Geoffrey T Manley

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
    G T Manley
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Nat Med 6:159-63. 2000
  2. ncbi Controlled cortical impact in swine: pathophysiology and biomechanics
    Geoffrey T Manley
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    J Neurotrauma 23:128-39. 2006
  3. ncbi New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice
    G T Manley
    Department of Neurological Surgery, Cardiovascular Research Institute, University of California San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94143 0112, USA
    Neuroscience 129:983-91. 2004
  4. ncbi Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, USA
    Crit Care Med 36:1917-24. 2008
  5. ncbi Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, San Francisco, 94110, USA
    Glia 53:631-6. 2006
  6. ncbi Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco UCSF, San Francisco, California, USA
    J Neurotrauma 25:291-8. 2008
  7. ncbi Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess
    Orin Bloch
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Neurochem 95:254-62. 2005
  8. ncbi Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds
    Jennifer J Wan
    Department of Surgery, University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California, USA
    J Trauma 66:353-7. 2009
  9. ncbi Increased seizure threshold in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143, USA
    Neuroreport 15:259-62. 2004
  10. ncbi Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation
    Geoffrey T Manley
    School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
    Adv Exp Med Biol 530:311-7. 2003

Detail Information

Publications94

  1. ncbi Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
    G T Manley
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Nat Med 6:159-63. 2000
    ..These results implicate a key role for AQP4 in modulating brain water transport, and suggest that AQP4 inhibition may provide a new therapeutic option for reducing brain edema in a wide variety of cerebral disorders...
  2. ncbi Controlled cortical impact in swine: pathophysiology and biomechanics
    Geoffrey T Manley
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    J Neurotrauma 23:128-39. 2006
    ..Physiological parameters after injury are readily monitored in a setting mimicking conditions of an intensive care unit, establishing a more clinically relevant experimental model for future investigations...
  3. ncbi New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice
    G T Manley
    Department of Neurological Surgery, Cardiovascular Research Institute, University of California San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94143 0112, USA
    Neuroscience 129:983-91. 2004
    ....
  4. ncbi Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, USA
    Crit Care Med 36:1917-24. 2008
    ..The objective of this study was to evaluate whether P(bt)O2 more closely reflects variables related to cerebral oxygen diffusion or reflects cerebral oxygen delivery and metabolism...
  5. ncbi Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, San Francisco, 94110, USA
    Glia 53:631-6. 2006
    ..5 +/- 0.1 and 6.6 +/- 0.7 s, respectively). These results implicate AQP4 in the expression and termination of seizure activity and support the hypothesis that AQP4 is coupled to potassium homeostasis in vivo...
  6. ncbi Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco UCSF, San Francisco, California, USA
    J Neurotrauma 25:291-8. 2008
    ..In a large, retrospective study of high-frequency ICP data, we have quantitatively shown that mannitol's effect on ICP is dose-dependent and that higher doses provide a more durable reduction in ICP...
  7. ncbi Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess
    Orin Bloch
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Neurochem 95:254-62. 2005
    ..Our findings demonstrate a protective effect of AQP4 on brain swelling in bacterial abscess, suggesting that AQP4 induction may reduce vasogenic edema associated with cerebral infection...
  8. ncbi Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds
    Jennifer J Wan
    Department of Surgery, University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California, USA
    J Trauma 66:353-7. 2009
    ..We further hypothesized that PmO2 would decrease even as PbrO2 increased when vasopressor therapy was used...
  9. ncbi Increased seizure threshold in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143, USA
    Neuroreport 15:259-62. 2004
    ..These results suggest that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity...
  10. ncbi Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation
    Geoffrey T Manley
    School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
    Adv Exp Med Biol 530:311-7. 2003
    ..These results suggest that a small-volume bolus of HBOC-201 may provide adequate oxygen and pressure support during the initial management of hemorrhage...
  11. ncbi Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201
    M Margaret Knudson
    San Francisco Injury Center, University of California, USA
    J Trauma 54:242-52. 2003
    ..We further hypothesized that changes in tissue oxygen tension measurements in the deltoid muscle would reflect the changes seen in the liver and could thus be used as a monitor of splanchnic resuscitation...
  12. ncbi Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema
    Marios C Papadopoulos
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA, 94143 0521, USA
    FASEB J 18:1291-3. 2004
    ..Thus, AQP4-mediated transcellular water movement is crucial for fluid clearance in vasogenic brain edema, suggesting AQP4 activation and/or up-regulation as a novel therapeutic option in vasogenic brain edema...
