Alan G Marshall

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Petroleomics: the next grand challenge for chemical analysis
    Alan G Marshall
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA
    Acc Chem Res 37:53-9. 2004
  2. doi request reprint Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation
    Huan He
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, USA
    J Proteome Res 9:2098-108. 2010
  3. doi request reprint Selective ionization of dissolved organic nitrogen by positive ion atmospheric pressure photoionization coupled with Fourier transform ion cyclotron resonance mass spectrometry
    David C Podgorski
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32306 4390, United States
    Anal Chem 84:5085-90. 2012
  4. pmc Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry
    Sasa Kazazic
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, FL 32310 4005, USA
    J Am Soc Mass Spectrom 21:550-8. 2010
  5. doi request reprint Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry
    Qian Zhang
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA
    J Am Soc Mass Spectrom 24:1016-25. 2013
  6. pmc Metallofullerene and fullerene formation from condensing carbon gas under conditions of stellar outflows and implication to stardust
    Paul W Dunk
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306
    Proc Natl Acad Sci U S A 110:18081-6. 2013
  7. pmc Polar aprotic modifiers for chromatographic separation and back-exchange reduction for protein hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Santosh G Valeja
    Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, FL 32306, USA
    J Am Soc Mass Spectrom 23:699-707. 2012
  8. pmc Epitope mapping of a 95 kDa antigen in complex with antibody by solution-phase amide backbone hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Qian Zhang
    Department Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States
    Anal Chem 83:7129-36. 2011
  9. doi request reprint Valence parity to distinguish c' and z• ions from electron capture dissociation/electron transfer dissociation of peptides: effects of isomers, isobars, and proteolysis specificity
    Yuan Mao
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32303, USA
    Anal Chem 83:8024-8. 2011
  10. pmc Enhanced digestion efficiency, peptide ionization efficiency, and sequence resolution for protein hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Hui Min Zhang
    Molecular Biophysics Program, Florida State University, Tallahassee, Florida 32306, USA
    Anal Chem 80:9034-41. 2008

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Petroleomics: the next grand challenge for chemical analysis
    Alan G Marshall
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA
    Acc Chem Res 37:53-9. 2004
    ..The same methods are also being applied successfully to analysis of humic and fulvic acids, coals, and other complex natural mixtures, often without prior or on-line chromatographic separation...
  2. doi request reprint Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation
    Huan He
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, USA
    J Proteome Res 9:2098-108. 2010
    ..The synergies derived by the combination of glycomic, transcriptomic and phosphoproteomic data may aid our understanding of intracellular and cell-surface events associated with CSC differentiation...
  3. doi request reprint Selective ionization of dissolved organic nitrogen by positive ion atmospheric pressure photoionization coupled with Fourier transform ion cyclotron resonance mass spectrometry
    David C Podgorski
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32306 4390, United States
    Anal Chem 84:5085-90. 2012
    ....
  4. pmc Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry
    Sasa Kazazic
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, FL 32310 4005, USA
    J Am Soc Mass Spectrom 21:550-8. 2010
    ....
  5. doi request reprint Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry
    Qian Zhang
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA
    J Am Soc Mass Spectrom 24:1016-25. 2013
    ..Complexed and uncomplexed (free) rAna o 2 were then subjected to HDX-MS analysis. Four regions protected from H/D exchange upon pAb binding are identified as potential epitopes and mapped onto a homologous model...
  6. pmc Metallofullerene and fullerene formation from condensing carbon gas under conditions of stellar outflows and implication to stardust
    Paul W Dunk
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306
    Proc Natl Acad Sci U S A 110:18081-6. 2013
    ..In addition, gas-phase reactions of fullerenes with polycyclic aromatic hydrocarbons are investigated to probe "build-up" and formation of carbon stardust, and provide insight into fullerene astrochemistry. ..
