STEPHEN MANUCK

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers
    Sarah M Conklin
    Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychiatry Res 152:1-10. 2007
  2. doi Gene-environment interaction
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 email
    Annu Rev Psychol 65:41-70. 2014
  3. pmc Sleep quality and neural circuit function supporting emotion regulation
    Jared D Minkel
    Laboratory of Neurogenetics, Department of Psychology and Neuroscience, Duke University, 417 Chapel Dr, Durham, NC 27708, USA
    Biol Mood Anxiety Disord 2:22. 2012
  4. pmc Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Soc Cogn Affect Neurosci 8:499-508. 2013
  5. ncbi A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
    S B Manuck
    Department of Psychology, Behavioral Physiology Laboratory, University of Pittsburgh, PA 15260, USA
    Psychiatry Res 95:9-23. 2000
  6. pmc Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychoneuroendocrinology 35:94-104. 2010
  7. ncbi Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 29:651-68. 2004
  8. ncbi The socio-economic status of communities predicts variation in brain serotonergic responsivity
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
    Psychol Med 35:519-28. 2005
  9. pmc Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α
    Stephen B Manuck
    Behavioral Physiology Laboratory, University of Pittsburgh, 506 OEH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Dev Psychopathol 23:69-83. 2011
  10. ncbi Central nervous system serotonergic responsivity and aggressive disposition in men
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
    Physiol Behav 77:705-9. 2002

Research Grants

  1. BIOBEHAVIORAL STUDIES OF CARDIOVASCULAR DISEASE
    STEPHEN MANUCK; Fiscal Year: 2007
  2. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2000
  3. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2001
  4. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2002
  5. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2003

