Tomas Marques-Bonet

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    BMC Genomics 9:384. 2008
  2. pmc Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses
    Belen Hurle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Evol Biol 11:23. 2011
  3. doi request reprint Sequencing primate genomes: what have we learned?
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98105, USA
    Annu Rev Genomics Hum Genet 10:355-86. 2009
  4. pmc The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2
    Mario Ventura
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Genome Res 22:1036-49. 2012
  5. pmc A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk
    Francesca Antonacci
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    Nat Genet 42:745-50. 2010
  6. ncbi request reprint Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution
    Zhaoshi Jiang
    Department of Genome Sciences, University of Washington School of Medicine and the Howard Hughes Medical Institute, 1705 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Genet 39:1361-8. 2007
  7. pmc A burst of segmental duplications in the genome of the African great ape ancestor
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA
    Nature 457:877-81. 2009
  8. pmc Death and resurrection of the human IRGM gene
    Cemalettin Bekpen
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 5:e1000403. 2009
  9. pmc Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee
    Mario Ventura
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Genome Res 21:1640-9. 2011
  10. pmc The origins and impact of primate segmental duplications
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Trends Genet 25:443-54. 2009

Collaborators

Detail Information

Publications15

  1. pmc The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    BMC Genomics 9:384. 2008
    ....
  2. pmc Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses
    Belen Hurle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Evol Biol 11:23. 2011
    ....
  3. doi request reprint Sequencing primate genomes: what have we learned?
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98105, USA
    Annu Rev Genomics Hum Genet 10:355-86. 2009
    ....
  4. pmc The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2
    Mario Ventura
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Genome Res 22:1036-49. 2012
    ..Our findings highlight the complex interplay between duplicated sequences and chromosomal rearrangements that rapidly alter the cytogenetic landscape in a short period of evolutionary time...
  5. pmc A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk
    Francesca Antonacci
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    Nat Genet 42:745-50. 2010
    ..Notably, we show that the S2 configuration harbors directly oriented duplications, specifically predisposing this chromosome to disease-associated rearrangement...
  6. ncbi request reprint Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution
    Zhaoshi Jiang
    Department of Genome Sciences, University of Washington School of Medicine and the Howard Hughes Medical Institute, 1705 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Genet 39:1361-8. 2007
    ....
  7. pmc A burst of segmental duplications in the genome of the African great ape ancestor
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA
    Nature 457:877-81. 2009
    ....
  8. pmc Death and resurrection of the human IRGM gene
    Cemalettin Bekpen
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 5:e1000403. 2009
    ..Such dynamism in structure and evolution may be critical for a gene family locked in an arms race with an ever-changing repertoire of intracellular parasites...
  9. pmc Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee
    Mario Ventura
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Genome Res 21:1640-9. 2011
    ..Our analysis suggests that the chimpanzee and gorilla genomes are structurally more derived than either orangutan or human genomes...
  10. pmc The origins and impact of primate segmental duplications
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Trends Genet 25:443-54. 2009
    ..Although many genomes will be sequenced in the future, resolution of this aspect of genomic architecture still requires high quality sequences and detailed analyses...
  11. pmc Personalized copy number and segmental duplication maps using next-generation sequencing
    Can Alkan
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    Nat Genet 41:1061-7. 2009
    ..2 x 10(-16)). Our method can distinguish between different copies of highly identical genes, providing a more accurate assessment of gene content and insight into functional constraint without the limitations of array-based technology...
  12. pmc Rates and patterns of great ape retrotransposition
    Fereydoun Hormozdiari
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 110:13457-62. 2013
    ..We conclude that Alu retrotransposition has been the most variable form of genetic variation during recent human-great ape evolution, with increases and decreases occurring over very short periods of evolutionary time...
  13. pmc Evolution and diversity of copy number variation in the great ape lineage
    Peter H Sudmant
    Department of Genome Sciences, University of Washington, Seattle, Washington 98105, USA
    Genome Res 23:1373-82. 2013
    ....
  14. pmc Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites
    Santhosh Girirajan
    Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Genome Res 19:178-90. 2009
    ....
  15. pmc Characterization of six human disease-associated inversion polymorphisms
    Francesca Antonacci
    Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 18:2555-66. 2009
    ..In these cases, discovery and genotyping methods based on SNPs may be confounded and molecular cytogenetics remains the only method to genotype these inversions...