Research Topics
| J J MaoSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
| Collaborators
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Detail Information
Publications
Matrix and gene expression in the rat cranial base growth plateMinghui Tang
Tissue Engineering Laboratory, Rm 237, University of Illinois at Chicago MC 841, 801 South Paulina Street, Chicago, IL 60612 7211, USA
Cell Tissue Res 324:467-74. 2006..Mechanical modulation of decorin expression is consistent with recent reports of its susceptibility to mechanical loading in several connective tissues...- Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffoldXuejun Xin
Department of Biomedical Engineering, Columbia University, College of Dental Medicine, Fu Foundation School of Engineering and Applied Sciences, New York, NY 10032, USA
Biomaterials 28:316-25. 2007..Consistent with previous work, these findings also suggest that nanofibers may serve as accommodative milieu for not only hMSCs, but also as a 3D carrier vehicle for lineage specific cells... - Modulation of neonatal growth plate development by ex vivo intermittent mechanical stressHasan Othman
Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Sciences, College of Dental Medicine, Columbia University, 630 W 168 Street, PH7 East SDOS, New York, NY 10032, USA
J Biomech 40:2686-93. 2007..Whether hyaluronan-mediated pathway is involved in the biological responses of growth plate to mechanical loading warrants additional investigations... - Strain induced osteogenesis of the craniofacial suture upon controlled delivery of low-frequency cyclic forcesJeremy J Mao
Tissue Engineering Laboratory Rm 237, Department of Orthodontics, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612 7211, USA
Front Biosci 8:a10-7. 2003..These data demonstrate, for the first time, that application of brief doses of cyclic forces induces sutural osteogenesis more effectively than static forces with matching peak magnitude... - Growth and development: hereditary and mechanical modulationsJeremy J Mao
Department of Orthodontics, University of Illinois at Chicago, MC 841, 801 S Paulina Street, Chicago, IL 60621, USA
Am J Orthod Dentofacial Orthop 125:676-89. 2004.... - Heterogeneous nanostructural and nanoelastic properties of pericellular and interterritorial matrices of chondrocytes by atomic force microscopyDaniel M Allen
Tissue Engineering Laboratory Rm 237, Departments of Bioengineering and Orthodontics MC 841, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612 7211, USA
J Struct Biol 145:196-204. 2004..These distinctive nanostructural and nanomechanical properties may have implications in nutrient diffusion and fluid dynamics, both of which are of vital importance for cartilage health and function... - Stem-cell-driven regeneration of synovial jointsJeremy J Mao
Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA
Biol Cell 97:289-301. 2005..Current approaches to regenerate the synovial joint condyle from stem-cell-derived multiple cell lineages may also offer clues for engineering complex organs such as the kidney or liver... - Biomechanics of craniofacial sutures: orthopedic implicationsJeremy J Mao
Department of Orthodontics, University of Illinois at Chicago, Chicago, Ill 60612, USA
Angle Orthod 73:128-35. 2003..Various orthopedic therapies, including headgear, facemask, and functional appliances may induce sutural strain, leading to modification of otherwise natural suture growth... - Nanostructural and nanomechanical properties of synostosed postnatal human cranial suturesNayra Grau
Tissue Engineering Laboratory M C 841, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Craniofac Surg 17:91-8; discussion 98-9. 2006..7 +/- 0.2 MPa was significantly higher than the synostosed metopic suture at 0.5 +/- 0.1 MPa (P < 0.01). These data suggest that various synostosed cranial sutures may have different structural and mechanical characteristics... - Microstructural and elastic properties of the extracellular matrices of the superficial zone of neonatal articular cartilage by atomic force microscopyRupal V Patel
Department of Orthodontics, University of Illinois at Chicago, 801 S Paulina Street, Chicago, IL 60612, USA
