PENELOPE N MARKHAM

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr
    P N Markham
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60607, USA
    Biochem Biophys Res Commun 239:269-72. 1997
  2. pmc Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine
    P N Markham
    Influx, Inc, Chicago, Illinois 60612, USA
    Antimicrob Agents Chemother 43:988-9. 1999
  3. pmc Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus
    P N Markham
    Influx, Inc, Chicago, Illinois 60612, USA
    Antimicrob Agents Chemother 43:2404-8. 1999

Research Grants

  1. Bactericidal agents for slow-growing bacteria
    PENELOPE MARKHAM; Fiscal Year: 2003
  2. POTENTIATORS OF FLUCONAZOLE ACTIVITY IN CANDIDA
    PENELOPE MARKHAM; Fiscal Year: 2002

Detail Information

Publications3

  1. ncbi request reprint Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr
    P N Markham
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60607, USA
    Biochem Biophys Res Commun 239:269-72. 1997
    ..These results confirm that this soluble protein, like the membrane transporter it regulates, has a uniquely broad substrate specificity...
  2. pmc Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine
    P N Markham
    Influx, Inc, Chicago, Illinois 60612, USA
    Antimicrob Agents Chemother 43:988-9. 1999
    ..pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics...
  3. pmc Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus
    P N Markham
    Influx, Inc, Chicago, Illinois 60612, USA
    Antimicrob Agents Chemother 43:2404-8. 1999
    ..aureus upon in vitro selection with this drug. Some of these new inhibitors, or their derivatives, may prove useful for augmentation of the antibacterial activities of fluoroquinolones in the clinical setting...

Research Grants2

  1. Bactericidal agents for slow-growing bacteria
    PENELOPE MARKHAM; Fiscal Year: 2003
    ..PTE compounds could provide a unique opportunity for eradication of infections associated with slow bacterial growth. ..
  2. POTENTIATORS OF FLUCONAZOLE ACTIVITY IN CANDIDA
    PENELOPE MARKHAM; Fiscal Year: 2002
    ..Such a product would have a major impact on the therapeutic and prophylactic treatment options for systemic Candida infections ..