Laura Marcu

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy
    L Marcu
    Laser Research and Technology Development, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 21:1244-50. 2001
  2. ncbi request reprint Fluorescence lifetime spectroscopy of glioblastoma multiforme
    Laura Marcu
    Biophotonics Research and Technology Development Laboratory, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Photochem Photobiol 80:98-103. 2004
  3. pmc In vivo detection of macrophages in a rabbit atherosclerotic model by time-resolved laser-induced fluorescence spectroscopy
    Laura Marcu
    Biophotonics Research and Technology Development, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 181:295-303. 2005
  4. pmc Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy
    William H Yong
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Front Biosci 11:1255-63. 2006
  5. doi request reprint Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy
    Pramod V Butte
    Cedars Sinai Medical Center, Department of Neurosurgery, 8631 West 3rd Street, Suite 800E, Los Angeles, California 90048, USA
    J Biomed Opt 15:027008. 2010
  6. ncbi request reprint Fluorescence microscopy imaging of electroperturbation in mammalian cells
    Yinghua Sun
    University of Southern California, Department of Chemical Engineering and Materials Science, Los Angeles, California, USA
    J Biomed Opt 11:024010. 2006
  7. ncbi request reprint Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis
    JingJing Wang
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 12:044021. 2007
  8. pmc Diagnosis of meningioma by time-resolved fluorescence spectroscopy
    Pramod V Butte
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 10:064026. 2005
  9. pmc A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions
    Olga V Ivanova
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    Ann Biomed Eng 33:531-44. 2005
  10. ncbi request reprint Fast model-free deconvolution of fluorescence decay for analysis of biological systems
    Javier A Jo
    Cedars Sinai Medical Center, Department of Surgery, Biophotonics Research and Technology Development, Los Angeles, California 90048, USA
    J Biomed Opt 9:743-52. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Discrimination of human coronary artery atherosclerotic lipid-rich lesions by time-resolved laser-induced fluorescence spectroscopy
    L Marcu
    Laser Research and Technology Development, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 21:1244-50. 2001
    ....
  2. ncbi request reprint Fluorescence lifetime spectroscopy of glioblastoma multiforme
    Laura Marcu
    Biophotonics Research and Technology Development Laboratory, Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Photochem Photobiol 80:98-103. 2004
    ..Combined information from both the spectral- and the time domain can enhance the ability of fluorescence-based techniques to diagnose and detect brain tumor margins intraoperatively...
  3. pmc In vivo detection of macrophages in a rabbit atherosclerotic model by time-resolved laser-induced fluorescence spectroscopy
    Laura Marcu
    Biophotonics Research and Technology Development, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 181:295-303. 2005
    ..Our results suggest that TR-LIFS technique can be used in clinical applications for identification of inflammatory cells important in plaque formation and rupture...
  4. pmc Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy
    William H Yong
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Front Biosci 11:1255-63. 2006
    ..Taking advantage of tissue autofluorescence, this technique facilitates a direct and rapid investigation of surgically obtained tissue...
  5. doi request reprint Intraoperative delineation of primary brain tumors using time-resolved fluorescence spectroscopy
    Pramod V Butte
    Cedars Sinai Medical Center, Department of Neurosurgery, 8631 West 3rd Street, Suite 800E, Los Angeles, California 90048, USA
    J Biomed Opt 15:027008. 2010
    ..In addition, this study evaluates similarities and differences between TR-LIFS signatures of brain tumors obtained in vivo and those previously reported in ex vivo brain tumor specimens...
  6. ncbi request reprint Fluorescence microscopy imaging of electroperturbation in mammalian cells
    Yinghua Sun
    University of Southern California, Department of Chemical Engineering and Materials Science, Los Angeles, California, USA
    J Biomed Opt 11:024010. 2006
    ....
  7. ncbi request reprint Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis
    JingJing Wang
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 12:044021. 2007
    ..These findings demonstrate that QD-labeled antibodies can provide a quick and accurate method for characterizing the presence or absence of a specific predictive biomarker...
  8. pmc Diagnosis of meningioma by time-resolved fluorescence spectroscopy
    Pramod V Butte
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 10:064026. 2005
    ....
  9. pmc A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions
    Olga V Ivanova
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    Ann Biomed Eng 33:531-44. 2005
    ..The FIRK retrieved using this method can further facilitate modeling and recognition of pathological and physiological conditions in tissues...
  10. ncbi request reprint Fast model-free deconvolution of fluorescence decay for analysis of biological systems
    Javier A Jo
    Cedars Sinai Medical Center, Department of Surgery, Biophotonics Research and Technology Development, Los Angeles, California 90048, USA
    J Biomed Opt 9:743-52. 2004
    ....
