Research Topics
| P E MarikSummaryAffiliation: University of Pittsburgh Country: USA Publications
| Collaborators
|
Detail Information
Publications
Aspiration pneumonia and dysphagia in the elderlyPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 124:328-36. 2003..This may include swallow therapy, dietary modification, aggressive oral care, and consideration for treatment with an angiotensin-converting enzyme inhibitor...
Clinical review: the management of hypertensive crisesJoseph Varon
Pulmonary and Critical Care Section, Baylor College of Medicine, The University of Texas Health Science Center, Houston, USA
Crit Care 7:374-84. 2003..This article reviews current concepts, and common misconceptions and pitfalls in the diagnosis and management of patients with acutely elevated blood pressure...
Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitisPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
BMJ 328:1407. 2004..To compare the safety and clinical outcomes of enteral and parenteral nutrition in patients with acute pancreatitis...
The management of status epilepticusPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Chest 126:582-91. 2004..This article reviews current information regarding the management of status epilepticus in adults...
Stress-hyperglycemia, insulin and immunomodulation in sepsisPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh Medical Center, 640A Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 30:748-56. 2004..This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder...
Low-dose dopamine: a systematic reviewP E Marik
Anesthesiology and Critical Care, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 640A Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Intensive Care Med 28:877-83. 2002..To determine the magnitude of the treatment effect of low-dose dopamine on renal function in patients at risk of and in patients with early renal injury...
Propofol: therapeutic indications and side-effectsPaul E Marik
Department of Critical Car Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Curr Pharm Des 10:3639-49. 2004..This is a rare complication first reported in pediatric patients and believed to be due to decreased transmembrane electrical potential and alteration of electron transport across the inner mitochondrial membrane...
Severe autoimmune hemolytic anemia treated by paralysis, induced hypothermia, and splenic embolizationRonna Campbell
Department of Critical Care, University of Pittsburgh, 640A Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA
Chest 127:678-81. 2005..We present a case of an adult with life-threatening AIHA secondary to ulcerative colitis emergently managed with neuromuscular paralysis, induced hypothermia, and splenic embolization...
Management of head traumaPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 122:699-711. 2002..However, it is likely that many patients with TBI are not treated according to current treatment principles. This article presents an overview of the current management of patients with TBI...
Stress hyperglycemia and adrenal insufficiency in the critically illMurugan Raghavan
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Semin Respir Crit Care Med 27:274-85. 2006....
Early enteral nutrition in acutely ill patients: a systematic reviewP E Marik
Critical Care Medicine, The Mercy Hospital of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 29:2264-70. 2001..The results of this meta-analysis must, however, be interpreted with some caution because of the significant heterogeneity between studies...
Adrenal insufficiency in the critically ill: a new look at an old problemPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Chest 122:1784-96. 2002..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
The diagnosis and management of hypertensive crisesJ Varon
Department of Medicine, Baylor College of Medicine, Houston TX, USA
Chest 118:214-27. 2000..This article reviews some of the current concepts and common misconceptions in the management of patients with acutely elevated BP...
Critical care and the World Wide WebJ Varon
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Crit Care Clin 15:593-604, vii. 1999..This article presents some of the historical developments of the Internet as well as common applications that are useful for critical care practitioners...
The incidence of deep venous thrombosis in ICU patientsP E Marik
Department of Critical Care Medicine, St Vincent Hospital, Worcester, MA 01604, USA
Chest 111:661-4. 1997..To determine the incidence, clinical presentation, and risk factors of deep venous thrombosis (DVT) in a high-risk group of ICU patients receiving DVT prophylaxis...
Sublingual capnography: a clinical validation studyP E Marik
Critical Care Medicine, The Mercy Hospital of Pittsburgh, Pittsburgh, PA 15219 5166, USA
Chest 120:923-7. 2001..To compare sublingual PCO(2) (PslCO(2)) measurements with gastric intramucosal PCO(2) (PimCO(2)) as well as with the traditional indexes of tissue oxygenation in hemodynamically unstable ICU patients...
