Susan S Margulies

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Reproducible uniform equibiaxial stretch of precision-cut lung slices
    N Davidovich
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 304:L210-20. 2013
  2. pmc Combination therapies for traumatic brain injury: prospective considerations
    Susan Margulies
    School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104 6321, USA
    J Neurotrauma 26:925-39. 2009
  3. ncbi request reprint Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in cats
    Michael J Brennick
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, United States
    Respir Physiol Neurobiol 156:154-64. 2007
  4. pmc Ocular hemorrhages in neonatal porcine eyes from single, rapid rotational events
    Brittany Coats
    Department of Bioengineering, Scheie Eye Institute, University of Pennsylvania, and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 51:4792-7. 2010
  5. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009
  6. ncbi request reprint Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, 19104, USA
    J Neurotrauma 21:307-16. 2004
  7. doi request reprint In situ deformations in the immature brain during rapid rotations
    Nicole G Ibrahim
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6321, USA
    J Biomech Eng 132:044501. 2010
  8. pmc Neurobehavioral functional deficits following closed head injury in the neonatal pig
    Stuart H Friess
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Exp Neurol 204:234-43. 2007
  9. ncbi request reprint Traumatic axonal injury after closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 19:843-53. 2002
  10. pmc Physiological and pathological responses to head rotations in toddler piglets
    Nicole G Ibrahim
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurotrauma 27:1021-35. 2010

