Michael S Marks

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Organelle biogenesis: en BLOC exchange for RAB32 and RAB38
    Michael S Marks
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 22:R963-5. 2012
  2. pmc Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic
    BRENDA WATT
    Department of Pathology and Laboratory Medicine and Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002286. 2011
  3. pmc Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis
    Joanne F Berson
    Dept of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    J Cell Biol 161:521-33. 2003
  4. pmc Lysosome-related organelles: unusual compartments become mainstream
    Michael S Marks
    Department of Pathology and Laboratory Medicine and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 25:495-505. 2013
  5. pmc Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells
    G Raposo
    Curie Institute, Research Section, Paris, 7505 France
    J Cell Biol 152:809-24. 2001
  6. ncbi request reprint Protein sorting within the MHC class II antigen-processing pathway
    M S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6082, USA
    Immunol Res 17:141-54. 1998
  7. ncbi request reprint Melanosomes and MHC class II antigen-processing compartments: a tinted view of intracellular trafficking and immunity
    Michael S Marks
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunol Res 27:409-26. 2003
  8. pmc FIG4, Charcot-Marie-Tooth disease, and hypopigmentation: a role for phosphoinositides in melanosome biogenesis?
    Michael S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pigment Cell Melanoma Res 21:11-4. 2008
  9. ncbi request reprint The melanosome: membrane dynamics in black and white
    M S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Nat Rev Mol Cell Biol 2:738-48. 2001
  10. pmc ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane
    Steven T Truschel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Traffic 10:1318-36. 2009

Research Grants

  1. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2009
  2. MELANOSOME PROTEIN SORTING, FOLDING & ANTIGEN PROCESSING
    Michael Marks; Fiscal Year: 2002
  3. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2007
  4. Melanosome Biogenesis
    Michael S Marks; Fiscal Year: 2010
  5. Hermansky Pudlak Syndrome & melanosome formation
    Michael Marks; Fiscal Year: 2007
  6. Nmb and melanosome function in eye pigment cells
    Michael Marks; Fiscal Year: 2005
  7. Hermansky Pudlak Syndrome & melanosome formation
    GRACA GRACA RAPOSO; Fiscal Year: 2010
  8. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2005
  9. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2009
  10. Iron and copper transporter trafficking in healthy and diseased melanocytes
    Michael Marks; Fiscal Year: 2007