Collaborators

Detail Information

Publications82

  1. ncbi Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers
    Sarah M Conklin
    Cardiovascular Behavioral Medicine Postdoctoral Training Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychiatry Res 152:1-10. 2007
    ..These findings suggest that omega-3 fatty acid status is associated with variability in affect regulation, personality and impulse control...
  2. doi Gene-environment interaction
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 email
    Annu Rev Psychol 65:41-70. 2014
    ....
  3. pmc Sleep quality and neural circuit function supporting emotion regulation
    Jared D Minkel
    Laboratory of Neurogenetics, Department of Psychology and Neuroscience, Duke University, 417 Chapel Dr, Durham, NC 27708, USA
    Biol Mood Anxiety Disord 2:22. 2012
    ..abstract:..
  4. pmc Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Soc Cogn Affect Neurosci 8:499-508. 2013
    ....
  5. ncbi A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
    S B Manuck
    Department of Psychology, Behavioral Physiology Laboratory, University of Pittsburgh, PA 15260, USA
    Psychiatry Res 95:9-23. 2000
    ..We conclude that the MAOA-uVNTR regulatory polymorphism may contribute, in part, to individual differences in both CNS serotonergic responsivity and personality traits germane to impulse control and antagonistic behavior...
  6. pmc Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Psychoneuroendocrinology 35:94-104. 2010
    ....
  7. ncbi Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 29:651-68. 2004
    ..We conclude that allelic variation at 5-HTTLPR moderates the influence of social position on CNS serotonergic responsivity...
  8. ncbi The socio-economic status of communities predicts variation in brain serotonergic responsivity
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
    Psychol Med 35:519-28. 2005
    ..Here we examine whether serotonergic responsivity covaries similarly with the SES of communities, as indexed by US Census data in the same study sample...
  9. pmc Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α
    Stephen B Manuck
    Behavioral Physiology Laboratory, University of Pittsburgh, 506 OEH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Dev Psychopathol 23:69-83. 2011
    ....
  10. ncbi Central nervous system serotonergic responsivity and aggressive disposition in men
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
    Physiol Behav 77:705-9. 2002
    ..This finding suggests that association of the MAO-A promoter polymorphism with this behavioral phenotype may be mediated, in part, by allele-specific variation in central serotonergic responsivity...
  11. ncbi Is cardiovascular reactivity associated with atherosclerosis among hypertensives?
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
    Hypertension 40:742-7. 2002
    ..Among hypertensives, exaggerated behaviorally evoked cardiovascular reactivity appears to be uniquely associated with greater carotid intima-media thickness but not with carotid plaque occurrence...
  12. doi Community socioeconomic status is associated with circulating interleukin-6 and C-reactive protein
    Karen L Petersen
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pennsylvania, USA
    Psychosom Med 70:646-52. 2008
    ..e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality...
  13. pmc Potential neural embedding of parental social standing
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Cogn Affect Neurosci 3:91-6. 2008
    ..Thus, these findings may provide insight into the neurodevelopmental pathways impacting socioeconomic disparities in health...
  14. ncbi High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism
    Sarah M Conklin
    Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
    Psychosom Med 69:932-4. 2007
    ..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults...
  15. pmc Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein
    Indrani Halder
    Behavioral Physiology Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 24:160-7. 2010
    ..In conclusion, we found that haplotypic variation in the CRP locus moderates an association of depressive symptoms with circulating CRP, which is partially mediated by BMI...
  16. ncbi Self-reported sleep quality is associated with the metabolic syndrome
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Sleep 30:219-23. 2007
    ..To determine whether a simple, structured self-report of overall sleep quality is associated with the presence of the metabolic syndrome and its component risk factors...
  17. ncbi Exaggerated blood pressure responses during mental stress are prospectively related to enhanced carotid atherosclerosis in middle-aged Finnish men
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh, E1329 WPIC, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Circulation 110:2198-203. 2004
    ..These are the first prospective results on this relationship...
  18. pmc Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers
    Stephen B Manuck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 72:35-45. 2010
    ....
  19. ncbi Reduced low-frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples
    Clara Gautier
    Department of Psychiatry and Psychology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Coron Artery Dis 18:97-104. 2007
    ..We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis...
  20. pmc Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala
    Peter J Gianaros
    Department of Psychiatry and Psychology, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 65:943-50. 2009
    ....
  21. ncbi Serotonergic function in the central nervous system is associated with daily ratings of positive mood
    Janine D Flory
    Department of Psychology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychiatry Res 129:11-9. 2004
    ..e., Neuroticism). These results suggest that deficiencies in serotonergic function may reflect the relative absence of positive mood...
  22. pmc Self-reported sleep duration is associated with the metabolic syndrome in midlife adults
    Martica H Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:635-43. 2008
    ..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease...
  23. ncbi A comparison of d, l-fenfluramine and citalopram challenges in healthy adults
