David J Margolis

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Validity of subject self-report for acne
    Chandrakala Menon
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Dermatology 217:164-8. 2008
  2. pmc Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:1961-6. 2013
  3. pmc Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 21:17-24. 2013
  4. pmc The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 130:912-7. 2012
  5. pmc Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study
    David J Margolis
    Department of Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Dermatol 148:326-32. 2012
  6. pmc Association between serious ischemic cardiac outcomes and medications used to treat diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:753-9. 2008
  7. doi request reprint Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 105:2610-6. 2010
  8. pmc The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes
    David J Margolis
    Department of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 18:445-51. 2010
  9. pmc Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes
    David J Margolis
    Department of Biostatistics and Epidemiology and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Diabetes Care 34:2363-7. 2011
  10. pmc Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease
    David J Margolis
    Center for Clinical Epidemiology and Biostatistics, 815 Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Ther 17:1822-9. 2009

Collaborators

Detail Information

Publications91

  1. doi request reprint Validity of subject self-report for acne
    Chandrakala Menon
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Dermatology 217:164-8. 2008
    ..Acne prevalence studies often use subject self-report as data source. Our aim was to evaluate the validity of acne self-report...
  2. pmc Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:1961-6. 2013
    ..The study goal was to compare the effectiveness of HBO with other conventional therapies administered in a wound care network for the treatment of a diabetic foot ulcer and prevention of lower-extremity amputation...
  3. pmc Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the chronic renal insufficiency cohort study
    David J Margolis
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 21:17-24. 2013
    ..97]) in whites and rs16849113 and rs6659759 (3.62 [1.11, 11.83] and 3.02 [0.82, 11.12], respectively) in African Americans. In conclusion, this is one of the first studies to show that NOS1AP gene variants are associated with DPN and LEA...
  4. pmc The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 130:912-7. 2012
    ..Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin (FLG) loss-of-function (FLG null) mutations have been associated with an increased risk of AD...
  5. pmc Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study
    David J Margolis
    Department of Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Dermatol 148:326-32. 2012
    ..To prospectively evaluate the association between antibiotics used to treat acne and pharyngitis...
  6. pmc Association between serious ischemic cardiac outcomes and medications used to treat diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:753-9. 2008
    ..Data on cardiovascular outcomes among treated diabetics have been inconsistent. Our goal was to compare cardiovascular outcomes associated with different treatments for diabetes...
  7. doi request reprint Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 105:2610-6. 2010
    ..The majority of patients prescribed isotretinoin for their acne are previously on an extended course of antibiotics. Therefore, it is important to consider antibiotic use as a confounding variable for the development of IBD...
  8. pmc The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes
    David J Margolis
    Department of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 18:445-51. 2010
    ..45 (0.22, 0.91) for the new onset of a LEA. In conclusion, among those with diabetes, exposure to ACEi as compared with ARB increases the risk of developing a DFU or LEA...
  9. pmc Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes
    David J Margolis
    Department of Biostatistics and Epidemiology and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Diabetes Care 34:2363-7. 2011
    ..S. overall, neighboring locations have unexpectedly similar amputation rates, some being uniformly high and others uniformly low...
  10. pmc Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease
    David J Margolis
    Center for Clinical Epidemiology and Biostatistics, 815 Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Ther 17:1822-9. 2009
    ..In this phase I study, we demonstrate the initial safety, feasibility, and biologic plausibility of using H5.020CMV.PDGF-beta to treat venous leg ulcer disease...
  11. pmc Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 31:1331-6. 2008
    ..The physicians participated in The Health Information Network of the U.K...
  12. doi request reprint A randomized trial and the treatment of pemphigus vulgaris
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 130:1964-6. 2010
    ..Mycophenolate mofetil has not become the "wonder drug" that had been anticipated based on initial clinical reports. Studies like that reported by Beissert et al. in this issue are essential to improve dermatologic care...
  13. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  14. ncbi request reprint The prevalence of psoriasis in African Americans: results from a population-based study
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, PA 19104, USA
    J Am Acad Dermatol 52:23-6. 2005
    ..The prevalence of psoriasis in African Americans has been previously reported as rare. However, there have been no population-based studies to assess the prevalence and burden of psoriasis in African Americans...