Collaborators

Detail Information

Publications24

  1. pmc Reproducible uniform equibiaxial stretch of precision-cut lung slices
    N Davidovich
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 304:L210-20. 2013
    ..Together with the ensuring uniform and equibiaxial stretch, the proposed methods provide an optimal model for VILI studies with PCLSs...
  2. pmc Combination therapies for traumatic brain injury: prospective considerations
    Susan Margulies
    School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104 6321, USA
    J Neurotrauma 26:925-39. 2009
    ..Overall there was great enthusiasm for working collaboratively to act on these recommendations...
  3. ncbi request reprint Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in cats
    Michael J Brennick
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, United States
    Respir Physiol Neurobiol 156:154-64. 2007
    ..The results indicate that selective stimulation of the genioglossus muscle dilates the nasopharynx and provide evidence that stimulation of the genioglossus alone does not alter airway compliance...
  4. pmc Ocular hemorrhages in neonatal porcine eyes from single, rapid rotational events
    Brittany Coats
    Department of Bioengineering, Scheie Eye Institute, University of Pennsylvania, and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 51:4792-7. 2010
    ..To characterize ocular hemorrhages from single, rapid head rotations in the neonatal pig...
  5. pmc Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury
    Chao Zhou
    University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Opt 14:034015. 2009
    ..In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit...
  6. ncbi request reprint Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, 19104, USA
    J Neurotrauma 21:307-16. 2004
    ..Collectively, these data are indicative of the graded response of the immature brain to rotational load magnitude, and importantly, the vulnerability to repeated, mild, non-impact loading conditions...
  7. doi request reprint In situ deformations in the immature brain during rapid rotations
    Nicole G Ibrahim
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6321, USA
    J Biomech Eng 132:044501. 2010
    ..Future studies will examine the brain-skull displacement and will be used to validate brain-skull interactions in computational models...
  8. pmc Neurobehavioral functional deficits following closed head injury in the neonatal pig
    Stuart H Friess
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Exp Neurol 204:234-43. 2007
    ....
  9. ncbi request reprint Traumatic axonal injury after closed head injury in the neonatal pig
    Ramesh Raghupathi
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 19:843-53. 2002
    ..Together, these data demonstrate that rapid rotation of the piglet head without impact results in SAH and TAI, similar to that observed in children following severe brain trauma...
  10. pmc Physiological and pathological responses to head rotations in toddler piglets
    Nicole G Ibrahim
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurotrauma 27:1021-35. 2010
    ..We conclude that the traditional mechanical engineering approach of scaling by brain mass and stiffness cannot explain the vulnerability of the infant brain to acceleration-deceleration movements, compared with the toddler...
  11. ncbi request reprint In vivo pons motion within the skull
    Songbai Ji
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biomech 40:92-9. 2007
    ..Based on these findings, we recommend that the brainstem-skull interface be treated as a sliding (with or without friction) boundary condition in FE models of the human head...
  12. pmc Repeated traumatic brain injury affects composite cognitive function in piglets
    Stuart H Friess
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurotrauma 26:1111-21. 2009
    ..These observations have important clinical translation to infants subjected to repeated inflicted head trauma...
  13. ncbi request reprint Anthropomorphic simulations of falls, shakes, and inflicted impacts in infants
    Michael T Prange
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6392, USA
    J Neurosurg 99:143-50. 2003
    ..The authors sought to compare rotational deceleration sustained by the head among free falls, from different heights onto different surfaces, with those sustained during shaking and inflicted impact...
  14. doi request reprint Biomechanics of the toddler head during low-height falls: an anthropomorphic dummy analysis
    Nicole G Ibrahim
    Department of Bioengineering, The University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurosurg Pediatr 6:57-68. 2010
    ..The authors previously found that toddlers had fewer skull fractures and scalp/facial soft-tissue injuries, and more frequent altered mental status than infants for the same low-height falls (<or=3 ft)...
  15. pmc Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia
    Brian C DiPaolo
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania19104 6321, USA
    Am J Physiol Cell Physiol 299:C345-53. 2010
    ..In summary, stretch of primary rat AEC monolayers forms PJARs and rapidly reorganized actin binding sites at the plasma membrane in a manner dependent on stretch magnitude and frequency...
  16. pmc Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flow
    Stephanie A Eucker
    Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 1326:128-34. 2010
    ....
  17. doi request reprint Potential for head injuries in infants from low-height falls
    Brittany Coats
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurosurg Pediatr 2:321-30. 2008
    ..The objective of this study was to determine impact forces and angular accelerations associated with low-height falls in infants...
  18. ncbi request reprint Parametric study of head impact in the infant
    Brittany Coats
    University of Pennsylvania, Department of Bioengineering, 240 Skirkanich Hall, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    Stapp Car Crash J 51:1-15. 2007
    ..In summary, the pediatric FEM response is not sensitive to small variations in anatomy or brain modulus, large deviations will significantly influence principal stress estimates and the prediction of skull fracture...
  19. ncbi request reprint Hypoxic-ischemic injury complicates inflicted and accidental traumatic brain injury in young children: the role of diffusion-weighted imaging
    Rebecca N Ichord
    Department of Neurology, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Neurotrauma 24:106-18. 2007
    ..HII predicted need for in-patient rehabilitation in a large majority of children...
  20. ncbi request reprint A transversely isotropic viscoelastic constitutive equation for brainstem undergoing finite deformation
    Xinguo Ning
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6382, USA
    J Biomech Eng 128:925-33. 2006
    ..0047 and 1.4538 s, respectively, implying rapid relaxation of shear stresses. The developed material model and parameter estimation technique are likely to find broad applications in neural and orthopaedic tissues...
  21. ncbi request reprint Material properties of porcine parietal cortex
    Brittany Coats
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104 6392, USA
    J Biomech 39:2521-5. 2006
    ..The assumption of gray matter homogeneity should be carefully considered in future finite element models of the head...
  22. ncbi request reprint Are in vivo and in situ brain tissues mechanically similar?
    Amit Gefen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Biomech 37:1339-52. 2004
    ..02), and perfusion had no effect on any other property. These findings support the concept that perfusion does not affect the stiffness of living cortical tissue...
  23. ncbi request reprint Age-dependent changes in material properties of the brain and braincase of the rat
    Amit Gefen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 20:1163-77. 2003
    ..Specifically, these results will assist in the selection of forces to induce comparable mechanical stresses, strains and consequent injury profiles in brain tissues of immature and adult animals...
  24. ncbi request reprint Regional, directional, and age-dependent properties of the brain undergoing large deformation
    Michael T Prange
    Department of Bioengineering, University of Pennsylvania, Philadelphia 19104 6392, USA
    J Biomech Eng 124:244-52. 2002
    ..Only the infant properties were significantly different (stiffer) from the adult...