    Janine D Flory
    Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 174:376-80. 2004
    ..49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity...
  24. ncbi Covariation of psychosocial characteristics associated with cardiovascular disease: genetic and environmental influences
    Douglas A Raynor
    Department of Psychology, University of Pittsburgh, 405 O Hara Street, Pittsburgh, PA 15260, USA
    Psychosom Med 64:191-203; discussion 204-5. 2002
    ..Therefore, the current study used a twin design to examine the relative contributions of genetic and environmental influences to the variation and covariation of these three psychosocial characteristics...
  25. ncbi Stress, immune reactivity and susceptibility to infectious disease
    Anna L Marsland
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:711-6. 2002
    ....
  26. pmc Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults
    Anna L Marsland
    Behavioral Immunology Laboratory, University of Pittsburgh, PA 15260, USA
    Biol Psychiatry 64:484-90. 2008
    ..In the current study, we extend this work to test whether systemic inflammation is associated with reduced grey matter volume of the hippocampus...
  27. pmc Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, 3943 O Hara Street, Pittsburgh, PA 15260, USA
    Brain Behav Immun 22:753-61. 2008
    ....
  28. pmc Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdala
    Peter J Gianaros
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:990-9. 2008
    ....
  29. pmc Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Nutr 140:848-53. 2010
    ..These findings suggest that DHA is related to brain health throughout the lifespan and may have implications for clinical trials of neuropsychiatric disorders...
  30. ncbi Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychosom Med 69:709-16. 2007
    ..As yet, no direct human evidence links parasympathetic activity to inflammatory competence...
  31. ncbi Sequence variation in the primate dopamine transporter gene and its relationship to social dominance
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, USA
    Mol Biol Evol 25:18-28. 2008
    ..This suggests that the DAT gene has followed different evolutionary trajectories during primate speciation...
  32. ncbi Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Stroke 38:2228-33. 2007
    ..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...
  33. ncbi Effects of six anti-hypertensive medications on cognitive performance
    Matthew F Muldoon
    Division of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Hypertens 20:1643-52. 2002
    ..To describe and compare the effects of six different antihypertensive medications on cognitive performance...
  34. pmc Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function
    Ahmad R Hariri
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 66:9-16. 2009
    ..Fatty acid amide hydrolase (FAAH) is a key enzyme in regulating endocannabinoid (eCB) signaling. A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity...
  35. pmc Citalopram intervention for hostility: results of a randomized clinical trial
    Thomas W Kamarck
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Consult Clin Psychol 77:174-88. 2009
    ..04). The findings have implications for understanding the central nervous system correlates of hostility, its associations with other psychosocial risk factors for CVD, and, potentially, the design of effective interventions...
  36. ncbi Retest reliability of prolactin response to dl-fenfluramine challenge in adults
    Janine D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 26:269-72. 2002
    ..57 for PRL "area under the curve," p <.0001). These findings are consistent with speculation that variability in indices of central serotonergic function reflects a temporally stable dimension of individual differences...
  37. pmc Systemic inflammation and the metabolic syndrome among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Metabolism 59:1801-8. 2010
    ..The inclusion of inflammatory markers in the clinical definition of metabolic syndrome seems warranted and may improve prognostic assessment of risk of type 2 diabetes mellitus and cardiovascular disease...
  38. pmc Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptoms
    Erika E Forbes
    University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 49:162-72.e1-5. 2010
    ..The current study focused on puberty-specific changes in brain function and their association with mood...
  39. ncbi Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive men
    Maria E Bleil
    Behavioral Physiology Laboratory, Department of Psychology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Eur J Cardiovasc Prev Rehabil 13:98-100. 2006
    ..The apolipoprotein E (apoE) polymorphism was evaluated alone, and in interaction with smoking status, in predicting carotid intima-medial thickness and plaque among 182 untreated, hypertensive, white men (mean age 56+/-8.9 years)...
  40. pmc A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteers
    Judith E Carroll
    MS, Behavioral Immunology Laboratory, University of Pittsburgh, Old Engineering Hall, Suite 600, 3943 O Hara St, Pittsburgh, PA 15260
    Psychosom Med 72:273-80. 2010
    ..One possibility is that hostility is associated with oxidative stress. Here, we explore relationships between hostility and a measure of systemic oxidative stress among a mid-life sample...
  41. pmc Greater intima-media thickness in the carotid bulb is associated with reduced baroreflex sensitivity
    Peter J Gianaros
    Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA
    Am J Hypertens 15:486-91. 2002
    ..These results suggest that subclinical atherosclerosis, specifically in a region with high baroreceptor density, is associated with a reduced sensitivity of the baroreflex...
  42. pmc Parental education is related to C-reactive protein among female middle-aged community volunteers
    Jennifer E Phillips
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Behav Immun 23:677-83. 2009
    ..This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortality conferred by low childhood socioeconomic status...
  43. pmc Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production
