B J Mann

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulence
    Aiping Qin
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Infect Immun 76:3086-92. 2008
  2. pmc Azithromycin effectiveness against intracellular infections of Francisella
    Saira Ahmad
    Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20120, USA
    BMC Microbiol 10:123. 2010
  3. pmc Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2
    Aiping Qin
    Department of Internal Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    BMC Microbiol 6:69. 2006
  4. pmc Rationally designed tularemia vaccines
    Barbara J Mann
    Departments of Medicine and Microbiology, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    Expert Rev Vaccines 8:877-85. 2009
  5. ncbi request reprint Molecular analysis of the Gal/GalNAc adhesin of Entamoeba histolytica
    B J Mann
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Eukaryot Microbiol 45:13S-16S. 1998
  6. ncbi request reprint Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
  7. ncbi request reprint Entamoeba histolytica Genome Project: an update
    Barbara J Mann
    University of Virginia School of Medicine, Health Sciences Center, PO Box 801340, Charlottesville, VA 22908 1340, USA
    Trends Parasitol 18:147-8. 2002
  8. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
  9. ncbi request reprint Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Mol Biochem Parasitol 147:163-76. 2006
  10. ncbi request reprint Structure and function of the Entamoeba histolytica Gal/GalNAc lectin
    Barbara J Mann
    Department of Internal Medicine and Microbiology, University of Virginia, Charlottesville 22908, USA
    Int Rev Cytol 216:59-80. 2002

Research Grants

  1. GALACTOSE LECTIN OF E HISTOLYTICA
    Barbara Mann; Fiscal Year: 2002
  2. Adhesins and Invasins of Francisella Tularensis
    Barbara Mann; Fiscal Year: 2004

