Research Topics
| Laura MarcuSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Fluorescence lifetime techniques in medical applicationsLaura Marcu
Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
Ann Biomed Eng 40:304-31. 2012....- Fluorescence lifetime in cardiovascular diagnosticsLaura Marcu
University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
J Biomed Opt 15:011106. 2010..Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications... - Detection of rupture-prone atherosclerotic plaques by time-resolved laser-induced fluorescence spectroscopyLaura Marcu
University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
Atherosclerosis 204:156-64. 2009..We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques... - Fluorescence lifetime imaging for the characterization of the biochemical composition of atherosclerotic plaquesJennifer Phipps
University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
J Biomed Opt 16:096018. 2011..g., ratios of lipid versus collagen versus elastin) can be evaluated with a flexible-fiber based FLIM technique without the need for fluorescence intensity information or contrast agents... - Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesionsJavier A Jo
University of California-Davis, Department of Biomedical Engineering, Davis, California 95616, USA
J Biomed Opt 11:021004. 2006..This study demonstrates the potential of the LDT for in-vivo tissue diagnosis, and specifically for the detection of macrophages infiltration in atherosclerotic lesions, a key marker of plaque vulnerability... 
Time-resolved fluorescence spectroscopy as a diagnostic technique of oral carcinoma: Validation in the hamster buccal pouch modelD Gregory Farwell
Department of Otolaryngology Head and Neck Surgery, University of California, Davis Medical Center, Sacramento, CA 95817, USA
Arch Otolaryngol Head Neck Surg 136:126-33. 2010..To investigate the benefit of using time-resolved, laser-induced fluorescence spectroscopy for diagnosing malignant and premalignant lesions of the oral cavity...- Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasoundJulien Bec
Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California 95616, USA
J Biomed Opt 17:106012. 2012..These results facilitate further development of a FLIm-IVUS technique for intravascular diagnosis of atherosclerotic cardiovascular diseases including vulnerable plaques... - In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinomaYang Sun
University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616, USA
J Biomed Opt 17:116003. 2012.... - Time-resolved laser-induced fluorescence spectroscopy as a diagnostic instrument in head and neck carcinomaJeremy D Meier
Department of Otolaryngology Head and Neck Surgery, University of California Davis, Sacramento, CA 95817, USA
Otolaryngol Head Neck Surg 142:838-44. 2010.... - Development of a dual-modal tissue diagnostic system combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopyYang Sun
Biomedical Engineering, University of California at Davis, Davis, California 95616, USA
Rev Sci Instrum 80:065104. 2009..Current design and performance of the hybrid system suggests potential applications in clinical diagnosis of atherosclerotic plaque... - Dynamic tissue analysis using time- and wavelength-resolved fluorescence spectroscopy for atherosclerosis diagnosisYinghua Sun
Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
Opt Express 19:3890-901. 2011..Current results demonstrate the potential of STWRFS as a tool for real-time optical characterization of arterial tissue composition and for atherosclerosis research and diagnosis... - A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaqueJennifer E Phipps
Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
Lasers Surg Med 44:564-71. 2012..FLIM and other time-resolved fluorescence techniques have recently been applied to the study of atherosclerosis based on the ability to assess biochemical composition... - Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopyYang Sun
Department of Biomedical Engineering, University of California Davis, Davis, CA, USA
Tissue Eng Part C Methods 18:215-26. 2012..Therefore, the technique was capable of nondestructively evaluating the composition of extracellular matrix and the microstructure of engineered tissue, demonstrating great potential as an alternative to traditional destructive assays... - Fluorescence lifetime imaging microscopy for brain tumor image-guided surgeryYinghua Sun
University of California, Davis, Department of Biomedical Engineering, Davis, California 95616, USA
J Biomed Opt 15:056022. 2010..05) and a longer lifetime τGBM-Amean=1.59±0.24 ns than normal cortex τNC-Amean=1.28±0.04 ns (p-value<0.005). Current results demonstrate the potential use of FLIM as a tool for image-guided surgery of brain tumors... - Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectorsEmilie Roncali
Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Phys Med Biol 57:6571-85. 2012..This novel approach is promising for calculating DOI using pulse shape discrimination in single-ended readout depth-encoding PET detectors... - Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosisHongtao Xie
University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, CA 95616, USA
Biomed Opt Express 3:1521-33. 2012.... - A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansionJing Liu
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
Phys Med Biol 57:843-65. 2012.... - Two-photon excited fluorescence lifetime measurements through a double-clad photonic crystal fiber for tissue micro-endoscopyFlorian Knorr
Department of Biomedical Engineering Davis, University of California, Davis, California 95616, USA
J Biophotonics 5:14-9. 2012..This simple setup, which offers larger penetration depth than one-photon-based techniques, may be combined with morphology-yielding techniques such as photoacoustic and ultrasound imaging... - Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imagingBrett Z Fite
Department of Biomedical Engineering, University of California, Davis, California 95616, USA
Tissue Eng Part C Methods 17:495-504. 2011..Although this study was directed toward monitoring chondrogenic tissue maturation, these data demonstrate the feasibility of this approach for multiple applications toward engineering other tissues, including bone and vascular grafts... 
Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosisYinghua Sun
Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California, 95616, USA
Opt Lett 33:630-2. 2008..The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems...- Intraluminal fluorescence spectroscopy catheter with ultrasound guidanceDouglas N Stephens
University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048
J Biomed Opt 14:030505. 2009..53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS... - Enzyme-containing hydrogel micropatterns serving a dual purpose of cell sequestration and metabolite detectionJun Yan
Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive 2519, Davis, CA 95616, United States
Biosens Bioelectron 24:2604-10. 2009..The novel cell culture system with integrated sensing elements described here may be enhanced in the future by incorporating additional biorecognition elements to enable multi-metabolite detection at the site of a cell... - A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaqueJennifer E Phipps
University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
J Biophotonics 4:650-8. 2011.... - Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinomaYinghua Sun
Department of Biomedical Engineering, University of California Davis, NSF Center for Biophotonics Science and Technology, Davis, CA 95616, USA
Opt Lett 34:2081-3. 2009..The time-resolved images were minimally affected by tissue morphology, endogenous absorbers, and illumination. These results demonstrate the potential of FLIM as an intraoperative diagnostic technique... - Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosisJingJing Wang
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
J Biomed Opt 12:044021. 2007..These findings demonstrate that QD-labeled antibodies can provide a quick and accurate method for characterizing the presence or absence of a specific predictive biomarker... - Diagnosis of meningioma by time-resolved fluorescence spectroscopyPramod V Butte
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90089, USA
J Biomed Opt 10:064026. 2005.... - A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensionsOlga V Ivanova
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
Ann Biomed Eng 33:531-44. 2005..The FIRK retrieved using this method can further facilitate modeling and recognition of pathological and physiological conditions in tissues...
Research Grants
- Rupture-prone plaque diagnosis by IVUS-guided time-resolved spectroscopyLaura Marcu; Fiscal Year: 2009..Also, the study will serve as paradigm for detection of vulnerable plaques in other arterial beds including coronary arteries. ..
- Rupture-prone plaque diagnosis by IVUS-guided time-resolved spectroscopyLaura Marcu; Fiscal Year: 2007..Also, the study will serve as paradigm for detection of vulnerable plaques in other arterial beds including coronary arteries. ..
- Fluorescence lifetime method for guided therapy of brain tumorsLaura Marcu; Fiscal Year: 2007..While this project is initially tailored to brain tumors demarcation, the device could potentially be also applied to diagnosis of other tumor types. ..
- MOEMS device for fluorescence spectroscopy of tissues and cellsLaura Marcu; Fiscal Year: 2006..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
- Time-Resolved Spectroscopy of Unstable Arterial PlaquesLaura Marcu; Fiscal Year: 2004..This study will facilitate translation of research findings on carotid lesions into clinical practice for identifying and treating those patients who are more likely to have an unstable plaque. ..