009
    ..Far from being irreducibly complex, centrioles appear to be based on a rather minimal underlying core structure requiring only a handful of genes to construct...
  17. pmc ASQ2 encodes a TBCC-like protein required for mother-daughter centriole linkage and mitotic spindle orientation
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Biol 19:1238-43. 2009
    ..The defects in centriole number control, centriole positioning, and spindle orientation appear to arise from perturbation of centriole linkage mediated by Tbccd1/Asq2p...
  18. doi request reprint Isolation and proteomic analysis of Chlamydomonas centrioles
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Methods Mol Biol 432:289-300. 2008
    ..Isolated centrioles can be used in combination with a wide variety of biochemical assays in addition to being utilized as a source for proteomic analysis...
  19. pmc Cilia orientation and the fluid mechanics of development
    Wallace F Marshall
    Department of Biochemistry and Biophysics, UCSF, San Fransciso, CA 94158, USA
    Curr Opin Cell Biol 20:48-52. 2008
    ..Errors in cilia orientation have been observed in human ciliary disease patients, suggesting that orientation defects may constitute a novel class of ciliopathies with a distinct etiology at the cell biological level...
  20. ncbi request reprint Gene expression and nuclear architecture during development and differentiation
    Wallace F Marshall
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mech Dev 120:1217-30. 2003
    ..The remainder of the review will examine developmental processes from the point of view of the nucleus...
  21. ncbi request reprint Centrioles: bad to be bald?
    Jessica L Feldman
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Curr Biol 14:R659-60. 2004
    ..In the alga Chlamydomonas, mutation of the gene encoding the novel centriolar component Bld10p results in seemingly acentriolar cells. Remarkably, bld10 cells are viable, highlighting the question of whether or not centrioles are essential...
  22. ncbi request reprint Cellular length control systems
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Annu Rev Cell Dev Biol 20:677-93. 2004
    ..The lessons learned from size control in linear structures should be applicable to organelles with more complex three-dimensional structures...
  23. pmc Flagellar length control system: testing a simple model based on intraflagellar transport and turnover
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:270-8. 2005
    ..These results are consistent with the balance-point model for length control. The three strategies used here are not limited to flagella and can in principle be adapted to probe size control systems for any organelle...
  24. pmc A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii
    Ivan Zamora
    Dept of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    BMC Biol 3:15. 2005
    ..The role of centrioles in mitotic spindle function remains unclear. One approach to investigate mitotic centriole function is to ask whether mutation of centriole-associated proteins can cause genomic instability...
  25. pmc De novo formation of left-right asymmetry by posterior tilt of nodal cilia
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, Japan
    PLoS Biol 3:e268. 2005
    ....
  26. ncbi request reprint Cilia: tuning in to the cell's antenna
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
    Curr Biol 16:R604-14. 2006
    ..While these diseases highlight the pivotal roles of cilia in physiology and development, the mechanistic link between cilia, physiology, and disease remains unclear...
  27. ncbi request reprint What is the function of centrioles?
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    J Cell Biochem 100:916-22. 2007
    ....
  28. ncbi request reprint Centriole assembly: the origin of nine-ness
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California, USA
    Curr Biol 17:R1057-9. 2007
    ..Recent studies of the Chlamydomonas bld10 mutant have revealed that the ninefold symmetry of the centriole is set by the length of the cartwheel spokes, which fixes the diameter, and thereby the circumference, of the centriole...
  29. pmc The cell biological basis of ciliary disease
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 180:17-21. 2008
    ..The clinical complexity of the ciliopathies can therefore only be understood in light of the basic cell biology of the cilia themselves, which I will discuss from the viewpoint of cell biological studies in model organisms...
  30. pmc Don'T blink: observing the ultra-fast contraction of spasmonemes
    Wallace F Marshall
    Department of Biochemistry and Biophysics Integrative Program in Quantitative Biology, University of California at San Francisco, San Francisco, California 94158, USA
    Biophys J 94:4-5. 2008
  31. pmc Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance
    Wallace F Marshall
    Department of Biochemistry and Biophysics and Integrative Program in Quantitative Biology, University of California, San Francisco, CA, USA
    Biophys J 93:1818-33. 2007
    ....
