Research Topics
| Susan S MarguliesSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
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Detail Information
Publications
Reproducible uniform equibiaxial stretch of precision-cut lung slicesN Davidovich
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Lung Cell Mol Physiol 304:L210-20. 2013..Together with the ensuring uniform and equibiaxial stretch, the proposed methods provide an optimal model for VILI studies with PCLSs...- Combination therapies for traumatic brain injury: prospective considerationsSusan Margulies
School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104 6321, USA
J Neurotrauma 26:925-39. 2009..Overall there was great enthusiasm for working collaboratively to act on these recommendations... 
Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in catsMichael J Brennick
Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, United States
Respir Physiol Neurobiol 156:154-64. 2007..The results indicate that selective stimulation of the genioglossus muscle dilates the nasopharynx and provide evidence that stimulation of the genioglossus alone does not alter airway compliance...- Ocular hemorrhages in neonatal porcine eyes from single, rapid rotational eventsBrittany Coats
Department of Bioengineering, Scheie Eye Institute, University of Pennsylvania, and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Invest Ophthalmol Vis Sci 51:4792-7. 2010..To characterize ocular hemorrhages from single, rapid head rotations in the neonatal pig... - Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injuryChao Zhou
University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:034015. 2009..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit... - Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pigRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania, Philadelphia, 19104, USA
J Neurotrauma 21:307-16. 2004..Collectively, these data are indicative of the graded response of the immature brain to rotational load magnitude, and importantly, the vulnerability to repeated, mild, non-impact loading conditions... 
In situ deformations in the immature brain during rapid rotationsNicole G Ibrahim
Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6321, USA
J Biomech Eng 132:044501. 2010..Future studies will examine the brain-skull displacement and will be used to validate brain-skull interactions in computational models...- Neurobehavioral functional deficits following closed head injury in the neonatal pigStuart H Friess
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Exp Neurol 204:234-43. 2007.... - Traumatic axonal injury after closed head injury in the neonatal pigRamesh Raghupathi
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurotrauma 19:843-53. 2002..Together, these data demonstrate that rapid rotation of the piglet head without impact results in SAH and TAI, similar to that observed in children following severe brain trauma... - Physiological and pathological responses to head rotations in toddler pigletsNicole G Ibrahim
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
J Neurotrauma 27:1021-35. 2010..We conclude that the traditional mechanical engineering approach of scaling by brain mass and stiffness cannot explain the vulnerability of the infant brain to acceleration-deceleration movements, compared with the toddler... - In vivo pons motion within the skullSongbai Ji
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
J Biomech 40:92-9. 2007..Based on these findings, we recommend that the brainstem-skull interface be treated as a sliding (with or without friction) boundary condition in FE models of the human head... - Repeated traumatic brain injury affects composite cognitive function in pigletsStuart H Friess
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Neurotrauma 26:1111-21. 2009..These observations have important clinical translation to infants subjected to repeated inflicted head trauma... - Anthropomorphic simulations of falls, shakes, and inflicted impacts in infantsMichael T Prange
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6392, USA
J Neurosurg 99:143-50. 2003..5 m or from shaking... - Biomechanics of the toddler head during low-height falls: an anthropomorphic dummy analysisNicole G Ibrahim
Department of Bioengineering, The University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
J Neurosurg Pediatr 6:57-68. 2010..The authors previously found that toddlers had fewer skull fractures and scalp/facial soft-tissue injuries, and more frequent altered mental status than infants for the same low-height falls (<or=3 ft)... - Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epitheliaBrian C DiPaolo
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania19104 6321, USA
Am J Physiol Cell Physiol 299:C345-53. 2010..In summary, stretch of primary rat AEC monolayers forms PJARs and rapidly reorganized actin binding sites at the plasma membrane in a manner dependent on stretch magnitude and frequency... - Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flowStephanie A Eucker
Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
Brain Res 1326:128-34. 2010.... - Potential for head injuries in infants from low-height fallsBrittany Coats
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
J Neurosurg Pediatr 2:321-30. 2008..The objective of this study was to determine impact forces and angular accelerations associated with low-height falls in infants... - Parametric study of head impact in the infantBrittany Coats
University of Pennsylvania, Department of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
Stapp Car Crash J 51:1-15. 2007..In summary, the pediatric FEM response is not sensitive to small variations in anatomy or brain modulus, large deviations will significantly influence principal stress estimates and the prediction of skull fracture... - Hypoxic-ischemic injury complicates inflicted and accidental traumatic brain injury in young children: the role of diffusion-weighted imagingRebecca N Ichord
Department of Neurology, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
J Neurotrauma 24:106-18. 2007..HII predicted need for in-patient rehabilitation in a large majority of children... - A transversely isotropic viscoelastic constitutive equation for brainstem undergoing finite deformationXinguo Ning
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6382, USA
J Biomech Eng 128:925-33. 2006..0047 and 1.4538 s, respectively, implying rapid relaxation of shear stresses. The developed material model and parameter estimation technique are likely to find broad applications in neural and orthopaedic tissues... - Material properties of porcine parietal cortexBrittany Coats
Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104-6392, USA
J Biomech 39:2521-5. 2006..The assumption of gray matter homogeneity should be carefully considered in future finite element models of the head... - Are in vivo and in situ brain tissues mechanically similar?Amit Gefen
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Biomech 37:1339-52. 2004..02), and perfusion had no effect on any other property. These findings support the concept that perfusion does not affect the stiffness of living cortical tissue... - Age-dependent changes in material properties of the brain and braincase of the ratAmit Gefen
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Neurotrauma 20:1163-77. 2003..Specifically, these results will assist in the selection of forces to induce comparable mechanical stresses, strains and consequent injury profiles in brain tissues of immature and adult animals... - Regional, directional, and age-dependent properties of the brain undergoing large deformationMichael T Prange
Department of Bioengineering, University of Pennsylvania, Philadelphia 19104 6392, USA
J Biomech Eng 124:244-52. 2002..Only the infant properties were significantly different (stiffer) from the adult...