Patrick W Mantyh

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi A mechanism-based understanding of bone cancer pain
    Patrick W Mantyh
    Neurosystems Center, Department of Preventive Sciences, University of Minnesota, 18 208 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Novartis Found Symp 261:194-214; discussion 214-9, 256-61. 2004
  2. ncbi Neurobiology of substance P and the NK1 receptor
    Patrick W Mantyh
    Department of Preventive Sciences, Psychiatry, and Neuroscience, University of Minnesota, Minneapolis, USA
    J Clin Psychiatry 63:6-10. 2002
  3. ncbi Cancer pain and its impact on diagnosis, survival and quality of life
    Patrick W Mantyh
    Neurosystems Center, 18 208 Moos Tower, University of Minnesota, 515 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Nat Rev Neurosci 7:797-809. 2006
  4. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
  5. ncbi Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture
    Juan M Jimenez-Andrade
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 133:183-96. 2007
  6. pmc Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer
    Kyle G Halvorson
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    J Pain Symptom Manage 36:289-303. 2008
  7. ncbi A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    Kyle G Halvorson
    Department of Diagnostic and Biological Sciences, University of Minnesota, MN 55455, USA
    Cancer Res 65:9426-35. 2005
  8. ncbi Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
    Molly A Sevcik
    Neurosystems Center and Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA
    Pain 115:128-41. 2005
  9. ncbi Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
    Christopher M Peters
    Neurosystems Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 193:85-100. 2005
  10. ncbi Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia
    Joseph R Ghilardi
    Department of Preventive Sciences and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:2727-32. 2004

