ALLYN MARK

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint State-of-the-art-lecture: Obesity-induced hypertension: new concepts from the emerging biology of obesity
    A L Mark
    Specialized Center of Research in Hypertension and Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 33:537-41. 1999
  2. doi request reprint Dietary therapy for obesity: an emperor with no clothes
    Allyn L Mark
    Carver College of Medicine, Center on Functional Genomics of Hypertension, and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1101, USA
    Hypertension 51:1426-34; discussion 1434. 2008
  3. ncbi request reprint Weight reduction for treatment of obesity-associated hypertension: nuances and challenges
    Allyn L Mark
    Cardiovascular Division, Department of Internal Medicine, Center on Functional Genomics of Hypertension, Carver College of Medicine, 3111 MERF, University of Iowa, Iowa City, IA 52242 1101 USA
    Curr Hypertens Rep 9:368-72. 2007
  4. ncbi request reprint Dietary therapy for obesity is a failure and pharmacotherapy is the future: a point of view
    Allyn L Mark
    Center on Physiologic Genomics of Hypertension, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Clin Exp Pharmacol Physiol 33:857-62. 2006
  5. ncbi request reprint Loss of leptin actions in obesity: two concepts with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Clin Exp Hypertens 26:629-36. 2004
  6. pmc Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney
    Allyn L Mark
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1101, USA
    Hypertension 53:375-80. 2009
  7. ncbi request reprint Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, The Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Medical Center, Iowa City, Iowa, USA
    J Hypertens 20:1245-50. 2002
  8. ncbi request reprint Clinician scientist training program: a proposal for training medical students in clinical research
    A L Mark
    University of Iowa College of Medicine, Iowa City 52242 1101, USA
    J Investig Med 49:486-90. 2001
  9. ncbi request reprint Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
    A L Mark
    Specialized Center of Research in Hypertension Genetics and the Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City, USA
    J Hypertens 17:1949-53. 1999
  10. ncbi request reprint The concept of selective leptin resistance: evidence from agouti yellow obese mice
    Marcelo L G Correia
    Hypertension Genetics Specialized Center of Research and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1101, USA
    Diabetes 51:439-42. 2002