Collaborators

Detail Information

Publications43

  1. pmc Organelle biogenesis: en BLOC exchange for RAB32 and RAB38
    Michael S Marks
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 22:R963-5. 2012
    ..New work identifies BLOC-3 as a guanine nucleotide exchange factor for two RAB GTPases previously implicated in lysosome-related organelle biogenesis...
  2. pmc Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic
    BRENDA WATT
    Department of Pathology and Laboratory Medicine and Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002286. 2011
    ..We speculate that PMEL mutations can model the conversion between physiological and pathological amyloid...
  3. pmc Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis
    Joanne F Berson
    Dept of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    J Cell Biol 161:521-33. 2003
    ..Like the pathologic process of amyloidogenesis, the formation of other tissue-specific organelle structures may be similarly dependent on proteolytic activation of physiological fibrillogenic substrates...
  4. pmc Lysosome-related organelles: unusual compartments become mainstream
    Michael S Marks
    Department of Pathology and Laboratory Medicine and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 25:495-505. 2013
    ....
  5. pmc Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells
    G Raposo
    Curie Institute, Research Section, Paris, 7505 France
    J Cell Biol 152:809-24. 2001
    ..Furthermore, they implicate an unusual clathrin-coated endosomal compartment as a site from which proteins destined for premelanosomes and lysosomes are sorted...
  6. ncbi request reprint Protein sorting within the MHC class II antigen-processing pathway
    M S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6082, USA
    Immunol Res 17:141-54. 1998
    ..By using a similar chimeric protein approach to target endogenous proteins to distinct compartments, we hope to address the role of processing events in each compartment in the generation of MHC class II ligands...
  7. ncbi request reprint Melanosomes and MHC class II antigen-processing compartments: a tinted view of intracellular trafficking and immunity
    Michael S Marks
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunol Res 27:409-26. 2003
    ..Our studies on melanosome biogenesis are providing new ways of thinking about antigen-processing compartments and the mechanisms regulating presentation of tumor-associated antigens...
  8. pmc FIG4, Charcot-Marie-Tooth disease, and hypopigmentation: a role for phosphoinositides in melanosome biogenesis?
    Michael S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pigment Cell Melanoma Res 21:11-4. 2008
  9. ncbi request reprint The melanosome: membrane dynamics in black and white
    M S Marks
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Nat Rev Mol Cell Biol 2:738-48. 2001
    ..The recent characterization of genes defective in these diseases has reinvigorated interest in the melanosome as a model system for understanding the molecular mechanisms that underlie intracellular membrane dynamics...
  10. pmc ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane
    Steven T Truschel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Traffic 10:1318-36. 2009
    ..Our data delineate a novel pathway for Tyrp1 trafficking and illustrate a requirement for ESCRT-I function in controlling protein sorting from vacuolar endosomes to the limiting membrane of a lysosome-related organelle...
  11. pmc Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes
    Dawn C Harper
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 283:2307-22. 2008
    ..These data have important implications for the site and mechanism of fibril formation...
  12. pmc BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles
    Subba Rao Gangi Setty
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 18:768-80. 2007
    ....
  13. pmc The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB
    Alexander C Theos
    Department of Pathology and Laboratory Medicine and Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pigment Cell Melanoma Res 26:470-86. 2013
    ..These results reveal the molecular basis for the distinct trafficking and morphogenetic properties of PMEL and GPNMB and support a deterministic function of the PMEL PKD domain in both protein sorting and amyloidogenesis. ..
  14. pmc Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
    Anand Sitaram
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 23:3178-92. 2012
    ..These data provide evidence for distinct roles of AP-1 and AP-3 in OCA2 transport to melanosomes and indicate that BLOC-1 can cooperate with either adaptor during cargo sorting to LROs...
  15. pmc SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models
    Ronghua Meng
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, 513 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    Blood 120:404-14. 2012
    ....
  16. pmc A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis
    Alexander C Theos
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 10:343-54. 2006
    ..These results establish an Hrs- and perhaps ESCRT-independent pathway of ILV sorting by lumenal determinants and a requirement for ILV sorting in fibril formation...
  17. pmc Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17
    Alexander C Theos
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 17:3598-612. 2006
    ..These data reveal a dual sorting defect in a natural mutant of Pmel17 and support a requirement of endocytic trafficking in Pmel17 fibril formation...
  18. pmc N-terminal domains elicit formation of functional Pmel17 amyloid fibrils
    BRENDA WATT
    Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:35543-55. 2009
    ..These data define the structural core of Pmel17 amyloid, imply that the RPT domain plays a regulatory role in timing amyloid conversion, and suggest that fibril formation might be physically linked with multivesicular body sorting...
  19. pmc The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function
    Alexander C Theos
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pigment Cell Res 18:322-36. 2005
    ..As such, we will refer to the protein in this review simply as pre-melanosomal protein (Pmel). This review will summarize the structural and functional aspects of Pmel and its role in melanosome biogenesis...
  20. pmc Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells
    Adriana R Mantegazza
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 36:782-94. 2012
    ..We propose that AP-3-dependent TLR delivery from endosomes to phagosomes and subsequent signaling mobilize peptide:MHC-II export from intracellular stores...
  21. pmc Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes
    Subba Rao Gangi Setty
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 454:1142-6. 2008
    ....
  22. pmc A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats
    Sarah E Nichols
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    J Invest Dermatol 121:821-30. 2003
    ..The expression of an alternatively spliced product may furthermore affect the cohort of peptides generated for recognition of melanoma cells by tumor-directed T lymphocytes...
  23. pmc Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function
    Anand Sitaram
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 20:1464-77. 2009
    ..We conclude that OCA2 is targeted to and functions within melanosomes but that residence within melanosomes may be regulated by secondary or alternative targeting to lysosomes...
  24. ncbi request reprint A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network
    Atsuko Yoshino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 116:4441-54. 2003
    ....
  25. pmc Mechanisms of protein delivery to melanosomes in pigment cells
    Anand Sitaram
    Cell and Molecular Biology Graduate Group, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 27:85-99. 2012
    ..This review describes current models of protein trafficking required for melanosome biogenesis in mammalian melanocytes...
  26. ncbi request reprint tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre
    Atsuko Yoshino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    J Cell Sci 118:2279-93. 2005
    ..These data demonstrate that tGolgin-1 functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements...
  27. pmc PMEL: a pigment cell-specific model for functional amyloid formation
    BRENDA WATT
    Department of Pathology and Laboratory Medicine, Department of Physiology, and Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pigment Cell Melanoma Res 26:300-15. 2013
    ..We then discuss how its progression through the secretory pathway into the endosomal system might allow for the regulated and non-toxic conversion of PMEL into an ordered amyloid polymer...
  28. pmc Nuclear translocation of urokinase-type plasminogen activator
    Victoria Stepanova
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Blood 112:100-10. 2008
    ..These data reveal a novel pathway by which uPA is rapidly translocated to the nucleus where it might participate in regulating gene expression...
  29. pmc Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking
    Sarah E Robertson
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Biol Cell 17:645-57. 2006
    ..These studies reveal a previously unappreciated link of Erk signaling to organelle dynamics and endosomal trafficking...
  30. pmc Presentation of phagocytosed antigens by MHC class I and II
    Adriana R Mantegazza
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Traffic 14:135-52. 2013
    ....
  31. pmc Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells
    Monika Damek-Poprawa
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:10877-89. 2009
    ..Collectively, these studies suggest that MREG is required for lysosome maturation and support a role for MREG in intracellular trafficking...
  32. ncbi request reprint A tumor-associated glycoprotein that blocks MHC class II-dependent antigen presentation by dendritic cells
    Ralf Gutzmer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:1023-32. 2004
    ..These results demonstrate a novel mechanism by which tumors may evade CD4(+) T cell-dependent immune responses through expression of a TAA...
  33. pmc Darkness descends with two Rabs
    Michael S Marks
    University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 175:199-200. 2006
    ..Wasmeier et al. (this issue, p. 271) reveal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specific lysosome-related organelle, the melanosome...
  34. pmc Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction
    Yuhuan Wang
    Division of Hematology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 118:6183-91. 2011
    ....
  35. ncbi request reprint Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development
    David A Cowan
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    DNA Cell Biol 21:505-17. 2002
    ..This expression pattern suggests that tGolgin-1 may play a role in specialized transport processes associated with maturation and/or differentiation of oligodendrocyte precursors...
  36. ncbi request reprint Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3
    Subba Rao Gangi Setty
    University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 421 Curie Boulevard, BRB 2 3, Room 1010, Philadelphia, PA 19104 6058, USA
    Curr Biol 13:401-4. 2003
    ..The similar requirements for localization of GRIP domains from yeast, mouse, and human when expressed in yeast, and the presence of Arl1p and Arl3p homologs in these species, suggest that this is an evolutionarily conserved mechanism...
  37. pmc BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes
    Santiago M Di Pietro
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Mol Biol Cell 17:4027-38. 2006
    ..These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of the endosomal protein trafficking machinery...
  38. pmc Lysosome-related organelles: driving post-Golgi compartments into specialisation
    Graca Raposo
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Curr Opin Cell Biol 19:394-401. 2007
    ..Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form...
  39. pmc Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes
    Alexander C Theos
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 16:5356-72. 2005
    ....
  40. pmc Functional amyloid formation within mammalian tissue
    Douglas M Fowler
    Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 4:e6. 2006
    ....
  41. pmc Melanosomes--dark organelles enlighten endosomal membrane transport
    Graca Raposo
    Institut Curie, Centre de Recherche, Paris, F 75248 France
    Nat Rev Mol Cell Biol 8:786-97. 2007
    ..Moreover, genetic disorders that affect the biogenesis of melanosomes and other lysosome-related organelles have shed light onto the molecular machinery that controls specialized endosomal sorting events...
  42. ncbi request reprint The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis
    Graca Raposo
    UMR 144, Institut Curie, CNRS, Paris, Cedex 75005, France
    Traffic 3:237-48. 2002
    ..Further dissection of the melanosomal system will likely shed light not only on the biogenesis of lysosome-related organelles but also on general aspects of vesicular transport in the endosomal system...
  43. ncbi request reprint Lysosome-related organelles: a view from immunity and pigmentation
    Graca Raposo
    Centre National de la Recherche Scientifique, UMR 144, Institut Curie, 75005 Paris, France
    Cell Struct Funct 27:443-56. 2002
    ..In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells...