Collaborators

Detail Information

Publications46

  1. ncbi A mechanism-based understanding of bone cancer pain
    Patrick W Mantyh
    Neurosystems Center, Department of Preventive Sciences, University of Minnesota, 18 208 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Novartis Found Symp 261:194-214; discussion 214-9, 256-61. 2004
    ..Therefore defining when and how these different components drive bone cancer pain may allow the development of more selective analgesic agents to treat this chronic pain state...
  2. ncbi Neurobiology of substance P and the NK1 receptor
    Patrick W Mantyh
    Department of Preventive Sciences, Psychiatry, and Neuroscience, University of Minnesota, Minneapolis, USA
    J Clin Psychiatry 63:6-10. 2002
    ....
  3. ncbi Cancer pain and its impact on diagnosis, survival and quality of life
    Patrick W Mantyh
    Neurosystems Center, 18 208 Moos Tower, University of Minnesota, 515 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Nat Rev Neurosci 7:797-809. 2006
    ....
  4. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
    ..An understanding of the factors involved in the development and maintenance of PN may lead to mechanism based therapies that prevent/treat PN and thus improve the survival and quality of life of patients receiving chemotherapy...
  5. ncbi Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture
    Juan M Jimenez-Andrade
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 133:183-96. 2007
    ..These results demonstrate that NGF plays a significant role in driving fracture pain and that NGF sequestering therapies may be efficacious in attenuating this pain...
  6. pmc Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer
    Kyle G Halvorson
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    J Pain Symptom Manage 36:289-303. 2008
    ..These results support limited clinical trials that suggest the potential of ibandronate to rapidly attenuate bone pain and illuminate the mechanisms that may be responsible for limiting pain and disease progression...
  7. ncbi A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    Kyle G Halvorson
    Department of Diagnostic and Biological Sciences, University of Minnesota, MN 55455, USA
    Cancer Res 65:9426-35. 2005
    ..The present results suggest that anti-NGF therapy may be effective in reducing pain and enhancing the quality of life in patients with prostate tumor-induced bone cancer pain...
  8. ncbi Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
    Molly A Sevcik
    Neurosystems Center and Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA
    Pain 115:128-41. 2005
    ....
  9. ncbi Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
    Christopher M Peters
    Neurosystems Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 193:85-100. 2005
    ..Tumor-derived, inflammatory, and neuropathic mechanisms may therefore be simultaneously driving this chronic pain state...
  10. ncbi Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia
    Joseph R Ghilardi
    Department of Preventive Sciences and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:2727-32. 2004
    ..These results suggest that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury...
  11. doi A fracture pain model in the rat: adaptation of a closed femur fracture model to study skeletal pain
    Katie T Freeman
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    Anesthesiology 108:473-83. 2008
    ....
  12. pmc An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat
    Christopher M Peters
    Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res 1168:46-59. 2007
    ..Understanding the cellular changes that generate and maintain this neuropathy may allow the development of mechanism-based therapies to attenuate or block this frequently painful and debilitating condition...
  13. pmc Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer
    Molly A Sevcik
    Neurosystems Center, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Gastroenterology 131:900-10. 2006
    ..Recent human imaging studies have shown a significant tonic modulation of visceral pain, raising the question of whether endogenous opioids tonically modulate the pain of visceral cancer...
  14. ncbi Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2
    Mary Ann C Sabino
    Neurosystems Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 62:7343-9. 2002
    ..The present results suggest that chronic administration of a COX-2 inhibitor blocks prostaglandin synthesis at multiple sites, and may have significant clinical utility in the management of bone cancer and bone cancer pain...
  15. ncbi Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis
    Molly A Sevcik
    Department of Preventive Sciences, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA
    Pain 111:169-80. 2004
    ..These data emphasize that it is essential to utilize a model where pain, skeletal remodeling and tumor growth can be simultaneously assessed, as each of these can significantly impact patient quality of life and survival...
  16. ncbi Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression
    Theodore H Lindsay
    Neurosystems Center, 18 208 Moos Tower, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Pain 119:233-46. 2005
    ..Defining the mechanisms that mask this pain in early and mid-stage disease and drive the pain in late-stage disease may aid in earlier diagnosis, survival, and increased quality of life of patients with pancreatic cancer...
  17. pmc Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint
    Joseph R Ghilardi
    Minneapolis VA Medical Center, Minneapolis, Minnesota, USA
    Arthritis Rheum 64:2223-32. 2012
    ..This study was undertaken to investigate whether there is significant sprouting of sensory and sympathetic nerve fibers in the painful arthritic knee joint and whether nerve growth factor (NGF) drives this pathologic reorganization...
  18. ncbi Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model
    Molly A Sevcik
    Neurosystems Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Pain 6:771-5. 2005
    ....
  19. ncbi Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
    Joseph R Ghilardi
    Neurosystems Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:3126-31. 2005
    ....
  20. ncbi Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis
    Christopher M Peters
    Department of Preventive Science, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 180:1-13. 2003
    ..Strategies aimed at blocking vascular ET(A)R/ET(B)R and astrocyte ET(B)Rs following spinal cord injury may reduce the resulting ischemia and astrogliosis and in doing so increase neuronal survival, regeneration, and function...
  21. ncbi Pathophysiology of bone cancer pain
    Mary Ann C Sabino
    Neurosystems Laboratory, Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Surgical Sciences, University of Minnesota, Minneapolis 55455, USA
    J Support Oncol 3:15-24. 2005
    ..Understanding the mechanisms involved in the pathophysiology of bone cancer pain will improve both our ability to provide mechanism-based therapies and the quality of life of cancer patients...
  22. ncbi NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla
    Denes Budai
    Department of Diagnostic and Biological Sciences, University of Minnesota, 515 Delaware Street SE, 17 252 Moos Tower, Minneapolis, MN 55455, USA
    J Neurophysiol 97:1388-95. 2007
    ..It is suggested that activation of NK-1 receptors in the RVM and the ensuing sensitization of on cells may contribute to the development of central sensitization and hyperalgesia after tissue injury and inflammation...
  23. ncbi Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system
    Mary Ann C Sabino
