Ian Marriott

Summary

Affiliation: University of North Carolina at Charlotte
Country: USA

Publications

  1. pmc Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation
    Samantha R Furr
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA
    Front Microbiol 3:201. 2012
  2. pmc Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte Charlotte, NC, USA
    Front Cell Infect Microbiol 3:101. 2013
  3. ncbi request reprint Therapeutic strategies against inflammation and bone loss associated with osteomyelitis
    Ian Marriott
    University of North Carolina at Charlotte, Department of Biology, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Curr Opin Investig Drugs 8:887-98. 2007
  4. ncbi request reprint Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibility
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Reprod Immunol 71:12-27. 2006
  5. ncbi request reprint Sexual dimorphism in innate immune responses to infectious organisms
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Immunol Res 34:177-92. 2006
  6. pmc Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge
    Ian Marriott
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Infect Immun 73:2967-73. 2005
  7. ncbi request reprint Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Bone 37:504-12. 2005
  8. pmc NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 57:414-23. 2009
  9. pmc Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi
    Vinita S Chauhan
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 180:8241-9. 2008
  10. ncbi request reprint Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microglia
    Amy Rasley
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 172:5707-13. 2004

Collaborators

Detail Information

Publications47

  1. pmc Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation
    Samantha R Furr
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA
    Front Microbiol 3:201. 2012
    ....
  2. pmc Apoptosis-associated uncoupling of bone formation and resorption in osteomyelitis
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte Charlotte, NC, USA
    Front Cell Infect Microbiol 3:101. 2013
    ..Furthermore, it remains to be determined whether the host would be best served by preventing osteoblast cell death or by promoting apoptosis in infected cells. ..
  3. ncbi request reprint Therapeutic strategies against inflammation and bone loss associated with osteomyelitis
    Ian Marriott
    University of North Carolina at Charlotte, Department of Biology, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Curr Opin Investig Drugs 8:887-98. 2007
    ....
  4. ncbi request reprint Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibility
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Reprod Immunol 71:12-27. 2006
    ....
  5. ncbi request reprint Sexual dimorphism in innate immune responses to infectious organisms
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Immunol Res 34:177-92. 2006
    ....
  6. pmc Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge
    Ian Marriott
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Infect Immun 73:2967-73. 2005
    ..As such, the presence of Nod proteins in osteoblasts could represent an important mechanism by which this cell type responds to intracellular bacterial pathogens of bone...
  7. ncbi request reprint Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Bone 37:504-12. 2005
    ....
  8. pmc NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 57:414-23. 2009
    ..As such, we have identified NOD2 as an important component in the generation of damaging CNS inflammation following bacterial infection...
  9. pmc Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi
    Vinita S Chauhan
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 180:8241-9. 2008
    ..Taken together, these studies indicate a potentially important role for neurogenic exacerbation of resident glial immune responses in CNS inflammatory diseases, such as bacterial meningitis...
  10. ncbi request reprint Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microglia
    Amy Rasley
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 172:5707-13. 2004
    ..burgdorferi-induced inflammatory responses in microglia in vitro may indicate a role for this neuropeptide in the development of CNS inflammation observed during human neuroborreliosis...
  11. ncbi request reprint Cultured astrocytes express toll-like receptors for bacterial products
    Christal C Bowman
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 43:281-91. 2003
    ....
  12. pmc Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Am J Pathol 164:1399-406. 2004
    ....
  13. ncbi request reprint Functional expression of NOD2, a novel pattern recognition receptor for bacterial motifs, in primary murine astrocytes
    David Sterka
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 53:322-30. 2006
    ....
  14. ncbi request reprint Borrelia burgdorferi induces inflammatory mediator production by murine microglia
    Amy Rasley
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, 28223, Charlotte, NC, USA
    J Neuroimmunol 130:22-31. 2002
    ..burgdorferi. Such production may play an important role during the development of Lyme neuroborreliosis...
  15. pmc Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Autoimmunity 46:399-408. 2013
    ..Taken together these studies are consistent with the notion of a gammaherpesvirus-induced CRYAB response in professional antigen presenting cells in this mouse model...
  16. ncbi request reprint Murine glia express the immunosuppressive cytokine, interleukin-10, following exposure to Borrelia burgdorferi or Neisseria meningitidis
    Amy Rasley
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Glia 53:583-92. 2006
    ....
  17. ncbi request reprint Differential roles for NOD2 in osteoblast inflammatory immune responses to bacterial pathogens of bone tissue
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Med Microbiol 59:755-62. 2010
    ....
  18. ncbi request reprint Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia
    David Sterka
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Neuroimmunol 179:65-75. 2006
    ..Together these data suggest that NOD2 may contribute to microglial immune responses to bacterial pathogens...
  19. doi request reprint Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivo
    Jennifer A Rettew
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Endocrinology 150:3877-84. 2009
    ..Taken together, these data provide a potential mechanism underlying the immunoenhancing effects of estrogens...
  20. pmc RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes
    Samantha R Furr
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Glia 58:1620-9. 2010
    ..These findings directly implicate RIG-I in the initiation of inflammatory immune responses by human glial cells and provide a potential mechanism underlying the neuronal cell death associated with acute viral CNS infections...
  21. pmc Functional CD40 expression induced following bacterial infection of mouse and human osteoblasts
    Laura W Schrum
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Infect Immun 71:1209-16. 2003
    ..This surprising result further supports the notion that bone-forming osteoblasts can directly interact with CD154-expressing cells (i.e., T lymphocytes) and can contribute to the host response during bone infection...
  22. pmc Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts
    Shankari N Somayaji
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Infect Immun 76:5120-6. 2008
    ..These data suggest a mechanism whereby osteoblasts regulate the production of RANK-L during infection...
  23. pmc Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts
    Denise R Madrazo
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Infect Immun 71:5418-21. 2003
    ..TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections...
  24. ncbi request reprint Bacterial infection induces expression of functional MHC class II molecules in murine and human osteoblasts
    Laura W Schrum
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Bone 33:812-21. 2003