  13. ncbi Computer-aided assessment of head computed tomography (CT) studies in patients with suspected traumatic brain injury
    Esther L Yuh
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143 0628, USA
    J Neurotrauma 25:1163-72. 2008
    ..Further studies are required to evaluate the potential favorable impact of this software on facilitating workflow and improving diagnostic accuracy when used as a screening aid by physicians with different levels of experience...
  14. ncbi The role of lung function in brain tissue oxygenation following traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, California, USA
    J Neurosurg 108:59-65. 2008
    ..The purpose of this study was to investigate the influence of lung function on PbtO2 with an oxygen challenge (increase in fraction of inspired oxygen [FiO2] concentration to 1.0)...
  15. ncbi Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, California, USA
    J Neurosurg 114:62-70. 2011
    ....
  16. ncbi Involvement of aquaporin-4 in astroglial cell migration and glial scar formation
    Samira Saadoun
    Department of Medicine, Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0521, USA
    J Cell Sci 118:5691-8. 2005
    ..Our findings provide evidence for the involvement of aquaporin-4 in astroglial cell migration, which occurs during glial scar formation in brain injury, stroke, tumor and focal abscess...
  17. ncbi Introduction: decompressive craniectomy for trauma and cerebrovascular disease
    Geoffrey T Manley
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    Neurosurg Focus 26:E1. 2009
    ..The last decade has seen a renewed interest in the use of decompressive craniectomy, but many questions remain regarding patient selection, timing of surgery, surgical technique, timing of cranioplasty, and complications...
  18. ncbi Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis
    Mitchell J Cohen
    Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care 14:R10. 2010
    ..We hypothesized that processing of multivariate data using hierarchical clustering techniques would allow identification of otherwise hidden patient physiologic patterns that would be predictive of outcome...
  19. ncbi Aquaporins: role in cerebral edema and brain water balance
    Zsolt Zador
    Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, CA 94110, USA
    Prog Brain Res 161:185-94. 2007
    ..These advances will require the development of AQP inhibitors and activators to establish the benefit modulating the function of these water channels...
  20. ncbi Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution
    Bradley Voytek
    Helen Wills Neuroscience, University of California, Berkeley, Berkeley, CA 94720 3190, USA
    J Cogn Neurosci 22:2491-502. 2010
    ..Taken together, these results provide evidence that the hemicraniectomy model provides a means for studying neural dynamics in humans with enhanced spatial and temporal resolution...
  21. ncbi Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury
    Kurtis I Auguste
    Department of Medicine and Physiology, University of California, San Francisco, San Francisco, CA, USA
    FASEB J 21:108-16. 2007
    ..These results provide in vivo evidence for AQP4-dependent astroglial migration and suggest that modulation of AQP4 expression or function might alter glial scarring...
  22. ncbi Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain
    Zsolt Zador
    Department of Medicine, University of California, San Francisco, CA, USA
    FASEB J 22:870-9. 2008
    ..Our results provide the first data on molecular diffusion in ECS deep in brain in vivo and demonstrate previously unrecognized hindrance and heterometricity for diffusion of large macromolecules in deep brain...
  23. ncbi Novel variants in human Aquaporin-4 reduce cellular water permeability
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA 94110, USA
    Hum Mol Genet 17:2379-89. 2008
    ..Our experiments provide insight into the function of the AQP4 protein. These nsSNPs may have clinical implications for patients with cerebral edema and related disorders...
  24. ncbi Predictive values of age and the Glasgow Coma Scale in traumatic brain injury patients treated with decompressive craniectomy
    Matthew B Potts
    Department of Neurological Surgery, University of California, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143 0112, USA
    Acta Neurochir Suppl 102:109-12. 2008
    ..While age and the Glasgow Coma Scale (GCS) are frequently correlated with outcome in TBI, their prognostic values after decompressive craniectomy are ill-defined...
  25. ncbi Motor trephine syndrome: a mechanistic hypothesis
    Shirley I Stiver
    Department of Neurosurgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 101, San Francisco, CA 94110 0899, USA
    Acta Neurochir Suppl 102:273-7. 2008
    ..The goal of this study was to define causal factors associated with this syndrome...
  26. ncbi New approaches to physiological informatics in neurocritical care
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, USA
    Neurocrit Care 7:45-52. 2007
    ..We propose that advances in monitoring must be accompanied by advances in methods of high-frequency, multivariate data analysis that integrate the multiple processes occurring in critically ill patients...
