Research Topics
Genomes and Genes | Ian MarriottSummaryAffiliation: University of North Carolina at Charlotte Country: USA Publications
Research Grants
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Publications
Therapeutic strategies against inflammation and bone loss associated with osteomyelitisIan Marriott
University of North Carolina at Charlotte, Department of Biology, 9201 University City Boulevard, Charlotte, NC 28223, USA
Curr Opin Investig Drugs 8:887-98. 2007....- Sexual dimorphism in innate immune responses to infectious organismsIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Immunol Res 34:177-92. 2006.... - Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissueIan Marriott
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
Bone 37:504-12. 2005.... - Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challengeIan Marriott
Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Infect Immun 73:2967-73. 2005..As such, the presence of Nod proteins in osteoblasts could represent an important mechanism by which this cell type responds to intracellular bacterial pathogens of bone... - Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibilityIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Reprod Immunol 71:12-27. 2006.... - NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogensVinita S Chauhan
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Glia 57:414-23. 2009..As such, we have identified NOD2 as an important component in the generation of damaging CNS inflammation following bacterial infection... - Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferiVinita S Chauhan
Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
J Immunol 180:8241-9. 2008..Taken together, these studies indicate a potentially important role for neurogenic exacerbation of resident glial immune responses in CNS inflammatory diseases, such as bacterial meningitis... - Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microgliaAmy Rasley
Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
J Immunol 172:5707-13. 2004..burgdorferi-induced inflammatory responses in microglia in vitro may indicate a role for this neuropeptide in the development of CNS inflammation observed during human neuroborreliosis... - Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissueIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Am J Pathol 164:1399-406. 2004.... - Borrelia burgdorferi induces inflammatory mediator production by murine microgliaAmy Rasley
Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, 28223, Charlotte, NC, USA
J Neuroimmunol 130:22-31. 2002..burgdorferi. Such production may play an important role during the development of Lyme neuroborreliosis... - Functional expression of NOD2, a novel pattern recognition receptor for bacterial motifs, in primary murine astrocytesDavid Sterka
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Glia 53:322-30. 2006.... - Cultured astrocytes express toll-like receptors for bacterial productsChristal C Bowman
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Glia 43:281-91. 2003.... - Murine glia express the immunosuppressive cytokine, interleukin-10, following exposure to Borrelia burgdorferi or Neisseria meningitidisAmy Rasley
Department of Biology, University of North Carolina at Charlotte, 28223, USA
Glia 53:583-92. 2006.... - Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microgliaDavid Sterka
Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Neuroimmunol 179:65-75. 2006..Together these data suggest that NOD2 may contribute to microglial immune responses to bacterial pathogens... - RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytesSamantha R Furr
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Glia 58:1620-9. 2010..These findings directly implicate RIG-I in the initiation of inflammatory immune responses by human glial cells and provide a potential mechanism underlying the neuronal cell death associated with acute viral CNS infections... - Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivoJennifer A Rettew
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Endocrinology 150:3877-84. 2009..Taken together, these data provide a potential mechanism underlying the immunoenhancing effects of estrogens... - Differential roles for NOD2 in osteoblast inflammatory immune responses to bacterial pathogens of bone tissueVinita S Chauhan
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Med Microbiol 59:755-62. 2010.... - Functional CD40 expression induced following bacterial infection of mouse and human osteoblastsLaura W Schrum
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Infect Immun 71:1209-16. 2003..This surprising result further supports the notion that bone-forming osteoblasts can directly interact with CD154-expressing cells (i.e., T lymphocytes) and can contribute to the host response during bone infection... - Murine gamma-herpesvirus 68 limits naturally occurring CD4+CD25+ T regulatory cell activity following infectionNancy Gasper-Smith
Department of Biology, University of North Carolina, 9201 University City Boulevard, Charlotte, NC 28223, USA
J Immunol 177:4670-8. 2006..These alterations in naturally occurring T regulatory cell function may help to explain the dysregulation of the host's immune response which allows the uncontrolled expansion of leukocytes as viral latency is established... - Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblastsShankari N Somayaji
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
Infect Immun 76:5120-6. 2008..These data suggest a mechanism whereby osteoblasts regulate the production of RANK-L during infection... - Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responsesVinita S Chauhan
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Virology 400:187-96. 2010..These results suggest that viral replication within resident glial cells might play an important role in CNS inflammation following infection with VSV and possibly other neurotropic nonsegmented negative-strand RNA viruses... - Bacterial infection induces expression of functional MHC class II molecules in murine and human osteoblastsLaura W Schrum
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Bone 33:812-21. 2003..Taken together, these data suggest a previously unappreciated role for osteoblasts in the initiation of T lymphocyte activation at sites of bacterial infection in bone tissue... - Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblastsDenise R Madrazo
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Infect Immun 71:5418-21. 2003..TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections... - Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblastsEmily H Alexander
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
