R E Marc

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Exploring the retinal connectome
    James R Anderson
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Mol Vis 17:355-79. 2011
  2. pmc Retinal connectomics: towards complete, accurate networks
    Robert E Marc
    University of Utah School of Medicine, Department of Ophthalmology, John A Moran Eye Center, 65 Mario Capecchi Dr, Salt Lake City, UT 84132, USA Electronic address
    Prog Retin Eye Res 37:141-62. 2013
  3. pmc Rapid glutamate receptor 2 trafficking during retinal degeneration
    Yanhua Lin
    Department of Ophthalmology, John A, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Mol Neurodegener 7:7. 2012
  4. pmc Retinoid receptors trigger neuritogenesis in retinal degenerations
    Yanhua Lin
    Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    FASEB J 26:81-92. 2012
  5. pmc Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration
    Robert E Marc
    Ophthalmology, University of Utah, John A Moran Eye Center, Salt Lake City, UT 84132, USA
    Mol Vis 14:782-806. 2008
  6. ncbi request reprint Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Comp Neurol 407:47-64. 1999
  7. ncbi request reprint Excitation mapping with the organic cation AGB2+
    Robert E Marc
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Vision Res 45:3454-68. 2005
  8. ncbi request reprint Retinal remodeling in inherited photoreceptor degenerations
    Robert E Marc
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Neurobiol 28:139-47. 2003
  9. ncbi request reprint Kainate activation of horizontal, bipolar, amacrine, and ganglion cells in the rabbit retina
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Comp Neurol 407:65-76. 1999
  10. ncbi request reprint Fundamental GABAergic amacrine cell circuitries in the retina: nested feedback, concatenated inhibition, and axosomatic synapses
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Comp Neurol 425:560-82. 2000

Research Grants

  1. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2007
  2. Retinal Remodeling
    Robert Marc; Fiscal Year: 2004
  3. Retinal Remodeling
    Robert Marc; Fiscal Year: 2007
  4. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2001
  5. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2004
  6. Retinal Remodeling
    Robert Marc; Fiscal Year: 2009
  7. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 1999
  8. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert E Marc; Fiscal Year: 2010
  9. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2010
  10. Retinal Remodeling
    Robert Marc; Fiscal Year: 2005

