Michael Marks

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay
    Outi Salminen
    Institute for Behavioral Genetics, University of Colorado, Boulder, 80309, USA
    Neuropharmacology 48:696-705. 2005
  2. ncbi request reprint Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
    Michael J Marks
    Institute for Behavioral Genetics, UCB447, University of Colorado, 1480 30th Street, Boulder, CO 80309, USA
    Neuropharmacology 46:1141-57. 2004
  3. ncbi request reprint Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
    Mol Pharmacol 70:947-59. 2006
  4. pmc Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
    Neuropharmacology 53:390-405. 2007
  5. pmc Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, 1480 30th St, Boulder, CO 80303, USA
    J Pharmacol Exp Ther 337:187-200. 2011
  6. ncbi request reprint Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    J Neurochem 81:1102-15. 2002
  7. pmc Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80301, USA
    J Neurosci 29:2272-82. 2009
  8. doi request reprint Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    J Mol Neurosci 40:91-5. 2010
  9. ncbi request reprint Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
    Sarah E McCallum
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 184:314-27. 2006
  10. ncbi request reprint Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Nicotine Tob Res 6:145-58. 2004

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay
    Outi Salminen
    Institute for Behavioral Genetics, University of Colorado, Boulder, 80309, USA
    Neuropharmacology 48:696-705. 2005
    ....
  2. ncbi request reprint Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
    Michael J Marks
    Institute for Behavioral Genetics, UCB447, University of Colorado, 1480 30th Street, Boulder, CO 80309, USA
    Neuropharmacology 46:1141-57. 2004
    ..Likely alpha3beta4-nAChR binding sites were unaffected even at the highest dose (4.0 mg/kg/h, approximately 210 ng/ml). A third set of diverse nAChR binding sites increased in some brain regions, but only after high-dose treatment...
  3. ncbi request reprint Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
    Mol Pharmacol 70:947-59. 2006
    ....
  4. pmc Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, Boulder, CO 80309, USA
    Neuropharmacology 53:390-405. 2007
    ..These effects are very similar to those following deletion of beta2. Thus, alpha4beta2*-nAChRs mediate a significant fraction of both phases of ACh stimulated 86Rb+ efflux...
  5. pmc Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain
    Michael J Marks
    Institute for Behavioral Genetics, 447 UCB, University of Colorado, 1480 30th St, Boulder, CO 80303, USA
    J Pharmacol Exp Ther 337:187-200. 2011
    ..The patterns of change measured using immunoprecipitation were comparable with those determined autoradiographically. Thus, increases in α4β2*-nAChR binding sites after chronic nicotine treatment reflect increased nAChR protein...
  6. ncbi request reprint Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    J Neurochem 81:1102-15. 2002
    ..Thus, beta2 null mutant mice express residual nicotinic activity with properties resembling those of alpha3beta4*-nAChR...
  7. pmc Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80301, USA
    J Neurosci 29:2272-82. 2009
    ....
  8. doi request reprint Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    J Mol Neurosci 40:91-5. 2010
    ..These results indicate that alpha-CtxMII-resistant DA release is mediated by alpha4alpha5beta2, (alpha4)(2)(beta2)(3) (HS), and (alpha4)(3)(beta2)(2) (LS) nAChRs...
  9. ncbi request reprint Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
    Sarah E McCallum
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 184:314-27. 2006
    ..However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed...
  10. ncbi request reprint Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Nicotine Tob Res 6:145-58. 2004
    ..0 mg/kg) blocked all responses following 1.0 mg/kg nicotine. This finding suggests receptors that include the beta2 nAChR subunit partially mediate nicotine's effects on locomotor activity and body temperature...
  11. pmc 86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization
    Michael J Marks
    Institute for Behavioral Genetics, 447UCB, University of Colorado, Boulder, CO 80309, USA
    Biochem Pharmacol 80:1238-51. 2010
    ..Although chronic nicotine treatment reduced maximal (86)Rb(+) efflux from thalamus, IC(50) values in both brain regions were unaffected by chronic nicotine treatment...
  12. ncbi request reprint Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice
    Outi Salminen
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Mol Pharmacol 65:1526-35. 2004
    ....