  15. ncbi request reprint Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  16. ncbi request reprint Clinical protocol. Phase I trial to evaluate the safety of H5.020CMV.PDGF-b and limb compression bandage for the treatment of venous leg ulcer: trial A
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19102, USA
    Hum Gene Ther 15:1003-19. 2004
  17. ncbi request reprint The risk of mortality in patients with psoriasis: results from a population-based study
    Joel M Gelfand
    MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1493-9. 2007
    ..To determine the risk of mortality in patients with psoriasis...
  18. pmc Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom
    Sinead M Langan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 132:556-62. 2012
    ..These findings suggest that screening for metabolic disease should be considered for psoriasis, especially when it is severe...
  19. doi request reprint The frequency and intensity of topical pimecrolimus treatment in children with physician-confirmed mild to moderate atopic dermatitis
    Roger Kapoor
    Department of Dermatology, Massachusetts General Hospital, Harvard University School of Medicine, Boston, Massachusetts 02114, USA
    Pediatr Dermatol 26:682-7. 2009
    ..Community-based use of topical pimecrolimus to treat AD is limited both with respect to the duration of exposure and amount or total dose of the exposure. If a topical therapy is persistent, it is most likely to a topical corticosteroid...
  20. ncbi request reprint Prevalence of cardiovascular risk factors in patients with psoriasis
    Andrea L Neimann
    Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 55:829-35. 2006
    ..Limited population-based data exist on this association, and few studies have determined which factors are independently associated with psoriasis...
  21. ncbi request reprint Prevalence and treatment of psoriasis in the United Kingdom: a population-based study
    Joel M Gelfand
    Center for Clinical Epidemiology and Biostatistics, and Department of Dermatology, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA 19104, USA
    Arch Dermatol 141:1537-41. 2005
    ..To measure the prevalence and treatment of psoriasis in the United Kingdom...
  22. doi request reprint Immunosuppressant medications and mortality in inflammatory bowel disease
    James D Lewis
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 103:1428-35; quiz 1436. 2008
    ..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies...
  23. pmc Geographic variation in pharmacotherapy decisions for U.S. Medicare enrollees with diabetes
    Michael R Sargen
    Department of Biostatistics and Epidemiology of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Diabetes Complications 26:301-7. 2012
    ..The goal of this study was to determine if non-clinical factors (patient race, ethnicity, gender, income) are associated with regional variation in pharmacotherapy decisions for diabetic patients enrolled in Medicare...
  24. ncbi request reprint Validity of patient self-reported history of skin cancer
    Michael E Ming
    Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 140:730-5. 2004
    ..To determine the validity of patient self-report of skin cancer history...
  25. pmc Extrinsic risk factors for pressure ulcers early in the hospital stay: a nested case-control study
    Mona Baumgarten
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Gerontol A Biol Sci Med Sci 63:408-13. 2008
    ....
  26. pmc Geographic variation in Medicare spending and mortality for diabetic patients with foot ulcers and amputations
    Michael R Sargen
    Department of Biostatistics and Epidemiology of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Diabetes Complications 27:128-33. 2013
    ..The purpose of this study was to identify the presence or absence of geographic variation in Medicare spending and mortality rates for diabetic patients with foot ulcers (DFU) and lower extremity amputations (LEA)...
  27. ncbi request reprint Diabetic neuropathic foot ulcers: the association of wound size, wound duration, and wound grade on healing
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes Care 25:1835-9. 2002
    ..The goal of this study was to evaluate whether simple risk factors can be identified that successfully characterize who will heal and who will not heal among patients who have received standard therapy for diabetic neuropathic foot ulcers...
  28. ncbi request reprint The accuracy of venous leg ulcer prognostic models in a wound care system
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 12:163-8. 2004
    ..Ultimately, these models can be applied by a clinician to help determine whom to continue to treat with standard care and perhaps whom to treat with adjuvant therapies. They may also aid in the design of clinical trials...
  29. ncbi request reprint Risk of myocardial infarction in patients with psoriasis
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 296:1735-41. 2006
    ..Psoriasis has been associated with cardiovascular diseases, but has only been investigated in hospital-based studies that did not control for major cardiovascular risk factors...
  30. ncbi request reprint Surrogate end points for the treatment of diabetic neuropathic foot ulcers
    David J Margolis
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes Care 26:1696-700. 2003
    ....
  31. ncbi request reprint Body dysmorphic disorder symptoms among patients with acne vulgaris
    Whitney P Bowe
    Department of Dermatology, The Children s Hospital of Philadelphia, USA
    J Am Acad Dermatol 57:222-30. 2007
    ....
