M L Marazita

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Genetic segregation analyses of serum IgG2 levels
    M L Marazita
    Cleft Palate Craniofacial Center, Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Hum Genet 58:1042-9. 1996
  2. pmc Genetic segregation analysis of early-onset recurrent unipolar depression
    M L Marazita
    Cleft Palate Craniofacial Center, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    Am J Hum Genet 61:1370-8. 1997
  3. pmc GWAS of dental caries patterns in the permanent dentition
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:38-44. 2013
  4. pmc Clustering tooth surfaces into biologically informative caries outcomes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:32-7. 2013
  5. pmc Genetic susceptibility to dental caries on pit and fissure and smooth surfaces
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Caries Res 46:38-46. 2012
  6. pmc Face shape of unaffected parents with cleft affected offspring: combining three-dimensional surface imaging and geometric morphometrics
    S M Weinberg
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Orthod Craniofac Res 12:271-81. 2009
  7. pmc Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition
    Z Zeng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 92:432-7. 2013
  8. pmc Genes and their effects on dental caries may differ between primary and permanent dentitions
    X Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Caries Res 44:277-84. 2010
  9. pmc Novel cleft susceptibility genes in chromosome 6q
    A Letra
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, University of Pittsburgh, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Dent Res 89:927-32. 2010
  10. ncbi request reprint Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only
    A R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Braz J Med Biol Res 41:689-93. 2008