    ..Taken together, these data suggest a previously unappreciated role for osteoblasts in the initiation of T lymphocyte activation at sites of bacterial infection in bone tissue...
  25. ncbi request reprint Murine gamma-herpesvirus 68 limits naturally occurring CD4+CD25+ T regulatory cell activity following infection
    Nancy Gasper-Smith
    Department of Biology, University of North Carolina, 9201 University City Boulevard, Charlotte, NC 28223, USA
    J Immunol 177:4670-8. 2006
    ..These alterations in naturally occurring T regulatory cell function may help to explain the dysregulation of the host's immune response which allows the uncontrolled expansion of leukocytes as viral latency is established...
  26. doi request reprint Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responses
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Virology 400:187-96. 2010
    ..These results suggest that viral replication within resident glial cells might play an important role in CNS inflammation following infection with VSV and possibly other neurotropic nonsegmented negative-strand RNA viruses...
  27. pmc Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4
    Nancy A Gasper
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Infect Immun 70:4075-82. 2002
    ..The fact that osteoblasts did not express CXCR3 mRNA, whereas T lymphocytes can express high levels of this receptor, suggests that osteoblast-derived CXCL10 may recruit T lymphocytes to the sites of bone infections...
  28. ncbi request reprint Murine gammaherpesvirus-68 elicits robust levels of interleukin-12 p40, but not interleukin-12 p70 production, by murine microglia and astrocytes
    Amy Rasley
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    J Neurovirol 10:171-80. 2004
    ..Indeed, the production of IL-12p40 may point to an anti-inflammatory role for these cells during herpesvirus infections of the CNS...
  29. pmc Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts
    Emily H Alexander
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Microbiol 3:5. 2003
    ..Staphylococcus aureus infection of normal osteoblasts induces expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
  30. ncbi request reprint Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity
    Jennifer A Rettew
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Biol Reprod 78:432-7. 2008
    ..Importantly, these effects were not apparent in orchidectomized animals that received exogenous testosterone treatment. As such, these data may represent an important mechanism underlying the immunosuppressive effects of testosterone...
  31. ncbi request reprint Murine gammaherpesvirus-68 infects microglia and induces high levels of pro-inflammatory cytokine production
    William R Taylor
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, 28223, USA
    J Neuroimmunol 136:75-83. 2003
    ..Such cytokine production may either contribute to protective host responses to viral challenges or could exacerbate damaging CNS inflammation...
  32. ncbi request reprint Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Interferon Cytokine Res 22:1049-55. 2002
    ..We suggest that osteoblasts are an unlikely source of these cytokines during the progression of bacterial infection of bone...
  33. pmc Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis
    Vinita S Chauhan
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Immunol 186:7255-63. 2011
    ..Together, these results suggest that targeting SP/NK-1R interactions is a strategy worthy of further study for the treatment of microbially induced neuroinflammation...
  34. ncbi request reprint Expression of hemokinin 1 mRNA by murine dendritic cells
    Daniel A Nelson
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    J Neuroimmunol 155:94-102. 2004
    ..There was preferential expression of PPT-C mRNA in dendritic cell subpopulations that were CD11b+, but not B220+ or GR-1+. These studies are the first to demonstrate PPT-C mRNA expression by cells of the myeloid lineage...
  35. pmc Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus
    Samantha R Furr
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    J Neurovirol 14:503-13. 2008
    ....
  36. ncbi request reprint Osteoblast responses to bacterial pathogens: a previously unappreciated role for bone-forming cells in host defense and disease progression
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Immunol Res 30:291-308. 2004
    ....
  37. pmc Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death
    Samuel H McCall
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, USA
    J Bone Miner Res 23:30-40. 2008
    ..We provide evidence for the functional expression in osteoblasts of NLRP3, a member of the NLR family of cytosolic receptors that has been implicated in the initiation of programmed cell death...
  38. pmc A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells
    Samantha R Furr
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Neuroinflammation 8:99. 2011
    ..To date, the expression and functional role of DAI in the inflammatory responses of resident CNS cells to neurotropic DNA viruses has not been reported...
  39. ncbi request reprint GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages
    Jennifer A Rettew
    Department of Biology, 9201 University City Boulevard, University of North Carolina at Charlotte, Charlotte, NC 28223, United States
    Mol Cell Endocrinol 328:87-92. 2010
    ..Based on these findings, we suggest that estrogen may utilize this non-classical estrogen receptor to limit potentially lethal acute inflammatory responses without compromising long-term host defense...
  40. doi request reprint Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts
    Amy B Young
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Bone 48:857-63. 2011
    ....
  41. ncbi request reprint The role of tachykinins in central nervous system inflammatory responses
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Front Biosci 9:2153-65. 2004
    ..The ability of substance P to augment immune responses of glial cells has important ramifications for the development of protective host responses within the CNS or, alternatively, the progression of damaging inflammation...
  42. ncbi request reprint Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68
    Sherine F Elsawa
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    J Immunol 170:2605-12. 2003
    ..These studies demonstrate that genetic elimination of substance P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response...
  43. ncbi request reprint Systemic host immuno-inflammatory response to dental extractions and periodontitis
    Farah K Bahrani-Mougeot
    Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:534-41. 2008
    ..The purpose of this pilot clinical study was to explore the effect of both periodontitis and dental extractions on the host systemic immuno-inflammatory response...
  44. doi request reprint Promotion of pro-osteogenic responses by a bioactive ceramic coating
    - Aniket
    Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    J Biomed Mater Res A 100:3314-25. 2012
    ..These results suggest that SCPC50 coating could enhance bone integration with orthopedic and maxillofacial implants while minimizing the induction of inflammatory bone cell responses...
  45. pmc Understanding and altering cell tropism of vesicular stomatitis virus
    Eric Hastie
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, United States
    Virus Res 176:16-32. 2013
    ..In addition, other VSV proteins and host proteins may function as determinants of VSV cell tropism. Various approaches have been successfully used to alter VSV tropism to benefit basic research and clinically relevant applications...
  46. ncbi request reprint Expression of functional NK-1 receptors in murine microglia
    Amy Rasley
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Glia 37:258-67. 2002
    ....
  47. pmc The role of Toll-like receptors in CNS response to microbial challenge
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9128, USA
    J Neurochem 99:1-12. 2006
    ..Although Toll-like receptor signaling is essential in antimicrobial defense, it may also lead to bystander injury of CNS tissue...