  32. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  33. ncbi request reprint Effectiveness of recombinant human platelet-derived growth factor for the treatment of diabetic neuropathic foot ulcers
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 13:531-6. 2005
    ....
  34. ncbi request reprint Diabetic neuropathic foot ulcers: predicting which ones will not heal
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med 115:627-31. 2003
    ..Neuropathic foot ulcers are a serious complication of diabetes. The purpose of this study was to develop a clinically useful prognostic model for identifying ulcers that are not likely to heal...
  35. ncbi request reprint The incidence and prevalence of pressure ulcers among elderly patients in general medical practice
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Epidemiol 12:321-5. 2002
    ..The objective of this study was to estimate the period prevalence and incidence of pressure ulcer among those 65 years of age and older...
  36. pmc Psoriasis severity and the prevalence of major medical comorbidity: a population-based study
    Howa Yeung
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Dermatol 149:1173-9. 2013
    ..Despite the growing literature on comorbidity risks in psoriasis, there remains a critical knowledge gap on the degree to which objectively measured psoriasis severity may affect the prevalence of major medical comorbidity...
  37. ncbi request reprint Diabetic neuropathic foot ulcers and amputation
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 13:230-6. 2005
    ..In conclusion, about 7% of those with a diabetic neuropathic foot ulcer will have an amputation and in the past 10 years there has been a remarkable increase in the number of minor as compared to major amputations...
  38. pmc Increased risk of diabetes mellitus and likelihood of receiving diabetes mellitus treatment in patients with psoriasis
    Rahat S Azfar
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 16104, USA
    Arch Dermatol 148:995-1000. 2012
    ..To assess the risk of incident diabetes mellitus (DM) in patients with psoriasis and to evaluate DM treatment patterns among patients with psoriasis and incident DM...
  39. ncbi request reprint Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    N Engl J Med 349:1628-35. 2003
    ..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
  40. pmc Hemoglobin A1c predicts healing rate in diabetic wounds
    Andrea L Christman
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Invest Dermatol 131:2121-7. 2011
    ..JID JOURNAL CLUB ARTICLE: For questions, answers, and open discussion about this article, please go to http://www.nature.com/jid/journalclub...
  41. ncbi request reprint Epidemiology of psoriatic arthritis in the population of the United States
    Joel M Gelfand
    Department of Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 53:573. 2005
    ..Estimates of the prevalence of psoriatic arthritis vary widely and are usually not determined by population-based studies...
  42. ncbi request reprint Represcription of penicillin after allergic-like events
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 113:764-70. 2004
    ..We sought to determine the frequency of represcription of penicillin to individuals with penicillin allergy and the risk of a second reaction in those who had a previous reaction...
  43. pmc Evaluation of the use of prognostic information for the care of individuals with venous leg ulcers or diabetic neuropathic foot ulcers
    Shanu K Kurd
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 17:318-25. 2009
    ..This intervention was easy to administer and likely had low associated costs. This method of dispersing prognostic information to healthcare providers should be expanded to include recently published treatment algorithms...
  44. doi request reprint Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Electronic address
    J Allergy Clin Immunol 133:784-9. 2014
    ..Atopic dermatitis (AD) is a common skin disease characterized by recurrent episodes of itching. Genetic variation associated with the persistence of AD has not been described for African American subjects...
  45. ncbi request reprint Reducing the incidence of foot ulceration and amputation in diabetes
    Cynthia L Bartus
    Department of Dermatology, University of Pennsylvania, 815 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Curr Diab Rep 4:413-8. 2004
    ..To reduce these complications, several preventive strategies have been devised, from reducing risk factors to improving treatment and management...
  46. doi request reprint Asthma and frequency of wheeze: risk factors for the persistence of atopic dermatitis in children
    Jackie P D Garrett
    Department of Pediatrics, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Allergy Asthma Immunol 110:146-9. 2013
    ....
  47. ncbi request reprint The risk of lymphoma in patients with psoriasis
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics University of Pennsylvania, Philadelphia, 19104, USA
    J Invest Dermatol 126:2194-201. 2006
    ..Although patients with psoriasis have an increased relative risk of lymphoma, the absolute risk attributable to psoriasis is low given that lymphoma is a rare disease and the magnitude of association is modest...