  13. ncbi request reprint Involvement of the alpha3 subunit in central nicotinic binding populations
    Paul Whiteaker
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 22:2522-9. 2002
    ..However, widespread but lower levels of alpha3-independent -resistant [125I]epibatidine binding were also seen. Again, this may indicate the existence of an additional, minor population of non-alpha3 -resistant sites...
  14. pmc The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Biochem Pharmacol 74:1235-46. 2007
    ....
  15. pmc Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, United States
    Biochem Pharmacol 78:795-802. 2009
    ..As one form of alpha6beta2* nAChR is sensitive to sub-muM concentrations, we propose that this receptor in particular may contribute to the enhanced cognitive performance following low doses of ABT-089...
  16. pmc John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    J Mol Neurosci 40:96-104. 2010
    ..Although these minor subtypes account for only 14% of total binding in whole brain, they are expressed at relatively high concentrations in specific brain areas indicating unique functional roles...
  17. ncbi request reprint Immunolabeling demonstrates the interdependence of mouse brain alpha4 and beta2 nicotinic acetylcholine receptor subunit expression
    Paul Whiteaker
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80303, USA
    J Comp Neurol 499:1016-38. 2006
    ..Consequently, it seems that the two subunits' effects on each other's expression are mediated at the protein, rather than gene expression level...
  18. ncbi request reprint Bovine serum albumin enhances nicotinic acetylcholine receptor function in mouse thalamic synaptosomes
    Christopher M Butt
    Institute for Behavioral Genetics, University of Colorado, Boulder Campus Box 447, Boulder, CO 80309, USA
    J Neurochem 83:48-56. 2002
    ..These results suggest that the removal of endogenous, inhibitory compounds is largely responsible for the rapid, potentiating action of BSA at nicotinic acetylcholine receptors expressed in the mouse thalamus...
  19. pmc Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Neuropharmacology 58:1054-66. 2010
    ..This approach has identified several compounds with agonist or partial agonist activity that display improved selectivity for alpha 6 beta 2*-nAChR...
  20. ncbi request reprint Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice
    Outi Salminen
    Institute for Behavioral Genetics, University of Colorado, 447UCB, Boulder, CO 80309, USA
    Mol Pharmacol 71:1563-71. 2007
    ..In conclusion, the gene deletion strategy enabled isolation of alpha6* subtypes, and these nAChR subtypes exhibited differential activation by nicotine and cytisine...
  21. ncbi request reprint Variability in response to nicotine in the LSxSS RI strains: potential role of polymorphisms in alpha4 and alpha6 nicotinic receptor genes
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Pharmacogenetics 12:197-208. 2002
    ..These results suggest that genetically determined differences in sensitivity to nicotine may be explained, in part, by variability associated with at least two of the neuronal nicotinic receptor genes, alpha4 and alpha6...
  22. ncbi request reprint Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    J Pharmacol Exp Ther 301:651-60. 2002
    ..The pharmacological properties of synaptosomal [(3)H]dopamine release appear similar across the four brain regions. The results suggest that all four regions express the same nAChRs, although subtle regional differences may exist...
  23. ncbi request reprint A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function
    Peter Dobelis
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    Mol Pharmacol 62:334-42. 2002
    ....
  24. ncbi request reprint Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation
    Yaroslav Teper
    Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia
    J Neurosci 27:10128-42. 2007
    ..Our model complements what is seen in other ADNFLE animal models. Together, these mice cover the spectrum of behavioral and electrographic events seen in the human condition...
  25. ncbi request reprint Functional diversity among 5-substituted nicotine analogs; in vitro and in vivo investigations
    Małgorzata Dukat
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Box 980540 VCU, Richmond, VA 23298 0540, USA
    Eur J Pharmacol 435:171-80. 2002
    ..These actions demonstrate that substitution at the 5-position of nicotine exerts a profound influence on the pharmacological profile as well as agonist/antagonist properties of nicotine...
  26. doi request reprint Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist
    Paul Whiteaker
    Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, USA
    J Pharmacol Exp Ther 325:910-9. 2008
    ..Furthermore, true equilibrium binding experiments could be performed on alpha7 nAChRs, something that is impossible with 125I-alpha-bungarotoxin...
  27. doi request reprint Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb+ efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits
    Cecilia Gotti
    Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, Institute of Neuroscience, Cellular and Molecular Pharmacology, Consiglio Nazionale delle Ricerche, University of Milan, Milan, Italy
    Mol Pharmacol 73:1796-807. 2008
    ..These results strongly suggest that alpha4beta2-nAChR with different stoichiometry are expressed in native tissue...
