Elyssa B Margolis

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons
    Elyssa B Margolis
    Joint University of California San Francisco University of California, Berkeley Bioengineering Graduate Group, San Francisco, California 94143 0775, USA
    J Neurosci 23:9981-6. 2003
  2. doi request reprint Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:8908-13. 2008
  3. pmc Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons
    Gregory O Hjelmstad
    Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 33:6454-9. 2013
  4. doi request reprint Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:12672-81. 2008
  5. doi request reprint Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area
    Yanfang Xia
    Ernest Gallo Clinic and Research Center, Wheeler Center for Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 31:7811-6. 2011
  6. ncbi request reprint Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement
    Howard L Fields
    Ernest Gallo Clinic and Research Center and Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, Emeryville, California 94608, USA
    Annu Rev Neurosci 30:289-316. 2007
  7. doi request reprint Intra-VTA Deltorphin, But Not DPDPE, Induces Place Preference in Ethanol-Drinking Rats: Distinct DOR-1 and DOR-2 Mechanisms Control Ethanol Consumption and Reward
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California Department of Neurology, University of California, San Francisco, California
    Alcohol Clin Exp Res 38:195-203. 2014
  8. pmc Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 103:2938-42. 2006
  9. pmc The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    J Physiol 577:907-24. 2006
  10. ncbi request reprint Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    J Neurophysiol 93:3086-93. 2005

Detail Information

Publications10

  1. ncbi request reprint Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons
    Elyssa B Margolis
    Joint University of California San Francisco University of California, Berkeley Bioengineering Graduate Group, San Francisco, California 94143 0775, USA
    J Neurosci 23:9981-6. 2003
    ..These results provide a cellular mechanism for the opposing behavioral effects of KOR and MOR agonists and shed light on how KORs might regulate the motivational effects of both natural rewards and addictive drugs...
  2. doi request reprint Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:8908-13. 2008
    ..Therefore, in the VTA, AP duration and inhibition by D(2)R agonists may be valid markers of DA content in neurons of known projection target...
  3. pmc Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons
    Gregory O Hjelmstad
    Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 33:6454-9. 2013
    ..Both of these actions decrease GABAergic input onto VTA neurons, revealing two mechanisms by which endogenous or exogenous opioids can activate VTA neurons, including DA neurons...
  4. doi request reprint Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:12672-81. 2008
    ..Together, our findings demonstrate the protective nature of VTA DORs and identify an important new target for therapeutic intervention for alcoholism...
  5. doi request reprint Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area
    Yanfang Xia
    Ernest Gallo Clinic and Research Center, Wheeler Center for Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 31:7811-6. 2011
    ..We found that the NAc directly targets non-dopaminergic VTA neurons, including some that project back to the NAc. These MSN GABAergic terminals are opioid sensitive and act via GABA(A) receptors...
  6. ncbi request reprint Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement
    Howard L Fields
    Ernest Gallo Clinic and Research Center and Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, Emeryville, California 94608, USA
    Annu Rev Neurosci 30:289-316. 2007
    ..Consequently, identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors...
  7. doi request reprint Intra-VTA Deltorphin, But Not DPDPE, Induces Place Preference in Ethanol-Drinking Rats: Distinct DOR-1 and DOR-2 Mechanisms Control Ethanol Consumption and Reward
    Jennifer M Mitchell
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California Department of Neurology, University of California, San Francisco, California
    Alcohol Clin Exp Res 38:195-203. 2014
    ....
  8. pmc Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 103:2938-42. 2006
    ..Selective control of VTA DA neurons projecting to the mPFC has important implications for understanding addiction, attention disorders, and schizophrenia, all of which are associated with DA dysfunction in the mPFC...
  9. pmc The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    J Physiol 577:907-24. 2006
    ..We conclude that reliable physiological criteria for VTA DA neuron identification have yet to be determined, and that the criteria currently being used are unreliable...
  10. ncbi request reprint Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    J Neurophysiol 93:3086-93. 2005
    ..These findings show that MOP-R and KOP-R agonists regulate excitatory input onto each VTA cell type...