Front Biosci 8:a18-25. 2003.... - Mechanobiology of craniofacial suturesJ J Mao
Department of Orthodontics MC 841, 801 South Paulina Street, University of Illinois at Chicago, Chicago, IL 60612 7211, USA
J Dent Res 81:810-6. 2002..It is concluded that small doses of oscillatory mechanical stimuli have the potential to modulate sutural growth effectively: either accelerating it or initiating net sutural bone resorption for various therapeutic objectives... - Nanomechanical properties of facial sutures and sutural mineralization frontP Radhakrishnan
Tissue Engineering Laboratory, Department of Orthodontics, 801 S. Paulina Street, University of Illinois at Chicago, Chicago, IL 60612-7211, USA
J Dent Res 83:470-5. 2004..The elastic properties of sutures and sutural mineralization fronts are potentially useful for improving our understanding of their roles in development... - Regional structural and viscoelastic properties of fibrocartilage upon dynamic nanoindentation of the articular condyleK Hu
Department of Orthodontics, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612, USA
J Struct Biol 136:46-52. 2001..A model of shear gradient and concentric gradient is proposed to describe the region-specific capacity of fibrocartilage to sustain shear stresses in tendons, ligaments, joints, and the healing bone across species... - Adult stem cell driven genesis of human-shaped articular condyleAdel Alhadlaq
Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
Ann Biomed Eng 32:911-23. 2004..These findings may serve as a primitive proof of concept for ultimate tissue-engineered replacement of degenerated articular condyles via a single population of adult mesenchymal stem cells... - Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stressesX Wang
Skeletal Tissue Engineering Laboratory, Rm 237, Department of Orthodontics and Bioengineering, Univ. of Illinois at Chicago MC 841, 801 South Paulina Street, Chicago, IL 60612-7211, USA
J Dent Res 81:701-5. 2002..Thus, chondrocyte proliferation is enhanced by mechanical stresses in vivo, especially those with oscillatory waveform. Analysis of these data suggests that genetically coded chondral growth is up-regulated by mechanical signals... - Zone-specific micromechanical properties of the extracellular matrices of growth plate cartilagePriya Radhakrishnan
Department of Orthodontics, University of Illinois at Chicago, Chicago, IL 60612-7211, USA
Ann Biomed Eng 32:284-91. 2004..77 +/- 0.12 MPa, significantly different from the same zone upon transverse indentation. Thus, the extracellular matrix of growth plate cartilage seems to be inhomogenous in its capacity to withstand mechanical stresses... - Heterogeneous nanomechanical properties of superficial and zonal regions of articular cartilage of the rabbit proximal radius condyle by atomic force microscopySara Tomkoria
Tissue Engineering Laboratory, Department of Orthodontics, University of Illinois at Chicago, Room 237, 801 South Paulina Street, MC 841, Chicago, IL 60612-7211, USA
Med Eng Phys 26:815-22. 2004..Heterogeneous biophysical properties of intercellular matrices along the depth from the superficial to calcifying zones suggest that chondrocytes likely reside in a heterogeneous matrix... - Tissue-engineered rabbit cranial suture from autologous fibroblasts and BMP2L Hong
Departments of Orthodontic, Bioengineering, and Anatomy, University of Illinois at Chicago, MC 841, 801 South Paulina Street, Chicago, IL 60612-7211, USA
J Dent Res 83:751-6. 2004..This approach may be refined for tissue engineering of cranial sutures for craniosynostosis patients... - Tissue-engineered neogenesis of human-shaped mandibular condyle from rat mesenchymal stem cellsA Alhadlaq
Tissue Engineering Laboratory, Rm. 237, Department of Orthodontics (MC 841, University of Illinois at Chicago, 801 S. Paulina Street, Chicago, IL 60612-7211, USA
J Dent Res 82:951-6. 2003..Microscopic evaluation of the tissue-engineered mandibular condyle demonstrated two stratified layers of histogenesis of cartilaginous and osseous phenotypes. The current approach is being refined for ultimate therapeutic applications... - Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: implications in soft tissue augmentation and reconstructionAdel Alhadlaq
Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, 60612, USA
Tissue Eng 11:556-66. 2005..These data demonstrate that adipose tissue engineered from human mesenchymal stem cells can retain predefined shape and dimensions for soft tissue augmentation and reconstruction... - Effects of condylar fibrocartilage on the biomechanical loading of the human temporomandibular joint in a three-dimensional, nonlinear finite element modelKai Hu
Tissue Engineering Laboratory, Department of Orthodontics, University of Illinois at Chicago, 60612, USA
Med Eng Phys 25:107-13. 2003..These findings lead to a hypothesis that the mandibular condyle more likely functions as a shock absorber than the disc... - Cytoskeletal changes of mesenchymal stem cells during differentiationGregory Yourek
Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA
ASAIO J 53:219-28. 2007..These data suggest human mesenchymal stem cells alter their cytoskeletal components during differentiation. Additional studies will address the mechanisms of cytoskeletal changes using biochemical and biophysical methods... - Expression of in vivo mechanical strain upon different wave forms of exogenous forces in rabbit craniofacial suturesRoss A Kopher
Tissue Engineering Laboratory, Department of Orthodontics, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL 60612-7211, USA
Ann Biomed Eng 31:1125-31. 2003..The present data provide room for exploring whether cyclic forces capable of inducing different sutural strain wave forms may accelerate sutural anabolic or catabolic responses... - Tissue-engineered osteochondral constructs in the shape of an articular condyleAdel Alhadlaq
Department of Anatomy, Tissue Engineering Laboratory, MC 841, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois 60612, USA
J Bone Joint Surg Am 87:936-44. 2005.... - Modulation of endochondral development of the distal femoral condyle by mechanical loadingSona Sundaramurthy
Tissue Engineering Laboratory, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois 60612, USA
J Orthop Res 24:229-41. 2006..Taken together, mechanical stresses accelerate the formation of the secondary ossification center, and therefore modulate endochondral ossification... 
Investigation of nano-mechanical properties of annulus fibrosus using atomic force microscopyNaama T Lewis
Department of Bioengineering, University of Illinois at Chicago, Science and Engineering Offices SEO, Room 218, 815 S Morgan Street m c 063, Chicago, IL 60607 7052, USA
Micron 39:1008-19. 2008....- Ex vivo adipose tissue engineering by human marrow stromal cell seeded gelatin spongeLiu Hong
Department of Orthodontics, University of Illinois at Chicago, Chicago, IL 60612 7211, USA
Ann Biomed Eng 33:511-7. 2005..The present study indicates that bone MSCs could be a cell resource in tissue engineering adipose tissue, while gelatin sponge could be a good scaffold in this approach to improve the outcome of clinical treatment... - Bone strain patterns of the zygomatic complex in response to simulated orthopedic forcesM C Oberheim
Department of Orthodontics, University of Illinois at Chicago, College of Dentistry, 801 South Paulina Street, 60612-7211, USA
J Dent Res 81:608-12. 2002..Thus, headgear-generated orthopedic forces evoke bending of the zygomatic arch and stresses of the temporal articular eminence in vitro, suggesting the need to verify whether bone strain induces in vivo bone modeling and remodeling... - Accelerated chondrogenesis of the rabbit cranial base growth plate by oscillatory mechanical stimuliXin Wang
Department of Orthodontics, University of Illinois at Chicago, 60612-7211, USA
J Bone Miner Res 17:1843-50. 2002..A cascade of oscillatory mechanical stimuli is likely capable of engineering chondral growth beyond naturally occurring chondrogenesis... - Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbitsIoana A Peptan
Department of Bioengineering, University of Illinois, Chicago, IL 60612-7211, USA
Plast Reconstr Surg 117:1462-70. 2006..However, the mechanism is still unidentified... - Fibroblastic differentiation of human mesenchymal stem cells using connective tissue growth factorChang H Lee