  7. pmc Polar aprotic modifiers for chromatographic separation and back-exchange reduction for protein hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Santosh G Valeja
    Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, FL 32306, USA
    J Am Soc Mass Spectrom 23:699-707. 2012
    ..The DMF modified solvent composition also improves chromatographic separation while reducing back-exchange relative to conventional solvent...
  8. pmc Epitope mapping of a 95 kDa antigen in complex with antibody by solution-phase amide backbone hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Qian Zhang
    Department Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States
    Anal Chem 83:7129-36. 2011
    ....
  9. doi request reprint Valence parity to distinguish c' and z• ions from electron capture dissociation/electron transfer dissociation of peptides: effects of isomers, isobars, and proteolysis specificity
    Yuan Mao
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32303, USA
    Anal Chem 83:8024-8. 2011
    ..1021/ac201624t), the number of ECD/ETD product ion amino acid compositions as a function of nominal mass increases exponentially with mass but with a superimposed modulation due to higher prevalence of certain elemental compositions...
  10. pmc Enhanced digestion efficiency, peptide ionization efficiency, and sequence resolution for protein hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry
    Hui Min Zhang
    Molecular Biophysics Program, Florida State University, Tallahassee, Florida 32306, USA
    Anal Chem 80:9034-41. 2008
    ..Such assignments of highly overlapped fragments promise to greatly enhance the accuracy and sequence resolution for determining conformational differences resulting from ligand binding or protein-protein interactions...
  11. ncbi request reprint Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry
    Matthew B Renfrow
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    J Biol Chem 280:19136-45. 2005
    ....
  12. ncbi request reprint Protein kinase A phosphorylation characterized by tandem Fourier transform ion cyclotron resonance mass spectrometry
    Michael J Chalmers
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310 4005, USA
    Proteomics 4:970-81. 2004
    ..The utility of activated ion ECD for the characterization of tryptic phosphopeptides was then demonstrated...
  13. doi request reprint Polar lipid remodeling and increased sulfatide expression are associated with the glioma therapeutic candidates, wild type p53 elevation and the topoisomerase-1 inhibitor, irinotecan
    Huan He
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    Glycoconj J 27:27-38. 2010
    ....
  14. ncbi request reprint Liquid chromatography electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric characterization of N-linked glycans and glycopeptides
    Xu Wang
    Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, Florida 32306, USA
    Anal Chem 82:6542-8. 2010
    ..Highly accurate FT-ICR mass measurement is essential for reliable identification...
  15. doi request reprint Top-down structural analysis of an intact monoclonal antibody by electron capture dissociation-Fourier transform ion cyclotron resonance-mass spectrometry
    Yuan Mao
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32303, United States
    Anal Chem 85:4239-46. 2013
    ....
  16. doi request reprint Tailored ion radius distribution for increased dynamic range in FT-ICR mass analysis of complex mixtures
    Nathan K Kaiser
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, 32310 4005, United States
    Anal Chem 85:265-72. 2013
    ....
  17. doi request reprint Laserspray and matrix-assisted ionization inlet coupled to high-field FT-ICR mass spectrometry for peptide and protein analysis
    Leonard Nyadong
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    J Am Soc Mass Spectrom 24:320-8. 2013
    ..We show an application of the generated copper-peptide complexes for protein charge state and molecular weight determination, particularly useful for an instrument such as a linear ion trap mass analyzer...
  18. pmc Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa
    Jeremiah D Tipton
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 84:2111-7. 2012
    ..Further, the results document routine identification of proteins at improved throughput based on accurate mass measurement (less than 10 ppm mass error) of precursor and fragment ions for proteins up to 50 kDa...
  19. doi request reprint Parts-per-billion fourier transform ion cyclotron resonance mass measurement accuracy with a "walking" calibration equation
    Joshua J Savory
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, United States
    Anal Chem 83:1732-6. 2011
    ..We are able to increase the number of assigned peaks by as much as 25%, while reducing the rms mass error by as much as 3-fold, for significantly improved confidence in elemental composition assignment...
