S C Manolagas

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    S C Manolagas
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocr Rev 21:115-37. 2000
  2. ncbi request reprint Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    S Kousteni
    Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Science 298:843-6. 2002
  3. pmc Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol
    G B Di Gregorio
    Division of Endocrinology and Metabolism, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Invest 107:803-12. 2001
  4. pmc Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    R S Weinstein
    Division of Endocrinology Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Affairs Medical Center GRECC, Little Rock, Arkansas 72205, USA
    J Clin Invest 102:274-82. 1998
  5. ncbi request reprint Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
  6. ncbi request reprint Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
    T Bellido
    Division of Endocrinology and Metabolism, and Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Endocrinology 146:4577-83. 2005
  7. ncbi request reprint Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells
    A T Mancino
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Surg Res 100:18-24. 2001
  8. ncbi request reprint Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha
    M Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Endocrinology 147:1986-96. 2006
  9. ncbi request reprint The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage
    R S Weinstein
    Division of Endocrinology Metabolism, McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocrinology 138:4013-21. 1997
  10. ncbi request reprint Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation
    T Bellido
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Administration Medical Center, Little Rock 72205, USA
    Endocrinology 138:3666-76. 1997

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    S C Manolagas
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocr Rev 21:115-37. 2000
    ....
  2. ncbi request reprint Reversal of bone loss in mice by nongenotropic signaling of sex steroids
    S Kousteni
    Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Science 298:843-6. 2002
    ..Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected]...
  3. pmc Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol
    G B Di Gregorio
    Division of Endocrinology and Metabolism, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Invest 107:803-12. 2001
    ....
  4. pmc Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    R S Weinstein
    Division of Endocrinology Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Affairs Medical Center GRECC, Little Rock, Arkansas 72205, USA
    J Clin Invest 102:274-82. 1998
    ..Furthermore, accumulation of apoptotic osteocytes may contribute to osteonecrosis. These findings provide evidence that glucocorticoid-induced bone disease arises from changes in the numbers of bone cells...
  5. ncbi request reprint Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  6. ncbi request reprint Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
    T Bellido
    Division of Endocrinology and Metabolism, and Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
    Endocrinology 146:4577-83. 2005
    ....
  7. ncbi request reprint Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells
    A T Mancino
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Surg Res 100:18-24. 2001
    ..The ability to stimulate osteoclasts may explain the ability to metastasize to bone...
  8. ncbi request reprint Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha
    M Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Endocrinology 147:1986-96. 2006
    ..These results support an extensive divergence in gene expression depending on the mode of ER activation...
  9. ncbi request reprint The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage
    R S Weinstein
    Division of Endocrinology Metabolism, McClellan Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocrinology 138:4013-21. 1997
    ..This evidence suggests that cells of the osteoblastic lineage are essential mediators of the changes in the rate of bone remodeling and loss of bone mass that ensue following loss of androgens...
  10. ncbi request reprint Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation
    T Bellido
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Administration Medical Center, Little Rock 72205, USA
    Endocrinology 138:3666-76. 1997
    ....
  11. ncbi request reprint Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines
    C A O'Brien
    Division of Endocrinology and Metabolism, Department of Medicine, Center for Osteoporosis and Metabolic Bone Diseases, and the McClellan VAMC, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Cell Biochem 79:532-41. 2000
    ....
  12. pmc Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
    R L Jilka
    Division of Endocrinology and Metabolism, UAMS Center for Osteoporosis and Metabolic Bone Diseases, and Central Arkansas Veterans Health Care System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Invest 104:439-46. 1999
    ..Moreover, it suggests novel pharmacotherapeutic strategies for osteoporosis and, perhaps, other pathologic conditions in which tissue mass diminution has compromised functional integrity...
  13. ncbi request reprint Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation
    E Abe
    Division of Endocrinology and Metabolism, John L McClellan VA Geriatric Research, Education, and Clinical Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Calcif Tissue Int 64:508-15. 1999
    ..These observations demonstrate that meltrins play a role in MGC and osteoclast formation from mononuclear precursors, as in the case with myotubes...
  14. pmc Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density
    D Jia
    Department of Internal Medicine, and the Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 587, Little Rock, Arkansas 72205, USA
    Endocrinology 147:5592-9. 2006
    ..These results demonstrate for the first time that the early, rapid loss of bone caused by glucocorticoid excess results from direct actions on osteoclasts...
  15. ncbi request reprint Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
    B Lecka-Czernik
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Little Rock, Arkansas 72205, USA
    J Cell Biochem 74:357-71. 1999
    ..These results strongly suggest that PPARgamma2 negatively regulates stromal cell plasticity by suppressing Osf2/Cbfa1 and osteoblast-like biosynthetic activity, while promoting terminal differentiation to adipocytes...
  16. ncbi request reprint Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures
    D Gaddy-Kurten
    Department of Physiology and Biophysics, Division of Endocrinology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Endocrinology 143:74-83. 2002
    ....
  17. ncbi request reprint Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells
    C A O'Brien
    Division of Endocrinology and Metabolism, Department of Medicine, Center for Osteoporosis and Metabolic Bone Diseases, and the Central Arkansas Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Bone 30:453-62. 2002
    ....
  18. ncbi request reprint Sex steroids and bone
    S C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Recent Prog Horm Res 57:385-409. 2002
    ..The same ligands may also circumvent the side effects associated with conventional hormone replacement therapy...
  19. ncbi request reprint STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid horm
    C A O'Brien
    Departments of Medicine and Pediatrics, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 274:19301-8. 1999
    ..In addition, this study demonstrates that activation of the gp130-STAT3 pathway in stromal/osteoblastic cells mediates the osteoclastogenic effects of IL-1, but not parathyroid hormone or 1, 25-dihydroxyvitamin D3...
  20. ncbi request reprint Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
    T Bellido
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Biol Chem 273:21137-44. 1998
    ..These results demonstrate that p21 is a downstream effector of gp130/Stat3 activation and a critical mediator of the pro-differentiating and anti-apoptotic effects of IL-6 type cytokines on human osteoblastic cells...
  21. ncbi request reprint Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip
    R S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    J Clin Endocrinol Metab 85:2907-12. 2000
    ....
  22. ncbi request reprint Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity
    T Bellido
    Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and Central Arkansas Veteterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 275:26328-32. 2000
    ....
  23. ncbi request reprint Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy
    T Yamate
    Department of Medicine, UAMS Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocrinology 138:3047-55. 1997
    ..These findings indicate that osteopontin is expressed during the early stages of the differentiation of osteoclast and osteoblast progenitors in the bone marrow and that its cell adhesion properties are required for osteoclastogenesis...
  24. ncbi request reprint Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
    L I Plotkin
    Div of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Cell Physiol 289:C633-43. 2005
    ....
  25. ncbi request reprint Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains
    H Benes
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, USA
    J Bone Miner Res 15:626-33. 2000
    ..Such recurrent appearance of QTLs, especially in crosses involving distantly-related strains, implies that polymorphism at these loci may be favored by evolution and might underlie variation in peak bone density among humans...
  26. pmc Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor
    T Bellido
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Clin Invest 95:2886-95. 1995
    ....
  27. ncbi request reprint Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin
    E Abe
    Division of Endocrinology and Metabolism and the UAMS Center for Osteoporosis and Metabolic Bone Diseases, Little Rock, Arkansas, USA
    J Bone Miner Res 15:663-73. 2000
    ..Hence, BMPs, perhaps in balance with noggin and possibly other antagonists, may provide the tonic baseline control of the rate of bone remodeling on which other inputs (e.g., hormonal, biomechanical, etc.) operate...