  48. ncbi request reprint The incidence and risks of failure to heal after lower extremity amputation for the treatment of diabetic neuropathic foot ulcer
    D Scot Malay
    Ankle and Foot Medical Center of the Delaware Valley, Philadephia, PA 19104, USA
    J Foot Ankle Surg 45:366-74. 2006
    ..These findings should be useful to clinicians treating diabetic neuropathic foot ulcers, and should aid surgeons in the determination of the most appropriate level for lower extremity amputation...
  49. ncbi request reprint Determinants of quality of life in patients with psoriasis: a study from the US population
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, USA
    J Am Acad Dermatol 51:704-8. 2004
    ..Psoriasis is a common disease with substantial effects on quality of life. Few quality of life studies have been performed in psoriasis patients from the general US population...
  50. pmc Antibiotics, acne, and Staphylococcus aureus colonization
    Matthew Fanelli
    Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 147:917-21. 2011
    ..To determine the frequency of Staphylococcus aureus colonization among patients with acne and to compare the susceptibility patterns between the patients who are using antibiotics and those who are not using antibiotics...
  51. ncbi request reprint Relative risks and confidence intervals were easily computed indirectly from multivariable logistic regression
    A Russell Localio
    Division of Biostatistics, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:874-82. 2007
    ..To assess alternative statistical methods for estimating relative risks and their confidence intervals from multivariable binary regression when outcomes are common...
  52. ncbi request reprint Prevalence of erectile dysfunction and active depression: an analytic cross-sectional study of general medical patients
    Jonathan Kantor
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Epidemiol 156:1035-42. 2002
    ..3, 95% CI: 0.5, 3.1; p = 0.565). Concomitant erectile dysfunction and depression represent a significant public health problem...
  53. ncbi request reprint Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers
    David J Margolis
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1275-80. 2007
    ..To explore an association between the use of beta-adrenergic receptor agonists or antagonists and the onset of venous leg ulcers (VLUs)...
  54. ncbi request reprint Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists
    Michael Shapiro
    Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Cutan Pathol 31:523-30. 2004
    ..A 1992 National Institutes of Health (NIH) Consensus Conference sought to unify nomenclature and suggested that the term "nevus with architectural disorder" be used along with a comment on melanocytic atypia...
  55. ncbi request reprint Lack of association between exposure to topical calcineurin inhibitors and skin cancer in adults
    David J Margolis
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dermatology 214:289-95. 2007
    ..Two topical calcineurin inhibitors (TCI) are available for the treatment of atopic dermatitis and there has been concern that their use could be associated with an increased risk of nonmelanoma skin cancer (NMSC)...
  56. ncbi request reprint Systemic therapy does not usually clear psoriasis, but treatment success does not require clearing
    Steven R Feldman
    Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Acad Dermatol 52:140-1. 2005
  57. doi request reprint Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis
    David J Margolis
    Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 2Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Dermatol 150:254-9. 2014
    ..Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in individuals with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials. ..
  58. pmc Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012
    Michael R Sargen
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 134:51-7. 2014
    ..Higher humidity (OR=0.90, 95% CI: 0.812-0.997, P=0.04) was also associated with poorly controlled disease, but the statistical significance of this association was lost in our multivariate analysis (P=0.44). ..
  59. ncbi request reprint Lymphoma rates are low but increased in patients with psoriasis: results from a population-based cohort study in the United Kingdom
    Joel M Gelfand
    Department of Dermatology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadephia 19104, USA
    Arch Dermatol 139:1425-9. 2003
    ..To determine if the rate of lymphoma in patients with a history of psoriasis is different from the rate of lymphoma in patients without psoriasis...
  60. ncbi request reprint Surrogate endpoints for the treatment of venous leg ulcers
    Joel M Gelfand
    Department of Dermatology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Invest Dermatol 119:1420-5. 2002
    ....
  61. ncbi request reprint The lack of a relationship between atopic dermatitis and nonmelanoma skin cancers
    Michael E Ming
    Department of Dermatology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 50:357-62. 2004
    ..Very little has been published on whether a relationship exists between atopic dermatitis (AD) and skin cancer...
  62. ncbi request reprint Antibiotics, acne, and upper respiratory tract infections
    David J Margolis
    Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
    LDI Issue Brief 11:1-4. 2006
    ..This Issue Brief summarizes a large study that evaluates the risk for upper respiratory and urinary tract infections among adolescents and young adults treated with antibiotics for acne...