  27. ncbi Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1
    Kotaro Oshio
    Department of Neurosurgery, University of California, San Francisco, California 94110, USA
    FASEB J 19:76-8. 2005
    ..The reduced ICP and CSF production in AQP1 null mice provides direct functional evidence for the involvement of AQP1 in CSF dynamics, suggesting AQP1 inhibition as a novel option for therapy of elevated ICP...
  28. ncbi The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage
    Justin S Smith
    Department of Neurological Surgery, UCSF Brain and Spinal Injury Center, San Francisco General Hospital and University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    J Trauma 63:75-82. 2007
    ..The purpose of this study was to investigate whether routine follow-up computed tomography (CT) for patients with head injury, in the absence of clinical indications, alters patient management...
  29. ncbi Race\ethnicity and outcome after traumatic brain injury at a single, diverse center
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, California 94110, USA
    J Trauma 67:75-80. 2009
    ..However, the role of race\ethnicity has typically been studied tangentially or in homogeneous settings. We investigated whether race\ethnicity was associated with medical outcomes at a single, diverse center...
  30. ncbi Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice
    Orin Bloch
    Department of Medicine, Cardiovascular Research Institute, San Francisco, California 94143-0521, USA
    J Cereb Blood Flow Metab 26:1527-37. 2006
    ..Our results indicate a significant role for AQP4-mediated transparenchymal CSF absorption in hydrocephalus and provide a rational basis for evaluation of AQP4 induction as a nonsurgical therapy for hydrocephalus...
  31. ncbi Impaired pain sensation in mice lacking Aquaporin-1 water channels
    Kotaro Oshio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 341:1022-8. 2006
    ..These results provide evidence for AQP1 expression in nociceptive neurons and suggest that AQP1 may play a role in pain signal transduction...
  32. ncbi Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head trauma
    Alisa D Gean
    Department of Radiology, University of California, San Francisco, San Francisco, Calif, USA
    Radiology 257:212-8. 2010
    ..To study the incidence, pathogenesis, imaging characteristics, and clinical importance of a unique subtype of epidural hematoma (EDH) associated with blunt head trauma...
  33. ncbi Aquaporin-4-deficient mice have increased extracellular space without tortuosity change
    Xiaoming Yao
    Department of Neurosurgery and Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 28:5460-4. 2008
    ..These findings provide direct evidence for involvement of AQP4 in modulation of the ECS volume fraction and provide a basis for future modeling of water and ion transport in the CNS...
  34. ncbi Brain tissue oxygen monitoring in intracerebral hemorrhage
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA, 94110, USA
    Neurocrit Care 3:260-70. 2005
    ..We report complementary preliminary studies in a large animal model and in patients that demonstrate the feasibility of PbrO2 monitoring after ICH...
  35. ncbi Genetic variation in human aquaporins and effects on phenotypes of water homeostasis
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, California 94143, USA
    Hum Mutat 29:1108-17. 2008
    ..Finally, we propose possible variant-based phenotypes for further research. Other open questions relate to the discovery of novel AQP gene variants as well as their functions and phenotypes...
  36. ncbi K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator
    Prashant Padmawar
    Department of Medicine, Cardiovascular Research Institute, 1246 Health Sciences East Tower, University of California, San Francisco, California 94143, USA
    Nat Methods 2:825-7. 2005
    ..4 +/- 0.5 mm/min, and K(+) release and reuptake half-times (t(1/2)) of 12 +/- 2 and 32 +/- 4 s, respectively. Aquaporin-4 (AQP4) deletion slowed K(+) reuptake about twofold, suggesting AQP4-dependent K(+) uptake by astroglia...
  37. ncbi Interobserver variability in the assessment of CT imaging features of traumatic brain injury
    Kimberly A Chun
    Department of Radiology, Neuroradiology Section, University of California San Francisco, San Francisco, California 94143 0628, USA
    J Neurotrauma 27:325-30. 2010
    ..In conclusion, there is good interobserver reproducibility between neuroradiologists and neurosurgeons in the interpretation of CT imaging features of TBI and calculation of Marshall and Rotterdam scores...
  38. ncbi Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine
    Seong K Lee
    San Francisco Injury Center, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
    Acad Emerg Med 9:969-76. 2002
    ..The results of this preliminary study demonstrate that HBOC-201 could potentially improve current resuscitation measures and that further investigations with HBOC-201 are warranted...