  20. doi request reprint Characterization of the phosphoproteome in androgen-repressed human prostate cancer cells by Fourier transform ion cyclotron resonance mass spectrometry
    Xu Wang
    Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, Florida 32306, United States
    J Proteome Res 10:3920-8. 2011
    ..Androgen-induced proliferation inhibitor (APRIN) was detected in its phosphorylated form, implicating a molecular mechanism underlying the ARCaP phenotype...
  21. pmc De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
    Sudarslal Sadasivan Nair
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, FL 32310 4005, USA
    Anal Chem 78:8082-8. 2006
    ..The ECD spectra of the native and partially modified peptide reveal a loss of bromine in a process that requires the presence of a disulfide bond...
  22. ncbi request reprint Evaluation and optimization of electron capture dissociation efficiency in fourier transform ion cyclotron resonance mass spectrometry
    Melinda A McFarland
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    J Am Soc Mass Spectrom 16:1060-6. 2005
    ..Several ion manipulation techniques and use of a large, movable dispenser cathode reduce the possibility that misalignment of the ion and electron beams limits ECD efficiency...
  23. pmc Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry
    Hui Min Zhang
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 82:1450-4. 2010
    ..This method yields dramatically increased sequence coverage and localization of solvent-exposed segments for mass-analyzed solution-phase H/D exchange of proteins containing disulfide bonds...
  24. doi request reprint Improved sequence resolution by global analysis of overlapped peptides in hydrogen/deuterium exchange mass spectrometry
    Piotr G Fajer
    Institute of Molecular Biophysics, Biological Sciences Department, Florida State University, Tallahassee, FL 32306, USA
    J Am Soc Mass Spectrom 23:1202-8. 2012
    ....
  25. pmc Unit mass baseline resolution for an intact 148 kDa therapeutic monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry
    Santosh G Valeja
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States
    Anal Chem 83:8391-5. 2011
    ..We also demonstrate up to 80% higher resolving power by phase correction to yield an absorption-mode mass spectrum...
  26. ncbi request reprint Charge location directs electron capture dissociation of peptide dications
    Yury O Tsybin
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory Florida State University, Tallahassee, Florida 32310 4005, USA
    J Am Soc Mass Spectrom 17:1704-11. 2006
    ..We propose that formation of zwitterionic peptide structures increases the likelihood of amide nitrogen protonation (versus basic side chains), which is responsible for the increase in a- and y-type ion formation...
  27. pmc Sequential proteolysis and high-field FTICR MS to determine disulfide connectivity and 4-maleimide TEMPO spin-label location in L126C GM2 activator protein
    Jeremiah D Tipton
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 81:7611-7. 2009
    ..The sequential multiple protease digestion strategy and ultrahigh mass accuracy provided by FTICR MS allow for rapid and unequivocal assignment of relevant peptides and provide a simple pipeline for analyzing other GM2AP constructs...
  28. pmc Fast reversed-phase liquid chromatography to reduce back exchange and increase throughput in H/D exchange monitored by FT-ICR mass spectrometry
    Hui Min Zhang
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    J Am Soc Mass Spectrom 20:520-4. 2009
    ..The rapid separation coupled with high-resolution FT-ICR MS at 14.5 T provides high amino acid sequence coverage, high sample throughput, and high reproducibility and reliability...
  29. ncbi request reprint Sites and extent of selenomethionine incorporation into recombinant Cas6 protein by top-down and bottom-up proteomics with 14.5 T Fourier transform ion cyclotron resonance mass spectrometry
    Xu Wang
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32306, USA
    Rapid Commun Mass Spectrom 24:2386-92. 2010
    ..Comparative bottom-up and top-down proteomics confirmed that all six methionines were fully replaced by selenomethionines in Se-Cas6...