  63. ncbi request reprint Upper respiratory tract infection in household contacts of acne patients
    Whitney P Bowe
    Department of Dermatology, University of Pennsylvania Center for Education and Research in Therapeutics, Philadelphia, PA, USA
    Dermatology 215:213-8. 2007
    ..Antibiotic use in acne patients has been associated with an increased risk of upper respiratory tract infection (URTI)...
  64. pmc Inhibition of propionibacterium acnes by bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius
    Whitney P Bowe
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Drugs Dermatol 5:868-70. 2006
    ..These findings suggest that BLIS may potentially be used for its anti-P. acnes activity in the treatment of acne...
  65. doi request reprint Epidemiology of foot ulceration and amputation: can global variation be explained?
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Med Clin North Am 97:791-805. 2013
    ..This area of study requires further investigation...
  66. ncbi request reprint Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction
    Robert S Stern
    Beth Israel Deaconess Medical Center, Department of Dermatology, Harvard Medical School, Department of Dermatology, Boston, Massachusetts, USA
    J Investig Dermatol Symp Proc 9:136-9. 2004
    ..Many individuals with little psoriasis at the time of interview considered the disease to be a large problem in everyday life...
  67. doi request reprint A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers
    Pamela A Morganroth
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 60:444-52. 2009
    ..We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery...
  68. ncbi request reprint Antibiotic treatment of acne may be associated with upper respiratory tract infections
    David J Margolis
    Departments of Dermatology and Biostatistics and Epidemiology, Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Dermatol 141:1132-6. 2005
    ..To determine if the long-term use of antibiotics for the treatment of acne results in an increase in either of 2 common infectious illnesses: upper respiratory tract infections (URTIs) or urinary tract infections...
  69. ncbi request reprint Venous leg ulcer: incidence and prevalence in the elderly
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 46:381-6. 2002
    ..Venous leg ulcer is a disease most common in those aged 65 years and older. However, the incidence and prevalence have not been well established...
  70. pmc Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy
    Stephen R Thom
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6068, USA
    Wound Repair Regen 19:149-61. 2011
    ..We conclude that HBO(2) T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds...
  71. ncbi request reprint Effect of antibiotics on the oropharyngeal flora in patients with acne
    Ross M Levy
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Dermatol 139:467-71. 2003
    ..To estimate the prevalence and resistance patterns of Streptococcus pyogenes and Staphylococcus aureus in the oropharynx of individuals with acne who were using or not using antibiotic therapy...
  72. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  73. ncbi request reprint Statistical characteristics of area under the receiver operating characteristic curve for a simple prognostic model using traditional and bootstrapped approaches
    David J Margolis
    Department of Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19004, USA
    J Clin Epidemiol 55:518-24. 2002
    ..We further show that for our simple prognostic model a bootstrap z-statistic approach is preferred over the trapezoidal method when comparing the AROCs of two related models...
  74. doi request reprint Delayed treatment and continued growth of nonmelanoma skin cancer
    Murad Alam
    Section of Cutaneous and Aesthetic Surgery, Department of Dermatology, Northwestern University, Chicago, Illinois 60611, USA
    J Am Acad Dermatol 64:839-48. 2011
    ..Patients may delay treatment for skin cancer for various reasons. Prior research on treatment delay has focused on melanoma rather than nonmelanoma skin cancer (NMSC), which is much more common...
  75. ncbi request reprint Management of leg ulcers
    Jonathan Kantor
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Semin Cutan Med Surg 22:212-21. 2003
    ..We discuss the evidence for using compression, vitamin and mineral supplementation, antibiotic use, growth factors, and other interventions in the management of these wounds...
  76. ncbi request reprint Medical conditions as risk factors for pressure ulcers in an outpatient setting
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Age Ageing 32:259-64. 2003
    ..the purpose of this study was to evaluate the likelihood that the presence of certain medical conditions in older ambulatory patients are associated with the risk of developing a new pressure ulcer...
  77. ncbi request reprint Use of photographs for the identification of pressure ulcers in elderly hospitalized patients: validity and reliability
    A Russell Localio
    Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Wound Repair Regen 14:506-13. 2006
    ..69 and 0.84, respectively. Trained research nurses can accurately classify pressure ulcers from photographs, even when patients are largely non-White and the photographs depict pressure ulcers spanning all pressure ulcer stages...
  78. ncbi request reprint Prevalence and factors associated with use of placebo control groups in randomized controlled trials in psoriasis: a cross-sectional study
    Kenneth A Katz
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 55:814-22. 2006
    ..The ethics and science of using placebo control groups in clinical trials have been widely debated. Few studies, however, have examined factors associated with choice of control group...