  39. ncbi Post-operative expansion of hemorrhagic contusions after unilateral decompressive hemicraniectomy in severe traumatic brain injury
    Alexander C Flint
    Department of Neurology, Neurovascular and Neurocritical Care Service, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
    J Neurotrauma 25:503-12. 2008
    ..Severity of initial CT findings may predict the risk of contusion expansion following hemicraniectomy, thereby identifying a subgroup of patients who might benefit from therapies aimed at augmenting the coagulation system...
  40. ncbi Quantitative CT improves outcome prediction in acute traumatic brain injury
    Esther L Yuh
    Department of Radiology, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94107, USA
    J Neurotrauma 29:735-46. 2012
    ..We believe that objective computational tools and data-driven analytical methods hold great promise for neurotrauma research, and may ultimately have a role in image analysis for clinical care...
  41. ncbi Emergent placement of halo orthosis after a traumatic cervical injury leading to a cerebral abscess
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery and The San Francisco Injury Center, San Francisco General Hospital, University of California School of Medicine, San Francisco, California 94143 0112, USA
    J Trauma 62:E11-3. 2007
  42. ncbi Marked reduction in wound complication rates following decompressive hemicraniectomy with an improved operative closure technique
    Michael E Sughrue
    Department of Neurological Surgery, Brain and Spinal Injury Center, University of California at San Francisco, 1001 Potrero Avenue, Building 1, Room 101, Box 0899, San Francisco, CA 94143, USA
    J Clin Neurosci 18:1201-5. 2011
    ..05), compared to other, more standard, techniques. Thus, attention to closure of hemicraniectomy wounds can markedly reduce the rate of wound complications, thus improving the risk-to-benefit ratio of this procedure...
  43. ncbi Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method
    Eugen Solenov
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0521, USA
    Am J Physiol Cell Physiol 286:C426-32. 2004
    ..3 +/- 0.5 vs. 5.5 +/- 0.4 kcal/mol). Our studies establish a calcein quenching method for measurement of cell membrane water permeability and indicate that AQP-4 provides the principal route for water transport in astrocytes...
  44. ncbi Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study
    Marcus L Ware
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 57:727-36; discussion 727-36. 2005
    ..These results warrant a rigorous evaluation of its efficacy as compared to mannitol in a prospective randomized controlled trial...
  45. ncbi Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury
    Shirley I Stiver
    Departments of Neurosurgery, University of California San Francisco, California, USA
    J Neurosurg 110:1242-6. 2009
    ..Aggressive intracranial monitoring and treatment of a Duret hemorrhage arising secondary to cerebral herniation may enable a good recovery in selected patients after severe TBI...
  46. ncbi The role of aquaporin-4 in cerebral water transport and edema
    Orin Bloch
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurg Focus 22:E3. 2007
    ..These findings also suggest that drug therapy targeting AQP4 function and expression may dramatically alter our ability to treat cerebral edema...
  47. ncbi Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA 94110, USA
    AJNR Am J Neuroradiol 26:1095-100. 2005
    ....
  48. ncbi Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury
    Shirley I Stiver
    Department of Neurosurgery, School of Medicine, University of California, San Francisco, California 94110 0899, USA
    J Neurosurg 109:245-54. 2008
    ..The authors set out to study motor function systematically in this patient population to define the incidence, contributing factors, and outcome of patients with motor trephine syndrome...
  49. ncbi Biaxial response of passive human cerebral arteries
    Kenneth L Monson
    Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Ave, Building 1, Room 101, San Francisco, CA 94110, USA
    Ann Biomed Eng 36:2028-41. 2008
    ..These results further define the biaxial response of the cerebral arteries and provide data required for more rigorous study of head injury mechanisms and development of cerebrovascular disease...
  50. ncbi Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI
    Hana Lee
    Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurotrauma 25:1049-56. 2008
    ....
  51. ncbi Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement
    Alexander C Flint
    Department of Neurosurgery, Kaiser Permanente, Redwood City, CA 94063, USA
    J Neurosurg 115:844-8. 2011
    ..In appropriately selected cases, patients with a hyperacute SDH may benefit from SEPS placement to quickly treat elevated ICP, as a bridge to definitive surgical treatment by craniotomy...
  52. ncbi Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA, USA San Francisco Injury Center, San Francisco, CA, USA
    Physiol Meas 26:373-86. 2005
    ..High frequency data acquisition may be necessary for more precise evaluation of secondary brain injury in neurocritical care...