Department of Orthodontics, University of Illinois, Chicago, IL 60612, USA
Conf Proc IEEE Eng Med Biol Soc 1:775-8. 2006..These findings have implications for engineering fibrous tissue by providing the initial evidence of a reproducible protocol for fibroblastic differentiation of hMSCs... - Sustained release of TGFbeta3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cellsEduardo K Moioli
Tissue Engineering Laboratory, University of Illinois at Chicago, Illinois, USA
Tissue Eng 12:537-46. 2006..35 ng/mL TGFbeta3 to cell culture (p > 0.05). These findings provide baseline data for potential uses of microencapsulated TGFbeta3 in wound healing and tissue-engineering applications... - Stem cell-based composite tissue constructs for regenerative medicineMohamed N Rahaman
Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St, Chicago, Illinois 60607, USA
Biotechnol Bioeng 91:261-84. 2005.... - Expression and mechanical modulation of matrix metalloproteinase-1 and -2 genes in facial and cranial suturesRasha Al-Mubarak
Tissue Engineering Laboratory, University of Illinois at Chicago, MC 841, Chicago, IL 60612 7211, USA
Cell Tissue Res 321:465-71. 2005.... - Modulation of bone ingrowth of rabbit femur titanium implants by in vivo axial micromechanical loadingPaul A Clark
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612-7211, USA
J Appl Physiol 98:1922-9. 2005..2 +/- 0.60 microm(3).microm(-2).day(-1), respectively; P < 0.01). Collectively, these data suggest that micromechanical forces delivered axially on intraosseous titanium implants may have anabolic effects on implant bone ingrowth... - Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stressesJohn M Collins
Tissue Engineering Laboratory Rm 237, University of Illinois at Chicago, MC 841, 801 South Paulina Street, Chicago, IL 60612 7211, USA
J Biomech 38:485-92. 2005..Taken together, these data suggest potentially important roles of MMP genes in the postnatal development of cranial sutures, and their susceptibility to mechanical stresses... - Geometry and cell density of rat craniofacial sutures during early postnatal development and upon in vivo cyclic loadingKapil Vij
Tissue Engineering Laboratory, University of Illinois at Chicago MC 841, 801 South Paulina Street, Chicago, IL 60612-7211, USA
Bone 38:722-30. 2006..Cyclic loading may have clinical implications as novel mechanical stimuli for modulating craniofacial growth in patients suffering from craniofacial anomalies and dentofacial deformities... - In vitro evaluation of macroporous hydrogels to facilitate stem cell infiltration, growth, and mineralizationVandana Keskar
Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL 60612 7231, USA
Tissue Eng Part A 15:1695-707. 2009.... - Mesenchymal stem cells: isolation and therapeuticsAdel Alhadlaq
Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
Stem Cells Dev 13:436-48. 2004..The present review not only outlines several approaches relevant to the isolation and therapeutic use of MSCs, but also presents several examples of phenotypic and functional characterization of isolated MSCs and their progeny... - Suture growth modulated by the oscillatory component of micromechanical strainRoss A Kopher
Department of Orthodontics, University of Illinois at Chicago, Chicago, Illinois 60612-7211, USA
J Bone Miner Res 18:521-8. 2003..The increased sutural growth by cyclic mechanical strain in the tensed NFS and compressed PMS suggests that both microscale tension and compression induce anabolic sutural growth response... - Chondrogenesis of mesenchymal stem cells by controlled delivery of transforming growth factor-beta3Eduardo K Moioli
Conf Proc IEEE Eng Med Biol Soc 1:2647-50. 2006..The present study investigates a tissue engineered construct that includes sustained delivery of TGFbeta3 and induces differentiation of hMSC into chondrocytes in situ using injectable thermosensitive gels... - Autologous stem cell regeneration in craniosynostosisEduardo K Moioli
Tissue Engineering and Regenerative Medicine Laboratory, Columbia University, College of Dental Medicine, New York, NY 10032, USA
Bone 42:332-40. 2008..The engineered soft tissue-bone interface may have implications in the repair of tendons, ligaments, periosteum and periodontal ligament... - Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loadingAlexandra I Peptan
