Research Topics
Genomes and Genes | R MarmorsteinSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Structure of SET domain proteins: a new twist on histone methylationRonen Marmorstein
The Wistar Institute, The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Trends Biochem Sci 28:59-62. 2003....
Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymesBrandi D Sanders
The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Cell 25:463-72. 2007..These results provide insights into the Sir2 mechanism of nicotinamide inhibition and have important implications for the development of Sir2-specific effectors...- Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzymeKeqin Li
The Wistar Institute University of Pennsylvania, Philadelphia, PA 19104, USA
J Mol Biol 372:194-204. 2007..Together, these studies provide new insights into Ubp3 recognition by Bre5 and into protein recognition by NTF2-like domains... - Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modificationMichael M Brent
The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Structure 16:1407-16. 2008.... - Protein modules that manipulate histone tails for chromatin regulationR Marmorstein
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Mol Cell Biol 2:422-32. 2001..It is becoming clear that appropriate coordination of histone modifications and their manipulations by conserved protein modules are integral to gene-specific transcriptional regulation within chromatin... - Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylasesR Marmorstein
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Biochem Soc Trans 32:904-9. 2004..These studies have implications for the structure-based design of Sir2-specific small molecule compounds, which might modulate Sir2 function for therapeutic application... - Modulation of DNA-binding domains for sequence-specific DNA recognitionRonen Marmorstein
Department of Chemistry, The Wistar Institute, University of Pennsylvania, 3601 Spruce Street, Philadelphia, PA 19104, USA
Gene 304:1-12. 2003..Together, these examples reveal a variety of ways in which such extrinsic factors can significantly extend the repertoire of DNA sites recognized by a given DNA-binding domain... - Structure and function of histone acetyltransferasesR Marmorstein
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA
Cell Mol Life Sci 58:693-703. 2001.... - Structure of histone deacetylases: insights into substrate recognition and catalysisR Marmorstein
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Structure 9:1127-33. 2001..Recent structural studies of histone deacetylases and their homologs from bacteria have provided important insights into the mode of substrate recognition and catalysis by these enzymes... - Structure of histone acetyltransferasesR Marmorstein
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Mol Biol 311:433-44. 2001..These correlations imply a related mode of catalysis and histone substrate binding by a diverse group of HAT enzymes... - Histone acetyltransferases: function, structure, and catalysisR Marmorstein
Structural Biology Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Curr Opin Genet Dev 11:155-61. 2001..Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation... - Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complexY Mo
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Mol Biol 314:495-506. 2001.... - Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNAY Mo
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Struct Biol 7:292-7. 2000.... - Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14W S Lo
Molecular Genetics Program, Wistar Institute, Philadelphia, Pennsylvania 19024, USA
Mol Cell 5:917-26. 2000..These observations suggest that transcriptional regulation occurs by multiple mechanistically linked covalent modifications of histones... - Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteinsY Mo
The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA
Mol Cell 2:201-12. 1998..Modeling studies of a SAP-1/SRF/DNA complex suggest that SRF may modulate SAP-1 binding to DNA by interacting with its ETS domain... - p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageL Liu
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 19:1202-9. 1999..These data indicate that site-specific acetylation of p53 increases under physiological conditions that activate p53 and identify CBP/p300 and PCAF as the probable enzymes that modify p53 in vivo... - Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutationsR Venkataramani
Wistar Institute, Philadelphia, Pennsylvania, USA
Nat Struct Biol 5:74-81. 1998..A subset of these residues suggest an INK4 binding surface for the cyclin-dependent kinases 4 and 6. This surface is centered around a region that shows structural features uncharacteristic of ankyrin-like repeat units... - Structure and function of bromodomains in chromatin-regulating complexesR Marmorstein
Structural Biology Program, The Wistar Institute, Philadelphia, PA, USA
Gene 272:1-9. 2001..Interactions between bromodomains and modified histones may be an important mechanism underlying chromatin structural changes and gene regulation... - Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoproteinX Li
The Wistar Institute, University of Pennsylvania, Philadelphia 19104, USA
Cancer Res 59:5275-82. 1999..Together, these studies form a structure-function framework for understanding BTB/POZ-mediated oligomerization and transcriptional repression properties... - Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolutionK Zhao
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, 19104, USA