  53. ncbi Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study
    John H Chi
    Department of Surgery, The University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California 94143, USA
    J Trauma 61:1134-41. 2006
    ....
  54. ncbi Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice
    E I Solenov
    Departments of Medicine and Physiology, 1246 Health Sciences East Tower, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Neurosci Methods 113:85-90. 2002
    ..These results establish a simple imaging method to map changes in water content of spinal cord slices, and provide evidence that aquaporins facilitate osmotic water transport in functionally relevant areas of the spinal cord...
  55. ncbi Expression of the aquaporin-1 water channel in human glial tumors
    Kotaro Oshio
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 56:375-81; discussion 375-81. 2005
    ....
  56. ncbi Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group
    Geoffrey T Manley
    University of California San Francisco, CA 94110, USA
    Arch Phys Med Rehabil 91:1667-72. 2010
    ....
  57. ncbi Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two cases
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, San Francisco General Hospital, University of California, 94143 0112, USA
    J Trauma 56:201-4. 2004
  58. ncbi Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report
    Devin K Binder
    Department of Neurological Surgery, M779 Moffitt Hospital, Box 0112, University of California San Francisco, San Francisco, CA 94143 0112, USA
    Neurosurgery 54:999-1002; discussion 1002-3. 2004
    ..Here, we demonstrate a case in which clinical, radiological, and electrophysiological findings were used together to define this syndrome...
  59. ncbi Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm
    John H Chi
    Department of Neurological Surgery, San Francisco General Hospital, University of California, San Francisco, California, USA
    Neurosurg Focus 19:E7. 2005
    ..Observation should be considered for symptomatic patients at greater than 32 weeks gestation. Surgery should be considered for patients with severe neurological deficits at less than 32 weeks of gestation...
  60. ncbi The ICH score: a simple, reliable grading scale for intracerebral hemorrhage
    J C Hemphill
    Department of Neurology, University of California, San Francisco, USA
    Stroke 32:891-7. 2001
    ..Despite several existing outcome prediction models for ICH, there is no standard clinical grading scale for ICH analogous to those for traumatic brain injury, subarachnoid hemorrhage, or ischemic stroke...
  61. ncbi Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0521, USA
    Exp Physiol 85:233S-241S. 2000
    ..The physiological data on aquaporin null mice suggest the utility of aquaporin blockers and aquaporin gene replacement in selected human diseases...
  62. ncbi Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production
    K Oshio
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Acta Neurochir Suppl 86:525-8. 2003
    ..14 +/- 0.15 microl/min (forskolin-treated), and reduced by up to 25% in AQP1 null mice. The impaired CSF production in AQP1 null mice provides direct functional evidence for the involvement of AQP1 in CSF formation...
  63. ncbi Coagulopathy after traumatic brain injury
    Mathieu Laroche
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 70:1334-45. 2012
    ..The current and emerging diagnostic tools, radiological findings, treatment options, and prognosis are discussed...
  64. ncbi Prehospital management of traumatic brain injury
    Shirley I Stiver
    Department of Neurosurgery, School of Medicine, University of California San Francisco, California 94110 0899, USA
    Neurosurg Focus 25:E5. 2008
    ..The quality of prehospital care is a major determinant of long-term outcome for patients with traumatic brain injury...
  65. ncbi Dose-response relationship of mannitol and intracranial pressure: a metaanalysis
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, CA 94110, USA
    J Neurosurg 108:80-7. 2008
    ..The goal of this metaanalysis was to aggregate and analyze data from studies in which authors have described the dose-response relationship between mannitol and ICP...
  66. ncbi Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports
    Daniel C Lu
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94107, USA
    Surg Neurol 69:226-9. 2008
    ..Here, we describe 2 cases of CSW in TBI patients with elevated BNP levels. This phenomenon has not been previously described...
  67. ncbi Airbag deployment and improperly restrained children: a lethal combination
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, San Francisco Injury Center, University of California San Francisco, San Francisco, California, USA
    J Trauma 59:729-33. 2005
    ..We also reviewed the relevant literature and provide information useful for caregivers and health care professionals in hopes of reducing future injuries...
  68. ncbi Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
    ..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients...
