Stavros Manolagas

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System, Little Rock, AR, USA
    J Bone Miner Res 25:769-81. 2010
  2. pmc Steroids and osteoporosis: the quest for mechanisms
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciencesand Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    J Clin Invest 123:1919-21. 2013
  3. pmc For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Bone 54:272-8. 2013
  4. pmc Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass
    Shoshana M Bartell
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, 4301 West Markham Street, MS 587, Little Rock, Arkansas 72205, USA
    Mol Endocrinol 27:649-56. 2013
  5. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
  6. pmc De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol
    Stavros C Manolagas
    Section of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, 4301 West Markham, No 587, Little Rock, AR 72205 7199, USA
    Endocrinology 149:3264-6. 2008
  7. pmc What old means to bone
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, AR 72205, USA
    Trends Endocrinol Metab 21:369-74. 2010
  8. ncbi request reprint Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205 7199, USA
    Mol Endocrinol 21:2605-14. 2007
  9. ncbi request reprint Sex steroids and bone
    S C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Recent Prog Horm Res 57:385-409. 2002
  10. ncbi request reprint Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    S Kousteni
    Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Science 298:843-6. 2002

Research Grants

  1. OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
    Stavros Manolagas; Fiscal Year: 2006
  2. Molecular & Cellular Mechanisms of Osteoporosis
    Stavros Manolagas; Fiscal Year: 2007