  30. ncbi request reprint Structural characterization of the GM1 ganglioside by infrared multiphoton dissociation, electron capture dissociation, and electron detachment dissociation electrospray ionization FT-ICR MS/MS
    Melinda A McFarland
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    J Am Soc Mass Spectrom 16:752-62. 2005
    ..We also show that analysis of MS/MS data for glycolipids is greatly simplified by classification of product ion masses to specific regions of the ganglioside based solely on mass defect graphical analysis...
  31. ncbi request reprint Instrumentation and method for ultrahigh resolution field desorption ionization fourier transform ion cyclotron resonance mass spectrometry of nonpolar species
    Tanner M Schaub
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 77:1317-24. 2005
    ..As an example, we demonstrate broadband speciation of a Gulf Coast crude oil, with respect to numerous heteroatomic classes, compound types (rings plus double bonds), and carbon number distributions...
  32. doi request reprint High-resolution mass spectrometers
    Alan G Marshall
    Florida State University, Tallahassee, 32310, USA
    Annu Rev Anal Chem (Palo Alto Calif) 1:579-99. 2008
    ....
  33. pmc Advantages of isotopic depletion of proteins for hydrogen/deuterium exchange experiments monitored by mass spectrometry
    George M Bou-Assaf
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA
    Anal Chem 82:3293-9. 2010
    ....
  34. ncbi request reprint Method for lipidomic analysis: p53 expression modulation of sulfatide, ganglioside, and phospholipid composition of U87 MG glioblastoma cells
    Huan He
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 79:8423-30. 2007
    ..An increase in hydroxylated phospholipids is especially noteworthy. Also, a decrease in the longer chain gangliosides, GD1 and GM1b, is observed in wild-type p53 (treated) cells...
  35. doi request reprint Expansion of the analytical window for oil spill characterization by ultrahigh resolution mass spectrometry: beyond gas chromatography
    Amy M McKenna
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, United States
    Environ Sci Technol 47:7530-9. 2013
    ....
  36. doi request reprint Unequivocal determination of site-specific protein disulfide bond reduction potentials by top-down FTICR MS: characterization of the N- and C-terminal redox-active sites in human thioredoxin 1
    Jenna Scotcher
    National High Magnetic Field Laboratory, Florida State University, 1800 E Paul Dirac Drive, Tallahassee, Florida 32310, United States
    Anal Chem 85:9164-72. 2013
    ..Intriguingly, that value corresponds to the intracellular glutathione/glutathione disulfide (GSH/GSSG) potential at the redox boundary between cellular differentiation and apoptosis. ..
  37. ncbi request reprint Artifacts induced by selective blanking of time-domain data in Fourier transform mass spectrometry
    Feng Xian
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, FL, 32310, USA
    J Am Soc Mass Spectrom 24:1722-6. 2013
    ..Although the artifacts are reduced by use of multiple Gaussian (rather than square wave) windowing, blanking appears to offer no advantages for identifying true peaks or for mass measurement. ..
  38. pmc Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry
    Qian Zhang
    Florida State University, Department of Chemistry, Tallahassee, FL 32306, USA
    Sci Rep 3:1247. 2013
    ..The 14-mer GroEL complex is the largest protein assembly yet accessed by HDX-MS, with sequence resolution of segments of as few as five amino acids...
  39. doi request reprint Atmospheric pressure laser-induced acoustic desorption chemical ionization mass spectrometry for analysis of saturated hydrocarbons
    Leonard Nyadong
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, USA
    Anal Chem 84:7131-7. 2012
    ..The overall speciation of nonpolar, aliphatic hydrocarbon base oil species offers a promising diagnostic probe to characterize crude oil and its products...
  40. doi request reprint Closed network growth of fullerenes
    Paul W Dunk
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, USA
    Nat Commun 3:855. 2012
    ..Further, the results should be of importance for illuminating astrophysical processes near carbon stars or supernovae that result in C(60) formation throughout the Universe...
