W F Maragos

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat
    W F Maragos
    Department of Neurology, University of Kentucky Medical Center, Lexington 40536 0284, USA
    Neuroscience 117:43-53. 2003
  2. pmc Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
    J Turchan
    Department of Neurology, University of Kentucky, Lexington, USA
    BMC Neurosci 2:3. 2001
  3. ncbi request reprint Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase
    W F Maragos
    Department of Neurology, Kentucky Clinic, Room L 445, University of Kentucky, Lexington, KY 40536 0284, USA
    Brain Res 878:218-22. 2000
  4. ncbi request reprint Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function
    William F Maragos
    Department of Neurology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurochem 83:955-63. 2002
  5. ncbi request reprint Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum
    S Theodore
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Neuroscience 137:925-35. 2006
  6. ncbi request reprint Dopamine induces proteasome inhibition in neural PC12 cell line
    J N Keller
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    Free Radic Biol Med 29:1037-42. 2000
  7. ncbi request reprint Acceleration of HIV dementia with methamphetamine and cocaine
    A Nath
    Department of Neurology, University of Kentucky, Lexington 40526-0284, USA
    J Neurovirol 7:66-71. 2001
  8. pmc Evidence that Par-4 participates in the pathogenesis of HIV encephalitis
    I I Kruman
    Sanders Brown Research Center on Aging, Department of Neurology, Lexington, Kentucky, USA
    Am J Pathol 155:39-46. 1999
  9. ncbi request reprint Progress in understanding basal ganglia dysfunction as a common target for methamphetamine abuse and HIV-1 neurodegeneration
    Shaji Theodore
    Department of Neurology, The University of Alabama at Birmingham, USA
    Curr HIV Res 5:301-13. 2007
  10. ncbi request reprint Human immunodeficiency virus-1 protein tat and methamphetamine interactions
    Shaji Theodore
    Department of Neurology, University of Kentucky, 260 Health Science Research Building, 1095 V A Drive, Lexington, KY 40536 0305, USA
    Ann N Y Acad Sci 1074:178-90. 2006

