P W Mantyh

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Brain Res 719:8-13. 1996
  2. ncbi request reprint Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Science 278:275-9. 1997
  3. ncbi request reprint Osteoprotegerin diminishes advanced bone cancer pain
    N M Luger
    Neurosystems Center, Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Res 61:4038-47. 2001
  4. ncbi request reprint Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception
    J D Pomonis
    Departments of Preventive Science, Neuroscience, and Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 21:999-1006. 2001
  5. ncbi request reprint Endothelin and the tumorigenic component of bone cancer pain
    C M Peters
    Neurosystems Center and Department of Preventive Sciences, 18 208 Moos Tower, University of Minnesota, 515 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Neuroscience 126:1043-52. 2004
  6. ncbi request reprint A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas
    T H Lindsay
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, and Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55455, USA
    Neuroscience 137:1417-26. 2006
  7. ncbi request reprint Radiation treatment decreases bone cancer pain, osteolysis and tumor size
    M Goblirsch
    Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Radiat Res 161:228-34. 2004
  8. ncbi request reprint Bone cancer pain and the role of RANKL/OPG
    D R Clohisy
    Dept of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Musculoskelet Neuronal Interact 4:293-300. 2004
  9. ncbi request reprint Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur
    D B Mach
    Neurosystems Center, University of Minnesota, 18 208 Moos Tower, 515 Delaware Street S E, Minneapolis, MN 55455, USA
    Neuroscience 113:155-66. 2002
  10. ncbi request reprint Primary afferent tachykinins are required to experience moderate to intense pain
    Y Q Cao
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, 94143 0452, USA
    Nature 392:390-4. 1998

Collaborators

  • D R Clohisy
  • P Honore
  • R G Wiley
  • J Li
  • B J Allen
  • G Y Wong
  • C M Peters
  • J D Pomonis
  • N M Luger
  • T H Lindsay
  • J R Ghilardi
  • D B Mach
  • S D Rogers
  • M Goblirsch
  • M J Schwei
  • Y Q Cao
  • M A Kuskowski
  • K G Halvorson
  • B J Gerbi
  • M A Sevcik
  • P Alaei
  • W Mathews
  • C Lynch
  • M C Sabino
  • C P Keyser
  • D J Adams
  • P O'Leary
  • M A Sabino
  • C J Epstein
  • A M Gillespie
  • A I Basbaum
  • E J Carlson

Detail Information

Publications10

  1. ncbi request reprint Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Brain Res 719:8-13. 1996
    ..These results imply that different tissues express different ratios of the two isoforms of the NK-1 receptor. This differential expression provides the theoretical basis for tissue specific pharmacological targeting of NK-1 receptors...
  2. ncbi request reprint Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Science 278:275-9. 1997
    ..Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia...
  3. ncbi request reprint Osteoprotegerin diminishes advanced bone cancer pain
    N M Luger
    Neurosystems Center, Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Res 61:4038-47. 2001
    ..Blockade of ongoing osteoclast activity appears to have the potential to reduce bone cancer pain in patients with advanced tumor-induced bone destruction...
  4. ncbi request reprint Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception
    J D Pomonis
    Departments of Preventive Science, Neuroscience, and Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 21:999-1006. 2001
    ..These data indicate that ETs can have direct, nociceptive effects on the peripheral sensory nervous system and that peripheral glia may be directly involved in signaling nociceptive events in peripheral tissues...
  5. ncbi request reprint Endothelin and the tumorigenic component of bone cancer pain
    C M Peters
    Neurosystems Center and Department of Preventive Sciences, 18 208 Moos Tower, University of Minnesota, 515 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Neuroscience 126:1043-52. 2004
    ....
  6. ncbi request reprint A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas
    T H Lindsay
    Neurosystems Center and Department of Diagnostic and Biological Sciences, University of Minnesota, and Research Service, Veterans Affairs Medical Center, Minneapolis, MN 55455, USA
    Neuroscience 137:1417-26. 2006
    ....
  7. ncbi request reprint Radiation treatment decreases bone cancer pain, osteolysis and tumor size
    M Goblirsch
    Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Radiat Res 161:228-34. 2004
    ..The findings indicated that radiation treatment reduced bone pain and supported reduced cancer burden and reduced osteolysis as mechanisms through which radiation reduces bone cancer pain...
  8. ncbi request reprint Bone cancer pain and the role of RANKL/OPG
    D R Clohisy
    Dept of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Musculoskelet Neuronal Interact 4:293-300. 2004
    ..Having established that RANK ligand contributed to cancer-induced osteoclastogenesis, it was determined that disruption of the RANKL-RANK axis with OPG inhibited tumor-induced osteoclastogenesis and decreased bone cancer pain...
  9. ncbi request reprint Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur
    D B Mach
    Neurosystems Center, University of Minnesota, 18 208 Moos Tower, 515 Delaware Street S E, Minneapolis, MN 55455, USA
    Neuroscience 113:155-66. 2002
    ..Understanding the sensory and sympathetic innervation of bone should provide a better understanding of the mechanisms that drive bone pain and aid in developing therapeutic strategies for treating skeletal pain...
  10. ncbi request reprint Primary afferent tachykinins are required to experience moderate to intense pain
    Y Q Cao
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, 94143 0452, USA
    Nature 392:390-4. 1998
    ..We conclude that the release of tachykinins from primary afferent pain-sensing receptors (nociceptors) is required to produce moderate to intense pain...