Wolfgang Maret

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Zinc coordination environments in proteins determine zinc functions
    Wolfgang Maret
    Division of Human Nutrition, Departments of Preventive Medicine and Community Health and Anesthesiology, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    J Trace Elem Med Biol 19:7-12. 2005
  2. ncbi request reprint Zinc requirements and the risks and benefits of zinc supplementation
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, Division of Human Nutrition, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    J Trace Elem Med Biol 20:3-18. 2006
  3. doi request reprint Metalloproteomics, metalloproteomes, and the annotation of metalloproteins
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77551, USA
    Metallomics 2:117-25. 2010
  4. ncbi request reprint Zinc coordination environments in proteins as redox sensors and signal transducers
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, 77555, USA
    Antioxid Redox Signal 8:1419-41. 2006
  5. pmc Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1109, USA
    Mol Med 13:371-5. 2007
  6. ncbi request reprint Zinc and sulfur: a critical biological partnership
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 700 Harborside Drive, Galveston, Texas 77555, USA
    Biochemistry 43:3301-9. 2004
  7. doi request reprint Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    Exp Gerontol 43:363-9. 2008
  8. doi request reprint A role for metallothionein in the pathogenesis of diabetes and its cardiovascular complications
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    Mol Genet Metab 94:1-3. 2008
  9. doi request reprint Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, Division of Human Nutrition, The University of Texas Medical Branch, 7Galveston, TX 77555 1109, USA
    Biometals 22:149-57. 2009
  10. doi request reprint Fluorescent probes for the structure and function of metallothionein
    Wolfgang Maret
    Departments of Preventive Medicine and Community Health and Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3378-83. 2009