Detail Information

Publications24

  1. ncbi request reprint Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat
    W F Maragos
    Department of Neurology, University of Kentucky Medical Center, Lexington 40536 0284, USA
    Neuroscience 117:43-53. 2003
    ..Our observations that patients with human immunodeficiency virus reveal a similar pattern of damage suggests that Tat protein may be pathophysiological relevant in human immunodeficiency virus encephalitis...
  2. pmc Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
    J Turchan
    Department of Neurology, University of Kentucky, Lexington, USA
    BMC Neurosci 2:3. 2001
    ..We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat...
  3. ncbi request reprint Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase
    W F Maragos
    Department of Neurology, Kentucky Clinic, Room L 445, University of Kentucky, Lexington, KY 40536 0284, USA
    Brain Res 878:218-22. 2000
    ..non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration...
  4. ncbi request reprint Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function
    William F Maragos
    Department of Neurology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurochem 83:955-63. 2002
    ..This study demonstrates that the HIV-1 'virotoxin' Tat enhances MA-induced striatal damage and suggests that HIV-1-infected individuals who abuse MA may be at increased risk of basal ganglia dysfunction...
  5. ncbi request reprint Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum
    S Theodore
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Neuroscience 137:925-35. 2006
    ....
  6. ncbi request reprint Dopamine induces proteasome inhibition in neural PC12 cell line
    J N Keller
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    Free Radic Biol Med 29:1037-42. 2000
    ..Together, these data indicate that dopamine induces proteasome inhibition that is dependent, in part, on ROS and dopamine uptake, and suggest a possible role for proteasome inhibition in dopamine toxicity...
  7. ncbi request reprint Acceleration of HIV dementia with methamphetamine and cocaine
    A Nath
    Department of Neurology, University of Kentucky, Lexington 40526-0284, USA
    J Neurovirol 7:66-71. 2001
    ..Careful attention and analysis to histories of remote non-injecting drug abuse may help substantiate our hypothesis...
  8. pmc Evidence that Par-4 participates in the pathogenesis of HIV encephalitis
    I I Kruman
    Sanders Brown Research Center on Aging, Department of Neurology, Lexington, Kentucky, USA
    Am J Pathol 155:39-46. 1999
    ....
  9. ncbi request reprint Progress in understanding basal ganglia dysfunction as a common target for methamphetamine abuse and HIV-1 neurodegeneration
    Shaji Theodore
    Department of Neurology, The University of Alabama at Birmingham, USA
    Curr HIV Res 5:301-13. 2007
    ....
  10. ncbi request reprint Human immunodeficiency virus-1 protein tat and methamphetamine interactions
    Shaji Theodore
    Department of Neurology, University of Kentucky, 260 Health Science Research Building, 1095 V A Drive, Lexington, KY 40536 0305, USA
    Ann N Y Acad Sci 1074:178-90. 2006
    ..Our data indicate that the synergistic loss of dopamine is likely the result of dopamine terminal degeneration. This injury is not a direct result of the number of activated glia but does involve TNF-alpha...
  11. ncbi request reprint Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction
    Shaji Theodore
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Neurobiol Dis 23:663-8. 2006
    ..The results suggest that Tat-induced elevation of TNF-alpha may predispose the dopaminergic terminals to subsequent damage by MA...
  12. ncbi request reprint Involvement of cytokines in human immunodeficiency virus-1 protein Tat and methamphetamine interactions in the striatum
    Shaji Theodore
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 199:490-8. 2006
    ..Our findings suggest that HIV-1 infection with concurrent drug abuse might profoundly increase chemokine levels in the striatum resulting in enhanced damage to the dopaminergic system...
  13. ncbi request reprint Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents
    Jignesh D Pandya
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 24:798-811. 2007
    ....
  14. ncbi request reprint The uncoupling agent 2,4-dinitrophenol improves mitochondrial homeostasis following striatal quinolinic acid injections
    Amit S Korde
    Department of Neurology, University of Kentucky, Lexington, KY 40536 0284, USA
    J Neurotrauma 22:1142-9. 2005
    ..Our findings indicate that DNP may confer protection against acute brain injury involving excitotoxic pathways by mechanisms that maintain mitochondrial function...
  15. ncbi request reprint Enhanced toxicity to the catecholamine tyramine in polyglutamine transfected SH-SY5Y cells
    Rebecca R Smith
    Department of Neurology, University of Kentucky, Lexington, KY 40536 0284, USA
    Neurochem Res 30:527-31. 2005
    ..These observations support the notion that the metabolism of dopamine plays a role in neuron death in Huntington's disease...
  16. ncbi request reprint The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia
    Amit S Korde
    Department of Neurology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    J Neurochem 94:1676-84. 2005
    ..These findings indicate that compounds with uncoupling properties may confer neuroprotection through a mechanism involving stabilization of mitochondrial function...
  17. ncbi request reprint The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord
    Ying Jin
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Cardinal Hill Rehabilitation Hospital, Lexington, Kentucky 40536, USA
    J Neurotrauma 21:1396-404. 2004
    ..These results indicate that treatment with mitochondrial uncoupling agents may provide a novel approach for the treatment of secondary injury following spinal cord contusion...
  18. ncbi request reprint Mitochondrial uncoupling as a potential therapeutic target in acute central nervous system injury
    William F Maragos
    Department of Neurology, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Neurochem 91:257-62. 2004
    ..The potential use of pharmacological agents with uncoupling properties may provide a novel therapeutic approach for the treatment of acute neuronal injury...
  19. ncbi request reprint Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice
    William F Maragos
    University of Kentucky, Department of Neurology, USA
    Neurochem Res 29:741-6. 2004
    ..These findings indicate that normal levels of MAO-A participate in expression of malonate toxicity by a mechanism involving oxidative stress...
  20. ncbi request reprint HIV-1 protein Tat potentiation of methamphetamine-induced decreases in evoked overflow of dopamine in the striatum of the rat
    Wayne A Cass
    Department of Anatomy and Neurobiology, MN 225 Chandler Medical Center, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Brain Res 984:133-42. 2003
    ....
  21. ncbi request reprint Pre- or post-treatment with the mitochondrial uncoupler 2,4-dinitrophenol attenuates striatal quinolinate lesions
    William F Maragos
    Department of Neurology, University of Kentucky Medical Center, Kentucky Clinic, Rm L 445, Lexington, KY 40536 0284, USA
    Brain Res 966:312-6. 2003
    ..These results indicate that DNP, and other compounds that diminish the mitochondrial membrane potential, might provide a novel approach to the treatment of acute neurological injury...
  22. ncbi request reprint Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes
    William F Maragos
    Department of Neurology, Kentucky Clinic, Room L 445, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Biochem Pharmacol 63:1499-505. 2002
    ..e. noncompetitive inhibition of the DAT...
  23. ncbi request reprint Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition
    Amit S Korde
    Department of Neurology, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    J Neurotrauma 24:895-908. 2007
    ..The neuroprotective effects of NIM811 were not due to drug-induced alterations in cerebral perfusion after ischemia. Activation of MPT appears to be an important process in ischemia/reperfusion injury and may be a therapeutic target...
  24. ncbi request reprint HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Neurochem 100:567-86. 2007
    ..In this review, we consider astroglial and microglial interactions and dysfunction in the pathogenesis of HIV-1 infection and examine how drug actions in glia contribute to neuroAIDS...