ATHINA contact MARKOU

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments
    Manoranjan S D'Souza
    Department of Psychiatry School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Addict Sci Clin Pract 6:4-16. 2011
  2. pmc Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C0603, La Jolla, CA 92093 0603, USA Electronic address
    Neurosci Biobehav Rev 37:2149-65. 2013
  3. pmc Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 14:1346-55. 2012
  4. pmc Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats
    Styliani Vlachou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 215:117-28. 2011
  5. pmc Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice
    Candice Contet
    Department of Psychiatry, Mail Code 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 212:283-99. 2010
  6. ncbi request reprint The role of metabotropic glutamate receptors in drug reward, motivation and dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California 92093 0603, USA
    Drug News Perspect 20:103-8. 2007
  7. pmc Review. Neurobiology of nicotine dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Philos Trans R Soc Lond B Biol Sci 363:3159-68. 2008
  8. pmc Removing obstacles in neuroscience drug discovery: the future path for animal models
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 34:74-89. 2009
  9. ncbi request reprint Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats
    Sietse Jonkman
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 400:140-5. 2006
  10. ncbi request reprint Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats
    Adrie W Bruijnzeel
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1058:91-100. 2005

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Detail Information

Publications72

  1. pmc Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments
    Manoranjan S D'Souza
    Department of Psychiatry School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Addict Sci Clin Pract 6:4-16. 2011
    ..Finally, the article discusses progress in the discovery and development of smoking-cessation medications...
  2. pmc Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C0603, La Jolla, CA 92093 0603, USA Electronic address
    Neurosci Biobehav Rev 37:2149-65. 2013
    ....
  3. pmc Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 14:1346-55. 2012
    ..The role of β4-containing nicotinic acetylcholine receptors (nAChRs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear...
  4. pmc Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats
    Styliani Vlachou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 215:117-28. 2011
    ..Because of their fewer adverse side effects compared with GABA(B) receptor agonists, GABA(B) receptor positive modulators are potentially improved therapeutic compounds for the treatment of drug dependence compared with agonists...
  5. pmc Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice
    Candice Contet
    Department of Psychiatry, Mail Code 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 212:283-99. 2010
    ..Testing genetically engineered mice in a reliable nicotine self-administration procedure could provide important insights into the molecular mechanisms underlying nicotine reinforcement...
  6. ncbi request reprint The role of metabotropic glutamate receptors in drug reward, motivation and dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California 92093 0603, USA
    Drug News Perspect 20:103-8. 2007
    ....
  7. pmc Review. Neurobiology of nicotine dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Philos Trans R Soc Lond B Biol Sci 363:3159-68. 2008
    ..In conclusion, glutamate, GABA and cholinergic transmission in limbic and frontal brain sites are critically involved in nicotine dependence...
  8. pmc Removing obstacles in neuroscience drug discovery: the future path for animal models
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 34:74-89. 2009
    ....
  9. ncbi request reprint Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats
    Sietse Jonkman
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 400:140-5. 2006
    ..These results suggest that nACh and D1-like signalling in the CeA and the dlBNST does not develop neuroadaptations with the development of nicotine dependence that may be involved in the depression-like aspects of nicotine withdrawal...
  10. ncbi request reprint Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats
    Adrie W Bruijnzeel
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1058:91-100. 2005
    ....
  11. ncbi request reprint Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 306:1068-76. 2003
    ..Furthermore, it is likely that mGluII receptors generate this reward deficit, at least in part, by decreasing glutamate transmission at AMPA/kainate receptors...
  12. doi request reprint Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 10:995-1008. 2008
    ..Rather, preclinical investigations suggest that bupropion attenuates nicotine-induced enhancement of brain reward function and reverses the anhedonic, somatic, and neurochemical correlates of nicotine withdrawal...
  13. pmc Spontaneous nicotine withdrawal potentiates the effects of stress in rats
    Sietse Jonkman
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 33:2131-8. 2008
    ..These findings support the hypothesis that nicotine withdrawal exacerbates stress responding, and indicate LES may be a useful model to examine withdrawal effects on anxiety...
