Research Topics
| Geoffrey ManleySummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysisMitchell J Cohen
Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Crit Care 14:R10. 2010..We hypothesized that processing of multivariate data using hierarchical clustering techniques would allow identification of otherwise hidden patient physiologic patterns that would be predictive of outcome...- Infection in the intensive care unit alters physiological networksAdam D Grossman
Department of Bioengineering, Stanford University, Stanford, California 94305, USA
BMC Bioinformatics 10:S4. 2009..However, medical sources of clinical physiological data are only now starting to find use in bioinformatics research... 
Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working groupGeoffrey T Manley
University of California San Francisco, CA 94110, USA
Arch Phys Med Rehabil 91:1667-72. 2010....
A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patientsChristopher W Barton
Department of Medicine, University of California, San Francisco, CA 94110, USA
Acad Emerg Med 12:1-6. 2005..The authors hypothesized that a new method that accounts for the cumulative depth and duration of SBIs would provide a more informative measure that better correlates with outcome...- Pupil examination: validity and clinical utility of an automated pupillometerMichele Meeker
Department of Neurological Surgery at UCSF San Francisco General Hospital, USA
J Neurosci Nurs 37:34-40. 2005..For these reasons, such a device may be a beneficial addition in the clinical assessment of neurologically impaired patients... - Prehospital management of traumatic brain injuryShirley I Stiver
Department of Neurosurgery, School of Medicine, University of California San Francisco, California 94110 0899, USA
Neurosurg Focus 25:E5. 2008..The quality of prehospital care is a major determinant of long-term outcome for patients with traumatic brain injury... - Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical careJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA, USA San Francisco Injury Center, San Francisco, CA, USA
Physiol Meas 26:373-86. 2005..High frequency data acquisition may be necessary for more precise evaluation of secondary brain injury in neurocritical care... - Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathwayMitchell Jay Cohen
Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
J Trauma 63:1254-61; discussion 1261-2. 2007..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients... - Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injuryShirley I Stiver
Department of Neurosurgery, School of Medicine, University of California, San Francisco, California 94110 0899, USA
J Neurosurg 109:245-54. 2008..The authors set out to study motor function systematically in this patient population to define the incidence, contributing factors, and outcome of patients with motor trephine syndrome... - Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter studyJohn H Chi
Department of Surgery, The University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California 94143, USA
J Trauma 61:1134-41. 2006.... - Motor trephine syndrome: a mechanistic hypothesisShirley I Stiver
Department of Neurosurgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 101, San Francisco, CA 94110 0899, USA
Acta Neurochir Suppl 102:273-7. 2008..The goal of this study was to define causal factors associated with this syndrome... - Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithmJohn H Chi
Department of Neurological Surgery, San Francisco General Hospital, University of California, San Francisco, California, USA
Neurosurg Focus 19:E7. 2005..Observation should be considered for symptomatic patients at greater than 32 weeks gestation. Surgery should be considered for patients with severe neurological deficits at less than 32 weeks of gestation... - Controlled cortical impact in swine: pathophysiology and biomechanicsGeoffrey T Manley
Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
J Neurotrauma 23:128-39. 2006..Physiological parameters after injury are readily monitored in a setting mimicking conditions of an intensive care unit, establishing a more clinically relevant experimental model for future investigations... - Brain tissue oxygen monitoring in intracerebral hemorrhageJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA, 94110, USA
Neurocrit Care 3:260-70. 2005..We report complementary preliminary studies in a large animal model and in patients that demonstrate the feasibility of PbrO2 monitoring after ICH... - Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injuryShirley I Stiver
Departments of Neurosurgery, University of California San Francisco, California, USA
J Neurosurg 110:1242-6. 2009..Aggressive intracranial monitoring and treatment of a Duret hemorrhage arising secondary to cerebral herniation may enable a good recovery in selected patients after severe TBI... - Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201M Margaret Knudson
San Francisco Injury Center, University of California, USA
J Trauma 54:242-52. 2003..We further hypothesized that changes in tissue oxygen tension measurements in the deltoid muscle would reflect the changes seen in the liver and could thus be used as a monitor of splanchnic resuscitation... - Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenationGeoffrey T Manley
School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
Adv Exp Med Biol 530:311-7. 2003..These results suggest that a small-volume bolus of HBOC-201 may provide adequate oxygen and pressure support during the initial management of hemorrhage... - Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two casesAlfredo Quinones-Hinojosa
Department of Neurosurgery, San Francisco General Hospital, University of California, 94143 0112, USA
J Trauma 56:201-4. 2004 - Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case reportDevin K Binder
Department of Neurological Surgery, M779 Moffitt Hospital, Box 0112, University of California San Francisco, San Francisco, CA 94143 0112, USA
Neurosurgery 54:999-1002; discussion 1002-3. 2004..Here, we demonstrate a case in which clinical, radiological, and electrophysiological findings were used together to define this syndrome... - Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head traumaAlisa D Gean