Collaborators

Detail Information

Publications63

  1. pmc Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System, Little Rock, AR, USA
    J Bone Miner Res 25:769-81. 2010
    ....
  2. pmc Steroids and osteoporosis: the quest for mechanisms
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciencesand Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    J Clin Invest 123:1919-21. 2013
    ..Altered redox balance is a proximal underlying mechanism of some of these effects, and sex steroid deficiency or glucocorticoid excess contributes to the aging of the skeleton...
  3. pmc For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Bone 54:272-8. 2013
    ....
  4. pmc Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass
    Shoshana M Bartell
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, 4301 West Markham Street, MS 587, Little Rock, Arkansas 72205, USA
    Mol Endocrinol 27:649-56. 2013
    ..These results demonstrate that the protection of cortical bone mass by estrogens is mediated, at least in part, via a mechanism that is distinct from the classic mechanism of estrogen action on reproductive organs...
  5. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
    ....
  6. pmc De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol
    Stavros C Manolagas
    Section of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, 4301 West Markham, No 587, Little Rock, AR 72205 7199, USA
    Endocrinology 149:3264-6. 2008
  7. pmc What old means to bone
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, AR 72205, USA
    Trends Endocrinol Metab 21:369-74. 2010
    ..Unraveling these mechanisms should improve understanding of the age-related increase in fractures and suggest novel targets for its prevention...
  8. ncbi request reprint Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205 7199, USA
    Mol Endocrinol 21:2605-14. 2007
    ....
  9. ncbi request reprint Sex steroids and bone
    S C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Recent Prog Horm Res 57:385-409. 2002
    ..The same ligands may also circumvent the side effects associated with conventional hormone replacement therapy...
  10. ncbi request reprint Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    S Kousteni
    Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Science 298:843-6. 2002
    ..Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected]...
  11. ncbi request reprint Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin
    E Abe
    Division of Endocrinology and Metabolism and the UAMS Center for Osteoporosis and Metabolic Bone Diseases, Little Rock, Arkansas, USA
    J Bone Miner Res 15:663-73. 2000
    ..Hence, BMPs, perhaps in balance with noggin and possibly other antagonists, may provide the tonic baseline control of the rate of bone remodeling on which other inputs (e.g., hormonal, biomechanical, etc.) operate...
  12. ncbi request reprint Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells
    A T Mancino
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Surg Res 100:18-24. 2001
    ..The ability to stimulate osteoclasts may explain the ability to metastasize to bone...
  13. pmc Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density
    D Jia
    Department of Internal Medicine, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 587, Little Rock, Arkansas 72205, USA
    Endocrinology 147:5592-9. 2006
    ..These results demonstrate for the first time that the early, rapid loss of bone caused by glucocorticoid excess results from direct actions on osteoclasts...
  14. ncbi request reprint Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy
    T Yamate
    Department of Medicine, UAMS Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocrinology 138:3047-55. 1997
    ..These findings indicate that osteopontin is expressed during the early stages of the differentiation of osteoclast and osteoblast progenitors in the bone marrow and that its cell adhesion properties are required for osteoclastogenesis...
  15. pmc Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor
    T Bellido
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Clin Invest 95:2886-95. 1995
    ....
  16. pmc Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    R S Weinstein
    Division of Endocrinology Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Affairs Medical Center GRECC, Little Rock, Arkansas 72205, USA
    J Clin Invest 102:274-82. 1998
    ..Furthermore, accumulation of apoptotic osteocytes may contribute to osteonecrosis. These findings provide evidence that glucocorticoid-induced bone disease arises from changes in the numbers of bone cells...
  17. ncbi request reprint Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells
    C A O'Brien
    Division of Endocrinology and Metabolism, Department of Medicine, Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Bone 30:453-62. 2002
    ....
  18. ncbi request reprint Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures
    D Gaddy-Kurten
    Department of Physiology and Biophysics, Division of Endocrinology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Endocrinology 143:74-83. 2002
    ....
  19. ncbi request reprint Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
    T Bellido
    Division of Endocrinology and Metabolism, and Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Endocrinology 146:4577-83. 2005
    ....
  20. pmc Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol
    G B Di Gregorio
    Division of Endocrinology and Metabolism, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Invest 107:803-12. 2001
    ....
  21. ncbi request reprint Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation
    T Bellido
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Administration Medical Center, Little Rock 72205, USA
    Endocrinology 138:3666-76. 1997
    ....
  22. ncbi request reprint Isolation and characterization of the human gp130 promoter. Regulation by STATS
    C A O'Brien
    Division of Endocrinology, University of Arkansas for Medical Sciences Center of Osteoporosis and Metabolic Bone Diseases, University of Little Rock, Arkansas 72205, USA
    J Biol Chem 272:15003-10. 1997
    ..These results establish that the DNA fragment we have isolated contains the human gp130 promoter and that interleukin-6 type cytokines may influence the activity of this promoter via activated STATs...
  23. ncbi request reprint The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage
    R S Weinstein
    Division of Endocrinology Metabolism, McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocrinology 138:4013-21. 1997
    ..This evidence suggests that cells of the osteoblastic lineage are essential mediators of the changes in the rate of bone remodeling and loss of bone mass that ensue following loss of androgens...
  24. ncbi request reprint Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
    T Bellido
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Biol Chem 273:21137-44. 1998
    ..These results demonstrate that p21 is a downstream effector of gp130/Stat3 activation and a critical mediator of the pro-differentiating and anti-apoptotic effects of IL-6 type cytokines on human osteoblastic cells...
  25. ncbi request reprint Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity
    T Bellido
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and Central Arkansas Veteterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 275:26328-32. 2000
    ....
  26. ncbi request reprint STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid horm
    C A O'Brien
    Departments of Medicine and Pediatrics, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 274:19301-8. 1999
    ..In addition, this study demonstrates that activation of the gp130-STAT3 pathway in stromal/osteoblastic cells mediates the osteoclastogenic effects of IL-1, but not parathyroid hormone or 1, 25-dihydroxyvitamin D3...
  27. ncbi request reprint Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
    B Lecka-Czernik
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Little Rock, Arkansas 72205, USA
    J Cell Biochem 74:357-71. 1999
    ..These results strongly suggest that PPARgamma2 negatively regulates stromal cell plasticity by suppressing Osf2/Cbfa1 and osteoblast-like biosynthetic activity, while promoting terminal differentiation to adipocytes...
  28. pmc Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
    R L Jilka
    Division of Endocrinology and Metabolism, UAMS Center for Osteoporosis and Metabolic Bone Diseases, and Central Arkansas Veterans Health Care System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Invest 104:439-46. 1999
    ..Moreover, it suggests novel pharmacotherapeutic strategies for osteoporosis and, perhaps, other pathologic conditions in which tissue mass diminution has compromised functional integrity...
  29. ncbi request reprint Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines
    C A O'Brien
    Division of Endocrinology and Metabolism, Department of Medicine, Center for Osteoporosis and Metabolic Bone Diseases, and the McClellan VAMC, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cell Biochem 79:532-41. 2000
    ....
  30. ncbi request reprint Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    S C Manolagas
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocr Rev 21:115-37. 2000
    ....
  31. ncbi request reprint Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip
    R S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    J Clin Endocrinol Metab 85:2907-12. 2000
    ....
  32. ncbi request reprint Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  33. ncbi request reprint Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation
    E Abe
    Division of Endocrinology and Metabolism, John L McClellan VA Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Calcif Tissue Int 64:508-15. 1999
    ..These observations demonstrate that meltrins play a role in MGC and osteoclast formation from mononuclear precursors, as in the case with myotubes...
  34. ncbi request reprint Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
    L I Plotkin
    Div of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Cell Physiol 289:C633-43. 2005
    ....
  35. ncbi request reprint Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha
    M Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Endocrinology 147:1986-96. 2006
    ..These results support an extensive divergence in gene expression depending on the mode of ER activation...
  36. ncbi request reprint Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains
    H Benes
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, USA
    J Bone Miner Res 15:626-33. 2000
    ..Such recurrent appearance of QTLs, especially in crosses involving distantly-related strains, implies that polymorphism at these loci may be favored by evolution and might underlie variation in peak bone density among humans...
  37. pmc Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor
    Stavroula Kousteni
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Mol Cell Biol 27:1516-30. 2007
    ..ER can either induce it or repress it, depending on whether the activating ligand (and presumably the resulting conformation of the receptor protein) precludes or accommodates ERE-mediated transcription...
  38. pmc A novel locus on the X chromosome regulates post-maturity bone density changes in mice
    Dorota Szumska
    Department of Geriatrics, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA
    Bone 40:758-66. 2007
    ..Hum Mol Genet 2005;14:3141-8]. A second locus, on chromosome 7, was observed in only one cross. Single-nucleotide polymorphisms (SNPs) are highly clustered near these loci, distinguishing the parental strains over only limited spans...
  39. ncbi request reprint Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis
    Lillian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    J Biol Chem 282:24120-30. 2007
    ....
  40. ncbi request reprint A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
    J Ignacio Aguirre
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 282:25501-8. 2007
    ....
  41. pmc Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    J Biol Chem 282:27285-97. 2007
    ..Loss of estrogens or androgens accelerates the effects of aging on bone by decreasing defense against oxidative stress...
  42. pmc Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass
    Carlo Galli
    Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, 4301 West Markham Street, MS 587, Little Rock, Arkansas 72205, USA
    Endocrinology 149:146-53. 2008
    ..These findings demonstrate that hormonal control of RANKL expression via the DCR is a critical determinant of the rate of bone remodeling...
  43. ncbi request reprint Quantifying osteoblast and osteocyte apoptosis: challenges and rewards
