Research Topics
Species | Todd P MargolisSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latencyWilliam P Halford
Dept of Veterinary Molecular Biology, Montana State University, Bozeman, MT, USA
Virol J 3:44. 2006....- CMV retinitis screening and treatment in a resource-poor setting: three-year experience from a primary care HIV/AIDS programme in MyanmarNini Tun
California Pacific Medical Center, San Francisco, USA
J Int AIDS Soc 14:41. 2011..Prior to this programme, CMV retinitis was not routinely examined for, or treated, in Myanmar... 
Fusarium--A new culprit in the contact lens caseTodd P Margolis
JAMA 296:985-7. 2006- Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory gangliaTodd P Margolis
Francis I Proctor Foundation, UCSF, Medical Sciences Building S 310, 513 Parnassus Ave, San Francisco, CA 94143 0412, USA
J Virol 81:11069-74. 2007..Since most cases of human viral shedding and reactivation are not associated with a known trigger, spontaneous ganglionic reactivation of HSV-1 may be a better model of human disease than existing models... - Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: role of latency-associated transcriptsTodd P Margolis
F I Proctor Foundation, University of California, San Francisco, San Francisco, CA 94143, USA
J Virol 81:1872-8. 2007.... 
Practice patterns and opinions in the management of recurrent or chronic herpes zoster ophthalmicusAileen Sy
Department of Ophthalmology, F I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA
Cornea 31:786-90. 2012..The objective of this study was to determine current practices and opinions among cornea specialists for treating and preventing recurrences of herpes zoster ophthalmicus (HZO)...- Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureusJulie Freidlin
F I Proctor Foundation, University of California, San Francisco, CA 94143, USA
Am J Ophthalmol 144:313-5. 2007..To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA)... - The clinical differentiation of bacterial and fungal keratitis: a photographic surveyCyril Dalmon
F I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Invest Ophthalmol Vis Sci 53:1787-91. 2012..The purpose of this study was to determine whether clinical signs of infectious keratitis can be used to identify the causative organism... - Epidemiology of ulcerative keratitis in Northern CaliforniaBennie H Jeng
Department of Ophthalmology, University of California, San Francisco, USA
Arch Ophthalmol 128:1022-8. 2010..To determine the incidence and associated risk factors for ulcerative keratitis in northern California... - "Steel wool keratopathy": a clinical sign of chronic inflammationGerami D Seitzman
Francis I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA
Cornea 25:742-4. 2006.... - Perifosine-related rapidly progressive corneal ring infiltrateJeremy D Keenan
F I Proctor Foundation and the Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143 0944, USA
Cornea 29:583-5. 2010..To report a case of unilateral rapidly progressing corneal ring infiltration in a patient being treated with the investigational drug perifosine for Waldenström's macroglobulinemia... - Uveitis-associated flap edema and lamellar interface fluid collection after LASIKStephen D McLeod
Francis I Proctor Foundation and the Department of Ophthalmology, University of California San Francisco, 10 Kirkham Street, San Francisco, CA 94143, USA
Am J Ophthalmol 139:1137-9. 2005..To report two cases of corneal pathology associated with anterior uveitis after laser in situ keratomileusis (LASIK)... - Management of prominent iris vascular tufts causing recurrent spontaneous hyphemaErich C Strauss
Francis I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143 0944, USA
Cornea 24:224-6. 2005..To report the management of recurrent, spontaneous hyphema associated with florid iris vascular tufts in a patient presenting for cataract surgery... - A new mutation (Leu569Arg) within exon 13 of the TGFBI (BIGH3) gene causes lattice corneal dystrophy type IJohn F Warren
Francis I Proctor Foundation and the Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
Am J Ophthalmol 136:872-8. 2003..To describe an American family with lattice corneal dystrophy type I, which associates with a novel mutation, Leu569Arg, of the TGFBI (BIGH3) gene... - Diagnosis of conjunctival B-cell lymphoma by polymerase chain reaction heteroduplex analysisErich C Strauss
Department of Ophthalmology, University of California San Francisco Medical Center, California, San Francisco, USA
Am J Ophthalmol 136:207-9. 2003..To report a case initially assessed as giant papillary conjunctivitis and subsequently as B-cell lymphoma by the molecular technique of polymerase chain reaction heteroduplex analysis... - Cigarette smoking as a risk factor for uveitisPhoebe Lin
F I Proctor Foundation, University of California, San Francisco, California 94143 0944, USA
Ophthalmology 117:585-90. 2010..To determine the association between tobacco smoking history and uveitis... - Rose bengal and lissamine green inhibit detection of herpes simplex virus by PCRGerami D Seitzman
Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California, USA
Am J Ophthalmol 141:756-8. 2006..CONCLUSIONS: Rose bengal, lissamine green, and calcium alginate can inhibit PCR detection of HSV DNA. Clinical scrapings to be sent for PCR diagnostic testing should be taken before instillation of rose bengal or lissamine green... - A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitroAndrea S Bertke
Department of Ophthalmology, University of California, San Francisco, Medical Sciences Building, s 310, 513 Parnassus Ave, Box 0412, San Francisco, CA 94143 0412, USA
J Virol 85:6669-77. 2011.... - Comparison of autophotomontage software programs in eyes with CMV retinitisJenny Chen
F I Proctor Foundation, San Francisco, California, USA