  14. ncbi request reprint Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Neuropharmacology, The Scripps Research Institute CVN 7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 47:572-9. 2004
    ..The adaptations in cholinergic transmission in the VTA are likely to mediate, at least partly, the affective signs of nicotine withdrawal in humans...
  15. ncbi request reprint Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:1203-11. 2006
    ....
  16. ncbi request reprint Nicotine withdrawal in adolescent and adult rats
    Laura E O'Dell
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1021:167-74. 2004
    ....
  17. ncbi request reprint Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats
    Neil E Paterson
    Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 173:64-72. 2004
    ..Most nicotine self-administration (NSA) studies in rats are performed under limited-access conditions. Few studies have examined the relationship between nicotine dependence and NSA...
  18. pmc Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ....
  19. ncbi request reprint Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine
    Svetlana Semenova
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:1249-64. 2003
    ..g., anhedonia), we hypothesized that treatment with clozapine may be effective against nicotine and amphetamine withdrawal...
  20. ncbi request reprint Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat
    John F Cryan
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:347-58. 2003
    ..Bupropion is an atypical antidepressant and the only non-nicotine-based therapy approved for smoking cessation. Its use has raised much debate as to how a non-nicotine-based agent can aid in smoking cessation...
  21. ncbi request reprint Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents
    John F Cryan
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:49-58. 2003
    ....
  22. ncbi request reprint Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats
    Karen L Skjei
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:280-92. 2003
    ..The aversive aspects of nicotine withdrawal contribute to high relapse rates to tobacco smoking after cessation attempts...
  23. pmc The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
    ....
  24. pmc Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Eur J Pharmacol 554:164-74. 2007
    ....
  25. pmc Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats
    Andre Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Behav Pharmacol 21:359-68. 2010
    ..Social interaction was not affected during withdrawal from either drug. These results indicate that withdrawal from chronic amphetamine exposure leads to an immediate and enduring anhedonic state...
  26. ncbi request reprint Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats
    Amanda A Harrison
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 160:56-66. 2002
    ..Nicotine-induced increases of dopamine in the nucleus accumbens are in part mediated by glutamatergic projections to the ventral tegmental area dopamine neurons...
  27. ncbi request reprint Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function
    Neil E Paterson
    Department of Molecular and Integrative Neuroscience, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:953-62. 2005
    ....
  28. ncbi request reprint Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell
    Neil E Paterson
    Department of Psychiatry, Basic Science Building, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Eur J Neurosci 25:3099-108. 2007
    ..In conclusion, the bupropion-induced increase in extracellular dopamine in the nucleus accumbens shell may ameliorate the anhedonia associated with nicotine withdrawal, which in turn may facilitate smoking cessation...
  29. ncbi request reprint Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Biochem Pharmacol 74:1299-307. 2007
    ..Thus, this mGlu2/3 agonist does not appear to significantly influence the affective depression-like aspects of nicotine withdrawal...
  30. ncbi request reprint Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:9077-85. 2007
    ..Together, these findings indicate an important role for mGlu2/3 receptors in the posterior VTA and the NAc shell in the mediation of the rewarding effects of nicotine and potentially in cue-induced nicotine-seeking behavior...
  31. pmc The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
    ..These aversive aspects of nicotine withdrawal and the rewarding effects of nicotine play major roles in maintaining nicotine dependence...
  32. ncbi request reprint Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
    Scott A Chen
    Department of Molecular and Integrative Neurosciences, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:180-93. 2007
    ..The results demonstrate that rats will self-administer nicotine to the point of producing dependence, as measured by somatic signs, resistance to extinction, and measures of food intake...
  33. ncbi request reprint Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
    ..Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear...
  34. ncbi request reprint Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 178:133-42. 2005
    ..2001)...
  35. ncbi request reprint Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats
    Adrie W Bruijnzeel
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Synapse 50:20-8. 2003
    ....