BMC Microbiol 3:5. 2003..Staphylococcus aureus infection of normal osteoblasts induces expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)... - Murine gammaherpesvirus-68 infects microglia and induces high levels of pro-inflammatory cytokine productionWilliam R Taylor
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, 28223, USA
J Neuroimmunol 136:75-83. 2003..Such cytokine production may either contribute to protective host responses to viral challenges or could exacerbate damaging CNS inflammation... - Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunityJennifer A Rettew
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Biol Reprod 78:432-7. 2008..Importantly, these effects were not apparent in orchidectomized animals that received exogenous testosterone treatment. As such, these data may represent an important mechanism underlying the immunosuppressive effects of testosterone... - Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4Nancy A Gasper
Department of Biology, University of North Carolina at Charlotte, 28223, USA
Infect Immun 70:4075-82. 2002..The fact that osteoblasts did not express CXCR3 mRNA, whereas T lymphocytes can express high levels of this receptor, suggests that osteoblast-derived CXCL10 may recruit T lymphocytes to the sites of bone infections... - Murine gammaherpesvirus-68 elicits robust levels of interleukin-12 p40, but not interleukin-12 p70 production, by murine microglia and astrocytesAmy Rasley
Department of Biology, University of North Carolina at Charlotte, 28223, USA
J Neurovirol 10:171-80. 2004..Indeed, the production of IL-12p40 may point to an anti-inflammatory role for these cells during herpesvirus infections of the CNS... - Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesisIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Interferon Cytokine Res 22:1049-55. 2002..We suggest that osteoblasts are an unlikely source of these cytokines during the progression of bacterial infection of bone... - Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virusSamantha R Furr
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
J Neurovirol 14:503-13. 2008.... - Expression of hemokinin 1 mRNA by murine dendritic cellsDaniel A Nelson
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
J Neuroimmunol 155:94-102. 2004..There was preferential expression of PPT-C mRNA in dendritic cell subpopulations that were CD11b+, but not B220+ or GR-1+. These studies are the first to demonstrate PPT-C mRNA expression by cells of the myeloid lineage... - Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitisVinita S Chauhan
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Immunol 186:7255-63. 2011..Together, these results suggest that targeting SP/NK-1R interactions is a strategy worthy of further study for the treatment of microbially induced neuroinflammation... - Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progressionIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Immunol Res 30:291-308. 2004.... - Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell deathSamuel H McCall
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, USA
J Bone Miner Res 23:30-40. 2008..We provide evidence for the functional expression in osteoblasts of NLRP3, a member of the NLR family of cytosolic receptors that has been implicated in the initiation of programmed cell death... - A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cellsSamantha R Furr
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
J Neuroinflammation 8:99. 2011..To date, the expression and functional role of DAI in the inflammatory responses of resident CNS cells to neurotropic DNA viruses has not been reported... - Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblastsAmy B Young
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Bone 48:857-63. 2011.... - GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophagesJennifer A Rettew
Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, United States
Mol Cell Endocrinol 328:87-92. 2010..Based on these findings, we suggest that estrogen may utilize this non-classical estrogen receptor to limit potentially lethal acute inflammatory responses without compromising long-term host defense... - Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68Sherine F Elsawa
Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
J Immunol 170:2605-12. 2003..These studies demonstrate that genetic elimination of substance P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response... - The role of tachykinins in central nervous system inflammatory responsesIan Marriott
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Front Biosci 9:2153-65. 2004..The ability of substance P to augment immune responses of glial cells has important ramifications for the development of protective host responses within the CNS or, alternatively, the progression of damaging inflammation... - Systemic host immuno-inflammatory response to dental extractions and periodontitisFarah K Bahrani-Mougeot
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:534-41. 2008..The purpose of this pilot clinical study was to explore the effect of both periodontitis and dental extractions on the host systemic immuno-inflammatory response... - Expression of functional NK-1 receptors in murine microgliaAmy Rasley
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
Glia 37:258-67. 2002.... - The role of Toll-like receptors in CNS response to microbial challengeGregory W Konat
Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
J Neurochem 99:1-12. 2006..Although Toll-like receptor signaling is essential in antimicrobial defense, it may also lead to bystander injury of CNS tissue... - Viral CNS infections: role of glial pattern recognition receptors in neuroinflammationSamantha R Furr
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA
Front Microbiol 3:201. 2012....
Research Grants
- Novel intracellular pattern recognition receptor expression by resident CNS cellsIan Marriott; Fiscal Year: 2007..Results from these studies will contribute significantly to our understanding of the events that underlie the development of either protective host responses within the brain or the progression of damaging CNS inflammation. ..
- Substance P exacerbation of CNS inflammationIan Marriott; Fiscal Year: 2007....
- Osteoblast-derived inflammatory mediators in infectionIan Marriott; Fiscal Year: 2004..aureus by the production of this pivotal inflammatory molecule, thereby expanding the recognized role of these cells to include being key components in host responses during bone infection. ..
- Bacterial infection induces cytokine productionIan Marriott; Fiscal Year: 2003..abstract_text> ..
- Substance P exacerbation of CNS inflammationIan Marriott; Fiscal Year: 2009....