Detail Information

Publications29

  1. pmc Exploring the retinal connectome
    James R Anderson
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Mol Vis 17:355-79. 2011
    ..Our goal was to produce a connectome data set for the inner plexiform layer of the mammalian retina. This paper describes our first retinal connectome, validates the method, and provides key initial findings...
  2. pmc Retinal connectomics: towards complete, accurate networks
    Robert E Marc
    University of Utah School of Medicine, Department of Ophthalmology, John A Moran Eye Center, 65 Mario Capecchi Dr, Salt Lake City, UT 84132, USA Electronic address
    Prog Retin Eye Res 37:141-62. 2013
    ..This is but the beginning, as the underlying principles of connectomics are readily transferrable to non-neural cell complexes and provide new contexts for assessing intercellular communication. ..
  3. pmc Rapid glutamate receptor 2 trafficking during retinal degeneration
    Yanhua Lin
    Department of Ophthalmology, John A, Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Mol Neurodegener 7:7. 2012
    ..Given our prior evidence of ionotropic glutamate receptor (iGluR) reprogramming in retinal degenerations, we hypothesized that the edited glutamate receptor 2 (GluR2) subunit and its trafficking may be modulated in retinal degenerations...
  4. pmc Retinoid receptors trigger neuritogenesis in retinal degenerations
    Yanhua Lin
    Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    FASEB J 26:81-92. 2012
    ..Thus, RXRs are in the final common path and may be therapeutic targets to attenuate retinal remodeling and facilitate global intervention methods in blinding diseases and other neurodegenerative disorders...
  5. pmc Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration
    Robert E Marc
    Ophthalmology, University of Utah, John A Moran Eye Center, Salt Lake City, UT 84132, USA
    Mol Vis 14:782-806. 2008
    ..An hypothesis emergent from data analysis is that the LIRD model closely mimics late-stage atrophic age relared macular degeneration (AMD)...
  6. ncbi request reprint Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Comp Neurol 407:47-64. 1999
    ..Cholinergic agonists evoked no permeation...
  7. ncbi request reprint Excitation mapping with the organic cation AGB2+
    Robert E Marc
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Vision Res 45:3454-68. 2005
    ....
  8. ncbi request reprint Retinal remodeling in inherited photoreceptor degenerations
    Robert E Marc
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Mol Neurobiol 28:139-47. 2003
    ....
  9. ncbi request reprint Kainate activation of horizontal, bipolar, amacrine, and ganglion cells in the rabbit retina
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Comp Neurol 407:65-76. 1999
    ..Some ganglion cells displayed weak KA responses, even with saturating doses, that may have been be due to an absence of AMPA/KA receptors or to the existence of AGB-impermeant AMPA/KA receptor complexes...
  10. ncbi request reprint Fundamental GABAergic amacrine cell circuitries in the retina: nested feedback, concatenated inhibition, and axosomatic synapses
    R E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Comp Neurol 425:560-82. 2000
    ..Conversely, simple feedback and feedforward synapses may often be chimeras: the result of an incomplete view of synaptic topology...
  11. ncbi request reprint A molecular phenotype atlas of the zebrafish retina
    R E Marc
    John Moran Eye Center, Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Neurocytol 30:593-654. 2001
    ..The marginal zone is strongly laminated and its nascent neurons display their characteristic signatures before taking their place in the retina proper...
  12. ncbi request reprint Molecular phenotyping of retinal ganglion cells
    Robert E Marc
    John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Neurosci 22:413-27. 2002
    ..Ganglion cell classes display markedly different ionotropic drives, which may partly explain the physiological brisk-sluggish spectrum of ganglion cell spiking patterns...
  13. pmc Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration
    B W Jones
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Comp Neurol 519:2713-33. 2011
    ..The relatively fast disease progression makes the TgP347L rabbit an excellent model for gene therapy, cell biological intervention, progenitor cell transplantation, surgical interventions, and bionic prosthetic studies...
  14. pmc Neural reprogramming in retinal degeneration
    Robert E Marc
    Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132
    Invest Ophthalmol Vis Sci 48:3364-71. 2007
    ..The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration...
  15. pmc Retinal remodeling
    B W Jones
    Department of Ophthalmology, Moran Eye Center, University of Utah, 65 Mario Capecchi Dr, Salt Lake City, UT 84132, USA
    Jpn J Ophthalmol 56:289-306. 2012
    ....
  16. ncbi request reprint Contribution of a glial glutamate transporter to GABA synthesis in the retina
    Vijay P Sarthy
    Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neuroreport 15:1895-8. 2004
    ..An increase in GABAergic activity can be expected to affect trigger features such as directional selective response of neurons in the GLAST-/- mouse retina...
  17. ncbi request reprint Neural remodeling in retinal degeneration
    Robert E Marc
    John A Moran Eye Center, Department of Ophthalmology, University of Utah School of Medicine, 50 N Medical Center, Salt Lake City, UT 84132, USA
    Prog Retin Eye Res 22:607-55. 2003
    ..However, survivor neurons appear to be stable, healthy, active cells and given the evidence of their reactivity to deafferentation, it may be possible to influence their emergent rewiring and migration habits...
  18. ncbi request reprint Neural plasticity revealed by light-induced photoreceptor lesions
    Bryan W Jones
    Ophthalmology, Univ Utah Moran Eye Center, Salt Lake City, UT, USA
    Adv Exp Med Biol 572:405-10. 2006
  19. pmc Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II
    Prachee Avasthi
    Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, Utah 84132, USA
    J Neurosci 29:14287-98. 2009
    ....
  20. ncbi request reprint Retinal remodeling during retinal degeneration
    Bryan W Jones
    Moran Eye Center, 75 North Medical Drive, Rm 3339A, Salt Lake City, UT 84132, USA
    Exp Eye Res 81:123-37. 2005
    ..As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations...
  21. ncbi request reprint Retinal remodeling triggered by photoreceptor degenerations
    Bryan W Jones
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132
    J Comp Neurol 464:1-16. 2003
    ..Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, it suggests that the neural retina may be more plastic than previously believed...
  22. ncbi request reprint Retinal remodelling
    Bryan W Jones
    Moran Eye Center, 75 N Medical Drive, Salt Lake City, Utah, 84132, USA
    Clin Exp Optom 88:282-91. 2005
    ..Retinal remodelling resembles CNS pathologic remodelling and constitutes a major challenge to all rescue strategies...
  23. pmc Automatic mosaicking and volume assembly for high-throughput serial-section transmission electron microscopy
    Tolga Tasdizen
    Electrical and Computer Engineering Department, University of Utah, Utah, USA
    J Neurosci Methods 193:132-44. 2010
    ..We also quantify the accuracy of the algorithm through a simulated image capture experiment. The publicly available software tools include the algorithms and a Graphical User Interface for easy access to the algorithms...
  24. pmc Detection of neuron membranes in electron microscopy images using a serial neural network architecture
    Elizabeth Jurrus
    Scientific Computing and Imaging Institute, Salt Lake City, UT 84112, United States
    Med Image Anal 14:770-83. 2010
    ..We also demonstrate advantages over previous membrane detection methods. The results are a significant step towards an automated system for the reconstruction of the connectome...
  25. pmc The Viking viewer for connectomics: scalable multi-user annotation and summarization of large volume data sets
    J R Anderson
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, U S A
    J Microsc 241:13-28. 2011
    ..4) It is capable of applying transformations in real-time. (5) It has an easily extensible user interface, allowing addition of specialized modules without rewriting the viewer...
  26. pmc Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina
    Baerbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charlston, SC 29425, USA
    Vis Neurosci 21:703-13. 2004
    ..These data indicate that there does not appear to be evidence for postsynaptic deficits in glutamatergic signaling in the ON and OFF bipolar cells of mice lacking trkB...
  27. pmc Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration
    M J Seiler
    Anatomy and Neurobiol Reeve Irvine Research Center, UC Irvine, Irvine, CA 92697 4265, USA
    Eur J Neurosci 35:1692-704. 2012
    ....
  28. pmc A computational framework for ultrastructural mapping of neural circuitry
    James R Anderson
    Department Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, USA
    PLoS Biol 7:e1000074. 2009
    ..Finally, this framework provides a mechanism for parallelization of ssTEM imaging, volume assembly, and data analysis across an international user base, enhancing the productivity of a large cohort of electron microscopists...
  29. ncbi request reprint Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia
    Jyh Chang Jean
    Pulmonary Center at Boston University School of Medicine, Massachusetts 02118, USA
    Am J Physiol Lung Cell Mol Physiol 283:L766-76. 2002
    ..These data indicate a critical role for GGT in lung glutathione homeostasis and antioxidant defense in normoxia and hyperoxia...