Collaborators

Detail Information

Publications27

  1. pmc Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulence
    Aiping Qin
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Infect Immun 76:3086-92. 2008
    ..We have shown that DsbB is a key participant in intracellular growth and virulence, and our results suggest that there are critical virulence factors that contain disulfide bonds...
  2. pmc Azithromycin effectiveness against intracellular infections of Francisella
    Saira Ahmad
    Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20120, USA
    BMC Microbiol 10:123. 2010
    ..We hypothesized that different strains/species of Francisella (including Type A) may have different susceptibilities to Az, a widely used and well-tolerated antibiotic...
  3. pmc Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2
    Aiping Qin
    Department of Internal Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    BMC Microbiol 6:69. 2006
    ..The molecular mechanisms that allow F. tularensis to invade and replicate within a host cell have not been well defined...
  4. pmc Rationally designed tularemia vaccines
    Barbara J Mann
    Departments of Medicine and Microbiology, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    Expert Rev Vaccines 8:877-85. 2009
    ....
  5. ncbi request reprint Molecular analysis of the Gal/GalNAc adhesin of Entamoeba histolytica
    B J Mann
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Eukaryot Microbiol 45:13S-16S. 1998
    ..coli, retained at least some of its native conformation...
  6. ncbi request reprint Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
    ..Recruitment of TSA by the GalNAc lectin suggests a novel mechanism of parasite defense against reactive oxygen intermediates generated by host peripheral mononuclear cells...
  7. ncbi request reprint Entamoeba histolytica Genome Project: an update
    Barbara J Mann
    University of Virginia School of Medicine, Health Sciences Center, PO Box 801340, Charlottesville, VA 22908 1340, USA
    Trends Parasitol 18:147-8. 2002
  8. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
    ..We concluded that EhHMGB1 was a bona fide HMGB protein with the capacity to recapitulate part of the modulation of parasite gene expression seen during adaptation to the host intestine...
  9. ncbi request reprint Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Mol Biochem Parasitol 147:163-76. 2006
    ....
  10. ncbi request reprint Structure and function of the Entamoeba histolytica Gal/GalNAc lectin
    Barbara J Mann
    Department of Internal Medicine and Microbiology, University of Virginia, Charlottesville 22908, USA
    Int Rev Cytol 216:59-80. 2002
    ..Current knowledge regarding both the structure and function of this unique multifunctional virulence factor are discussed...
  11. pmc Targets of the Entamoeba histolytica transcription factor URE3-BP
    Carol A Gilchrist
    Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Negl Trop Dis 2:e282. 2008
    ..histolytica in response to a calcium signal. Induction of URE3-BP leads to an increase in tranwell migration, suggesting a possible role in the regulation of cellular motility...
  12. pmc Identification of an essential Francisella tularensis subsp. tularensis virulence factor
    Aiping Qin
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Infect Immun 77:152-61. 2009
    ..These experiments identified the FTT1103 protein as an essential virulence factor and also demonstrated the feasibility of creating defined attenuated vaccines based on a type A strain...
  13. ncbi request reprint The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica
    William A Petri
    Division of Infectious Diseases, University of Virginia, MR4 Bldg Room 2115, Lane Road, Charlottesville 22908 1340, USA
    Annu Rev Microbiol 56:39-64. 2002
    ..The structure and function of the lectin that controls these divergent cell biologic processes are the subject of this review...
  14. ncbi request reprint Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly
    Upinder Singh
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 120:107-16. 2002
    ..The differing effect on transcription initiation in the hgl5 and fdx genes upon mutation of the GAAC element suggests a context-dependence of the GAAC-binding protein in gene expression...
  15. ncbi request reprint Identification of two Entamoeba histolytica sequence-specific URE4 enhancer-binding proteins with homology to the RNA-binding motif RRM
    J M Schaenman
    Departments of Microbiology, Internal Medicine, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:1602-9. 2001
    ..histolytica, should provide new insights into transcriptional regulation in this protozoan parasite...
  16. ncbi request reprint Proteomic analysis of Gal/GalNAc lectin-associated proteins in Entamoeba histolytica
    James J McCoy
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Exp Parasitol 110:220-5. 2005
    ..Along with the Gal/GalNAc lectin subunits, several cytoskeletal proteins, potential signaling proteins, and a novel transmembrane protein, consistently purified with the GalNAc-BSA beads...
  17. ncbi request reprint Histone acetyltransferases and deacetylase in Entamoeba histolytica
    Girija Ramakrishnan
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 138:205-16. 2004
    ..histolytica trophozoites. Our results suggest that mechanisms for histone acetylation and deacetylation are operational in E. histolytica...
  18. ncbi request reprint Calcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BP
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:4646-53. 2003
    ..Modulation of URE3-BP by calcium may represent an important mechanism of control of gene expression in E. histolytica...
  19. pmc Development of the Gateway system for cloning and expressing genes in Entamoeba histolytica
    Mayuresh M Abhyankar
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Parasitol Int 58:95-7. 2009
    ..This expression vector with the Gateway((R)) system should facilitate investigation into the functions of novel proteins in E. histolytica...
  20. ncbi request reprint Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs
    C A Gilchrist
    Departments of Internal Medicine, Microbiology, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:11838-43. 2001
    ..Characterization of URE3-BP should provide insight into transcription regulation and virulence control in this parasite...
  21. ncbi request reprint A Rho-like small GTPase of Entamoeba histolytica contains an unusual amino acid residue in a conserved GDP-stabilization region and is not a substrate for C3 exoenzyme
    Gene D Godbold
    Division of Infectious Diseases, Department of Internal Medicine, University of Virginia Health Sciences Center, Building MR4, Room 2115, P O Box 801340, Charlottesville, VA 22908 1340, USA
    Exp Parasitol 101:107-10. 2002
    ..It was also found that EhRho1 is not a substrate for the Rho-specific C3 exoenzyme. Thus EhRho1 appears to be an unusual member of the Ras family...
  22. pmc Entamoeba histolytica-induced dephosphorylation in host cells
    Jose E Teixeira
    Department of Internal Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Infect Immun 70:1816-23. 2002
    ..histolytica. These results suggest that E. histolytica-mediated host cell death occurs by a mechanism that involves PTPase activation...
  23. ncbi request reprint Regulation of Toll-like receptor-2 expression by the Gal-lectin of Entamoeba histolytica
    Srinivas J Kammanadiminti
    Institute of Parasitology of McGill University Macdonald Campus, Ste Anne de Bellevue, Quebec, Canada
    FASEB J 18:155-7. 2004
    ....
  24. ncbi request reprint The genome of the protist parasite Entamoeba histolytica
    Brendan Loftus
    TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 433:865-8. 2005
    ..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen...
  25. ncbi request reprint Characterization of Leishmania chagasi DNA topoisomerase II: a potential chemotherapeutic target
    Jacira M A De Sousa
    Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
    Scand J Infect Dis 35:826-9. 2003
    ..3%) and htopo II beta (26.4%). Differences between L. chagasi TOP2 and human TOP2 genes suggest that leishmanial topo II is a potential target for the development of new antileishmanial agents...
  26. ncbi request reprint Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis
    Mami Okada
    Department of Parasitology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Mol Biochem Parasitol 145:171-83. 2006
    ..These data should provide significant insights into molecular characterization of phagosome biogenesis, and help to elucidate the pathogenesis of this important infection...
  27. pmc Proteomic analysis of phagocytosis in the enteric protozoan parasite Entamoeba histolytica
    Mami Okada
    Department of Parasitology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Eukaryot Cell 4:827-31. 2005
    ..Phagosome localization of representative proteins was verified by immunofluorescence assay. This study should provide a basis for molecular identification and characterization of phagosome biogenesis...

Research Grants10

  1. GALACTOSE LECTIN OF E HISTOLYTICA
    Barbara Mann; Fiscal Year: 2002
    ..Successful completion of these experiments will provide insight into the role and identity of PTK/substrates in lectin-mediated killing and may establish the basis for novel therapeutic or prophylactic measures against amebiasis. ..
  2. Adhesins and Invasins of Francisella Tularensis
    Barbara Mann; Fiscal Year: 2004
    ..Understanding the basic mechanisms of pathogenicity will lead to a greater understanding of why this organism is such an effective pathogen, and the identification of new targets for therapies. ..