Research Grants

  1. Regulation of Celluar Zinc Distribution
    Wolfgang Maret; Fiscal Year: 2004

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Zinc coordination environments in proteins determine zinc functions
    Wolfgang Maret
    Division of Human Nutrition, Departments of Preventive Medicine and Community Health and Anesthesiology, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    J Trace Elem Med Biol 19:7-12. 2005
    ..Insights into all these functions are building an understanding of why zinc is so critical for such a multitude of life processes...
  2. ncbi request reprint Zinc requirements and the risks and benefits of zinc supplementation
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, Division of Human Nutrition, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    J Trace Elem Med Biol 20:3-18. 2006
    ..In our opinion, a multidisciplinary approach will most likely result in success in this fertile area for translational research...
  3. doi request reprint Metalloproteomics, metalloproteomes, and the annotation of metalloproteins
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77551, USA
    Metallomics 2:117-25. 2010
    ..Failure to recognize the principles of metal utilization has led to assigning the wrong metal in metalloproteins and has missed some of the regulatory functions of transition metal ions...
  4. ncbi request reprint Zinc coordination environments in proteins as redox sensors and signal transducers
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, 77555, USA
    Antioxid Redox Signal 8:1419-41. 2006
    ..Depending on its availability, zinc can be cytoprotective as a pro-antioxidant or cytotoxic as a pro-oxidant. Any condition with acute or chronic oxidative stress is expected to perturb zinc homeostasis...
  5. pmc Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1109, USA
    Mol Med 13:371-5. 2007
    ..The implications of these fundamental principles for zinc metabolism in type 2 diabetes are briefly discussed...
  6. ncbi request reprint Zinc and sulfur: a critical biological partnership
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 700 Harborside Drive, Galveston, Texas 77555, USA
    Biochemistry 43:3301-9. 2004
  7. doi request reprint Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    Exp Gerontol 43:363-9. 2008
    ....
  8. doi request reprint A role for metallothionein in the pathogenesis of diabetes and its cardiovascular complications
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    Mol Genet Metab 94:1-3. 2008
    ..Both zinc and metallothionein protect cells against the redox stress that occurs in diabetes and contributes to its progression towards diabetic complications, including heart disease...
  9. doi request reprint Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, Division of Human Nutrition, The University of Texas Medical Branch, 7Galveston, TX 77555 1109, USA
    Biometals 22:149-57. 2009
    ....
  10. doi request reprint Fluorescent probes for the structure and function of metallothionein
    Wolfgang Maret
    Departments of Preventive Medicine and Community Health and Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3378-83. 2009
    ..Attachment of fluorescent labels generated metallothionein FRET (fluorescence resonance energy transfer) sensors for investigating its structure and function in living cells...
  11. ncbi request reprint Dual nanomolar and picomolar Zn(II) binding properties of metallothionein
    Artur Krezel
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Am Chem Soc 129:10911-21. 2007
    ..These chemical characteristics match cellular requirements for Zn(II) and suggest how the molecular structures and redox chemistries of metallothionein and thionein determine Zn(II) availability for biological processes...
  12. ncbi request reprint The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling
    Artur Krezel
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Division of Human Nutrition, 700 Harborside Drive, Galveston, TX 77555, USA
    Arch Biochem Biophys 463:188-200. 2007
    ..At the center of zinc/redox signaling are the zinc/thiolate clusters of metallothionein. They can transduce zinc and redox signals and thereby attenuate or amplify these signals...
  13. pmc The relationship between transient zinc ion fluctuations and redox signaling in the pathways of secondary cellular injury: relevance to traumatic brain injury
    Yuan Li
    Division of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Brain Res 1330:131-41. 2010
    ..The combined results from the cellular and in vivo investigations caution against interpreting zinc ion fluctuations in the early phase (24h) after injury as a primarily cytotoxic event...
  14. ncbi request reprint Aldehydes release zinc from proteins. A pathway from oxidative stress/lipid peroxidation to cellular functions of zinc
    Qiang Hao
    Departments of Preventive Medicine and Community Health and Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    FEBS J 273:4300-10. 2006
    ..The zinc-releasing activity of aldehydes establishes relationships among cellular zinc, the functions of endogenous and xenobiotic aldehydes, and redox stress, with implications for pathobiochemical and toxicologic mechanisms...
  15. pmc Different redox states of metallothionein/thionein in biological tissue
    Artur Krezel
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Biochem J 402:551-8. 2007
    ....
  16. doi request reprint Transient fluctuations of intracellular zinc ions in cell proliferation
    Yuan Li
    Division of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Exp Cell Res 315:2463-70. 2009
    ..Interventions targeted at these picomolar Zn(2+) fluctuations may be a way of controlling cell growth in hyperplasia, neoplasia, and diseases associated with aberrant differentiation...
  17. ncbi request reprint Thionein/metallothionein control Zn(II) availability and the activity of enzymes
    Artur Krezel
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Inorg Chem 13:401-9. 2008