    Aric A Prather
    Department of Psychology, University of Pittsburgh, PA 15260, United States
    Biol Psychol 82:12-7. 2009
    ..Further exploration of this potential psychophysiological pathway linking sleep difficulty and inflammatory disease susceptibility is warranted...
  44. ncbi The serotonin transporter: sequence variation in Macaca fascicularis and its relationship to dominance
    Cassandra M Miller-Butterworth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 De Soto Street, Pittsburgh, PA, USA
    Behav Genet 37:678-96. 2007
    ..No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status...
  45. ncbi Anger-related personality traits and carotid artery atherosclerosis in untreated hypertensive men
    Maria E Bleil
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 4015 O Hara St, Pittsburgh, PA 15260, USA
    Psychosom Med 66:633-9. 2004
    ..To determine whether anger-related personality traits are associated with carotid artery atherosclerosis in untreated hypertensive patients...
  46. ncbi Trait positive affect and antibody response to hepatitis B vaccination
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, USA
    Brain Behav Immun 20:261-9. 2006
    ..These data provide initial evidence that individual differences in dispositional positive affect may be of health significance, being related to an in vivo immune response relevant for protection against infection...
  47. ncbi Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive men
    Karen L Petersen
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh School of Medicine, 4015 O Hara Street, Pittsburgh, PA 15218, USA
    Am J Hypertens 19:560-6. 2006
    ..In this study we examined whether community SES is similarly associated with preclinical vascular disease, as measured by carotid artery ultrasonography...
  48. ncbi The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
    ..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism...
  49. ncbi Stimulated production of interleukin-8 covaries with psychosocial risk factors for inflammatory disease among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Behav Immun 21:218-28. 2007
    ..Further exploration of this potential psychophysiological pathway is warranted...
  50. ncbi Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Med 117:823-9. 2004
    ..The current study was designed to confirm and extend those findings...
  51. ncbi Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
    Psychosom Med 68:895-903. 2006
    ..The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains...
  52. ncbi Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity
    Matthew F Muldoon
    Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Clin Endocrinol Metab 89:266-71. 2004
    ..These findings reveal a heretofore unrecognized association between reduced central serotonergic responsivity and the metabolic syndrome...
  53. ncbi Approach to a social stranger is associated with low central nervous system serotonergic responsivity in female cynomolgus monkeys (Macaca fascicularis)
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Primatol 61:187-94. 2003
    ..We conclude that in female cynomolgus monkeys, social impulsivity (vs. inhibition) correlates inversely with individual differences in CNS serotonergic activity, as assessed by neuroendocrine challenge...
  54. pmc Positive affective style covaries with stimulated IL-6 and IL-10 production in a middle-aged community sample
    Aric A Prather
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Behav Immun 21:1033-7. 2007
    ..Further exploration of this potential psychophysiological pathway is warranted...
  55. pmc Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety
    Luke W Hyde
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychologia 49:651-6. 2011
    ..Moreover, our results indicate that links between neural reactivity and behavior are not static but rather may be contingent on social resources...
  56. pmc Individual differences in typical reappraisal use predict amygdala and prefrontal responses
    Emily M Drabant
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 65:367-73. 2009
    ..Such spontaneous emotion regulation might play an important role in normal and pathological responses to the emotional challenges of everyday life...
  57. ncbi COMT val158Met and executive control: a test of the benefit of specific deficits to translational research
    Angus W MacDonald
    Department of Psychology, University of Pittsburgh, USA
    J Abnorm Psychol 116:306-12. 2007
    ..These data suggest that the interpretability gained by including task manipulations to uncover specific deficits can enhance associations between cognitive and genetic levels of analysis...
  58. ncbi Effects of hemoconcentration and sympathetic activation on serum lipid responses to brief mental stress
    Elizabeth A Bachen
    Department of Psychology, Mills College, Oakland, CA 94613, USA
    Psychosom Med 64:587-94. 2002
    ..This study evaluated these two hypotheses by manipulation of sympathetically mediated responses to stress using a nonselective adrenoceptor antagonist, labetalol...
  59. pmc Impulsiveness and cigarette smoking
    Janine D Flory
    Department of Psychology, Queens College, 65 30 Kissena Blvd, Flushing, NY 11367, USA
    Psychosom Med 71:431-7. 2009
    ..g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously...
  60. ncbi A convergent-divergent approach to context processing, general intellectual functioning, and the genetic liability to schizophrenia
    Angus W MacDonald
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    Neuropsychology 19:814-21. 2005
    ....
  61. ncbi Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  62. ncbi White-coat hypertension and autonomic nervous system dysregulation
    Serina A Neumann
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Hypertens 18:584-8. 2005
    ..The current study asks whether individuals with white-coat hypertension have abnormal autonomic-cardiac regulation, similar to that observed in sustained or persistent hypertension...
  63. ncbi Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and control
    Sarah M Brown
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Emotion 6:239-45. 2006
    ..Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits...