J Biol Chem 276:12120-7. 2001..We propose that the p53 core domain dimer that is seen in the crystals described here represents a physiologically relevant inactive form of p53 that must undergo structural rearrangement for sequence-specific DNA binding... - Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector designS C Hodawadekar
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Oncogene 26:5528-40. 2007..In this review, we will discuss what we have learned from the structures and related biochemistry of HATs and HDACs and the implications of these findings for the design of protein effectors to regulate gene expression and treat disease... - Crystal structure of a p53 core tetramer bound to DNAK A Malecka
The Wistar Institute, Philadelphia, PA 19104, USA
Oncogene 28:325-33. 2009..Surface residue conservation of the p53DBD tetramer bound to DNA highlights possible regions of other p53 domain or p53 cofactor interactions... - Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coliKehao Zhao
The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
J Mol Biol 337:731-41. 2004..Together, these studies suggest that substrate-specific binding by sirtuin proteins involves contributions from the zinc-binding domain of the enzyme and substrate regions distal to the acetyl-lysine-binding site... - Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptideKehao Zhao
The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Structure 11:1403-11. 2003.... - Structure and biochemical characterization of protein acetyltransferase from Sulfolobus solfataricusMichael M Brent
Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:19412-9. 2009..The structural similarity of PAT to eukaryotic HATs combined with its conserved role in chromatin regulation suggests that PAT is evolutionarily related to the eukaryotic HATs... - Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster proteinMary X Fitzgerald
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Structure 14:725-35. 2006..Broader implications of these findings are discussed... - Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear clusterK Swaminathan
Wistar Institute, University of Pennsylvania, Philadelphia 19104, USA
Nat Struct Biol 4:751-9. 1997..A comparison with the GAL4-DNA and PPR1-DNA complexes shows how a family of related DNA binding proteins can use a diverse set of mechanisms to discriminate between the base pairs separating conserved DNA half-sites... - Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactorKeqin Li
The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biol Chem 280:29176-85. 2005..Together, these studies provide novel insights into protein recognition by NTF2-like domains and provide a molecular scaffold for understanding how Ubp3 function is regulated by Bre5 cofactor binding... - Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA bindingKehao Zhao
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:26071-7. 2003..Implications for the mechanism by which histone acetylation modulates gene expression are discussed... - Generation and characterization of monoclonal antibodies against the E6 and E7 oncoproteins of HPVA P Wlazlo
The Wistar Institute, Philadelphia, PA 19104, USA
Hybridoma 20:257-63. 2001..The E7 MAb cross-reacted with the HPV-1a E7 oncoprotein. The binding sites of the MAbs were mapped to defined regions of each viral protein... - Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexesGuoping Da
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:2057-62. 2006..Together, these studies identify the SWIRM domain as an essential multifunctional module for the regulation of gene expression... - Structure of the p53 core domain dimer bound to DNAWilliam C Ho
The Wistar Institute, Pennsylvania 19104, USA
J Biol Chem 281:20494-502. 2006.... - Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cellsGowrishankar Banumathy
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Mol Cell Biol 29:758-70. 2009..UBN1 is indispensable for formation of SAHF. We conclude that UBN1 is an ortholog of yeast Hpc2p and a novel regulator of senescence... - The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targetingMarc A Holbert
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 0381, USA
J Biol Chem 282:36603-13. 2007..Our results reveal, for the first time, that enzymatic and DNA-targeting activities can be contained within the same chromatin regulatory domain... - Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBPYong Tang
Program in Gene Expression and Regulation, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nat Struct Mol Biol 15:738-45. 2008..The structure reveals a buried autoacetylated lysine residue that we show is also acetylated in the Rtt109 protein purified from yeast cells. Implications for understanding histone substrate and chaperone binding by Rtt109 are discussed... - Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substratesArienne N Poux
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Biochemistry 42:14366-74. 2003..Together, these studies provide a framework for understanding the substrate selectivity of HAT proteins... - Structural basis for dimerization in DNA recognition by Gal4Manqing Hong
The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Structure 16:1019-26. 2008..Associated biochemical studies show that the dimerization domain of Gal4 is important for DNA binding and protein thermostability. We also map the interaction surface of the Gal4 dimerization domain with Gal11P... - Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferaseAdrienne Clements
