Research Topics
| B J MannSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulenceAiping Qin
Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Infect Immun 76:3086-92. 2008..We have shown that DsbB is a key participant in intracellular growth and virulence, and our results suggest that there are critical virulence factors that contain disulfide bonds...- Azithromycin effectiveness against intracellular infections of FrancisellaSaira Ahmad
Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20120, USA
BMC Microbiol 10:123. 2010..We hypothesized that different strains/species of Francisella (including Type A) may have different susceptibilities to Az, a widely used and well-tolerated antibiotic... - Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2Aiping Qin
Department of Internal Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
BMC Microbiol 6:69. 2006..The molecular mechanisms that allow F. tularensis to invade and replicate within a host cell have not been well defined... - Rationally designed tularemia vaccinesBarbara J Mann
Departments of Medicine and Microbiology, University of Virginia Health Systems, Charlottesville, VA 22908, USA
Expert Rev Vaccines 8:877-85. 2009.... 
Molecular analysis of the Gal/GalNAc adhesin of Entamoeba histolyticaB J Mann
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Eukaryot Microbiol 45:13S-16S. 1998..coli, retained at least some of its native conformation...- Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated proteinMolly A Hughes
Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Mol Biochem Parasitol 127:113-20. 2003..Recruitment of TSA by the GalNAc lectin suggests a novel mechanism of parasite defense against reactive oxygen intermediates generated by host peripheral mononuclear cells... - Entamoeba histolytica Genome Project: an updateBarbara J Mann
University of Virginia School of Medicine, Health Sciences Center, PO Box 801340, Charlottesville, VA 22908-1340, USA
Trends Parasitol 18:147-8. 2002 - Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infectionMayuresh M Abhyankar
Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
Eukaryot Cell 7:1565-72. 2008..We concluded that EhHMGB1 was a bona fide HMGB protein with the capacity to recapitulate part of the modulation of parasite gene expression seen during adaptation to the host intestine... - Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptomeCarol A Gilchrist
Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
Mol Biochem Parasitol 147:163-76. 2006.... - Structure and function of the Entamoeba histolytica Gal/GalNAc lectinBarbara J Mann
Department of Internal Medicine and Microbiology, University of Virginia, Charlottesville 22908, USA
Int Rev Cytol 216:59-80. 2002..Current knowledge regarding both the structure and function of this unique multifunctional virulence factor are discussed... - Targets of the Entamoeba histolytica transcription factor URE3-BPCarol A Gilchrist
Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
PLoS Negl Trop Dis 2:e282. 2008..histolytica in response to a calcium signal. Induction of URE3-BP leads to an increase in tranwell migration, suggesting a possible role in the regulation of cellular motility... - Identification of an essential Francisella tularensis subsp. tularensis virulence factorAiping Qin
Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
Infect Immun 77:152-61. 2009..These experiments identified the FTT1103 protein as an essential virulence factor and also demonstrated the feasibility of creating defined attenuated vaccines based on a type A strain... - The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolyticaWilliam A Petri
Division of Infectious Diseases, University of Virginia, MR4 Bldg Room 2115, Lane Road, Charlottesville 22908 1340, USA
Annu Rev Microbiol 56:39-64. 2002..The structure and function of the lectin that controls these divergent cell biologic processes are the subject of this review... - Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assemblyUpinder Singh
Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Mol Biochem Parasitol 120:107-16. 2002..The differing effect on transcription initiation in the hgl5 and fdx genes upon mutation of the GAAC element suggests a context-dependence of the GAAC-binding protein in gene expression... - Identification of two Entamoeba histolytica sequence-specific URE4 enhancer-binding proteins with homology to the RNA-binding motif RRMJ M Schaenman
Departments of Microbiology, Internal Medicine, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 276:1602-9. 2001..histolytica, should provide new insights into transcriptional regulation in this protozoan parasite... - Proteomic analysis of Gal/GalNAc lectin-associated proteins in Entamoeba histolyticaJames J McCoy