Invest Ophthalmol Vis Sci 52:9339-44. 2011..This study compares the quality of the mosaic products of three autophotomontage software programs, using digital fundus photographs of eyes with cytomegalovirus (CMV) retinitis... - Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophyAnthony J Aldave
Cornea Service, The Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
Am J Ophthalmol 137:465-73. 2004..To further characterize the mutations within the CHST6 gene responsible for causing macular corneal dystrophy in a cohort of affected patients from the United States... - Thygeson superficial punctate keratitis and scarringRobert E Fintelmann
F I Proctor Foundation, San Francisco, CA, USA
Cornea 31:1446-8. 2012..We present 4 cases with TSPK who developed sight-altering scarring after a prolonged disease course... - Parasites on the rise: a new epidemic of Acanthamoeba keratitisNisha R Acharya
F I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA
Am J Ophthalmol 144:292-3. 2007 - Cytomegalovirus retinitis after intravitreous triamcinolone in an immunocompetent patientMichael A Saidel
Francis I Proctor Foundation, University of California at San Francisco, 95 Kirkham Street, San Francisco, CA 94143, USA
Am J Ophthalmol 140:1141-3. 2005..To report the case of a 75-year-old man with diabetes who developed cytomegalovirus (CMV) retinitis after intravitreous injection of triamcinolone acetonide (IVTA)... - Chronic recurrent varicella-zoster virus keratitis confirmed by polymerase chain reaction testingM Teresa Magone
Francis I Proctor Foundation, University of California San Francisco, San Francisco, CA 94143 0944, USA
Am J Ophthalmol 139:1135-6. 2005..To report a case of chronic recurrent varicella virus epithelial keratitis in a child... - Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degenerationJeremy D Keenan
F I Proctor Foundation, University of California, San Francisco, CA, USA
Cornea 30:825-7. 2011..To report a case of bilateral peripheral corneal thinning with an appearance of Fuchs superficial marginal keratitis in the right eye and Terrien marginal degeneration in the left eye... - Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritisNisha Acharya
Proctor Foundation, Department of Ophthalmology, University of California San Francisco, 95 Kirkham Street, San Francisco, CA 94143, USA
Am J Ophthalmol 141:584-5. 2006..To compare polymerase chain reaction (PCR) results to presumptive clinical diagnosis in patients with vitritis... - Atopic disease and herpes simplex eye disease: a population-based case-control studyTisha Prabriputaloong
Department Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA
Am J Ophthalmol 142:745-9. 2006..0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). CONCLUSIONS: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls... - Metaplastic squamous epithelial downgrowth after clear corneal cataract surgeryDonald U Stone
Proctor Foundation, University of California-San Francisco, San Francisco, CA 94143, USA
Am J Ophthalmol 142:695-7. 2006.... - Treatment of conjunctival squamous cell carcinoma with topical cidofovirMark D Sherman
Department of Ophthalmology, Southern California Permanente Medical Group, University of California, San Francisco, USA
Am J Ophthalmol 134:432-3. 2002..To describe a case of conjunctival squamous cell carcinoma in situ that was successfully treated with adjunctive topical cidofovir... - Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitisKirk R Wilhelmus
Sid W Richardson Ocular Microbiology Laboratory, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin St, Houston, TX 77030, USA
Arch Ophthalmol 127:161-6. 2009..To validate photographic bioimaging for evaluating the severity of herpes simplex virus keratitis... - Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic miceAnne M Gussow
Department of Molecular Genetics and Microbiology, Box 100266, University of Florida College of Medicine, Gainesville, FL 32610-0266, USA
J Virol 80:9414-23. 2006..Taken together, these data indicate that the regulation of expression and processing of LAT RNA within the mouse is highly cell-type specific and occurs in the absence of other viral cis- and trans-acting factors... - Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern IndiaJohn F Warren
Francis I Proctor Foundation and the Department of Ophthalmology, University of California San Francisco, 94143 0944, USA
Arch Ophthalmol 121:1608-12. 2003..To further characterize the role of the carbohydrate sulfotransferase (CHST6) gene in macular corneal dystrophy (MCD) through identification of causative mutations in a cohort of affected patients from southern India... - Ocular complications of smallpox vaccinationJay S Pepose
Pepose Vision Institute, Chesterfield, Missouri 63017, USA
Am J Ophthalmol 136:343-52. 2003..Vaccinia virus does not appear to be sensitive to acyclovir. Specific treatment recommendations are outlined for the spectrum of ocular manifestations... - Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implantIrene C Kuo
Francis I. Proctor Foundation and the Department of Ophthalmology, University of California San Francisco, 94143-0944, USA
Am J Ophthalmol 135:20-5. 2003..The ganciclovir implant can be an effective therapy for CMV retinitis caused by virus with certain UL97 and UL54 resistance mutations. Cytomegalovirus UL54 genotypes can differ between eyes in patients with bilateral retinitis... - Does asymptomatic shedding of herpes simplex virus on the ocular surface lead to false-positive diagnostic PCR results?Julie F Leigh
Br J Ophthalmol 92:435-6. 2008 - Spontaneous molecular reactivation of herpes simplex virus type 1 latency in miceLawrence T Feldman
Department of Microbiology and Immunology, University of California Medical Center, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 99:978-83. 2002..In the absence of detectable infectious virus in these ganglia, we propose the term "spontaneous molecular reactivation" to describe this ongoing process...