  69. ncbi The effect of decompressive hemicraniectomy on brain temperature after severe brain injury
    Kazuma Nakagawa
    Department of Neurovascular Service, University of California San Francisco, 505 Parnassus Avenue, M 830, San Francisco, CA 94143 0114, USA
    Neurocrit Care 15:101-6. 2011
    ..Since the skull acts as a potential thermal insulator, we hypothesized that decompressive hemicraniectomy facilitates surface cooling and lowers brain temperature...
  70. ncbi Infrared pupillometry during uncal herniation
    Geoffrey T Manley
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Anesthesiol 14:223-8. 2002
    ....
  71. ncbi Evaluation of the portable infrared pupillometer
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 57:198-203; discussion 198-203. 2005
  72. ncbi Significance of source and size in the mechanical response of human cerebral blood vessels
    Kenneth L Monson
    Department of Mechanical Engineering, University of California, San Francisco, Berkeley, CA 94720, USA
    J Biomech 38:737-44. 2005
    ..These effects are, however, secondary to differences identified between arteries and veins in the previous study...
  73. ncbi Volumetric proton spectroscopic imaging of mild traumatic brain injury
    Varanavasi Govindaraju
    Northern California Institute for Research and Education, MR Spectroscopy Unit, Veterans Affairs Medical Center, San Francisco, California, USA
    AJNR Am J Neuroradiol 25:730-7. 2004
    ..Although the association with injury assessment and outcome is weak, this preliminary study demonstrates the applicability of volumetric proton MRSI for evaluating diffuse injury associated with MTBI...
  74. ncbi Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema
    K Oshio
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Acta Neurochir Suppl 86:499-502. 2003
    ....
  75. ncbi Expression of aquaporin water channels in mouse spinal cord
    K Oshio
    Department of Neurological Surgery, University of California, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA
    Neuroscience 127:685-93. 2004
    ..The aquaporin expression pattern in spinal cord suggests involvement in water homeostasis and diseases associated with abnormal water fluxes such as spinal cord injury and syringomyelia...
  76. ncbi Increased seizure duration in mice lacking aquaporin-4 water channels
    D K Binder
    Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA
    Acta Neurochir Suppl 96:389-92. 2006
    ..These results implicate AQP4 in water and potassium regulation associated with neuronal activity and seizures...
  77. ncbi Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds
    Susan L Bratton
    J Neurotrauma 24:S65-70. 2007
  78. ncbi The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    Anne C Mosenthal
    Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
    J Trauma 56:1042-8. 2004
    ..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization...
  79. ncbi Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury
    Anne Vik
    Department of Neurosurgery, St Olav University Hospital, and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurosurg 109:678-84. 2008
    ..The objective of this study was to determine whether the calculated "ICP dose"-the ICP AUC-is related to mortality rate, outcome, and Marshall CT classification...
  80. ncbi Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial
    David H Livingston
    Department of Surgery, New Jersey Trauma Center, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 59:1298-304; discussion 1304. 2005
    ..Age is an exceedingly important parameter affecting recovery from isolated TBI...
  81. ncbi Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...
  82. ncbi Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation
    Susan L Bratton
    J Neurotrauma 24:S7-13. 2007
  83. ncbi Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia
    Susan L Bratton
    J Neurotrauma 24:S21-5. 2007
  84. ncbi Guidelines for the management of severe traumatic brain injury. XV. Steroids
    Susan L Bratton
    J Neurotrauma 24:S91-5. 2007
  85. ncbi Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives
    Susan L Bratton
    J Neurotrauma 24:S71-6. 2007
  86. ncbi Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds
    Susan L Bratton
    J Neurotrauma 24:S59-64. 2007
  87. ncbi Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds
    Susan L Bratton
    J Neurotrauma 24:S55-8. 2007
  88. ncbi Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology
    Susan L Bratton
    J Neurotrauma 24:S45-54. 2007
  89. ncbi Guidelines for the management of severe traumatic brain injury. XII. Nutrition
    Susan L Bratton
    J Neurotrauma 24:S77-82. 2007
  90. ncbi Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring
    Susan L Bratton
    J Neurotrauma 24:S37-44. 2007
  91. ncbi Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxis
    Susan L Bratton
    J Neurotrauma 24:S32-6. 2007
  92. ncbi Guidelines for the management of severe traumatic brain injury. IV. Infection prophylaxis
    Susan L Bratton
    J Neurotrauma 24:S26-31. 2007
  93. ncbi Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy
    Susan L Bratton
    J Neurotrauma 24:S14-20. 2007
  94. ncbi Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation
    Susan L Bratton
    J Neurotrauma 24:S87-90. 2007