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Exp Parasitol 110:220-5. 2005..Along with the Gal/GalNAc lectin subunits, several cytoskeletal proteins, potential signaling proteins, and a novel transmembrane protein, consistently purified with the GalNAc-BSA beads... - Histone acetyltransferases and deacetylase in Entamoeba histolyticaGirija Ramakrishnan
Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Mol Biochem Parasitol 138:205-16. 2004..histolytica trophozoites. Our results suggest that mechanisms for histone acetylation and deacetylation are operational in E. histolytica... - Calcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BPCarol A Gilchrist
Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 278:4646-53. 2003..Modulation of URE3-BP by calcium may represent an important mechanism of control of gene expression in E. histolytica... - Development of the Gateway system for cloning and expressing genes in Entamoeba histolyticaMayuresh M Abhyankar
Department of Medicine, University of Virginia, Charlottesville, VA, USA
Parasitol Int 58:95-7. 2009..This expression vector with the Gateway((R)) system should facilitate investigation into the functions of novel proteins in E. histolytica... - Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifsC A Gilchrist
Departments of Internal Medicine, Microbiology, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 276:11838-43. 2001..Characterization of URE3-BP should provide insight into transcription regulation and virulence control in this parasite... - A Rho-like small GTPase of Entamoeba histolytica contains an unusual amino acid residue in a conserved GDP-stabilization region and is not a substrate for C3 exoenzymeGene D Godbold
Division of Infectious Diseases, Department of Internal Medicine, University of Virginia Health Sciences Center, Building MR4, Room 2115, P.O. Box 801340, Charlottesville, VA 22908-1340, USA
Exp Parasitol 101:107-10. 2002..It was also found that EhRho1 is not a substrate for the Rho-specific C3 exoenzyme. Thus EhRho1 appears to be an unusual member of the Ras family... - Entamoeba histolytica-induced dephosphorylation in host cellsJose E Teixeira
Department of Internal Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Infect Immun 70:1816-23. 2002..histolytica. These results suggest that E. histolytica-mediated host cell death occurs by a mechanism that involves PTPase activation... - Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolyticaSrinivas J Kammanadiminti
Institute of Parasitology of McGill University Macdonald Campus, Ste. Anne de Bellevue, Quebec, Canada
FASEB J 18:155-7. 2004.... - The genome of the protist parasite Entamoeba histolyticaBrendan Loftus
TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 433:865-8. 2005..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen... - Characterization of Leishmania chagasi DNA topoisomerase II: a potential chemotherapeutic targetJacira M A De Sousa
Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
Scand J Infect Dis 35:826-9. 2003..3%) and htopo II beta (26.4%). Differences between L. chagasi TOP2 and human TOP2 genes suggest that leishmanial topo II is a potential target for the development of new antileishmanial agents... - Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysisMami Okada
Department of Parasitology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
Mol Biochem Parasitol 145:171-83. 2006..These data should provide significant insights into molecular characterization of phagosome biogenesis, and help to elucidate the pathogenesis of this important infection... - Proteomic analysis of phagocytosis in the enteric protozoan parasite Entamoeba histolyticaMami Okada
Department of Parasitology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
Eukaryot Cell 4:827-31. 2005..Phagosome localization of representative proteins was verified by immunofluorescence assay. This study should provide a basis for molecular identification and characterization of phagosome biogenesis...
Research Grants
- GALACTOSE LECTIN OF E HISTOLYTICABarbara Mann; Fiscal Year: 2002..Successful completion of these experiments will provide insight into the role and identity of PTK/substrates in lectin-mediated killing and may establish the basis for novel therapeutic or prophylactic measures against amebiasis. ..
- Adhesins and Invasins of Francisella TularensisBarbara Mann; Fiscal Year: 2004..Understanding the basic mechanisms of pathogenicity will lead to a greater understanding of why this organism is such an effective pathogen, and the identification of new targets for therapies. ..