Laura Marcu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis
    Hongtao Xie
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA
    Biomed Opt Express 3:1521-33. 2012
  2. pmc Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis
    Yinghua Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Opt Express 19:3890-901. 2011
  3. pmc Fluorescence lifetime techniques in medical applications
    Laura Marcu
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Ann Biomed Eng 40:304-31. 2012
  4. pmc Fluorescence lifetime in cardiovascular diagnostics
    Laura Marcu
    University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 15:011106. 2010
  5. pmc Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy
    Laura Marcu
    University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
    Atherosclerosis 204:156-64. 2009
  6. pmc Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions
    Javier A Jo
    University of California Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 11:021004. 2006
  7. pmc Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques
    Jennifer Phipps
    University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 16:096018. 2011
  8. pmc Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma
    Yinghua Sun
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Microsc Microanal 19:791-8. 2013
  9. pmc Time-resolved laser-induced fluorescence spectroscopy as a diagnostic instrument in head and neck carcinoma
    Jeremy D Meier
    Department of Otolaryngology Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USA
    Otolaryngol Head Neck Surg 142:838-44. 2010
  10. pmc Time-resolved fluorescence spectroscopy as a diagnostic technique of oral carcinoma: Validation in the hamster buccal pouch model
    D Gregory Farwell
    Department of Otolaryngology Head and Neck Surgery, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Otolaryngol Head Neck Surg 136:126-33. 2010