  79. doi request reprint Does inflammation have a role in the pathogenesis of venous ulcers? A critical review of the evidence
    Yen Chen Liu
    Department of Dermatology, University of California, Davis, California 95616, USA
    J Invest Dermatol 131:818-27. 2011
    ..At the same time, there are few reviews that critically analyze and evaluate these data. Therefore, in this paper, we will provide summaries of the background data and evolution of these theories and examine their supporting evidence...
  80. ncbi request reprint Evidence-based dermatology
    David J Margolis
    From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Cutis 75:8-12; discussion 33-6. 2005
    ..For the treatment of rosacea, oral tetracycline, topical metronidazole, topical azelaic acid, and topical sulfur/sodium sulfacetamide have been validated by more than one randomized controlled trial...
  81. ncbi request reprint Statistical reviewing policies in dermatology journals: results of a questionnaire survey of editors
    Kenneth A Katz
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    J Am Acad Dermatol 51:234-40. 2004
    ..Problems with statistical methods and reporting have been noted in articles published in dermatology journals. Conclusions presented in published reports may be misleading if based on inappropriate or misinterpreted statistical analysis...
  82. ncbi request reprint Mail surveys can achieve high response rates in a dermatology patient population
    Jennifer C Filip
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 122:39-43. 2004
    ..Dillman's Total Design Method appears to be an effective tool for researchers studying the burden of skin disease in a large sample of dermatology patients...
  83. ncbi request reprint Digital imaging of wounds: are measurements reproducible among observers?
    Susan Y Quan
    Department of Dermatology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    Int J Low Extrem Wounds 6:245-8. 2007
    ..This supports the use of digital images of wounds to follow clinical progress as well as analyze the effects of new clinical interventions in clinical trials...
  84. ncbi request reprint Guidelines for the treatment of venous ulcers
    Martin C Robson
    University of South Florida, Tampa, FL, USA
    Wound Repair Regen 14:649-62. 2006
  85. ncbi request reprint Traditional systemic treatments have not fully met the needs of psoriasis patients: results from a national survey
    Tamar Nijsten
    Department of Dermatology at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Acad Dermatol 52:434-44. 2005
    ..Many psoriasis patients are dissatisfied with current therapies. However, patient-centered levels of satisfaction with individual treatments have not been well described...
  86. ncbi request reprint Risk of amputation in patients with diabetic foot ulcers: a claims-based study
    Jeffrey S Markowitz
    Health Data Analytics, Princeton Junction, New Jersey 08550, USA
    Wound Repair Regen 14:11-7. 2006
    ....
  87. ncbi request reprint Pressure ulcers among elderly patients early in the hospital stay
    Mona Baumgarten
    Department of Epidemiology and Preventive Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 61:749-54. 2006
    ..The goals of this study were to estimate the incidence of hospital-acquired pressure ulcers in the first 2 days of the hospital stay and to identify patient characteristics associated with higher incidence...
  88. ncbi request reprint Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers
    David J Margolis
    Lancet 359:675-7. 2002
    ..65 [95% CI 0.61-0.69]) or a pressure ulcer (0.68 [0.62-0.76]) than those who did not use HRT. Therefore, we believe that HRT could be beneficial for the prevention of these wounds...
  89. ncbi request reprint The prevalence of atopic triad in children with physician-confirmed atopic dermatitis
    Roger Kapoor
    George Washington University School of Medicine, Washington, District of Columbia
    J Am Acad Dermatol 58:68-73. 2008
    ..Atopic dermatitis (AD) is often associated with comorbidities such as allergic rhinitis and asthma...
  90. ncbi request reprint Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines"
    Jon M Hanifin
    American Academy of Dermatology, PO Box 4014, Schaumburg, IL 60168 4014, USA
    J Am Acad Dermatol 50:391-404. 2004
  91. ncbi request reprint Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins: multicenter retrospective analysis of 48 consecutive cases
    Christa Prins
    Department of Dermatology, Geneva University Medical School, Switzerland
    Arch Dermatol 139:26-32. 2003
    ..To evaluate the effect of high-dose intravenous immunoglobulin (IVIG) in toxic epidermal necrolysis (TEN), parameters that may affect response to treatment, and the effect of different IVIG batches on Fas-mediated cell death...