Gastric versus post-pyloric feeding: a systematic reviewPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 7:R46-51. 2003..Our objective was to evaluate the impact of gastric versus post-pyloric feeding on the incidence of pneumonia, caloric intake, intensive care unit (ICU) length of stay (LOS), and mortality in critically ill and injured ICU patients...
Management of the critically ill geriatric patientPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 34:S176-82. 2006..To review the effect of an aging society on the utilization of critical care services and the physiology of aging as it applies to critical illness and prognosis and management issues in the intensive care unit (ICU)...
The management of acute severe asthmaPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
J Emerg Med 23:257-68. 2002..Mechanical ventilation is usually well tolerated and may be lifesaving in patients with refractory asthma. Precautions are required to prevent dynamic hyperinflation during assisted ventilation...
Therapy of intracranial hypertension in patients with fulminant hepatic failureMurugan Raghavan
Liver Transplant ICU, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Neurocrit Care 4:179-89. 2006..In this article, we review the pathophysiology of IH in patients with FHF and outline various therapeutic strategies currently available in managing these patients in the critical care setting...
Adrenal insufficiency in critically ill patients with human immunodeficiency virusPaul E Marik
Mercy Hospital of Pittsburgh, PA, USA
Crit Care Med 30:1267-73. 2002..Because of the high incidence of inadequate adrenal function, all critically ill HIV-infected patients should undergo an evaluation for adrenal insufficiency with the stress cortisol concentration and LD-ACTH stimulation tests...
The effect of aging on circulating levels of proinflammatory cytokines during septic shock. Norasept II Study InvestigatorsP E Marik
Department of Critical Care Medicine, Mercy Hospital of Pittsburgh, PA 15219-5166, USA
J Am Geriatr Soc 49:5-9. 2001..03). There was no gender difference in survival or cytokine levels. CONCLUSIONS: Contrary to our expectations, we found that aging was not associated with a decline in the circulating levels of proinflammatory cytokines...
The definition of septic shock: implications for treatmentPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Resusc 9:101-3. 2007....
Anemia, allogenic blood transfusion, and immunomodulation in the critically illMurugan Raghavan
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Chest 127:295-307. 2005..In this article, we review the immune-modulatory role of allogenic RBC transfusions in critically ill patients...
Association between time of admission to the ICU and mortality: a systematic review and metaanalysisRodrigo Cavallazzi
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Chest 138:68-75. 2010..A change in the ICU staffing structure frequently occurs at nighttime and on weekends (off-hours). We postulated that patients who are admitted to an ICU during off hours may be at an increased risk of death...
Maximizing efficacy from parenteral nutrition in critical care: appropriate patient populations, supplemental parenteral nutrition, glucose control, parenteral glutamine, and alternative fat sourcesPaul E Marik
Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA, 19107, USA
Curr Gastroenterol Rep 9:345-53. 2007..A lipid emulsion containing fish oil, olive oil, or both should replace soybean-containing emulsions. Supplemental glutamine, 0.2 g/kg/d to 0.5 g/kg/d, has been shown to reduce the risk of infection and to improve glycemic control...
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care MedicinePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:1937-49. 2008..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
Multiple venous thromboses in a young man with sarcoidosis: is there a relation between sarcoidosis and venous thrombosis?Bobbak Vahid
Department of Pulmonary and Critical Care Medicine, e Thomas Jefferson University, Philadelphia, PA, USA
South Med J 99:998-9. 2006..Lymph node tissue culture and special stains were negative for mycobacterial or fungal infection. This is an unusual case of multiple deep venous thromboses and sarcoidosis. The subject of sarcoidosis and venous thrombosis is discussed...
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literaturePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:2667-74. 2008..However, the hematocrit that should be maintained in any particular patient because the risks of further transfusion of RBC outweigh the benefits remains unclear...
Recurrent episodes of dermatomyositis-associated pneumonitis masquerading as hypersensitivity pneumonitisBobbak Vahid
Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Mt Sinai J Med 73:895-7. 2006..Further work-up showed clinical and serologic evidence of dermatomyositis-associated pneumonitis. The patient was treated with oral prednisone and azathioprine. The subject of dermatomyositis-associated pneumonitis is discussed...
