William J Marks

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    William J Marks
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0138, USA
    Lancet Neurol 7:400-8. 2008
  2. ncbi request reprint Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco 94143, USA
    J Neurosurg 104:488-501. 2006
  3. ncbi request reprint Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaque
    Philip A Starr
    Dept of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, 779 Moffitt, San Francisco, CA 94143, USA
    J Neurophysiol 93:3165-76. 2005
  4. doi request reprint Development of Parkinson's disease in patients with Narcolepsy
    Chadwick W Christine
    Department of Neurology, University of California, San Francisco, 400 Parnassus Avenue, Box 0348, San Francisco, CA 94143, USA
    J Neural Transm 119:697-9. 2012
  5. doi request reprint Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
    William J Marks
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Lancet Neurol 9:1164-72. 2010
  6. ncbi request reprint Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
    Ken Nakamura
    Department of Neurology, University of California, San Francisco, CA, USA
    Mov Disord 22:619-26. 2007
  7. ncbi request reprint Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease
    Philip V Theodosopoulos
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Mov Disord 18:791-8. 2003
  8. ncbi request reprint Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 17:E4. 2004
  9. doi request reprint Shorter disease duration correlates with improved long-term deep brain stimulation outcomes in young-onset DYT1 dystonia
    Leslie C Markun
    Department of Neurology, University of California, San Francisco, California 94115, USA
    Neurosurgery 71:325-30. 2012
  10. ncbi request reprint Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome)
    Jill L Ostrem
    Department of Neurology, University of California, San Francisco, California 94143, USA
    Mov Disord 22:1885-91. 2007

Detail Information

Publications19

  1. doi request reprint Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    William J Marks
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0138, USA
    Lancet Neurol 7:400-8. 2008
    ..The aim of this study was to assess the safety, tolerability, and potential efficacy of gene delivery of the neurotrophic factor neurturin...
  2. ncbi request reprint Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco 94143, USA
    J Neurosurg 104:488-501. 2006
    ....
  3. ncbi request reprint Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaque
    Philip A Starr
    Dept of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, 779 Moffitt, San Francisco, CA 94143, USA
    J Neurophysiol 93:3165-76. 2005
    ....
  4. doi request reprint Development of Parkinson's disease in patients with Narcolepsy
    Chadwick W Christine
    Department of Neurology, University of California, San Francisco, 400 Parnassus Avenue, Box 0348, San Francisco, CA 94143, USA
    J Neural Transm 119:697-9. 2012
    ..Although preliminary, this observation raises the possibility that some factors intrinsic to narcolepsy or its treatment may be a risk factor for PD...
  5. doi request reprint Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
    William J Marks
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Lancet Neurol 9:1164-72. 2010
    ..We aimed to assess the safety and efficacy of AAV2-neurturin in a double-blind, phase 2 randomised trial...
  6. ncbi request reprint Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
    Ken Nakamura
    Department of Neurology, University of California, San Francisco, CA, USA
    Mov Disord 22:619-26. 2007
    ..Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short-term follow-up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks...
  7. ncbi request reprint Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease
    Philip V Theodosopoulos
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Mov Disord 18:791-8. 2003
    ..Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate...
  8. ncbi request reprint Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 17:E4. 2004
    ..Patients with juvenile-onset primary dystonia and those with the tardive form benefited greatly from this procedure, whereas benefits for most secondary dystonias and the adult-onset craniocervical form of this disorder were more modest...
  9. doi request reprint Shorter disease duration correlates with improved long-term deep brain stimulation outcomes in young-onset DYT1 dystonia
    Leslie C Markun
    Department of Neurology, University of California, San Francisco, California 94115, USA
    Neurosurgery 71:325-30. 2012
    ....
  10. ncbi request reprint Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome)
    Jill L Ostrem
    Department of Neurology, University of California, San Francisco, California 94143, USA
    Mov Disord 22:1885-91. 2007
    ..Although GPi DBS was effective in these patients, the influence of GPi DBS on nondystonic body regions deserves further investigation...
  11. ncbi request reprint Neuropsychological performance following staged bilateral pallidal or subthalamic nucleus deep brain stimulation for Parkinson's disease
    Johannes C Rothlind
    Mental Health Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Int Neuropsychol Soc 13:68-79. 2007
    ..Findings are discussed with reference to possible causes of neuropsychological decline and the need for further controlled studies of specific neuropsychological effects of DBS...
  12. pmc Induction of bradykinesia with pallidal deep brain stimulation in patients with cranial-cervical dystonia
    Brian D Berman
    Department of Neurology, University of California, San Francisco, Calif, USA
    Stereotact Funct Neurosurg 87:37-44. 2009
    ..More recently, it has been applied as a treatment for focal and segmental dystonias. This patient population offers an opportunity to study the effects of alteration of pallidal outflow on previously normal limb function...
  13. doi request reprint Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
    Jeff M Bronstein
    University of California, Los Angeles, School of Medicine, Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 68:165. 2011
    ..To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD)...
  14. doi request reprint An update on gene therapy in Parkinson's disease
    Jennifer Witt
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94115, USA
    Curr Neurol Neurosci Rep 11:362-70. 2011
    ..Thus far, safety data from phase 1 trials have been encouraging for all four agents and one phase 2 trial suggests modest symptomatic efficacy, but definitive conclusions on efficacy cannot yet be drawn...
  15. doi request reprint Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging
    Wang Zhan
    Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
    Mov Disord 27:90-7. 2012
    ..Our data suggest that microstructural alterations detected with diffusion tensor might serve as a potential biomarker for PD...
  16. ncbi request reprint Deep brain stimulation for the treatment of Parkinson's disease: overview and impact on gait and mobility
    Melinda Piper
    Parkinsons Disease Research, Education, and Clinical Center, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    NeuroRehabilitation 20:223-32. 2005
    ..The combination of deep brain stimulation, pharmacotherapy, and rehabilitation training may result in more effective comprehensive approaches to the reduced mobility associated with Parkinson's disease...
  17. ncbi request reprint Epidemiology of Parkinson's disease
    Suketu M Khandhar
    Northern California Kaiser Permanente, Surgical Movement Disorders Program, San Francisco, California, USA
    Dis Mon 53:200-5. 2007
  18. ncbi request reprint Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease
    JOSEPH O'NEILL
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    Mov Disord 17:917-27. 2002
    ..64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects...
  19. ncbi request reprint Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locations
    Philip A Starr
    Department of Neurological Surgery, University of California, San Francisco 94143, USA
    J Neurosurg 97:370-87. 2002
    ..The authors present the technical approach used to implant 76 stimulators into the STNs of patients with PD and the lead locations, which were verified on postoperative magnetic resonance (MR) images...