  41. ncbi request reprint The smallest stable fullerene, M@C28 (m = Ti, Zr, U): stabilization and growth from carbon vapor
    Paul W Dunk
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, 32306, United States
    J Am Chem Soc 134:9380-9. 2012
    ..In fact, it appears that the encapsulating metal species may catalyze or nucleate endohedral fullerene formation...
  42. doi request reprint Characterization of pyrogenic black carbon by desorption atmospheric pressure photoionization Fourier transform ion cyclotron resonance mass spectrometry
    David C Podgorski
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Anal Chem 84:1281-7. 2012
    ....
  43. ncbi request reprint Identification of water-soluble heavy crude oil organic-acids, bases, and neutrals by electrospray ionization and field desorption ionization fourier transform ion cyclotron resonance mass spectrometry
    Lateefah A Stanford
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, FL 32310 4005, USA
    Environ Sci Technol 41:2696-702. 2007
    ..Water-soluble heteroatomic basic classes detected at >1% relative abundance include N, NO, NO2, NS, NS2, NOS, NO2S, N2, N2O, N2O2, OS, O2S, and O2S2...
  44. ncbi request reprint Combined electron capture and infrared multiphoton dissociation for multistage MS/MS in a Fourier transform ion cyclotron resonance mass spectrometer
    Kristina Hakansson
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, Florida 32310 3706, USA
    Anal Chem 75:3256-62. 2003
    ..Mass-selective external ion accumulation is essential for the structural characterization of these low-abundance (modified) peptides...
  45. ncbi request reprint Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells
    Promod Mehndiratta
    Graduate Program in Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Protein Expr Purif 33:274-87. 2004
    ..The ability to generate recombinant glycoproteins with restricted carbohydrate heterogeneity is the first step toward the systematic study of structure-function relationships in intact glycoproteins...
  46. doi request reprint Oil spill source identification by principal component analysis of electrospray ionization Fourier transform ion cyclotron resonance mass spectra
    Yuri E Corilo
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, United States
    Anal Chem 85:9064-9. 2013
    ....
  47. doi request reprint Atmospheric pressure laser-induced acoustic desorption chemical ionization fourier transform ion cyclotron resonance mass spectrometry for the analysis of complex mixtures
    Leonard Nyadong
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32303, United States
    Anal Chem 83:1616-23. 2011
    ....
  48. doi request reprint Relative stability of peptide sequence ions generated by tandem mass spectrometry
    Benjamin J Bythell
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA
    J Am Soc Mass Spectrom 23:644-54. 2012
    ....
  49. pmc New reagents for enhanced liquid chromatographic separation and charging of intact protein ions for electrospray ionization mass spectrometry
    Santosh G Valeja
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 82:7515-9. 2010
    ..Moreover, incorporation of the same modifiers into reversed-phase liquid chromatography solvents improves sensitivity, charging, and chromatographic resolution for intact proteins...
  50. ncbi request reprint Theoretical and experimental prospects for protein identification based solely on accurate mass measurement
    Fei He
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    J Proteome Res 3:61-7. 2004
    ..4 mDa. We demonstrate experimental resolution of another pair of peptides differing by 11 mDa, even when present in a complex mixture of hundreds of other peptides...
  51. ncbi request reprint Identification and analysis of phosphopeptides
    Michael J Chalmers
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, FL 32310 3706, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 803:111-20. 2004
    ..In this review, we offer an overview of the different methods/technologies currently available to identify protein phosphorylation sites...
  52. ncbi request reprint Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry
    Ying Xiong
    Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    J Proteome Res 4:855-61. 2005
    ..84 M. tuberculosis H37Rv proteins, including 42 integral membrane proteins, are described for the first time...
  53. ncbi request reprint A novel 9.4 tesla FTICR mass spectrometer with improved sensitivity, mass resolution, and mass range
    Nathan K Kaiser
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    J Am Soc Mass Spectrom 22:1343-51. 2011
    ..The design simplifies access to the ICR cell, and the modular vacuum flange accommodates new ICR cell technology, including linearized excitation, high surface area detection, and tunable electrostatic trapping potential...