Dyslipidemia in the critically illPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 1015 Chestnut Street, Suite M 100, Philadelphia, PA, 19107, USA
Crit Care Clin 22:151-9, viii. 2006..Hypocholesterolemia may predispose the critically ill patient to sepsis and adrenal failure. Early enteral nutrition and tight glycemic control accelerate the recovery of the cholesterol levels...
Adrenal-exhaustion syndrome in patients with liver diseasePaul E Marik
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Intensive Care Med 32:275-80. 2006..The goal of this study was to further characterize this syndrome...
The hepatoadrenal syndrome: a common yet unrecognized clinical conditionPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 33:1254-9. 2005..Treatment of patients with adrenal failure may improve outcome. High baseline serum cortisol levels may be a maker of disease severity and portend a poor prognosis...
Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patientsPaul E Marik
Department of Critical Care Medicine, Mercy Hospital of Pittsburgh, PA, USA
Crit Care Med 31:818-22. 2003..The P(SL)CO2-diff and/or P(SL)CO2 may prove to be a useful marker for goal-directed therapy and for assessing the response to clinical interventions aimed at improving tissue oxygenation...
The optimal endpoint of resuscitation in trauma patientsPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Crit Care 7:19-20. 2003
Adrenal insufficiency during septic shockPaul E Marik
Department of Critical Care Medicine, University of Pittsburgh, PA, USA
Crit Care Med 31:141-5. 2003..However, we believe that a random cortisol concentration of <25 microg/dL in a highly stressed patient is a useful diagnostic threshold for the diagnosis of adrenal insufficiency...
One good turn deserves another!Paul E Marik
Crit Care Med 30:2146-8. 2002
Noninvasive hemodynamic monitoring in the intensive care unitPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
Crit Care Clin 23:383-400. 2007..In addition this article reviews some of the surrogate markers that can be used to assess adequacy of cardiac output...
Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon?Paul E Marik
Pulmonary and Critical Care, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, United States
Resuscitation 74:191-3. 2007..Indeed, recent randomized controlled studies have been unable to demonstrate any benefit from tight glucemic control. We suggest that the widespread adoption of tight glycemic control be abandoned at this time...
Therapeutic sedation: has its time come?Paul E Marik
Crit Care Med 30:949-52. 2002
Death by TPN... the final chapter?Paul E Marik
Crit Care Med 36:1964-5. 2008
Using corticosteroids in intensive carePaul E Marik
Arch Surg 141:946-7; author reply 947. 2006
Comment on "Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient?" by Heidegger et alPaul E Marik
Intensive Care Med 33:1855; author reply 1857. 2007
Steroids in cardiac arrest: not ready for prime time?Joseph Varon
Am J Emerg Med 25:376-7. 2007
Arginine: too much of a good thing may be bad!Paul E Marik
Crit Care Med 34:2844-7. 2006
Noninvasive positive-pressure ventilation in patients with malignancyPaul E Marik
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Am J Hosp Palliat Care 24:417-21. 2007..In rare instances, NIPPV may have a role in treating patients with advanced cancer who have intractable dyspnea; however, NIPPV should not be used for the sole purpose of prolonging life in patients with terminal respiratory failure...
Acute unilateral pneumonitis in a patient with polymyositis: a unique presentation of polymyositis-associated pneumonitisBobbak Vahid
Santa Cruz Pulmonary Medical Group, Dominican Hospital, 700 Frederick St, Suite 203, Santa Cruz, CA 95060, USA
Respir Care 52:1774-8. 2007..Lung biopsy showed organizing pneumonia. The patient was treated with systemic corticosteroids and had complete resolution of respiratory failure and pulmonary infiltrates. We discuss polymyositis/dermatomyositis-associated pneumonitis...
Captain of the shipPaul E Marik
Chest 121:1382. 2002
Death by total parenteral nutrition: part deauxPaul E Marik
Crit Care Med 34:3062; author reply 3062-3. 2006
The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?Paul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Walnut Street, Philadelphia, Pennsylvania 19107, USA
Crit Care 10:176. 2006..In those patients in whom the diagnosis of adrenal insufficiency may be important, this diagnosis may best be made based on the free cortisol level or the total cortisol level stratified by serum albumin...