Collaborators

Detail Information

Publications34

  1. pmc Genetic segregation analyses of serum IgG2 levels
    M L Marazita
    Cleft Palate Craniofacial Center, Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Hum Genet 58:1042-9. 1996
    ..Smoking and GM23 are also known to affect IgG2 levels. If additional adjustments are made for smoking and GM23, the best-fitting model is still a codominant major locus but with no significant residual correlations...
  2. pmc Genetic segregation analysis of early-onset recurrent unipolar depression
    M L Marazita
    Cleft Palate Craniofacial Center, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    Am J Hum Genet 61:1370-8. 1997
    ..Under the broad-definition assumption, the best-fitting model is a Mendelian codominant major locus with significant residual parental and spousal effects...
  3. pmc GWAS of dental caries patterns in the permanent dentition
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:38-44. 2013
    ..Suggestive genetic associations were also observed for ABCG2, PKD2, the dentin/bone SCPP sub-family, EDNRA, TJFBR1, NKX2-3, IFT88, TWSG1, IL17D, and SMAD7 (p values < 7e-6). We nominate these novel genes for future study...
  4. pmc Clustering tooth surfaces into biologically informative caries outcomes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:32-7. 2013
    ....
  5. pmc Genetic susceptibility to dental caries on pit and fissure and smooth surfaces
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Caries Res 46:38-46. 2012
    ..001), indicating that genetic factors may exert differential effects on caries risk in PFS versus SMS in the primary dentition...
  6. pmc Face shape of unaffected parents with cleft affected offspring: combining three-dimensional surface imaging and geometric morphometrics
    S M Weinberg
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Orthod Craniofac Res 12:271-81. 2009
    ..In the present study, 3D surface imaging and statistical shape analysis were used to evaluate face shape differences between the unaffected (non-cleft) parents of individuals with CL / P and unrelated controls...
  7. pmc Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition
    Z Zeng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 92:432-7. 2013
    ..g., CXCR1 and CXCR2, p value = 1.9E-6). This study supports the notion that genes differentially affect cariogenesis across the surfaces of the permanent dentition, and nominates several novel genes for investigation...
  8. pmc Genes and their effects on dental caries may differ between primary and permanent dentitions
    X Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Caries Res 44:277-84. 2010
    ..Moreover, metrics for quantifying caries that incorporate white-spot lesions may serve as better phenotypes in genetic studies of the causes of tooth decay...
  9. pmc Novel cleft susceptibility genes in chromosome 6q
    A Letra
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, University of Pittsburgh, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Dent Res 89:927-32. 2010
    ..We provide further evidence of the involvement of chromosome 6q in cleft lip/palate and suggest PRSS35 as a novel candidate gene...
  10. ncbi request reprint Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only
    A R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Braz J Med Biol Res 41:689-93. 2008
    ..Our results provide a new indication that variation in RFC1 may contribute to cleft lip only. Future studies should investigate the association between oral clefts and RFC1 based on more discrete phenotypes...
  11. ncbi request reprint Parental craniofacial morphology in cleft lip with or without cleft palate as determined by cephalometry: a meta-analysis
    S M Weinberg
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Orthod Craniofac Res 9:18-30. 2006
    ..To integrate findings from previous cephalometric studies comparing the craniofacial complex of unaffected parents with cleft lip with or without cleft palate (CL/P) children to controls with no history of the disease...
  12. ncbi request reprint Social anxiety in Chinese adults with oral-facial clefts
    N W Berk
    Cleft Palate Craniofacial Center, University of Pittsburgh School of Dental Medicine, Pennsylvania 15261, USA
    Cleft Palate Craniofac J 38:126-33. 2001
    ..This study examined social anxiety and measures of psychosocial adjustment in Chinese adults with oral-facial clefts, their unaffected siblings, and age-matched controls...
  13. pmc Taste genes associated with dental caries
    S Wendell
    Center for Oral Health Research in Appalachia, University of Pittsburgh, PA, USA
    J Dent Res 89:1198-202. 2010
    ..Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection...
  14. ncbi request reprint Medical genetics on the cleft palate-craniofacial team: understanding parental preference
    N W Berk
    Cleft Palate Craniofacial Center, University of Pittsburgh School of Dental Medicine, Pennsylvania 15261, USA
    Cleft Palate Craniofac J 36:30-5. 1999
    ....
  15. ncbi request reprint Quantitative trait linkage analysis of the liability underlying a common oligogenic disease
    B S Maher
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genet Epidemiol 21:S720-5. 2001
    ....
  16. ncbi request reprint Evidence of genetic heterogeneity for hereditary gingival fibromatosis
    T C Hart
    Division of Oral Biology, University of Pittsburgh School of Dental Medicine, PA 15261, USA
    J Dent Res 79:1758-64. 2000
    ..Analysis of these data provides direct evidence that at least two genetically distinct loci are responsible for autosomal-dominant hereditary gingival fibromatosis...
  17. pmc Genome-wide association scan for childhood caries implicates novel genes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 90:1457-62. 2011
    ..Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries...
  18. ncbi request reprint Genetic segregation analysis of autonomic nervous system dysfunction in families of probands with idiopathic congenital central hypoventilation syndrome
    M L Marazita
    Department of Oral and Maxillofacial Surgery and Division of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet 100:229-36. 2001
    ....
  19. ncbi request reprint Sequence variations in CREB1 cosegregate with depressive disorders in women
    G S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 8:611-8. 2003
    ..These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions...
  20. pmc Genome-wide association studies: prospects and challenges for oral health
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, A300 Crabtree Hall, Pittsburgh, PA 15260, USA
    J Dent Res 91:637-41. 2012
    ..e., hundreds of thousands to millions) of genetic variants for association. This article discusses the issues surrounding the GWAS approach with emphasis on the prospects and challenges relevant to the oral health research community...
  21. ncbi request reprint Genome-wide scan finds suggestive caries loci
    A R Vieira
    Department of Oral Biology, Universityof Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
    J Dent Res 87:435-9. 2008
    ..1 and 14q24.3). Genes that may be related to saliva flow and diet preferences are proposed as possible candidates. A protective locus for caries in the X chromosome may explain the gender differences seen in caries frequency...
  22. ncbi request reprint Segregation analysis of mandibular prognathism in Libya
    A A El-Gheriani
    Department of Human Genetics, Graduate School of Public Health, 500 Cellomics Bldg, University of Pittsburgh, 100 Technology Dr, Pittsburgh, PA 15219, USA
    J Dent Res 82:523-7. 2003
    ..Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious...
  23. ncbi request reprint Cleft lip with or without cleft palate and dermatoglyphic asymmetry: evaluation of a Chinese population
    K Neiswanger
    Division of Oral Biology, Department of Oral and Maxillofacial Surgery, School of Dental, Medicine, University of Pittsburgh, PA, USA
    Orthod Craniofac Res 5:140-6. 2002
    ..To determine if Chinese individuals with non syndromic cleft lip with or without cleft palate (CL/P) display more dermatoglyphic asymmetry than unaffected relatives or controls...
  24. ncbi request reprint TP63 mutation and clefting modifier genes in an EEC syndrome family
    A K Ray
    Department of Anthropology, University of Toronto, Toronto, Canada
    Clin Genet 66:217-22. 2004
    ....
  25. pmc A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23
    B M Riley
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:846-52. 2007
    ..Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 (recessive multipoint HLOD 1.07) and BAG4 (recessive multipoint HLOD 1.31)...
  26. pmc Contributions of PTCH gene variants to isolated cleft lip and palate
    M A Mansilla
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Cleft Palate Craniofac J 43:21-9. 2006
    ....
  27. ncbi request reprint Tuftelin, mutans streptococci, and dental caries susceptibility
    R L Slayton
    Department of Pediatric Dentistry, University of Washington School of Dentistry, Box 357136, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Dent Res 84:711-4. 2005
    ..8% of the variation in dmfs explained by the interaction. Future research will focus on the identification of these additional factors and the development of functional assays so that these interactions can be better understood...
  28. ncbi request reprint Epidemiological and genetic study of 121 cases of oral clefts in Kuwait
    S A al-Bustan
    Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, Safat 13060, Kuwait
    Orthod Craniofac Res 5:154-60. 2002
    ....
  29. ncbi request reprint Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families
    R E Schultz
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 125:17-22. 2004
    ..While no region was definitively confirmed for linkage to NS CL/P, the data do support further investigation using larger sample sizes and candidate gene studies at 2p13.2, 4p16.2, 4q31, 6p23, and 16q22-24...
  30. ncbi request reprint MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
    ..These results suggest that MSX1 and TGFB3 mutations make a contribution to clefts in South American populations...
  31. pmc Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation
    T C Hart
    Department of Oral Medicine Pathology, University of Pittsburgh, School of Dental Medicine, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Med Genet 37:95-101. 2000
    ..This is the first reported gene mutation for non-syndromic periodontitis and shows that non-syndromic PPP is an allelic variant of the type IV palmoplantar ectodermal dysplasias...
  32. pmc Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population
    K Deeley
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Caries Res 42:8-13. 2008
    ..The approach of comparing individuals with extremely distinct caries experiences could be valuable for decreasing the potential influence of environmental factors on genetic studies of caries...
  33. pmc Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery
    K M Steffen
    University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Perinatol 27:672-80. 2007
    ..To examine the contribution of variants in fetal and maternal cholesterol metabolism genes in preterm delivery (PTD)...
  34. ncbi request reprint Estimating the recombination frequency for the PTC-Kell linkage
    M Anne-Spence
    Hum Genet 67:183-6. 1984
    ..29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies...