Christina Marra

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Neurocognitive impairment in HIV-infected individuals with previous syphilis
    C M Marra
    Department of Neurology, University of Washington, Seattle, WA, USA
    Int J STD AIDS 24:351-5. 2013
  2. pmc A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people
    Jeffrey T Schouten
    Department of Surgery, University of Washington, Seattle, USA
    BMC Infect Dis 6:28. 2006
  3. ncbi request reprint Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104 2499, USA
    J Infect Dis 194:1771-3. 2006
  4. ncbi request reprint Neurosyphilis
    Christina M Marra
    University of Washington School of Medicine, Harborview Medical Center, Neurology, Box 359775, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Curr Neurol Neurosci Rep 4:435-40. 2004
  5. ncbi request reprint Syphilis and human immunodeficiency virus: prevention and politics
    Christina M Marra
    Departments of Neurology and Medicine, University of Washington School of Medicine, Seattle, Wash, USA
    Arch Neurol 61:1505-8. 2004
  6. ncbi request reprint Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals
    C M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Neurology 63:85-8. 2004
  7. pmc Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy
    Christina M Marra
    Harborview Medical Center, University of Washington, Seattle, WA, USA
    BMC Infect Dis 7:37. 2007
  8. ncbi request reprint Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter?
    Christina M Marra
    Department of Neurology, Division of Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA
    Clin Infect Dis 38:1001-6. 2004
  9. ncbi request reprint Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Infect Dis 189:369-76. 2004
  10. pmc Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis
    Christina M Marra
    Department of Neurology, Division of Infectious Diseases, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 47:893-9. 2008

Research Grants

  1. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
  2. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2004
  3. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2005
  4. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2006
  5. Rapid and Simple CSF Tests for Neurosyphillis Diagnosis
    Christina Marra; Fiscal Year: 2006
  6. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2007
  7. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2009
  8. Persistence of CNS T. pallidum in HIV Infection
    Christina M Marra; Fiscal Year: 2010
  9. Persistence of CNS T.pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2003
  10. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2003