  64. doi An evaluation of the stress-negative affect model in explaining alcohol use: the role of components of negative affect and coping style
    Sarah Siodmok Dermody
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Subst Use Misuse 48:297-308. 2013
    ..Sadness, anger, and guilt were significant mediators and the significant pathways differed based on coping style. The implications and limitations of the study are discussed...
  65. pmc Hostile mood and social strain during daily life: a test of the transactional model
    Elizabeth J Vella
    Department of Psychology, University of Southern Maine, Portland, ME 04103, USA
    Ann Behav Med 44:341-52. 2012
    ..Hostility is a multidimensional construct related to cardiovascular (CV) disease risk. Daily hostile mood and social interactions may precipitate stress-related CV responses in hostile individuals...
  66. ncbi Delay discounting and smoking: association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per day
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 10:1571-5. 2008
    ..These results suggest that DD among smokers is not simply the result of nicotine exposure, but may be an important marker for dependence, especially urgency to smoke in the morning...
  67. pmc Neurobiological pathways linking socioeconomic position and health
    Peter J Gianaros
    Department of Psychiatry, Thomas Detre Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychosom Med 72:450-61. 2010
    ....
  68. ncbi Heart rate variability is associated with polymorphic variation in the choline transporter gene
    Serina A Neumann
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychosom Med 67:168-71. 2005
    ....
  69. ncbi Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults
    Sarah M Conklin
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, United States
    Neurosci Lett 421:209-12. 2007
    ..Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity...
  70. ncbi Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity
    Ahmad R Hariri
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 26:13213-7. 2006
    ..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction...
  71. ncbi Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge
    Jeanne M McCaffery
    Centers for Behavioral and Preventive Medicine, Brown Medical School and The Miriam Hospital, Providence, Rhode Island 02903, USA
    J Hypertens 20:1105-14. 2002
    ....
  72. ncbi Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent
    Jeanne M McCaffery
    Centers for Behavioral and Preventive Medicine, Brown Medical School and The Miriam Hospital, Providence, RI 02903, USA
    Psychosom Med 65:721-8. 2003
    ..To examine the effect of length variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on individual differences in cardiovascular response to psychological challenge...
  73. ncbi The association between racial identity and hypertension in African-American adults: elevated resting and ambulatory blood pressure as outcomes
    Hayley S Thompson
    Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ethn Dis 12:20-8. 2002
    ..It was also hypothesized that the experience of stress and hostility or cynical mistrust associated with transitional identity would account for this association...
  74. doi Trait negative affect: toward an integrated model of understanding psychological risk for impairment in cardiac autonomic function
    Maria E Bleil
    Department of Psychiatry, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94143 0848, USA
    Psychosom Med 70:328-37. 2008
    ..g., autonomic nervous system [ANS] dysfunction), the degree to which a general tendency to experience negative emotions may account for these relations is not known...
  75. ncbi Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  76. ncbi Effects of exercise on cardiovascular outcomes in monkeys with risk factors for coronary heart disease
    J Koudy Williams
    Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 23:864-71. 2003
    ..However, the mechanisms mediating the beneficial effects of exercise remain ambiguous. In particular, it is uncertain whether exercise inhibits the development of atherosclerosis, a major pathobiologic process underlying heart disease...
  77. ncbi Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function
    Serina A Neumann
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
    Biol Psychiatry 60:1155-62. 2006
    ..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function...
  78. ncbi Ovarian dysfunction, stress, and disease: a primate continuum
    Jay R Kaplan
    Department of Pathology, Wake Forest University, School of Medicine, Winston Salem, NC, USA
    ILAR J 45:89-115. 2004
    ..g., sedentary lifestyle, high-fat diet) permissive to the development of chronic disease...
  79. ncbi Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Biol Psychiatry 55:739-44. 2004
    ..Further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology...
  80. ncbi Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis)
    Jay R Kaplan
    Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Neuropsychopharmacology 26:431-43. 2002
    ..05). The Dominance-HVA association observed here is consistent with recent speculation that social extraversion, a dominance-related personality trait in humans, may also reflect heightened central nervous system dopaminergic activity...
  81. ncbi Temporal stability of individual differences in amygdala reactivity
    Stephen B Manuck
    Am J Psychiatry 164:1613-4. 2007
  82. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...

Research Grants6

  1. BIOBEHAVIORAL STUDIES OF CARDIOVASCULAR DISEASE
    STEPHEN MANUCK; Fiscal Year: 2007
    ..abstract_text> ..
  2. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2000
    ..This application is the resubmission of a prior proposal of the same title. ..
  3. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2001
    ..This application is the resubmission of a prior proposal of the same title. ..
  4. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2002
    ..This application is the resubmission of a prior proposal of the same title. ..
  5. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2003
    ..This application is the resubmission of a prior proposal of the same title. ..