Management of patients with metastatic malignancy in the intensive care unitPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Hosp Palliat Care 23:479-82. 2006..Intensivists, who are charged with making the best use of limited resources, should ultimately be the individuals who determine the appropriateness of admitting such patients to the intensive care unit...
Certification and training in critical care ultrasoundPaul E Marik
Intensive Care Med 34:215-7. 2008
Fungal infections in bone marrow transplant recipientsTuhina Raman
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Expert Opin Pharmacother 7:307-15. 2006..Treatment options include therapy with azoles, including the newer agent voriconazole, amphotericin and caspofungin...
Open versus closed units: chaos versus a well-oiled machinePaul E Marik
Crit Care Med 31:2567-8; author reply 2568. 2003
Cardiovascular dysfunction of sepsis: a nitric oxide- and l-arginine-deficient state?Paul E Marik
Crit Care Med 31:971-3. 2003
Clinical information systems and the electronic medical record in the intensive care unitJoseph Varon
Baylor College of Medicine and The University of Texas Health Science Center, Houston, Texas, USA
Curr Opin Crit Care 8:616-24. 2002....
IV 2beta or not 2beta, that is the question!Joseph Varon
Chest 122:1116-8. 2002
Promoting enteral feeding 101Samuel A Tisherman
Crit Care Med 30:1653-4. 2002
Oral vs inhaled corticosteroids following emergency department discharge of patients with acute asthmaPaul E Marik
Chest 121:1735-6. 2002
Acupuncture for asthma: fact or fiction?Joseph Varon
Chest 121:1387-8. 2002
Definition of sepsis: not quite time to dump SIRS?Paul E Marik
Crit Care Med 30:706-8. 2002
Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adultJudith Jacobi
Crit Care Med 30:119-41. 2002
Steroids and drotrecogin alfa (activated) for severe sepsisPaul E Marik
Chest 124:2033-4. 2003
Treatment of cardiac arrest with automatic external defibrillators: impact on outcomeJoseph Varon
University of Texas Health Science Center, Houston, Texas 77030, USA
Am J Cardiovasc Drugs 3:265-70. 2003..As technology evolves costs will decline, however, the current economic reality requires careful consideration of the cost effectiveness of specific AED placement...
Fungal infections in solid organ transplantationPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Expert Opin Pharmacother 7:297-305. 2006..This article will review the risk factors, clinical presentation and treatment of invasive fungal infections in solid organ transplant patients, and evaluate the role of prophylactic therapy in this group of patients...
Bedside ultrasonography in the ICU: part 2Yanick Beaulieu
Division of Cardiology and Critical Care Medicine, Hôpital Sacré Coeur de Montréal, Universite de Montreal, 5400 boul Gouin O, Montreal, Quebec, Canada, H4J 1C5
Chest 128:1766-81. 2005..This technology, as a powerful adjunct to the physical examination, will become an indispensable tool in the management of critically ill patients...
Regional carbon dioxide monitoring to assess the adequacy of tissue perfusionPaul E Marik
Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Curr Opin Crit Care 11:245-51. 2005..Regional carbon dioxide monitoring appears to be ideally suited to monitoring the adequacy of resuscitation. This review provides an update on this evolving technology...
Propofol: an immunomodulating agentPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Pharmacotherapy 25:28S-33S. 2005..The antiinflammatory and antioxidant properties of propofol may have beneficial effects in patients with sepsis and systemic inflammatory response syndrome...
Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the badHolt Murray
Chest 127:707-9. 2005
ICU care at the end of lifeKelly A Wood
Chest 126:1403-6. 2004
Death by parenteral nutritionPaul E Marik
Intensive Care Med 29:867-9. 2003
Aspiration pneumonia: mixing apples with oranges and tangerinesPaul E Marik
Crit Care Med 32:1236; author reply 1236-7. 2004
Unraveling the mystery of adrenal failure in the critically illPaul E Marik
Crit Care Med 32:596-7. 2004
The central nervous system hypothalamic-pituitary-adrenal axis in sepsisPaul E Marik
Crit Care Med 30:490-1. 2002