    Robert L Jilka
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Bone Miner Res 22:1492-501. 2007
    ....
  44. ncbi request reprint Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    J Biol Chem 282:27298-305. 2007
    ....
  45. pmc Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer
    Qiang Fu
    University of Arkansas for Medical Sciences, 4301 W Markham St, Mail Slot 587, Little Rock, AR 72205, USA
    Mol Cell Biol 26:6453-68. 2006
    ..Thus, PTH responsiveness of the RANKL gene is determined by a distant regulatory region that responds to cAMP in a cell-type-specific manner and Runx2 may contribute to such cell-type specificity...
  46. ncbi request reprint Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 587, Little Rock, AR 72205, USA
    Bone 39:443-52. 2006
    ....
  47. pmc Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
    Robert S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205 7199, USA
    J Clin Invest 109:1041-8. 2002
    ..Therefore, the early beneficial effects of these agents must be due, in part, to prolonging the life span of osteoblasts...
  48. ncbi request reprint Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation
    Beata Lecka-Czernik
    Department of Geriatrics, Reynolds Center on Aging, Division of Endocrinology and Metabolism, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Endocrinology 143:2376-84. 2002
    ..Moreover, there may be selective PPAR gamma 2 modulators that block the adverse effects of fatty acid oxidation products while retaining beneficial activities such as insulin sensitization...
  49. ncbi request reprint Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein
    Qiang Fu
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Biol Chem 277:48868-75. 2002
    ..These results demonstrate that PTH directly stimulates RANKL expression via a PKA-CREB pathway and that CREB may be a central regulator of RANKL expression. Furthermore, they suggest that PTH suppression of OPG involves CREB and c-fos...
  50. pmc Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
    Stavroula Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Clin Invest 111:1651-64. 2003
    ....
  51. ncbi request reprint Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism
    Teresita Bellido
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 278:50259-72. 2003
    ..The self-limiting nature of PTH-induced survival signaling might explain why intermittent administration of the hormone is required for bone anabolism...
  52. ncbi request reprint Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength
    CHARLES A O'BRIEN
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    Endocrinology 145:1835-41. 2004
    ..Furthermore, our results suggest that glucocorticoid-induced loss of bone strength results in part from increased death of osteocytes, independent of bone loss...
  53. ncbi request reprint The skeletal effects of glucocorticoid excess override those of orchidectomy in mice
    Robert S Weinstein
    Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    Endocrinology 145:1980-7. 2004
    ..These data demonstrate that hypogonadism does not occur in or contribute to glucocorticoid-induced osteoporosis and that the adverse skeletal effects of glucocorticoid excess override those of orchidectomy...
  54. ncbi request reprint Transduction of cell survival signals by connexin-43 hemichannels
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:8648-57. 2002
    ....
  55. ncbi request reprint In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging
    Jian Zhang
    Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA
    Exp Gerontol 39:239-47. 2004
    ..We conclude that ability of ROS to act as secondary messengers and induce gene expression may contribute to the aging process...
  56. ncbi request reprint Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens
    Jin Ran Chen
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:4632-8. 2005
    ....
  57. ncbi request reprint Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation
    Lilian I Plotkin
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, the Central Arkansas Veterans Affairs Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    J Biol Chem 280:7317-25. 2005
    ....
  58. ncbi request reprint Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation
    A Afshan Ali
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Slot 587, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Endocrinology 146:1226-35. 2005
    ....
  59. ncbi request reprint Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases
    Anthony M Vertino
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:14130-7. 2005
    ....
  60. ncbi request reprint IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice
    CHARLES A O'BRIEN
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 289:E784-93. 2005
    ..These results demonstrate that IL-6 is not required for the osteoclast formation and bone loss that accompanies continuous elevation of PTH...
  61. ncbi request reprint Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:41342-51. 2005
    ....
  62. ncbi request reprint Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss
    J Ignacio Aguirre
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 21:605-15. 2006
    ..We report here that, conversely, reduced mechanical forces in the murine model of unloading by tail suspension increases the prevalence of osteocyte apoptosis, followed by bone resorption and loss of mineral and strength...
  63. ncbi request reprint Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts
    Xiao Dong Chen
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 22:1943-56. 2007
    ..We conclude that the marrow ECM facilitates expansion of mesenchymal progenitors and hypothesize that it plays an important role in the maintenance of MSC stemness...

Research Grants4

  1. OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
    Stavros Manolagas; Fiscal Year: 2006
    ..Results of these studies could provide essential understanding for mechanisms to control bone anabolism. ..
  2. Molecular & Cellular Mechanisms of Osteoporosis
    Stavros Manolagas; Fiscal Year: 2007
    ..This work should help us better understand why elderly people suffer from osteoporosis a lot more than young people; and perhaps identify the optimal anti-osteoporosis therapy for this particular segment of the population. ..