Research Grants10

  1. Substance P exacerbation of CNS inflammation
    Ian Marriott; Fiscal Year: 2009
    ....
  2. Bacterial infection induces cytokine production
    Ian Marriott; Fiscal Year: 2003
    ..abstract_text> ..
  3. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2003
    ..aureus by the production of this pivotal inflammatory molecule, thereby expanding the recognized role of these cells to include being key components in host responses during bone infection. ..
  4. Substance P exacerbation of CNS inflammation
    Ian Marriott; Fiscal Year: 2006
    ....
  5. Novel intracellular pattern recognition receptor expression by resident CNS cells
    Ian Marriott; Fiscal Year: 2007
    ..Results from these studies will contribute significantly to our understanding of the events that underlie the development of either protective host responses within the brain or the progression of damaging CNS inflammation. ..
  6. Substance P exacerbation of CNS inflammation
    Ian Marriott; Fiscal Year: 2007
    ....
  7. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2004
    ..aureus by the production of this pivotal inflammatory molecule, thereby expanding the recognized role of these cells to include being key components in host responses during bone infection. ..
  8. Osteoblast-derived inflammatory mediators in infection
    Ian Marriott; Fiscal Year: 2002
    ..aureus by the production of this pivotal inflammatory molecule, thereby expanding the recognized role of these cells to include being key components in host responses during bone infection. ..