Detail Information

Publications38

  1. doi request reprint Neurocognitive impairment in HIV-infected individuals with previous syphilis
    C M Marra
    Department of Neurology, University of Washington, Seattle, WA, USA
    Int J STD AIDS 24:351-5. 2013
    ..46] versus 0.31 [0.33], P = 0.03), and more were impaired in the NP learning domain (36 [42.9%] of 84 versus 13 [25.0%] of 52, P = 0.04). These effects of prior syphilis remained after controlling for education and premorbid intelligence...
  2. pmc A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people
    Jeffrey T Schouten
    Department of Surgery, University of Washington, Seattle, USA
    BMC Infect Dis 6:28. 2006
    ..The goal of this study was to conduct a prospective assessment of the contribution of zidovudine (ZDV) and didanosine (ddI) to hearing loss...
  3. ncbi request reprint Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104 2499, USA
    J Infect Dis 194:1771-3. 2006
    ..2 (95% confidence interval, 1.1-4.4; P=.02). The macrolide-resistant strains were not identical. These findings suggest that macrolide resistance may be increasing in multiple strains in response to antibiotic pressure...
  4. ncbi request reprint Neurosyphilis
    Christina M Marra
    University of Washington School of Medicine, Harborview Medical Center, Neurology, Box 359775, 325 9th Avenue, Seattle, WA 98104 2499, USA
    Curr Neurol Neurosci Rep 4:435-40. 2004
    ..Particular attention is given to current controversies. In the developed world, these issues are particularly relevant to persons who are infected with HIV...
  5. ncbi request reprint Syphilis and human immunodeficiency virus: prevention and politics
    Christina M Marra
    Departments of Neurology and Medicine, University of Washington School of Medicine, Seattle, Wash, USA
    Arch Neurol 61:1505-8. 2004
  6. ncbi request reprint Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals
    C M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Neurology 63:85-8. 2004
    ..To identify alternatives to the CSF-Venereal Disease Research Laboratory (VDRL) test for the diagnosis of neurosyphilis in HIV-infected individuals...
  7. pmc Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy
    Christina M Marra
    Harborview Medical Center, University of Washington, Seattle, WA, USA
    BMC Infect Dis 7:37. 2007
    ....
  8. ncbi request reprint Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter?
    Christina M Marra
    Department of Neurology, Division of Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA
    Clin Infect Dis 38:1001-6. 2004
    ..Future studies should address whether more intensive therapy for neurosyphilis is warranted in HIV-infected individuals...
  9. ncbi request reprint Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Infect Dis 189:369-76. 2004
    ..To define clinical and laboratory features that identify patients with neurosyphilis...
  10. pmc Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis
    Christina M Marra
    Department of Neurology, Division of Infectious Diseases, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 47:893-9. 2008
    ..The goal of this study was to determine whether normalization of serum rapid plasma reagin (RPR) titer could accurately predict treatment success...
  11. pmc Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy
    C M Marra
    Department of Neurology, School of Medicine, University of Washington, Seattle, USA
    Neurology 60:1388-90. 2003
    ..001 and p = 0.02), and those treated with zidovudine or indinavir had greater improvement in NPZ-4 at both visits compared to those treated with other drugs (p = 0.003 and p = 0.01)...
  12. pmc Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    AIDS 23:1359-66. 2009
    ..To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cognition...
  13. ncbi request reprint Diagnostic accuracy of HIV-associated central nervous system toxoplasmosis
    C M Marra
    Department of Neurology, School of Medicine, University of Washington, Seattle, USA
    Int J STD AIDS 9:761-4. 1998
    ..3, 95% CI 0.1-0.7). Diagnosis of CNS toxoplasmosis is often incorrect. Another diagnosis is most likely in patients who are anti-Toxoplasma seronegative or who are receiving prophylactic TMP-SMX...
  14. pmc CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis
    Christina M Marra
    Departments of Neurology, University of Washington School of Medicine, Seattle, 98104, USA
    Sex Transm Dis 37:283-7. 2010
    ..The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B cell chemoattractant, chemokine (C-X-C motif) ligand 13 (CXCL13) concentration may also be elevated...
  15. pmc Relationships among neurocognitive status, medication adherence measured by pharmacy refill records, and virologic suppression in HIV-infected persons
    Adriana S A Andrade
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 62:282-92. 2013
    ..Pharmacy refill records offer a promising and practical tool to assess adherence...
  16. ncbi request reprint Cerebrospinal fluid testing for the diagnosis of central nervous system infection
    J R Zunt
    Acting Assistant Professor, Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Neurol Clin 17:675-89. 1999
    ..This article discusses how these CSF tests are performed and addresses the sensitivity and specificity of such tests for the diagnosis of selected CNS infections...
  17. pmc Role of metabolic syndrome components in HIV-associated sensory neuropathy
    Beau M Ances
    Department of Neurology, Washington University, St Louis, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    AIDS 23:2317-22. 2009
    ..We examined whether MetS or its components predispose individuals to HIV-associated sensory neuropathy (HIV-SN)...
  18. pmc Second assessment of NeuroAIDS in Africa
    Kevin Robertson
    Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
    J Neurovirol 14:87-101. 2008
    ..The conference presentations summarized here highlight the need for further research on neuroAIDS in Africa and methods for assessing HIV-related neurological disorders...
  19. ncbi request reprint Alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infection
    C M Marra
    Department of Medicine, University of Washington, Seattle
    J Infect Dis 165:1020-5. 1992
    ..pallidum antigens. These results support the contention that retrovirus-induced immunodeficiency delays clearance of T. pallidum from sites of infection and may impair the humoral immune response to syphilis...
  20. ncbi request reprint Cerebrospinal fluid treponemal antibodies in untreated early syphilis
    C M Marra
    Department of Medicine, University of Washington, Seattle
    Arch Neurol 52:68-72. 1995
    ..Nonreactive CSF treponemal tests may help to exclude a diagnosis of neurosyphilis in patients with early syphilis...
  21. ncbi request reprint A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment
    D B Clifford
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 59:1568-73. 2002
    ..It has neuroprotective properties in model systems for HIV-associated neurotoxicity and thus is a candidate for neuroprotective therapy in humans with HIV-associated CNS disease...
  22. ncbi request reprint HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neurology 52:623-5. 1999
    ..This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV...
  23. ncbi request reprint Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy
    L Zhou
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Neurology 68:2113-9. 2007
    ..To demonstrate the relationship between epidermal nerve fiber density (ENFD) in the leg and the phenotype of HIV-associated distal sensory polyneuropathy (HIV-DSP) in a multicenter prospective study (ACTG A5117)...
  24. ncbi request reprint A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment
    G Schifitto
    Department of Neurology, Movement and Inherited Neurologic Disorders, Clinical Trials Coordination Center, 1351 Mount Hope Avenue, Suite 223, Rochester, NY 14620, USA
    Neurology 69:1314-21. 2007
    ..This rationale has led to the design and implementation of this Selegiline Transdermal System (STS) study with the primary aims of assessing safety and tolerability of STS as well as improvement in cognitive performance...
  25. ncbi request reprint Immune surveillance in multiple sclerosis patients treated with natalizumab
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, USA
    Ann Neurol 59:743-7. 2006
    ....
  26. ncbi request reprint Isolation and laboratory maintenance of Treponema pallidum
    Sheila A Lukehart
    University of Washington, Seattle, Washington, USA
    Curr Protoc Microbiol . 2007
    ..pallidum, and techniques for maintenance of frozen stocks of these treponemes...
  27. ncbi request reprint Update on syphilis: resurgence of an old problem
    Matthew R Golden
    Division of Infectious Diseases, the Center for AIDS and STD, University of Washington, Seattle, USA
    JAMA 290:1510-4. 2003
  28. ncbi request reprint Relapse of secondary syphilis after benzathine penicillin G: molecular analysis
    Michael Myint
    Department of Medicine Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA
    Sex Transm Dis 31:196-9. 2004
    ..It is difficult to distinguish between relapse and reinfection in patients who develop a second episode of syphilis after treatment...
  29. ncbi request reprint Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090
    Scott R Evans
    Harvard School of Public Health, Boston, Massachusetts, USA
    HIV Clin Trials 8:437-46. 2007
    ..To assess the long-term safety (primary aim) and efficacy (secondary aim) of the MAO-B inhibitor Selegiline Transdermal System (STS) for the treatment of HIV-associated cognitive impairment...
  30. ncbi request reprint Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    AIDS 21:1877-86. 2007
    ..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
  31. ncbi request reprint Macrolide resistance in Treponema pallidum in the United States and Ireland
    Sheila A Lukehart
    Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 351:154-8. 2004
  32. ncbi request reprint Déjà vu all over again: when to perform a lumbar puncture in HIV-infected patients with syphilis
    Christina M Marra
    Sex Transm Dis 34:145-6. 2007
  33. ncbi request reprint Treponema pallidum strain-specific differences in neuroinvasion and clinical phenotype in a rabbit model
    Lauren C Tantalo
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104 2499, USA
    J Infect Dis 191:75-80. 2005
    ..pallidum strains, and the clinical phenotype of infection varies with infecting strain. This information could ultimately be used to identify patients at increased risk for neuroinvasion and, thus, at risk for neurosyphilis...
  34. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  35. ncbi request reprint Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Lazio Region, Rome, Italy
    AIDS 22:1759-67. 2008
    ..To establish the effectiveness of cidofovir for AIDS-related progressive multifocal leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral therapy...
  36. ncbi request reprint A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS
    Christina M Marra
    Department of Neurology and Medicine, University of Washington School of Medicine, Seattle, WA, USA
    AIDS 16:1791-7. 2002
    ..To assess the safety, tolerability and effect of cidofovir for HIV-1 associated progressive multifocal leukoencephalopathy...
  37. ncbi request reprint Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    Olaf Stuve
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, USA
    Arch Neurol 63:1383-7. 2006
    ....
  38. ncbi request reprint A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    J Neurovirol 12:328-31. 2006
    ..Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP...