  36. pmc Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603 La Jolla, California 92093, USA
    Pharmacol Biochem Behav 87:360-8. 2007
    ..These results provide evidence that chronic, but not acute, nicotine administration induced accuracy improvement under baseline conditions, while nicotine withdrawal produced some limited performance deficits...
  37. ncbi request reprint Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration
    Svetlana Semenova
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Eur J Pharmacol 472:99-110. 2003
    ..Thus, nicotine withdrawal results in modest, but yet detectable, changes in the behavior of mice...
  38. pmc Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008
    ..The current study is one of the first to demonstrate reward deficits associated with both spontaneous and nAChR antagonist-precipitated nicotine withdrawal in C57BL/6J mice...
  39. pmc Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    J Pharmacol Exp Ther 326:306-14. 2008
    ..Thus, GABA(B) receptor-positive modulators may be useful antismoking medications...
  40. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  41. ncbi request reprint Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 30:119-28. 2005
    ..125 and 0.25 mg/kg) dose-dependently decreased cue-induced reinstatement of nicotine-seeking behavior...
  42. ncbi request reprint Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
    Paul J Kenny
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:5894-900. 2006
    ..Thus, conditioned stimuli predicting the onset of heroin withdrawal, and hence the reward deficits coupled with this state, may play a critical role in provoking craving and relapse in human opiate addicts...
  43. ncbi request reprint Increased GABA neurotransmission via administration of gamma-vinyl GABA decreased nicotine self-administration in the rat
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Synapse 44:252-3. 2002
  44. ncbi request reprint Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
    ..In conclusion, the present data show that nicotine withdrawal is mildly anxiogenic in C57BL/6J mice under the conditions used in the present experiments...
  45. ncbi request reprint Withdrawal from chronic phencyclidine treatment induces long-lasting depression in brain reward function
    Cecile Spielewoy
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 28:1106-16. 2003
    ....
  46. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  47. ncbi request reprint Both the shell of the nucleus accumbens and the central nucleus of the amygdala support amphetamine self-administration in rats
    Jessica Chevrette
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 71:501-7. 2002
    ..Further, the present study provides additional evidence about the functional homogeneity of the forebrain continuum called the "extended amygdala."..
  48. doi request reprint Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
    ....
  49. pmc Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 202:275-86. 2009
    ..Schizophrenia patients exhibit higher smoking rates compared with the general population, suggesting that attempts to self-medicate cognitive schizophrenia deficits may underlie these high smoking levels...
  50. ncbi request reprint Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 193:521-37. 2007
    ..The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits...
  51. ncbi request reprint A 'crash' course on psychostimulant withdrawal as a model of depression
    Alasdair M Barr
    Associate Professor, Dept of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 23:475-82. 2002
    ..Current advances and limitations in the development of this model, together with recent evidence that psychostimulant withdrawal in rodents can be used to screen for novel, rapidly acting antidepressant treatments, are discussed...
  52. ncbi request reprint Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 17:191-5. 2003
    ....
  53. ncbi request reprint The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003
    ..Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbens and may play a role in modulating the post-synaptic response to both glutamate and dopamine...
  54. ncbi request reprint Conditioned facilitation of brain reward function after repeated cocaine administration
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Neurosci 117:1103-7. 2003
    ..These data demonstrate that cocaine-predictive conditioned stimuli induce a conditioned facilitation of brain reward function...
  55. ncbi request reprint The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat
    Neil E Paterson
    Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 172:179-86. 2004
    ..Specifically, GABA(B) receptor agonists decreased cocaine, heroin and nicotine self-administration in rats...
  56. ncbi request reprint Strain-specificity in nicotine attenuation of phencyclidine-induced disruption of prepulse inhibition in mice: relevance to smoking in schizophrenia patients
    Cecile Spielewoy
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Behav Genet 34:343-54. 2004
    ....
  57. ncbi request reprint Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1025:491-503. 2004
    ..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans...