  11. pmc Fluorescence lifetime spectroscopy for guided therapy of brain tumors
    Pramod V Butte
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Neuroimage 54:S125-35. 2011
    ....
  12. doi request reprint A novel noninvasive all optical technique to monitor physiology of an exercising muscle
    Vishal Saxena
    Department of Radiology, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Phys Med Biol 53:6211-25. 2008
    ..The understanding of tissue oxygenation status and the behavior of the physiological parameters derived from thermometry may provide a useful insight into muscle physiology, therapeutic response and treatment...
  13. ncbi request reprint Time-resolved fluorescence spectra of arterial fluorescent compounds: reconstruction with the Laguerre expansion technique
    J M Maarek
    Department of Biomedical Engineering, University of Southern California, Los Angeles 90089 1451, USA
    Photochem Photobiol 71:178-87. 2000
    ....
  14. ncbi request reprint Time-resolved fluorescence of human aortic wall: use for improved identification of atherosclerotic lesions
    J M Maarek
    Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USA
    Lasers Surg Med 27:241-54. 2000
    ..This study characterized aortic time-resolved fluorescence spectra for stratified levels of atherosclerosis and proposed interpretation of spectrotemporal variations in terms of histologic changes...
  15. doi request reprint Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo
    Kuo Chih Liao
    Alfred E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    Biosens Bioelectron 23:1458-65. 2008
    ..Chronic animal implantation studies have demonstrated good biocompatibility and durability for clinical applications...
  16. ncbi request reprint In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies
    Edward B Garon
    Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Int J Cancer 121:675-82. 2007
    ..Therefore, nanoelectropulse therapy deserves further study as a potentially effective cancer therapy...
  17. ncbi request reprint Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm
    Thanassis Papaioannou
    Biophotonics Research and Technology Development, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Appl Opt 43:2846-60. 2004
    ..The findings can be applied toward optimization of fiber-optic probe designs for quantitative optical spectroscopy of turbid media including biological tissues...
  18. ncbi request reprint Electrode microchamber for noninvasive perturbation of mammalian cells with nanosecond pulsed electric fields
    Yinghua Sun
    Materials Science Department, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Nanobioscience 4:277-83. 2005
    ..Experimental studies utilizing the electrode microchamber include live-cell imaging of nanoelectropulse-induced intracellular calcium bursts and membrane phospholipid translocation...
  19. pmc Nanoelectropulse-induced phosphatidylserine translocation
    P Thomas Vernier
    Department of Electrical Engineering Electrophysics, School of Engineering, MOSIS, University of Southern California, Los Angeles, California, USA
    Biophys J 86:4040-8. 2004
    ....
  20. ncbi request reprint Calcium bursts induced by nanosecond electric pulses
    P Thomas Vernier
    Department of Electrical Engineering Electrophysics, School of Engineering, University of Southern California, Los Angeles, CA 90089 0271, USA
    Biochem Biophys Res Commun 310:286-95. 2003
    ..Nanosecond pulsed electric fields, because their duration is less than the plasma membrane charging time, develop voltages across intracellular structures without porating the cell...
  21. ncbi request reprint Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy
    Peter Ashjian
    Laboratory for Regenerative Bioengineering and Repair, Departments of Surgery and Orthopedics, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Tissue Eng 10:411-20. 2004
    ....
  22. ncbi request reprint Intraluminal fluorescence spectroscopy catheter with ultrasound guidance
    Douglas N Stephens
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048
    J Biomed Opt 14:030505. 2009
    ..53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS...
  23. pmc Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase
    Mahsa Rouhanizadeh
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089 1451, USA
    Free Radic Biol Med 39:1512-22. 2005
    ..Treatment with ox-PAPC also increased MMP-2 mRNA expression accompanied by a 1.5-fold increase in MMP-2 activity. Ox-PAPC induced vascular endothelial OO2-(.) production that appears to be mediated largely by NADPH oxidase activity...
  24. ncbi request reprint Nanosecond pulsed electric fields perturb membrane phospholipids in T lymphoblasts
    P Thomas Vernier
    Department of Materials Science, School of Engineering, University of Southern California, Los Angeles, CA 90089 0271, USA
    FEBS Lett 572:103-8. 2004
    ....
  25. pmc Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions
    Javier A Jo
    University of California Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 11:021004. 2006
    ..This study demonstrates the potential of the LDT for in-vivo tissue diagnosis, and specifically for the detection of macrophages infiltration in atherosclerotic lesions, a key marker of plaque vulnerability...
  26. ncbi request reprint Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis
    Yinghua Sun
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California, 95616, USA
    Opt Lett 33:630-2. 2008
    ..The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems...