GERARD JOSEPH DAVID MARRIOTT

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells
    Gerard Marriott
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 105:17789-94. 2008
  2. ncbi request reprint Analysis of protein interactions using fluorescence technologies
    Yuling Yan
    Department of Physiology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Curr Opin Chem Biol 7:635-40. 2003
  3. pmc Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides
    Junichi Tanaka
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:13851-6. 2003
  4. doi request reprint Synthetic mimetics of actin-binding macrolides: rational design of actin-targeted drugs
    Richard D Perrins
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Chem Biol 15:287-94. 2008
  5. pmc Tropomyosin dynamics in cardiac thin filaments: a multisite forster resonance energy transfer and anisotropy study
    Hui Wang
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biophys J 94:4358-69. 2008
  6. pmc Optical lock-in detection of FRET using synthetic and genetically encoded optical switches
    Shu Mao
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Biophys J 94:4515-24. 2008
  7. pmc Optically switchable chelates: optical control and sensing of metal ions
    Tomoyo Sakata
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706, USA
    J Org Chem 73:227-33. 2008
  8. ncbi request reprint Structural basis of swinholide A binding to actin
    Vadim A Klenchin
    Department of Biochemistry, University of Wisconsin at Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Chem Biol 12:287-91. 2005
  9. pmc Optical switching of dipolar interactions on proteins
    Tomoyo Sakata
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 102:4759-64. 2005
  10. ncbi request reprint Absolute stereochemistry of ulapualide A
    John S Allingham
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Org Lett 6:597-9. 2004

Collaborators

  • Junichi Tanaka
  • Ehud Y Isacoff
  • Ian Paterson
  • Shu Mao
  • Tomoyo Sakata
  • Yuling Yan
  • Vadim A Klenchin
  • Ivan Rayment
  • John S Allingham
  • Hui Wang
  • Richard D Perrins
  • Ryan King
  • Richard K P Benninger
  • David K Jackson
  • Chutima Petchprayoon
  • David Jackson
  • David W Piston
  • Joseph M Chalovich
  • Christopher J Easley
  • Giuseppe Cecere

Detail Information

Publications11

  1. pmc Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells
    Gerard Marriott
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 105:17789-94. 2008
    ....
  2. ncbi request reprint Analysis of protein interactions using fluorescence technologies
    Yuling Yan
    Department of Physiology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Curr Opin Chem Biol 7:635-40. 2003
    ..One could therefore argue that a systematic functional analysis of the human proteome requires technologies that are capable of time and spatially resolved, multiplexed analysis of protein interactions within cells...
  3. pmc Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides
    Junichi Tanaka
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:13851-6. 2003
    ..KabC and related macrolides are useful probes to study the regulation of the actin filament (+) end and may lead to new therapies to treat diseases of the actin cytoskeleton...
  4. doi request reprint Synthetic mimetics of actin-binding macrolides: rational design of actin-targeted drugs
    Richard D Perrins
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Chem Biol 15:287-94. 2008
    ..Synthetic compounds derived from this tail region could therefore be used as a mimetic of the natural product, providing a range of designer compounds to treat actin-associated diseases or as probes to study actin polymerization...
  5. pmc Tropomyosin dynamics in cardiac thin filaments: a multisite forster resonance energy transfer and anisotropy study
    Hui Wang
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biophys J 94:4358-69. 2008
    ....
  6. pmc Optical lock-in detection of FRET using synthetic and genetically encoded optical switches
    Shu Mao
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Biophys J 94:4515-24. 2008
    ....
  7. pmc Optically switchable chelates: optical control and sensing of metal ions
    Tomoyo Sakata
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706, USA
    J Org Chem 73:227-33. 2008
    ..Fluorescence imaging of the MC state of nitroBIPS-8-TriA was used to quantify the rate and efficiency of optical switching and to provide a real-time readout of the state of the optically switchable chelate within living cells...
  8. ncbi request reprint Structural basis of swinholide A binding to actin
    Vadim A Klenchin
    Department of Biochemistry, University of Wisconsin at Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Chem Biol 12:287-91. 2005
    ..The observed structure reveals the mechanism of action of swinholide A and provides a structural framework about which to design new agents directed at the cytoskeleton...
  9. pmc Optical switching of dipolar interactions on proteins
    Tomoyo Sakata
    Department of Physiology, University of Wisconsin, 1300 University Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 102:4759-64. 2005
    ..We propose, therefore, that optical switching between SP and MC within an appropriately labeled conjugate could be used to inhibit a functional interaction with a ligand in the MC, but not the SP, state...
  10. ncbi request reprint Absolute stereochemistry of ulapualide A
    John S Allingham
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Org Lett 6:597-9. 2004
    ..structure: see text] The structure of ulapualide A (1) has been solved by X-ray crystallography in a complex with G-actin. The stereochemical configuration was assigned as 3S,9S,22S,23R,24S,26S,27S,31R,32R,33R...
  11. ncbi request reprint Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin
    Vadim A Klenchin
    Department of Biochemistry, University of Wisconsin at Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Nat Struct Biol 10:1058-63. 2003
    ..Consequently, these macrolides may be viewed as small molecule biomimetics of an entire class of actin-binding proteins...