Research Grants23

  1. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  2. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2004
    ....
  3. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2005
    ....
  4. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2006
    ....
  5. Rapid and Simple CSF Tests for Neurosyphillis Diagnosis
    Christina Marra; Fiscal Year: 2006
    ..The results of this study will be used to design field trials in the areas of greatest need. ..
  6. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2007
    ....
  7. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2009
    ..Our proposed research builds on our previous work and will lead to ways to better diagnose and treat neurosyphilis. ..
  8. Persistence of CNS T. pallidum in HIV Infection
    Christina M Marra; Fiscal Year: 2010
    ..Our proposed research builds on our previous work and will lead to ways to better diagnose and treat neurosyphilis. ..
  9. Persistence of CNS T.pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2003
    ..The studies proposed in this application are directly relevant to the care of patients with HIV-1 and with syphilis and will ultimately improve our ability to diagnose and treat neurosyphilis. ..
  10. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2003
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  11. Novel Methods to Access Brain Function in HIV-1
    Christina Marra; Fiscal Year: 2003
    ..abstract_text> ..
  12. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2000
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  13. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2001
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  14. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2001
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  15. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2002
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  16. Persistence of CNS T. pallidum in HIV Infection
    Christina Marra; Fiscal Year: 2002
    ..The studies proposed in this application are directly relevant to the care of patients with HIV-1 and with syphilis and will ultimately improve our ability to diagnose and treat neurosyphilis. ..
  17. Persistence of CNS T. pallidum in HIV Infection
    Christina M Marra; Fiscal Year: 2010
    ..Our proposed research builds on our previous work and will lead to ways to better diagnose and treat neurosyphilis. ..