Collaborators

Detail Information

Publications32

  1. pmc Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis
    Hongtao Xie
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA
    Biomed Opt Express 3:1521-33. 2012
    ....
  2. pmc Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosis
    Yinghua Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Opt Express 19:3890-901. 2011
    ..Current results demonstrate the potential of STWRFS as a tool for real-time optical characterization of arterial tissue composition and for atherosclerosis research and diagnosis...
  3. pmc Fluorescence lifetime techniques in medical applications
    Laura Marcu
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Ann Biomed Eng 40:304-31. 2012
    ....
  4. pmc Fluorescence lifetime in cardiovascular diagnostics
    Laura Marcu
    University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 15:011106. 2010
    ..Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications...
  5. pmc Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopy
    Laura Marcu
    University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
    Atherosclerosis 204:156-64. 2009
    ..We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques...
  6. pmc Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions
    Javier A Jo
    University of California Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 11:021004. 2006
    ..This study demonstrates the potential of the LDT for in-vivo tissue diagnosis, and specifically for the detection of macrophages infiltration in atherosclerotic lesions, a key marker of plaque vulnerability...
  7. pmc Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaques
    Jennifer Phipps
    University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 16:096018. 2011
    ..g., ratios of lipid versus collagen versus elastin) can be evaluated with a flexible-fiber based FLIM technique without the need for fluorescence intensity information or contrast agents...
  8. pmc Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma
    Yinghua Sun
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Microsc Microanal 19:791-8. 2013
    ..21 ± 0.04 ns) than the surrounding normal tissue (τN = 1.49 ± 0.06 ns). This work demonstrates the potential of FLIM for label-free head and neck tumor demarcation during intraoperative surgical procedures...
  9. pmc Time-resolved laser-induced fluorescence spectroscopy as a diagnostic instrument in head and neck carcinoma
    Jeremy D Meier
    Department of Otolaryngology Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USA
    Otolaryngol Head Neck Surg 142:838-44. 2010
    ....
  10. pmc Time-resolved fluorescence spectroscopy as a diagnostic technique of oral carcinoma: Validation in the hamster buccal pouch model
    D Gregory Farwell
    Department of Otolaryngology Head and Neck Surgery, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Otolaryngol Head Neck Surg 136:126-33. 2010
    ..To investigate the benefit of using time-resolved, laser-induced fluorescence spectroscopy for diagnosing malignant and premalignant lesions of the oral cavity...
  11. pmc Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound
    Julien Bec
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California 95616, USA
    J Biomed Opt 17:106012. 2012
    ..These results facilitate further development of a FLIm-IVUS technique for intravascular diagnosis of atherosclerotic cardiovascular diseases including vulnerable plaques...
  12. pmc In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma
    Yang Sun
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616, USA
    J Biomed Opt 17:116003. 2012
    ....
  13. ncbi Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis
    Yinghua Sun
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California, 95616, USA
    Opt Lett 33:630-2. 2008
    ..The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems...
  14. pmc Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy
    Yang Sun
    Biomedical Engineering, University of California at Davis, Davis, California 95616, USA
    Rev Sci Instrum 80:065104. 2009
    ..Current design and performance of the hybrid system suggests potential applications in clinical diagnosis of atherosclerotic plaque...
  15. pmc Two-photon excited fluorescence lifetime measurements through a double-clad photonic crystal fiber for tissue micro-endoscopy
    Florian Knorr
    Department of Biomedical Engineering Davis, University of California, Davis, California 95616, USA
    J Biophotonics 5:14-9. 2012
    ..This simple setup, which offers larger penetration depth than one-photon-based techniques, may be combined with morphology-yielding techniques such as photoacoustic and ultrasound imaging...
  16. pmc Design and evaluation of a device for fast multispectral time-resolved fluorescence spectroscopy and imaging
    Diego R Yankelevich
    Department of Electrical and Computer Engineering, University of California, 3101 Kemper Hall, Davis, California 95616, USA
    Rev Sci Instrum 85:034303. 2014
    ..The ms-TRFS is a compact apparatus that makes possible the fast, accurate, and precise multispectral time-resolved fluorescence lifetime measurements of low quantum efficiency sub-nanosecond fluorophores. ..
  17. pmc A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque
    Jennifer E Phipps
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    Lasers Surg Med 44:564-71. 2012
    ..FLIM and other time-resolved fluorescence techniques have recently been applied to the study of atherosclerosis based on the ability to assess biochemical composition...
  18. pmc Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy
    Yang Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA, USA
    Tissue Eng Part C Methods 18:215-26. 2012
    ..Therefore, the technique was capable of nondestructively evaluating the composition of extracellular matrix and the microstructure of engineered tissue, demonstrating great potential as an alternative to traditional destructive assays...
  19. pmc Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery
    Yinghua Sun
    University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
    J Biomed Opt 15:056022. 2010
    ..05) and a longer lifetime τGBM-Amean=1.59±0.24 ns than normal cortex τNC-Amean=1.28±0.04 ns (p-value<0.005). Current results demonstrate the potential use of FLIM as a tool for image-guided surgery of brain tumors...
  20. pmc Rotational multispectral fluorescence lifetime imaging and intravascular ultrasound: bimodal system for intravascular applications
    Dinglong Ma
    University of California, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616
    J Biomed Opt 19:066004. 2014
    ..The current finding demonstrates the compatibility of FLIm instrumentation with in vivo clinical investigations and its potential to complement conventional IVUS during catheterization procedures...
  21. ncbi Multispectral fluorescence lifetime imaging system for intravascular diagnostics with ultrasound guidance: in vivo validation in swine arteries
    Julien Bec
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, CA, 95616, USA
    J Biophotonics 7:281-5. 2014
    ....
  22. pmc Enzyme-containing hydrogel micropatterns serving a dual purpose of cell sequestration and metabolite detection
    Jun Yan
    Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive 2519, Davis, CA 95616, United States
    Biosens Bioelectron 24:2604-10. 2009
    ..The novel cell culture system with integrated sensing elements described here may be enhanced in the future by incorporating additional biorecognition elements to enable multi-metabolite detection at the site of a cell...
  23. pmc Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinoma
    Yinghua Sun
    Department of Biomedical Engineering, University of California Davis, NSF Center for Biophotonics Science and Technology, Davis, CA 95616, USA
    Opt Lett 34:2081-3. 2009
    ..The time-resolved images were minimally affected by tissue morphology, endogenous absorbers, and illumination. These results demonstrate the potential of FLIM as an intraoperative diagnostic technique...
  24. pmc Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors
    Emilie Roncali
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 57:6571-85. 2012
    ..This novel approach is promising for calculating DOI using pulse shape discrimination in single-ended readout depth-encoding PET detectors...
  25. pmc A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion
    Jing Liu
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med Biol 57:843-65. 2012
    ....
  26. pmc Intraluminal fluorescence spectroscopy catheter with ultrasound guidance
    Douglas N Stephens
    University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048
    J Biomed Opt 14:030505. 2009
    ..53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS...
  27. pmc Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging
    Brett Z Fite
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Tissue Eng Part C Methods 17:495-504. 2011
    ..Although this study was directed toward monitoring chondrogenic tissue maturation, these data demonstrate the feasibility of this approach for multiple applications toward engineering other tissues, including bone and vascular grafts...
  28. ncbi Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis
    JingJing Wang
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 12:044021. 2007
    ..These findings demonstrate that QD-labeled antibodies can provide a quick and accurate method for characterizing the presence or absence of a specific predictive biomarker...
  29. pmc A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque
    Jennifer E Phipps
    University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
    J Biophotonics 4:650-8. 2011
    ....
  30. pmc Diagnosis of meningioma by time-resolved fluorescence spectroscopy
    Pramod V Butte
    University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
    J Biomed Opt 10:064026. 2005
    ....
  31. pmc A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions
    Olga V Ivanova
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    Ann Biomed Eng 33:531-44. 2005
    ..The FIRK retrieved using this method can further facilitate modeling and recognition of pathological and physiological conditions in tissues...