  32. ncbi request reprint Flagellar length control in chlamydomonas--paradigm for organelle size regulation
    Kimberly A Wemmer
    Department of Biochemistry, University of California, San Francisco, California 94158, USA
    Int Rev Cytol 260:175-212. 2007
    ..Studies in this organism using genetics, biochemistry, imaging, and mathematical modeling have revealed many genes involved in length control of cilia and flagella, and have suggested several testable models for length regulation...
  33. pmc Influence of centriole number on mitotic spindle length and symmetry
    Lani C Keller
    Department of Biochemistry and Biophysics, UCSF, San Francisco, California 94158, USA
    Cytoskeleton (Hoboken) 67:504-18. 2010
    ....
  34. ncbi request reprint Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Biol 15:1090-8. 2005
    ..Centrioles also act as basal bodies during interphase to nucleate the assembly of cilia and flagella. There are currently only a handful of known centriole proteins...
  35. doi request reprint Basal bodies platforms for building cilia
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA
    Curr Top Dev Biol 85:1-22. 2008
    ..The "parts list" of basal body proteins and genes is rapidly being completed, opening the way to more mechanistic studies in the future...
  36. pmc Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:81-9. 2009
    ....
  37. doi request reprint Ciliary secretion: switching the cellular antenna to 'transmit'
    Prachee Avasthi
    Department of Biochemistry and Biophysics, UCSF Mission Bay, San Francisco, CA 94143 2200, USA
    Curr Biol 23:R471-3. 2013
    ..New work in Chlamydomonas demonstrates that cilia can also act as secretory organelles by budding enzyme-containing vesicles from the flagellar membrane for post-mitotic hatching of daughters from the mother cell wall...
  38. doi request reprint Use of transcriptomic data to support organelle proteomic analysis
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
    Methods Mol Biol 432:403-14. 2008
    ..Such an approach can be used to narrow down a preliminary proteomic data set and help us to focus on a smaller sub-set of proteins that are supported by transcriptomic cross-validation...
  39. ncbi request reprint Flagellar motility: all pull together
    Kimberly A Wemmer
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, USA
    Curr Biol 14:R992-3. 2004
    ..Eukaryotic flagella produce a swimming force by coordinating thousands of dynein motor proteins. Recent work provides new clues into how this coordination is achieved...
  40. ncbi request reprint PCR-based assay for mating type and diploidy in Chlamydomonas
    Ivan Zamora
    University of California, San Francisco, CA 94143, USA
    Biotechniques 37:534-6. 2004
  41. ncbi request reprint Quantitative modeling in cell biology: what is it good for?
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, 95616, USA
    Dev Cell 11:279-87. 2006
    ....
  42. doi request reprint A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow
    Benjamin D Engel
    Department of Biochemistry and Biophysics, University of California, San Francisco, USA
    Cytoskeleton (Hoboken) 68:188-203. 2011
    ....

Research Grants7

  1. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2006
    ..These mutants, as well as mutants altering centriole ultrastructure, will be used to test the role of centrioles in chromosome segregation, mitotic spindle organization, nuclear positioning, and cytokinesis. ..
  2. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2007
    ..These mutants, as well as mutants altering centriole ultrastructure, will be used to test the role of centrioles in chromosome segregation, mitotic spindle organization, nuclear positioning, and cytokinesis. ..
  3. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2009
    ..These mutants, as well as mutants altering centriole ultrastructure, will be used to test the role of centrioles in chromosome segregation, mitotic spindle organization, nuclear positioning, and cytokinesis. ..
  4. Pattern formation & regeneration in a single cell
    Wallace Marshall; Fiscal Year: 2009
    ..We propose an alternative approach, which is to induce the injured cells to repair themselves. Towards this end, we will study a classical single-celled organism that has the ability to regenerate itself following damage. ..
  5. Genetic Analysis of Centriole Duplication and Function
    Wallace Marshall; Fiscal Year: 2010
    ..These mutants, as well as mutants altering centriole ultrastructure, will be used to test the role of centrioles in chromosome segregation, mitotic spindle organization, nuclear positioning, and cytokinesis. ..
  6. Pattern formation & regeneration in a single cell
    Wallace Marshall; Fiscal Year: 2010
    ..We propose an alternative approach, which is to induce the injured cells to repair themselves. Towards this end, we will study a classical single-celled organism that has the ability to regenerate itself following damage. ..