Research Grants25

  1. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2007
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  2. Retinal Remodeling
    Robert Marc; Fiscal Year: 2004
    ..Restoring retinas must eventually involve guiding remodeled and implanted cells to assume functional architectures. Failing that, remodeling must be prevented or rescues instituted prior to remodeling onset. ..
  3. Retinal Remodeling
    Robert Marc; Fiscal Year: 2007
    ..Restoring retinas must eventually involve guiding remodeled and implanted cells to assume functional architectures. Failing that, remodeling must be prevented or rescues instituted prior to remodeling onset. ..
  4. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2001
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..
  5. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2004
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..
  6. Retinal Remodeling
    Robert Marc; Fiscal Year: 2009
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  7. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 1999
    ..This catalogue will assign not only a primary neurotransmitter but also a comprehensive signature to a specific morphology and synaptology. ..
  8. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert E Marc; Fiscal Year: 2010
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  9. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2010
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  10. Retinal Remodeling
    Robert Marc; Fiscal Year: 2005
    ..Restoring retinas must eventually involve guiding remodeled and implanted cells to assume functional architectures. Failing that, remodeling must be prevented or rescues instituted prior to remodeling onset. ..
  11. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2011
    ..These anomalies progressively impede development of therapies. Discovering the mechanisms of the many forms of remodeling may facilitate neuroprotective drug development or identification of existing drugs. ..
  12. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2002
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..
  13. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2006
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  14. Retinal Remodeling
    Robert Marc; Fiscal Year: 2006
    ..Restoring retinas must eventually involve guiding remodeled and implanted cells to assume functional architectures. Failing that, remodeling must be prevented or rescues instituted prior to remodeling onset. ..
  15. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2009
    ..Any strategies to restore vision must preserve or restore to the molecular profiles of the key pathways defined in Specific Aim 1. ..
  16. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2005
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..
  17. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2000
    ..This catalogue will assign not only a primary neurotransmitter but also a comprehensive signature to a specific morphology and synaptology. ..
  18. STRUCTURAL NEUROCHEMISTRY OF RETINAL CIRCUITS
    Robert Marc; Fiscal Year: 2003
    ..Significance: Current retinal models fail to capture the true circuit designs of the retina, including circuits with new and unexpected features that may be pivotal in crafting useful artificial vision systems. ..