Research Grants11

  1. Rupture-prone plaque diagnosis by IVUS-guided time-resolved spectroscopy
    Laura Marcu; Fiscal Year: 2009
    ..Also, the study will serve as paradigm for detection of vulnerable plaques in other arterial beds including coronary arteries. ..
  2. Rupture-prone plaque diagnosis by IVUS-guided time-resolved spectroscopy
    Laura Marcu; Fiscal Year: 2007
    ..Also, the study will serve as paradigm for detection of vulnerable plaques in other arterial beds including coronary arteries. ..
  3. Fluorescence lifetime method for guided therapy of brain tumors
    Laura Marcu; Fiscal Year: 2007
    ..While this project is initially tailored to brain tumors demarcation, the device could potentially be also applied to diagnosis of other tumor types. ..
  4. Time-Resolved Spectroscopy of Unstable Arterial Plaques
    Laura Marcu; Fiscal Year: 2001
    ..This study will facilitate translation of research findings on carotid lesions into clinical practice for identifying and treating those patients who are more likely to have an unstable plaque. ..
  5. MOEMS device for fluorescence spectroscopy of tissues and cells
    Laura Marcu; Fiscal Year: 2005
    ..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
  6. MOEMS device for fluorescence spectroscopy of tissues and cells
    Laura Marcu; Fiscal Year: 2006
    ..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
  7. Rupture-prone plaque diagnosis by IVUS-guided time-resolved spectroscopy
    Laura Marcu; Fiscal Year: 2006
    ..Also, the study will serve as paradigm for detection of vulnerable plaques in other arterial beds including coronary arteries. ..
  8. Time-Resolved Spectroscopy of Unstable Arterial Plaques
    Laura Marcu; Fiscal Year: 2004
    ..This study will facilitate translation of research findings on carotid lesions into clinical practice for identifying and treating those patients who are more likely to have an unstable plaque. ..
  9. Time-Resolved Spectroscopy of Unstable Arterial Plaques
    Laura Marcu; Fiscal Year: 2003
    ..This study will facilitate translation of research findings on carotid lesions into clinical practice for identifying and treating those patients who are more likely to have an unstable plaque. ..
  10. Time-Resolved Spectroscopy of Unstable Arterial Plaques
    Laura Marcu; Fiscal Year: 2002
    ..This study will facilitate translation of research findings on carotid lesions into clinical practice for identifying and treating those patients who are more likely to have an unstable plaque. ..