  54. pmc Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry
    Sarah Murray
    Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306 4380, USA
    J Virol 80:6171-6. 2006
    ..Peptide mapping and structural analysis by Fourier transform ion cyclotron resonance mass spectrometry demonstrates, however, no glycosylation of the capsid protein for virus prepared in cultured HeLa cells...
  55. pmc Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry
    Hui Min Zhang
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    Protein Sci 19:703-15. 2010
    ..This result correlates with the V560D mutant exhibiting a sensitivity to sunitinib that is less than for WT KIT but greater than for KIT D816H. These findings support the elucidation of the resistance mechanism for the KIT mutants...
  56. ncbi request reprint Combined top-down and bottom-up mass spectrometric approach to characterization of biomarkers for renal disease
    Michael J Chalmers
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee, 32310 4005, USA
    Anal Chem 77:7163-71. 2005
    ..Critically, we maintain connectivity between the CE TOF MS data and the ICR data used for biomarker identification...
  57. doi request reprint Automated broadband phase correction of Fourier transform ion cyclotron resonance mass spectra
    Feng Xian
    Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, Florida 32310, United States, Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, United States, and S C Beu Consulting, 12449 Los Indios Trail, Austin, Texas 78729, United States
    Anal Chem 82:8807-12. 2010
    ....
  58. doi request reprint Elemental composition validation from stored waveform inverse Fourier transform (SWIFT) isolation FT-ICR MS isotopic fine structure
    Brian M Ruddy
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306, USA
    J Am Soc Mass Spectrom 24:1608-11. 2013
    ..Dynamic range is enhanced by external quadrupole and internal stored waveform inverse Fourier transform (SWIFT) isolation to facilitate detection of low abundance heavy atom isotopologues...
  59. doi request reprint Charge reversal fourier transform ion cyclotron resonance mass spectrometry
    Vladislav V Lobodin
    National High Magnetic Field Laboratory, Tallahassee, FL, 32310, USA
    J Am Soc Mass Spectrom 24:213-21. 2013
    ....
  60. pmc A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry
    Alex J Noble
    Department of Physics, Florida State University, Tallahassee, Florida, USA
    Nat Struct Mol Biol 20:167-73. 2013
    ..Furthermore, we found that the two-fold symmetry of the Sec31 dimeric region in Sec13-Sec31 is broken upon cage formation and that the resulting hinge is essential to form the proper edge geometry in COPII cages...
  61. ncbi request reprint Structural analysis of 2D-gel-separated glycoproteins from human cerebrospinal fluid by tandem high-resolution mass spectrometry
    Kristina Hakansson
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 3706, USA
    J Proteome Res 2:581-8. 2003
    ..IRMPD obviates the need for glycan release, which prevents sample dispersal, and allows the assignment of glycan structures to specific sites of N-glycosylation...
  62. ncbi request reprint Electrically compensated Fourier transform ion cyclotron resonance cell for complex mixture mass analysis
    Nathan K Kaiser
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    Anal Chem 83:6907-10. 2011
    ..6 s transient duration), and 124 part per billion root mean square (rms) error. The tunability of the compensation electrodes is critical for optimal performance...
  63. doi request reprint Differential phosphopeptide expression in a benign breast tissue, and triple-negative primary and metastatic breast cancer tissues from the same African-American woman by LC-LTQ/FT-ICR mass spectrometry
    Suzan M Semaan
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306 4390, USA
    Biochem Biophys Res Commun 412:127-31. 2011
    ..Identified phosphoproteins are known to be involved in breast cancer signal transduction pathways and these results may identify new diagnostic and therapeutic targets for TNBC...