  58. ncbi request reprint Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  59. ncbi request reprint Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
    Alasdair M Barr
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 51:457-65. 2006
    ..The absence of effect in isolation-reared rats may be due to the relatively small effect size of isolation rearing on PPI or dose of iloperidone...
  60. ncbi request reprint Animal models and treatments for addiction and depression co-morbidity
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0603, La Jolla, CA 92093, USA
    Neurotox Res 11:1-32. 2007
    ....
  61. ncbi request reprint Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?
    Athina Markou
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:17-22. 2007
    ..Metabotropic glutamate 2/3 receptor antagonists may also be therapeutics for non-drug-induced depressions...
  62. ncbi request reprint The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:255-61. 2005
    ..The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse...
  63. ncbi request reprint Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 952:188-99. 2002
    ....
  64. pmc The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
    ..Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT...
  65. pmc Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Pharmacol Biochem Behav 93:248-57. 2009
    ....
  66. pmc Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Eur J Pharmacol 639:67-80. 2010
    ..Our findings also suggest that additional mechanisms, besides cortical glutamatergic transmission, may be involved in certain cognitive dysfunctions in schizophrenia...
  67. pmc Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Biol Psychiatry 68:5-16. 2010
    ..Thus, disruption of 5-CSRTT performance by NMDA antagonists represents a valuable tool for exploring the neurobiological bases of cognitive dysfunction in schizophrenia...
  68. ncbi request reprint Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion
    John F Cryan
    Neuroscience Disease Area, The Novartis Institutes for BioMedical Research, WSJ 386 344Novartis Pharma AG CH 4002, Basel, Switzerland
    Drug Discov Today 8:1025-34. 2003
    ....
  69. ncbi request reprint Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs
    Nina Lindblom
    Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Karolinska Institutet, Nanna Svartz vag 2, 171 77, Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 372:182-94. 2005
    ..Furthermore, since the withdrawal syndrome in rats was attenuated by immunisation, the nicotine withdrawal in smokers should not be worsened but may even be ameliorated during a quit attempt...
  70. ncbi request reprint Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037
    J Neurosci 25:6208-12. 2005
    ....
  71. ncbi request reprint Psychostimulant withdrawal as an inducing condition in animal models of depression
    Alasdair M Barr
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
    Neurosci Biobehav Rev 29:675-706. 2005
    ..Recent progress and limitations in the development of this model, as well as future directions for research, are evaluated and discussed...
  72. ncbi request reprint Assessing antidepressant activity in rodents: recent developments and future needs
    John F Cryan
    Neuromodulation Unit, Nervous System Research, Novartis Pharma AG, WSJ 386 344, CH 4002 Basel, Switzerland
    Trends Pharmacol Sci 23:238-45. 2002
    ....

Research Grants25

  1. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2004
    ....
  2. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2010
    ....
  3. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2010
    ....
  4. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2009
    ....
  5. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2009
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  6. Group II mGluR antagonists and negative modulators in depression
    ATHINA contact MARKOU; Fiscal Year: 2010
    ..This project is very innovative and promises to have a highly significant overall impact by promoting the discovery of new treatments for this devastating disorder. ..
  7. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2006
    ..Such studies will lead to better treatments for schizophrenia. ..
  8. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2006
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  9. GABA B compounds for depression and smoking cessation
    Athina Markou; Fiscal Year: 2007
    ..abstract_text> ..
  10. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2007
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  11. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2009
    ....
  12. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2007
    ....
  13. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2007
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  14. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2006
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  15. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2006
    ..Such studies will lead to better treatments for schizophrenia. ..
  16. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2005
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  17. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2002
    ..Such studies will lead to better treatments for schizophrenia. ..
  18. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2002
    ....
  19. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2003
    ....
  20. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2003
    ..Such studies will lead to better treatments for schizophrenia. ..
  21. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2004
    ..Such studies will lead to better treatments for schizophrenia. ..
  22. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2005
    ..Such studies will lead to better treatments for schizophrenia. ..
  23. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2001
    ....