The Wistar Institute, Philadelphia, PA 19104, USA
Mol Cell 12:461-73. 2003..Together, these studies reveal how one histone modification can modulate another to affect distinct transcriptional signals... - The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domainHongzhuang Peng
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
J Mol Biol 370:269-89. 2007..This is the first example of a structurally disordered repressor domain that is the most widely conserved silencing domain in tetrapods... - Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assemblyYong Tang
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Nat Struct Mol Biol 13:921-9. 2006..Together, these studies begin to define the molecular determinants of assembly of functionally diverse macromolecular histone chaperone complexes... - Structure of Vps75 and implications for histone chaperone functionYong Tang
Program in Gene Expression and Regulation, Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:12206-11. 2008..Taken together, our data provide a structural framework for understanding how Vps75 mediates both nucleosome assembly and histone acetylation by Rtt109... - Dehydrogenases, NAD, and transcription--what's the connection?Ronen Marmorstein
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Structure 10:1465-6. 2002.... - Structure and autoregulation of the yeast Hst2 homolog of Sir2Kehao Zhao
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Struct Biol 10:864-71. 2003..Together, these studies indicate that the sequence-divergent N- and C-terminal regions of the eukaryotic Sir2 proteins may have a particularly important role in their distinct substrate-binding properties, biological activities or both... - Transcription initiation at its most basic levelRonen Marmorstein
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 115:370-2. 2003.... - High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compoundsWilliam C Ho
The Wistar Institute, Philadelphia, PA 19104, USA
Acta Crystallogr D Biol Crystallogr 62:1484-93. 2006..Together, these studies provide a molecular scaffold for the structure-based design of p53-stabilization compounds for development as possible therapeutic agents... - Insights into structure and function of GCN5/PCAF and yEsa 1 histone acetyltransferase domains:Adrienne Clements
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Methods Enzymol 371:545-64. 2003 - Structural and chemical basis of histone acetylationRonen Marmorstein
The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Novartis Found Symp 259:78-98; discussion 98-101, 163-9. 2004..In this paper I will review structural work from my laboratory on histone acetyltransferases (HATs) and the Sir2 family of histone deacetylases (HDACs), with a specific focus on catalysis and substrate-specific binding by these enzymes... - Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencingN C Tolga Emre
Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
Mol Cell 17:585-94. 2005..Our results suggest that these H2B-deubiquitylating enzymes have distinct genomic functions... - Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressorXin Liu
Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Genes Dev 21:2711-6. 2007.... - Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain proteinTroy Eugene Messick
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 283:11038-49. 2008..Together, these studies provide new insights into ubiquitin binding and hydrolysis by yeast Otu1 and other OTU domain-containing proteins... 
The structural basis of protein acetylation by the p300/CBP transcriptional coactivatorXin Liu
Program in Gene Expression and Regulation, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nature 451:846-50. 2008..Several disease-associated mutations can also be readily accounted for by the p300 HAT structure. These studies pave the way for new epigenetic therapies involving modulation of p300/CBP HAT activity...- Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory regionRuchi Anand
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Biochemistry 47:6719-26. 2008..Together, our studies provide new insights into how MST1 substrate selectivity is modulated with implications for understanding apoptotic signaling through MST1 kinase... - Biochemical and structural characterization of recombinant histone acetyltransferase proteinsRonen Marmorstein
Structural Biology Program, The Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA
Methods Enzymol 376:106-19. 2004 - Structure and mechanism of lysine-specific demethylase enzymesRuchi Anand
Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania, USA
J Biol Chem 282:35425-9. 2007.... - Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitorArienne N Poux
The Wistar Institute, and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:14065-70. 2002..The structure also provides a structural scaffold for the design of HAT-specific inhibitors that may have therapeutic applications for the treatment of HAT-mediated cancers... - Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein familyVinod Nayak
The Wistar Institute, University of Pennsylvania, Philadelphia 19104, USA
Structure 14:477-85. 2006..Taken together, these studies suggest another layer of kinase regulation within the Snf1/AMPK family, and an avenue for development of AMPK-specific activating compounds... - Structure and activity of enzymes that remove histone modificationsMarc A Holbert
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Opin Struct Biol 15:673-80. 2005.... - Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressorXin Liu