Department of Radiology, University of California, San Francisco, San Francisco, Calif, USA
Radiology 257:212-8. 2010..To study the incidence, pathogenesis, imaging characteristics, and clinical importance of a unique subtype of epidural hematoma (EDH) associated with blunt head trauma... - Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reportsDaniel C Lu
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94107, USA
Surg Neurol 69:226-9. 2008..Here, we describe 2 cases of CSW in TBI patients with elevated BNP levels. This phenomenon has not been previously described... - Post-operative expansion of hemorrhagic contusions after unilateral decompressive hemicraniectomy in severe traumatic brain injuryAlexander C Flint
Department of Neurology, Neurovascular and Neurocritical Care Service, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
J Neurotrauma 25:503-12. 2008..Severity of initial CT findings may predict the risk of contusion expansion following hemicraniectomy, thereby identifying a subgroup of patients who might benefit from therapies aimed at augmenting the coagulation system... - Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial resultsJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA 94110, USA
AJNR Am J Neuroradiol 26:1095-100. 2005.... - Interobserver variability in the assessment of CT imaging features of traumatic brain injuryKimberly A Chun
Department of Radiology, Neuroradiology Section, University of California San Francisco, San Francisco, California 94143 0628, USA
J Neurotrauma 27:325-30. 2010..In conclusion, there is good interobserver reproducibility between neuroradiologists and neurosurgeons in the interpretation of CT imaging features of TBI and calculation of Marshall and Rotterdam scores... - Dose-response relationship of mannitol and intracranial pressure: a metaanalysisMARCO D SORANI
Program in Biological and Medical Informatics, University of California, San Francisco, CA 94110, USA
J Neurosurg 108:80-7. 2008..The goal of this metaanalysis was to aggregate and analyze data from studies in which authors have described the dose-response relationship between mannitol and ICP... - Aquaporins: role in cerebral edema and brain water balanceZsolt Zador
Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, CA 94110, USA
Prog Brain Res 161:185-94. 2007..These advances will require the development of AQP inhibitors and activators to establish the benefit modulating the function of these water channels... - Novel variants in human Aquaporin-4 reduce cellular water permeabilityMARCO D SORANI
Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA 94110, USA
Hum Mol Genet 17:2379-89. 2008..Our experiments provide insight into the function of the AQP4 protein. These nsSNPs may have clinical implications for patients with cerebral edema and related disorders... - Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swineSeong K Lee
San Francisco Injury Center, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Acad Emerg Med 9:969-76. 2002..The results of this preliminary study demonstrate that HBOC-201 could potentially improve current resuscitation measures and that further investigations with HBOC-201 are warranted... - The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trialAnne C Mosenthal
Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
J Trauma 56:1042-8. 2004..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization... - The role of lung function in brain tissue oxygenation following traumatic brain injuryGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, California, USA
J Neurosurg 108:59-65. 2008..The purpose of this study was to investigate the influence of lung function on PbtO2 with an oxygen challenge (increase in fraction of inspired oxygen [FiO2] concentration to 1.0)... - Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary studyMarcus L Ware
Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
Neurosurgery 57:727-36; discussion 727-36. 2005..These results warrant a rigorous evaluation of its efficacy as compared to mannitol in a prospective randomized controlled trial... - Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection systemMARCO D SORANI
Program in Biological and Medical Informatics, University of California, San Francisco UCSF, San Francisco, California, USA
J Neurotrauma 25:291-8. 2008..In a large, retrospective study of high-frequency ICP data, we have quantitatively shown that mannitol's effect on ICP is dose-dependent and that higher doses provide a more durable reduction in ICP... - Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenationSusan L Bratton
J Neurotrauma 24:S7-13. 2007 - Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholdsSusan L Bratton
J Neurotrauma 24:S65-70. 2007 - Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injuryAnne Vik
Department of Neurosurgery, St Olav University Hospital, and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
J Neurosurg 109:678-84. 2008..The objective of this study was to determine whether the calculated "ICP dose"-the ICP AUC-is related to mortality rate, outcome, and Marshall CT classification... - Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trialDavid H Livingston
Department of Surgery, New Jersey Trauma Center, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA
J Trauma 59:1298-304; discussion 1304. 2005..Age is an exceedingly important parameter affecting recovery from isolated TBI... - Infrared pupillometry during uncal herniationGeoffrey T Manley
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg Anesthesiol 14:223-8. 2002.... - Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injuryGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, USA
Crit Care Med 36:1917-24. 2008..The objective of this study was to evaluate whether P(bt)O2 more closely reflects variables related to cerebral oxygen diffusion or reflects cerebral oxygen delivery and metabolism... - Classification of traumatic brain injury for targeted therapiesKathryn E Saatman
University of Kentucky, Lexington, KY, USA
J Neurotrauma 25:719-38. 2008..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials... - New approaches to physiological informatics in neurocritical careMARCO D SORANI