  28. pmc In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors
    Ryan M Drenan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 60:123-36. 2008
    ..alpha6*-specific agonists or antagonists may, by targeting endogenous cholinergic mechanisms in midbrain or striatum, provide a method for manipulating DA transmission in neural disorders...
  29. ncbi request reprint Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice
    Andrew R Tapper
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Physiol Genomics 31:422-8. 2007
    ....
  30. ncbi request reprint Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path
    Raad Nashmi
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 27:8202-18. 2007
    ....
  31. ncbi request reprint Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
    Mol Pharmacol 63:1169-79. 2003
    ..These data suggest that the declines in nAChR sites observed in Parkinson's disease brains may be of functional significance...
  32. ncbi request reprint Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior
    Sarah L King
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 23:3837-43. 2003
    ....
  33. ncbi request reprint L-DOPA treatment modulates nicotinic receptors in monkey striatum
    Maryka Quik
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
    Mol Pharmacol 64:619-28. 2003
    ..These declines in nAChRs with l-DOPA may be relevant to both the therapeutic and side effect profiles of l-DOPA therapy in Parkinson's disease...
  34. ncbi request reprint The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors
    Changhai Cui
    Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Neurosci 23:11045-53. 2003
    ....
  35. ncbi request reprint Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors
    J Michael McIntosh
    Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA
    Mol Pharmacol 65:944-52. 2004
    ..3 nM). Thus, structure-function analysis of alpha-conotoxin MII enabled the creation of novel selective antagonists for discriminating among nAChRs containing alpha3 and alpha6 subunits...
  36. ncbi request reprint Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion
    Cecilia Gotti
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 67:2007-15. 2005
    ..However, beta3 subunit expression is not essential for the expression of alpha6*, high-affinity alpha-CtxMII binding nAChRs...
  37. ncbi request reprint Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(alpha5 o
    Cecilia Gotti
    CNR, Institute of Neuroscience, Section of Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Italy
    Mol Pharmacol 68:1162-71. 2005
    ....
  38. ncbi request reprint Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors
    Carlos Fonck
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 25:11396-411. 2005
    ..Our findings show that hypersensitive alpha4* nicotinic receptors in mice mediate changes in the sleep-wake cycle and nicotine-induced seizures resembling ADNFLE...
  39. ncbi request reprint Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, R47W Bldg AP9A 3, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Mol Pharmacol 70:227-40. 2006
    ....
  40. ncbi request reprint Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization
    Andrew R Tapper
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 306:1029-32. 2004
    ..These data indicate that activation of a4* receptors is sufficient for nicotine-induced reward, tolerance, and sensitization...
  41. ncbi request reprint Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors
    Carlos Fonck
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 23:2582-90. 2003
    ..These data support the possible involvement of gain-of-function alpha4 receptors in autosomal dominant nocturnal frontal-lobe epilepsy...
  42. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...

Research Grants10

  1. GENETICS OF NICOTINE TOLERANCE: ROLE OF RECEPTORS
    Michael Marks; Fiscal Year: 2009
    ..We will study the responses that chronic nicotine treatment elicits in mice that express fewer or different receptors to determine how these molecular differences affect aspects of nicotine dependence. ..
  2. ALPHA CONOTOXIN MII--SELECTIVE NICOTINIC RECEPTOR PROBE
    Michael Marks; Fiscal Year: 2006
    ..The proposed studies will provide further insights into the nature of three novel, native nAChRs sensitive to inhibition by aCtxMII and may lead to better understanding of the basis of the effects of nicotine ..
  3. ALPHA-CONOTOXIN MII--SELECTIVE NICOTINIC RECEPTOR PROBE
    Michael Marks; Fiscal Year: 2001
    ..Hopefully, this knowledge will lead to a better understanding of the basis (of) nicotine's centrally mediated effects, and may lead to the development of improved nicotinic drugs and/or treatments for nicotine dependence. ..
  4. GENETICS OF NICOTINE TOLERANCE: ROLE OF RECEPTORS
    Michael J Marks; Fiscal Year: 2010
    ..We will study the responses that chronic nicotine treatment elicits in mice that express fewer or different receptors to determine how these molecular differences affect aspects of nicotine dependence. ..