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 281:578-86. 2006.... - Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesKehao Zhao
The Wistar Institute, Department of Biochemistry and Biophysics, School of Medicine, and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104
Proc Natl Acad Sci U S A 101:8563-8. 2004..Together, these studies provide insights into the chemistry of NAD(+) cleavage and acetylation by Sir2 proteins and have implications for the design of Sir2-specific regulatory molecules... - Histone modifying enzymes: structures, mechanisms, and specificitiesRonen Marmorstein
Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1789:58-68. 2009.... - The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediateYuan Yan
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Struct Biol 9:862-9. 2002..These results demonstrate that different HAT subfamilies can use distinct catalytic mechanisms, which have implications for their distinct biological roles and for the development of HAT-specific inhibitors... - Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivityPeng Xie
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
ACS Chem Biol 3:305-16. 2008.... - Targeting large kinase active site with rigid, bulky octahedral ruthenium complexesJasna Maksimoska
The Wistar Institute and University of Pennsylvania, Department of Chemistry, Philadelphia, Pennsylvania 19104, USA
J Am Chem Soc 130:15764-5. 2008.... - Acetylation of the p53 DNA-binding domain regulates apoptosis inductionStephen M Sykes
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Mol Cell 24:841-51. 2006..Furthermore, the acetyllysine 120 (acetyl-K120) form of p53 specifically accumulates at proapoptotic target genes. These data suggest that K120 acetylation may help distinguish the cell-cycle arrest and apoptotic functions of p53... - Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitorRuchi Anand
Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
J Med Chem 52:1602-11. 2009.... - Structural basis for sirtuin function: what we know and what we don'tBrandi D Sanders
The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1804:1604-16. 2010..Implications for future structural studies to address outstanding questions in the field are also discussed... - Identification of BRAF inhibitors through in silico screeningCheng Luo
Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Med Chem 51:6121-7. 2008..The binding modes of these inhibitors to BRAF are analyzed through molecular docking to derive structure-activity relationships and to assist in the future development of more potent and more specific BRAF inhibitors... - Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulationBing Xiao
Division of Protein Structure, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 100:2363-8. 2003..Finally, our data reveal that the tight binding of the human papillomavirus E7 oncoprotein to pRb prevents subsequent interactions with the marked box region of E2F but not with its core binding region... - Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivationHye Sook Kwon
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
Cell Host Microbe 3:158-67. 2008..These events likely contribute to the state of immune cell hyperactivation found in HIV-infected individuals... - Ankyrin for methylated lysinesMichael M Brent
Nat Struct Mol Biol 15:221-2. 2008 - 14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylationWendy Walter
Division of Molecular Genetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3 QU, United Kingdom
Mol Cell Biol 28:2840-9. 2008..The importance of acetylation in this interaction is also seen in vivo, where K14 acetylation is required for optimal Bmh1 recruitment to the GAL1 promoter during transcriptional activation... - Nuclear export modulates the cytoplasmic Sir2 homologue Hst2Jeanne M Wilson
Division of Biological Sciences, Section of Molecular Biology, University of California, San Diego, 9500 Gilman Drive, 0347, La Jolla, California 92093, USA
EMBO Rep 7:1247-51. 2006..Our identification of putative nuclear export sequences in numerous vertebrate SIRT2 proteins shows that active nuclear export can be a conserved mechanism for regulating Sir2 homologues... - Multiple roles for acetylation in the interaction of p300 HAT with ATF-2Balasubramanyam Karanam
Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Biochemistry 46:8207-16. 2007..Taken together, these studies suggest multiple roles for protein acetylation in the regulation of transcription by p300/CBP and ATF-2... - Acridine derivatives activate p53 and induce tumor cell death through BaxWenge Wang
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Cancer Biol Ther 4:893-8. 2005..These findings provide insights into p53 regulation in response to DNA intercalating drugs and may assist new anti-cancer drug design... - A mechanism-based inactivator for histone demethylase LSD1Jeffrey C Culhane
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Am Chem Soc 128:4536-7. 2006..Compound 1 is thus a selective, mechanism-based inactivator of LSD1 and is likely to serve as a useful tool in the study of histone modifications and chromatin remodeling...
Research Grants
- Predoctoral Training at the Chemistry-Biology InterfaceRonen Marmorstein; Fiscal Year: 2007....
- TRAINING PROGRAM IN BASIC CANCER RESEARCHRonen Marmorstein; Fiscal Year: 2007..Altogether, this training program offers training in "cutting edge" basic cancer research that will prepare the participating trainees for a productive career in science that will advance our understanding of the malignant process. ..