Research Grants23

  1. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2009
    ..PmeU 7 forms amyloid-like fibers within pigment cells. By defining the mechanism, we may uncover potential cures for albinism, hyperpigmented lesions, and/or neurodegenerative amyloid diseases like Alzheimer's. ..
  2. MELANOSOME PROTEIN SORTING, FOLDING & ANTIGEN PROCESSING
    Michael Marks; Fiscal Year: 2002
    ..The effect of altering the protein sorting and/or retention properties of tyrosinase and gp100 on recognition by specific T cell clones will be determined. ..
  3. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2007
    ..PmeU 7 forms amyloid-like fibers within pigment cells. By defining the mechanism, we may uncover potential cures for albinism, hyperpigmented lesions, and/or neurodegenerative amyloid diseases like Alzheimer's. ..
  4. Melanosome Biogenesis
    Michael S Marks; Fiscal Year: 2010
    ..PmeU 7 forms amyloid-like fibers within pigment cells. By defining the mechanism, we may uncover potential cures for albinism, hyperpigmented lesions, and/or neurodegenerative amyloid diseases like Alzheimer's. ..
  5. Hermansky Pudlak Syndrome & melanosome formation
    Michael Marks; Fiscal Year: 2007
    ..3. To test the hypothesis that HPS-associated gene products function in protein sorting at the stage I melanosome. ..
  6. Nmb and melanosome function in eye pigment cells
    Michael Marks; Fiscal Year: 2005
    ..3. Determine the range of Nmb localization and splice variation in eye tissue of disease-free donors and pigmentary glaucoma patients. ..
  7. Hermansky Pudlak Syndrome & melanosome formation
    GRACA GRACA RAPOSO; Fiscal Year: 2010
    ....
  8. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2005
    ..3. Determine the molecular form of Pmel17 found within striation- containing premelanosomes. 4. Determine whether additional premelanosomal components contribute to striation formation. ..
  9. Melanosome Biogenesis
    Michael Marks; Fiscal Year: 2009
    ..PmeU 7 forms amyloid-like fibers within pigment cells. By defining the mechanism, we may uncover potential cures for albinism, hyperpigmented lesions, and/or neurodegenerative amyloid diseases like Alzheimer's. ..
  10. Iron and copper transporter trafficking in healthy and diseased melanocytes
    Michael Marks; Fiscal Year: 2007
    ..This proposal tests the hypothesis that Hermansky Pudlak Syndrome results from iron and copper dysregulation in the affected cell types. ..