Department of Biomedical Engineering, Columbia University, College of Dental Medicine, New York, NY 10032, USA
Bone 42:432-8. 2008..Due to the structural complexity of cranial vault and facial sutures, either tensile or compressive forces likely are transmitted as shear stresses and upregulate genes and gene products responsible for sutural growth... - More research needed to understand how orthodontists communicate with cellsJeremy J Mao
Am J Orthod Dentofacial Orthop 127:400. 2005 - Stem cells and the future of dental careJeremy J Mao
Columbia University College of Dental Medicine, USA
N Y State Dent J 74:20-4. 2008..Metallic alloys, composites and even titanium implants are not permanent solutions. In contrast, stem cell technology will generate native tissue analogs that are compatible with the patient's own... - In vitro degradation behavior of photopolymerized PEG hydrogels as tissue engineering scaffoldAntonio X Xin
Dept. of Dental Med. and Biomed. Eng, Columbia Univ, New York, NY 10032, USA
Conf Proc IEEE Eng Med Biol Soc 1:2091-3. 2006..The results indicate that the PEGDA formed hydrogels can be tailored with prompted properties specifically for various cell-based tissue engineering needs... - Matrices and scaffolds for drug delivery in dental, oral and craniofacial tissue engineeringEduardo K Moioli
Columbia University, Tissue Engineering and Regenerative Medicine Laboratory TERML, College of Dental Medicine, Fu Foundation School of Engineering and Applied Sciences, Department of Biomedical Engineering, New York, NY 10032, USA
Adv Drug Deliv Rev 59:308-24. 2007.... - Transmission of bone strain in the craniofacial bones of edentulous human skulls upon dental implant loadingNidal Yacoub
School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Prosthet Dent 88:192-9. 2002..The large-diameter implant was more facilitative of stress transfer to cortical bone than the small-diameter implant tested... - Mesenchymal stem cells and tissue engineeringNicholas W Marion
College of Dental Medicine - Fu Foundation School of Engineering and Applied Sciences, Columbia University, New York, New York, USA
Methods Enzymol 420:339-61. 2006.... - Adipose tissue engineering from human adult stem cells: clinical implications in plastic and reconstructive surgeryMichael S Stosich
College of Dental Medicine and Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA
Plast Reconstr Surg 119:71-83; discussion 84-5. 2007..This study investigated the shape and dimension maintenance of engineered adipose tissue from adult human mesenchymal stem cells... - Inhibition of osteogenic differentiation of human mesenchymal stem cellsEduardo K Moioli
Department of Biomedical Engineering, College of Dental Medicine, Columbia University, Fu Foundation School of Engineering and Applied Sciences, New York, New York 10032, USA
Wound Repair Regen 15:413-21. 2007.... 
Porous implants as drug delivery vehicles to augment host tissue integrationPaul A Clark
Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin, USA
FASEB J 22:1684-93. 2008..These findings suggest that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control-released bioactive cues augment host tissue integration...- Vascularized adipose tissue grafts from human mesenchymal stem cells with bioactive cues and microchannel conduitsMichael S Stosich
Tissue Engineering and Regenerative Medicine Laboratory, College of Dental Medicine, Columbia University, New York, New York 10032, USA
Tissue Eng 13:2881-90. 2007..Especially, engineered microchannels may provide a generic approach for modifying existing biomaterials by providing conduits for vascularization and/or diffusion... - Labeling of mesenchymal stem cells by bioconjugated quantum dotsBhranti S Shah
College of Dental Medicine, Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Sciences, Columbia University, New York, New York 10032, USA
Nano Lett 7:3071-9. 2007..QD-labeled hMSCs remained viable as unlabeled hMSCs from the same subpopulation. These findings suggest the use of bioconjugated QDs as an effective probe for long-term labeling of stem cells...