Research Grants

Detail Information

Publications23

  1. ncbi request reprint State-of-the-art-lecture: Obesity-induced hypertension: new concepts from the emerging biology of obesity
    A L Mark
    Specialized Center of Research in Hypertension and Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 33:537-41. 1999
    ..Second, obesity is not consistently associated with increased blood pressure, at least in rodent models. Third, the blood pressure response to obesity may be critically influenced by modifying alleles in the genetic background...
  2. doi request reprint Dietary therapy for obesity: an emperor with no clothes
    Allyn L Mark
    Carver College of Medicine, Center on Functional Genomics of Hypertension, and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1101, USA
    Hypertension 51:1426-34; discussion 1434. 2008
  3. ncbi request reprint Weight reduction for treatment of obesity-associated hypertension: nuances and challenges
    Allyn L Mark
    Cardiovascular Division, Department of Internal Medicine, Center on Functional Genomics of Hypertension, Carver College of Medicine, 3111 MERF, University of Iowa, Iowa City, IA 52242 1101 USA
    Curr Hypertens Rep 9:368-72. 2007
    ..This article reviews these issues and highlights the nuances and challenges in the effectiveness of weight loss for treatment of obesity-induced hypertension...
  4. ncbi request reprint Dietary therapy for obesity is a failure and pharmacotherapy is the future: a point of view
    Allyn L Mark
    Center on Physiologic Genomics of Hypertension, Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Clin Exp Pharmacol Physiol 33:857-62. 2006
    ....
  5. ncbi request reprint Loss of leptin actions in obesity: two concepts with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Clin Exp Hypertens 26:629-36. 2004
    ....
  6. pmc Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney
    Allyn L Mark
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1101, USA
    Hypertension 53:375-80. 2009
    ..The study strengthens the concept of a distributed brain network of leptin action and demonstrates that these distributed brain sites can mediate contrasting sympathetic responses to leptin...
  7. ncbi request reprint Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    Allyn L Mark
    Hypertension Genetics Specialized Center of Research, The Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Medical Center, Iowa City, Iowa, USA
    J Hypertens 20:1245-50. 2002
    ..If selective leptin resistance occurs in obese humans, then leptin could contribute to the sympathetic overactivity and hypertension despite resistance to its metabolic actions...
  8. ncbi request reprint Clinician scientist training program: a proposal for training medical students in clinical research
    A L Mark
    University of Iowa College of Medicine, Iowa City 52242 1101, USA
    J Investig Med 49:486-90. 2001
    ..If the success of the Medical Scientist Training Program in training medical students in basic research is a guide, the CSTP could become a linchpin for training future generations of clinician scientists...
  9. ncbi request reprint Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
    A L Mark
    Specialized Center of Research in Hypertension Genetics and the Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City, USA
    J Hypertens 17:1949-53. 1999
    ..In contrast, agouti yellow obese(Ay) mice have overexpression of an agouti peptide that blocks melanocortin receptors. Stimulation of melanocortin receptors by alpha-melanocyte-stimulating hormone decreases arterial pressure...
  10. ncbi request reprint The concept of selective leptin resistance: evidence from agouti yellow obese mice
    Marcelo L G Correia
    Hypertension Genetics Specialized Center of Research and Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1101, USA
    Diabetes 51:439-42. 2002
    ..If leptin resistance is selective in obese humans, then leptin could contribute to sympathetic overactivity and its adverse consequences in human obesity...
  11. ncbi request reprint Role of selective leptin resistance in diet-induced obesity hypertension
    Kamal Rahmouni
    Cardiovascular Research Center, 524 MRC, University of Iowa, Iowa City, IA 52242, USA
    Diabetes 54:2012-8. 2005
    ..However, there is preservation of the renal sympathetic and arterial pressure responses to leptin, which represent a potential mechanism for the adverse cardiovascular consequences of obesity...
  12. ncbi request reprint Hemodynamic consequences of neuropeptide Y-induced obesity
    Marcelo L G Correia
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Am J Hypertens 15:137-42. 2002
    ..Chronic intracerebroventricular (ICV) administration of NPY produces obesity in rats. Obesity has been shown to increase arterial pressure...
  13. ncbi request reprint Obesity-associated hypertension: new insights into mechanisms
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 45:9-14. 2005
    ..These recent discoveries should lead to novel strategies for treatment of obesity and hypertension...
  14. ncbi request reprint Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Department of Internal Medical, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Endocrinol Metab 286:E891-5. 2004
    ..Our findings also suggest that 1.2 kb of regulatory sequences present in the hAGT transgene are sufficient to transcriptionally respond to a high-fat diet in an adipose-specific and depot-specific manner...
  15. ncbi request reprint Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
    ..In addition, the renal sympathoexcitatory responses to leptin and insulin are dependent on the MC-4R, demonstrating an important role for the MC-4R in the regulation of renal sympathetic nerve outflow by leptin and insulin...
  16. ncbi request reprint Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics and the Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Hypertension 41:763-7. 2003
    ..Our data demonstrate that PI3K appears to play an important role in the transduction of leptin-induced changes in renal sympathetic outflow...
  17. ncbi request reprint Selective resistance to central neural administration of leptin in agouti obese mice
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, and Department of Internal Medicine, University of Iowa, and the Veterans Administration Medical Center, Iowa City, Iowa 52242 1101, USA
    Hypertension 39:486-90. 2002
    ..It seems to result instead from alterations in the central neural pathways mediating effects of leptin...
  18. ncbi request reprint Differential modulation of leptin-induced sympathoexcitation by baroreflex activation
    Martin Hausberg
    Department of Internal Medicine D, University of Munster, Munster, Germany
    J Hypertens 20:1633-41. 2002
    ..The aim of the present study was to test the hypothesis that the increases in sympathetic nerve activity induced by leptin in different regions respond differentially to baroreflex activation...
  19. ncbi request reprint Leptin potentiates thermogenic sympathetic responses to hypothermia: a receptor-mediated effect
    Martin Hausberg
    Department of Internal Medicine D, University of Muenster, Muenster, Germany
    Diabetes 51:2434-40. 2002
    ..The effect depends on intact and functional leptin receptors because it occurs neither in rats with a leptin receptor defect nor in rats with acquired leptin resistance...
  20. ncbi request reprint Cardiovascular and sympathetic effects of leptin
    Kamal Rahmouni
    SCOR Hypertension Genetics and Department of Internal Medicine, University of Iowa, 524 MRC, Iowa City, IA 52242, USA
    Curr Hypertens Rep 4:119-25. 2002
    ..A detailed understanding of the multitude and complexity of integrated neuronal circuits and neuropeptide-containing pathways in leptin action will help in understanding the pathogenesis of obesity and related disorders...
  21. pmc Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, Cardiovascular Research Center, and Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    J Clin Invest 114:652-8. 2004
    ..These data demonstrate that PI3K and MAPK are specific and regionally selective mediators of the action of insulin on the sympathetic nervous system...
  22. ncbi request reprint Uncoupling metabolism and coupling leptin to cardiovascular disease
    Allyn L Mark
    Arterioscler Thromb Vasc Biol 22:881-3. 2002
  23. ncbi request reprint Pharmacotherapy of obesity: lessons from clinical trials in hypertension
    William G Haynes
    J Hypertens 20:1731-5. 2002

Research Grants5

  1. Mentored Clinical Research Scholar Program at Iowa
    ALLYN MARK; Fiscal Year: 2007
    ..These and other University research programs extend into the community--statewide and beyond--and include numerous disease registers and a broad network of collaborating institutions. ..