  64. ncbi request reprint Liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometric characterization of protein kinase C phosphorylation
    Michael J Chalmers
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 3706, USA
    J Proteome Res 2:373-82. 2003
    ..The combination of accurate-mass MS and MS/MS offers a powerful new tool for identifying the presence and site(s) of phosphorylation in peptides, without the need for additional wet chemical derivatization...
  65. ncbi request reprint Structural characterization of an unusually stable cyclic peptide, kalata B2 from Oldenlandia affinis
    Sudarslal Sadasivan Nair
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    Biochim Biophys Acta 1764:1568-76. 2006
    ..Infrared multiphoton dissociation establishes the disulfide bond linkages in kalata B2 as I-IV, II-V and III-VI...
  66. ncbi request reprint Characterization of vegetable oils: detailed compositional fingerprints derived from electrospray ionization fourier transform ion cyclotron resonance mass spectrometry
    Zhigang Wu
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 4005, USA
    J Agric Food Chem 52:5322-8. 2004
    ..We suggest that the detailed chemical compositions of vegetable oils can be used to characterize them and to detect and identify adulterants...
  67. doi request reprint Petroleomics: advanced molecular probe for petroleum heavy ends
    Chang S Hsu
    Future Fuels Institute, Florida State University, Tallahassee, FL 32306, USA
    J Mass Spectrom 46:337-43. 2011
    ..A database of more than 100 000 components of different elemental composition has been generated at NHMFL. Copyright © 2011 John Wiley & Sons, Ltd...
  68. ncbi request reprint Improved mass analysis of oligoribonucleotides by 13C, 15N double depletion and electrospray ionization FT-ICR mass spectrometry
    Ying Xiong
    Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    Anal Chem 76:1804-9. 2004
    ..The abrupt onset and high magnitude of the monoisotopic species promise to facilitate accurate mass measurement of RNA's...
  69. pmc Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm
    Kexi Yi
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Mol Biol Cell 20:3200-8. 2009
    ..Our results suggest that interaction between PP2A and MFP3 leads to local disassembly of the MSP cytoskeleton at the base of the lamellipod in sperm that in turn pulls the trailing cell body forward...
  70. ncbi request reprint Comprehensive characterization of marine dissolved organic matter by Fourier transform ion cyclotron resonance mass spectrometry with electrospray and atmospheric pressure photoionization
    Thorsten Dittmar
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 4390, USA
    Rapid Commun Mass Spectrom 24:643-50. 2010
    ..Because the mass spectra obtained by ESI and APPI are significantly different, both are necessary to obtain a more complete description of the molecular composition of marine DOM. Copyright (c) 2010 John Wiley & Sons, Ltd...
  71. ncbi request reprint Resolution of 11,000 compositionally distinct components in a single electrospray ionization Fourier transform ion cyclotron resonance mass spectrum of crude oil
    Christine A Hughey
    National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    Anal Chem 74:4145-9. 2002
    ..These results set a new standard and illustrate the potential of high-resolution mass spectrometry for analysis of compositionally complex chemical mixtures...
  72. ncbi request reprint Ionization and fragmentation of humic substances in electrospray ionization Fourier transform-ion cyclotron resonance mass spectrometry
    Alexandra C Stenson
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee 32306, USA
    Anal Chem 74:4397-409. 2002
    ..Although these high molecular weight PEG mixtures fragment extensively under traditional positive-ion mode ESI conditions, similar fragmentation could not be confirmed for humic and fulvic acid mixtures...
  73. ncbi request reprint Mapping of protein:protein contact surfaces by hydrogen/deuterium exchange, followed by on-line high-performance liquid chromatography-electrospray ionization Fourier-transform ion-cyclotron-resonance mass analysis
    TuKiet T Lam
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA
    J Chromatogr A 982:85-95. 2002
    ..The method is used to study the assembled human immunodeficiency virus type capsid protein (CA) and its soluble form...
  74. ncbi request reprint Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of metal-ion selected dynamic protein libraries
    Helen J Cooper
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 3706, USA
    J Am Chem Soc 125:5331-9. 2003
    ..The experiments also suggest the presence of secondary structure in the gas phase, possibly due to partial retention of the solution-phase coiled coil structure...