    Department of Preventive Sciences, University of Minnesota, Minneapolis, MN, USA
    Int J Cancer 104:550-8. 2003
    ..These data suggest that bone cancer pain is not caused by a single factor such as increased pressure induced by intramedullary tumor growth, but rather that multiple factors are involved in generating and maintaining bone cancer pain...
  24. ncbi Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer
    Kyle G Halvorson
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, 55455, USA
    Clin J Pain 22:587-600. 2006
    ..As analgesics can also influence disease progression, findings from these studies may lead to therapies that have the potential to improve the quality of life and survival of patients with skeletal malignancies...
  25. ncbi Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat
    Juan Miguel Jimenez-Andrade
    Neurosystems Center, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, United States
    Neurosci Lett 405:62-7. 2006
    ..These results provide a pathological basis for the anatomical distribution of paclitaxel-induced symptoms in patients receiving therapeutic regimens of paclitaxel...
  26. ncbi Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    Sergey G Khasabov
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:9086-98. 2002
    ..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization...
  27. ncbi Effects of a monoclonal antibody raised against nerve growth factor on skeletal pain and bone healing after fracture of the C57BL/6J mouse femur
    Nathan J Koewler
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    J Bone Miner Res 22:1732-42. 2007
    ..Anti-NGF therapy did not interfere with bone healing as assessed by mechanical testing and histomorphometric analysis...
  28. ncbi Bone cancer pain
    Denis R Clohisy
    Department of Orthopedic Surgery and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer 97:866-73. 2003
    ..Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease...
  29. ncbi Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus
    Sergey G Khasabov
    Department of Oral Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 93:998-1006. 2005
    ..These results demonstrate that spinal neurons expressing the NK-1 receptor appear to play a pivotal role in regulating descending systems that modulate activity of nociceptive dorsal horn neurons...
  30. ncbi Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain
    Carl D Martin
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Neurosci Lett 427:148-52. 2007
    ....
  31. ncbi Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain
    Nancy M Luger
    Department of Preventive Sciences, Schools of Dentistry and Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 99:397-406. 2002
    ..inflammatory pain. These results indicate that this model may be useful in defining drug therapies that are targeted for complex bone cancer pain syndromes...
  32. pmc Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain
    Joseph R Ghilardi
    Research Service, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Mol Pain 6:87. 2010
    ..Developing targeted therapies that relieve cancer pain without the side effects of current analgesics has the potential to significantly improve the quality of life and functional status of cancer patients...
  33. ncbi Bone cancer pain: from model to mechanism to therapy
    Nancy M Luger
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    J Pain Symptom Manage 29:S32-46. 2005
    ..These results indicate that this model will be useful in defining drug therapies that are targeted for complex bone cancer pain syndromes...
  34. ncbi Mechanisms that generate and maintain bone cancer pain
    Patrick W Mantyh
    Department of Preventive Sciences, University of Minnesota, 18 208 Moos Tower, 515 Delatvare Street SE, Minneapolis, MN 55455, USA
    Novartis Found Symp 260:221-38; discussion 238-40, 277-9. 2004
    ..Together these advances should reduce tumour-induced pain and suffering and significantly improve the quality of life of cancer patients...
  35. pmc Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers
    Joseph R Ghilardi
    Research Service, VA Medical Center, Minneapolis, MN 55417, USA
    Bone 48:389-98. 2011
    ....
  36. ncbi Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
    Scott D Rogers
    Molecular Neurobiology Laboratory, Veterans Affairs Medical Center, Minneapolis, Minnesota 55455, USA
    Glia 41:180-90. 2003
    ..These data suggest that pharmacological blockade of astrocyte ET(B)R receptors following CNS injury modulates glial scar formation and may provide a more permissive substrate for neuronal survival and regeneration...
  37. ncbi Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity
    Patrick W Mantyh
    Neurosystems Center, Cancer Center and Department of Preventive Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Neurosci 27:582-4. 2004
    ..These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic...
  38. ncbi Radiation treatment decreases bone cancer pain through direct effect on tumor cells
    Michael Goblirsch
    Department of Orthopedic Surgery, The University of Minnesota, Minneapolis, Minnesota 55455, USA
    Radiat Res 164:400-8. 2005
    ..0005) and bone cancer pain (P < 0.05). The findings in this study demonstrate that one mechanism through which radiation decreases bone cancer pain is by direct effects on tumor cells...
  39. ncbi Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain
    Mary Ann C Sabino
    Department of Preventive Sciences, University of Minnesota, 18 208 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Pain 95:175-86. 2002
    ..Defining the population of neurons activated in orofacial pain and whether analgesics modify the activation of these neurons should provide insight into the mechanisms that generate and maintain acute and chronic orofacial pain...
  40. ncbi Molecular mechanisms of cancer pain
    Patrick W Mantyh
    Department of Preventive Sciences, University of Minnesota, Minneapolis 55455, USA
    Nat Rev Cancer 2:201-9. 2002
    ..New insights into these mechanisms are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled...
  41. ncbi The cerebral signature for pain perception and its modulation
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, OX3 9DU Oxford, England, UK
    Neuron 55:377-91. 2007
    ....
  42. ncbi Spinal neurons involved in the generation of at-level pain following spinal injury in the rat
    Robert P Yezierski
    Department of Orthodontics, University of Florida, Gainesville, FL 32610, USA
    Neurosci Lett 361:232-6. 2004
    ..The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord...
  43. ncbi Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice
    Sara Morcuende
    Department of Anatomy and Developmental Biology, Medawar Building, UCL, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 18:1828-36. 2003
    ..They support the hypothesis that increased neurogenesis, perhaps accompanied by higher levels of brain-derived neurotrophic factor, may contribute to the efficacy of antidepressant drug therapy...
  44. ncbi A mechanism based understanding of cancer pain
    Patrick W Mantyh
    Pain 96:1-2. 2002
  45. pmc Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies
    Juan M Jimenez-Andrade
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Mol Pain 4:10. 2008
    ....
  46. ncbi Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs
    Jeffrey W Allen
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0818, USA
    Toxicol Sci 91:286-98. 2006
    ..These data indicate no adverse toxicity at doses up to 10 times those necessary for producing loss of superficial NK1r-bearing neurons in a large animal model...