    ..The match between the Zn(II) buffering capacity of MT and the Zn(II) affinity of proteins suggests a function of MT in controlling cellular Zn(II) availability...
  18. ncbi request reprint Zinc-buffering capacity of a eukaryotic cell at physiological pZn
    Artur Krezel
    Division of Human Nutrition, Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Inorg Chem 11:1049-62. 2006
    ..Jointly, metallothionein and thionein function as the major zinc buffer under conditions of increased cellular zinc...
  19. ncbi request reprint Lipid raft-dependent endocytosis of metallothionein in HepG2 cells
    Qiang Hao
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Cell Physiol 210:428-35. 2007
    ..Together with results from other studies demonstrating secretion of MT from different cells and the presence of MT in extracellular fluids, the results suggest a function of MT in intercellular communication...
  20. ncbi request reprint Possible roles of zinc nutriture in the fetal origins of disease
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    Exp Gerontol 43:378-81. 2008
    ..We suspect that zinc deficiency is a far greater human health problem than is generally recognized...
  21. ncbi request reprint Imbalance between pro-oxidant and pro-antioxidant functions of zinc in disease
    Qiang Hao
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Alzheimers Dis 8:161-70; discussion 209-15. 2005
    ....
  22. ncbi request reprint Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biology
    Cathleen Frederickson
    NeuroBioTex, Galveston, TX 77550, USA
    Sci STKE 2007:pe61. 2007
    ....
  23. ncbi request reprint Zinc and excitotoxic brain injury: a new model
    Christopher J Frederickson
    NeuroBioTex, Inc, Galveston, Texas 77550, USA
    Neuroscientist 10:18-25. 2004
    ..The authors present a new model of zinc currents and zinc toxicity that offers expanded opportunities for zinc-selective therapeutic chelation interventions...
  24. ncbi request reprint A differential assay for the reduced and oxidized states of metallothionein and thionein
    Hajo Haase
    Department of Pathology, Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Bldg 600, 3rd Floor, Cambridge, MA 02139, USA
    Anal Biochem 333:19-26. 2004
    ..It should also greatly facilitate the characterization of the redox and metal-binding properties of zinc/thiolate coordination environments of other proteins such as zinc finger proteins...
  25. ncbi request reprint Optical methods for measuring zinc binding and release, zinc coordination environments in zinc finger proteins, and redox sensitivity and activity of zinc-bound thiols
    Wolfgang Maret
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Methods Enzymol 348:230-7. 2002
  26. pmc A fluorescence resonance energy transfer sensor for the beta-domain of metallothionein
    Sung Hye Hong
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Building 600, 3rd Floor, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:2255-60. 2003
    ..Energy transfer between Alexa 488 (donor) and Alexa 546 (acceptor) in double-labeled MT allows the monitoring of metal binding and conformational changes in the N-terminal beta-domain of the protein...
  27. ncbi request reprint S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation
    Yu Chen
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Building 600, Cambridge, Massachusetts 02139, USA
    Biochemistry 41:8360-7. 2002
    ..This could bear importantly on the physiological action of MT-III, whose biological activity as a neuronal growth inhibitory factor is unique, and for brain diseases that have been related to oxidative or nitrosative stress...
  28. ncbi request reprint Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases
    Hajo Haase
    Center for Biochemical and Biophysical Sciences and Medicine, Department of Pathology, Harvard Medical School, Cambridge, MA 02115, USA
    J Trace Elem Med Biol 19:37-42. 2005
    ..In conclusion, a pool of cellular, available zinc participates in phosphorylation/dephosphorylation cascades, suggesting the existence of a cellular signaling system based on zinc as a second messenger...
  29. ncbi request reprint Cellular zinc and redox states converge in the metallothionein/thionein pair
    Wolfgang Maret
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Cambridge, MA 02139, USA
    J Nutr 133:1460S-2S. 2003
    ..Thus, hitherto unknown interactions between the essential micronutrients zinc and selenium on the one hand and zinc and redox metabolism on the other are key features of the cellular homeostatic zinc system...
  30. ncbi request reprint Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling
    Hajo Haase
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Bldg 600, 3rd Floor, Cambridge, MA 02139, USA
    Exp Cell Res 291:289-98. 2003
    ..In the context of the emerging concept that intracellular zinc is tightly regulated and fluctuates dynamically, these results suggest that a pool of cellular zinc modulates phosphorylation signaling...
  31. ncbi request reprint Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants
    Hajo Haase
    Institute of Immunology, University Hospital RWTH Aachen, Germany
    Biometals 18:333-8. 2005
    ..Zinc deficiency activates stress pathways and may result in a loss of tyrosine phosphatase control, thereby causing insulin resistance...
  32. ncbi request reprint Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 332:853-8. 2005
    ..The m-aconitase, not the cytosolic aconitase (c-aconitase), was co-immunoprecipitated with MT. This study demonstrates that MT transfers zinc to m-aconitase through a direct interaction...
  33. ncbi request reprint The ATP/metallothionein interaction: NMR and STM
    Wolfgang Maret
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Seeley G Mudd Building, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 41:1689-94. 2002
    ..Both MT and ATP are localized there, and MT and thionein alternately bind and release zinc, thereby affecting mitochondrial respiration...

Research Grants4

  1. Regulation of Celluar Zinc Distribution
    Wolfgang Maret; Fiscal Year: 2004
    ..abstract_text> ..