  75. ncbi request reprint Characterization of amino acid side chain losses in electron capture dissociation
    Helen J Cooper
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    J Am Soc Mass Spectrom 13:241-9. 2002
    ..Losses from arginine, histidine, and asparigine/glutamine can be used to ascertain their presence, as in the analysis of unknown peptides, particularly those with non-linear structures...
  76. ncbi request reprint Scaling MS plateaus with high-resolution FT-ICRMS
    Alan G Marshall
    National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    Anal Chem 74:252A-259A. 2002
  77. ncbi request reprint Assigning product ions from complex MS/MS spectra: the importance of mass uncertainty and resolving power
    Lekha Sleno
    Institute for Marine Biosciences, National Research Council, Halifax, Nova Scotia, Canada
    J Am Soc Mass Spectrom 16:183-98. 2005
    ..External mass calibration from commercial FT-ICR and QqTOF instruments gave similar results...
  78. ncbi request reprint Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction
    Helen J Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Anal Chem 77:6310-9. 2005
    ....
  79. ncbi request reprint Determination of the activation energy for unimolecular dissociation of a non-covalent gas-phase peptide: substrate complex by infrared multiphoton dissociation fourier transform ion cyclotron resonance mass spectrometry
    Mathias Schäfer
    Institute for Organic Chemistry, University Cologne, Koln, Germany
    J Am Soc Mass Spectrom 14:1282-9. 2003
    ..We obtain EaI(laser) = 0.67 eV (Dunbar approximation) and EaII(laser) = 1.12 eV (Paech et al. approximation). Differences between the two approaches are discussed with respect to non-covalent complexes...
  80. ncbi request reprint Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library
    Maria Wigger
    J Am Soc Mass Spectrom 13:1162-9. 2002
    ....
  81. ncbi request reprint Letter: the diagnostic value of amino acid side-chain losses in electron capture dissociation of polypeptides. Comment on: "Can the (M(.)-X) region in electron capture dissociation provide reliable information on amino acid composition of polypeptide
    Helen J Cooper
    Eur J Mass Spectrom (Chichester, Eng) 9:221-2. 2003
  82. ncbi request reprint An antibiotic linked to peptides and proteins is released by electron capture dissociation fourier transform ion cyclotron resonance mass spectrometry
    Clifton K Fagerquist
    United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, Pennsylvania 19038, USA
    J Am Soc Mass Spectrom 14:302-10. 2003
    ..ECD of [insulin + DFC + 4H](4+) shows preferential dissociative loss of DFC. Combined with HPLC, ECD FT-ICR-MS may be an efficient screening method for detection of drug-biomolecule binding...
  83. ncbi request reprint Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry
    Michael J Chalmers
    Scripps Research Institute, 5353 Parkside Drive RF 1, Jupiter, FL 33458, USA
    Anal Chem 78:1005-14. 2006
    ..To facilitate analysis of H/D exchange of large protein complexes, we performed the experiment with a 14.5-T Fourier transform ion cyclotron resonance mass spectrometer capable of measuring mass with accuracy in the ppb range...
  84. ncbi request reprint Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy
    Matthew B Renfrow
    UAB Biomedical FT ICR MS Laboratory, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, MCLM 570 1530 3rd AVE S, Birmingham, AL 35294 0005, USA
    Anal Bioanal Chem 389:1397-407. 2007
    ..These results suggest that future analysis of IgA1 HR from IgAN patients and normal healthy controls should be feasible...
  85. ncbi request reprint Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach
    Helen J Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Anal Chem 76:6982-8. 2004
    ..Assignments were confirmed by AI ECD or IRMPD. The Gly-Gly modification is stable and both tandem mass spectrometric techniques are suitable, providing extensive sequence coverage and retention of the modification on backbone fragments...