Nancy R Manley
Affiliation: University of Georgia
Xiao S, Shterev I, Zhang W, Young L, Shieh J, Moore M, et al
. Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. J Immunol. 2017;199:2701-2712 pubmed publisher
..Our findings may impact evaluation and therapeutic intervention of human TBI events. ..
Peissig K, Condie B, Manley N. Embryology of the Parathyroid Glands. Endocrinol Metab Clin North Am. 2018;47:733-742 pubmed publisher
..Therefore, understanding the normal development of the parathyroid will provide insight into the origins of parathyroid disorders. ..
Manley N, Richie E, Blackburn C, Condie B, Sage J. Structure and function of the thymic microenvironment. Front Biosci (Landmark Ed). 2011;16:2461-77 pubmed
..This review will summarize the current state of understanding of the composition and organization of thymic microenvironments and the mechanisms that promote their proper development and function. ..
Chojnowski J, Trau H, Masuda K, Manley N. Temporal and spatial requirements for Hoxa3 in mouse embryonic development. Dev Biol. 2016;415:33-45 pubmed publisher
Gordon J, Xiao S, Hughes B, Su D, Navarre S, Condie B, et al
. Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol. 2007;7:69 pubmed
..We also discuss evidence indicating that gene targeting into the 3' UTR is a technique that may be broadly applicable for the generation of genetically neutral driver strains. ..
Chojnowski J, Masuda K, Trau H, Thomas K, Capecchi M, Manley N. Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014;141:3697-708 pubmed publisher
..These data show that Hoxa3 has multiple complex and tissue-specific functions during patterning, differentiation and morphogenesis of the thymus and parathyroids. ..
Manley N, Selleri L, Brendolan A, Gordon J, Cleary M. Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol. 2004;276:301-12 pubmed
..However, some aspects of the Pbx1 mutant phenotype included specific defects that were less severe than those found in known Hox mutant mice, suggesting that some functions of Hox proteins in this region are Pbx1-independent...
Bain V, Gordon J, O Neil J, Ramos I, Richie E, Manley N. Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016;143:4027-4037 pubmed
..These data support a model in which SHH signaling plays both positive and negative roles in patterning and organogenesis of the thymus and parathyroids. ..