Program in Biological and Medical Informatics, University of California, San Francisco, USA
Neurocrit Care 7:45-52. 2007..We propose that advances in monitoring must be accompanied by advances in methods of high-frequency, multivariate data analysis that integrate the multiple processes occurring in critically ill patients... - Aquaporin-4-deficient mice have increased extracellular space without tortuosity changeXiaoming Yao
Department of Neurosurgery and Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, California 94110, USA
J Neurosci 28:5460-4. 2008..These findings provide direct evidence for involvement of AQP4 in modulation of the ECS volume fraction and provide a basis for future modeling of water and ion transport in the CNS... - Volumetric proton spectroscopic imaging of mild traumatic brain injuryVaranavasi Govindaraju
Northern California Institute for Research and Education, MR Spectroscopy Unit, Veterans Affairs Medical Center, San Francisco, California, USA
AJNR Am J Neuroradiol 25:730-7. 2004..Although the association with injury assessment and outcome is weak, this preliminary study demonstrates the applicability of volumetric proton MRSI for evaluating diffuse injury associated with MTBI... - The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhageJustin S Smith
Department of Neurological Surgery, UCSF Brain and Spinal Injury Center, San Francisco General Hospital and University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
J Trauma 63:75-82. 2007..The purpose of this study was to investigate whether routine follow-up computed tomography (CT) for patients with head injury, in the absence of clinical indications, alters patient management... - Guidelines for the management of severe traumatic brain injury. XV. SteroidsSusan L Bratton
J Neurotrauma 24:S91-5. 2007 - Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapySusan L Bratton
J Neurotrauma 24:S14-20. 2007 - Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient miceOrin Bloch
Department of Medicine, Cardiovascular Research Institute, San Francisco, California 94143-0521, USA
J Cereb Blood Flow Metab 26:1527-37. 2006..Our results indicate a significant role for AQP4-mediated transparenchymal CSF absorption in hydrocephalus and provide a rational basis for evaluation of AQP4 induction as a nonsurgical therapy for hydrocephalus... - Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channelsDevin K Binder
Department of Neurological Surgery, University of California, San Francisco, 94110, USA
Glia 53:631-6. 2006..5 +/- 0.1 and 6.6 +/- 0.7 s, respectively). These results implicate AQP4 in the expression and termination of seizure activity and support the hypothesis that AQP4 is coupled to potassium homeostasis in vivo... - K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicatorPrashant Padmawar
Department of Medicine, Cardiovascular Research Institute, 1246 Health Sciences East Tower, University of California, San Francisco, California 94143, USA
Nat Methods 2:825-7. 2005..4 +/- 0.5 mm/min, and K(+) release and reuptake half-times (t(1/2)) of 12 +/- 2 and 32 +/- 4 s, respectively. Aquaporin-4 (AQP4) deletion slowed K(+) reuptake about twofold, suggesting AQP4-dependent K(+) uptake by astroglia... - Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscessOrin Bloch
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
J Neurochem 95:254-62. 2005..Our findings demonstrate a protective effect of AQP4 on brain swelling in bacterial abscess, suggesting that AQP4 induction may reduce vasogenic edema associated with cerebral infection... - Optical measurement of swelling and water transport in spinal cord slices from aquaporin null miceE I Solenov
Departments of Medicine and Physiology, 1246 Health Sciences East Tower, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
J Neurosci Methods 113:85-90. 2002..These results establish a simple imaging method to map changes in water content of spinal cord slices, and provide evidence that aquaporins facilitate osmotic water transport in functionally relevant areas of the spinal cord... - Significance of source and size in the mechanical response of human cerebral blood vesselsKenneth L Monson
Department of Mechanical Engineering, University of California, San Francisco, Berkeley, CA 94720, USA
J Biomech 38:737-44. 2005..These effects are, however, secondary to differences identified between arteries and veins in the previous study... - Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1Kotaro Oshio
Department of Neurosurgery, University of California, San Francisco, California 94110, USA
FASEB J 19:76-8. 2005..The reduced ICP and CSF production in AQP1 null mice provides direct functional evidence for the involvement of AQP1 in CSF dynamics, suggesting AQP1 inhibition as a novel option for therapy of elevated ICP... - Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edemaMarios C Papadopoulos
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA, 94143 0521, USA
FASEB J 18:1291-3. 2004..Thus, AQP4-mediated transcellular water movement is crucial for fluid clearance in vasogenic brain edema, suggesting AQP4 activation and/or up-regulation as a novel therapeutic option in vasogenic brain edema... - Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermiaSusan L Bratton
J Neurotrauma 24:S21-5. 2007 - Guidelines for the management of severe traumatic brain injury. IV. Infection prophylaxisSusan L Bratton
J Neurotrauma 24:S26-31. 2007 - Guidelines for the management of severe traumatic brain injury. XIV. HyperventilationSusan L Bratton
J Neurotrauma 24:S87-90. 2007 - Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxisSusan L Bratton
J Neurotrauma 24:S83-6. 2007 - Guidelines for the management of severe traumatic brain injury. XII. NutritionSusan L Bratton
J Neurotrauma 24:S77-82. 2007 - Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedativesSusan L Bratton
J Neurotrauma 24:S71-6. 2007 - Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholdsSusan L Bratton
J Neurotrauma 24:S59-64. 2007 - Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholdsSusan L Bratton
J Neurotrauma 24:S55-8. 2007 - Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technologySusan L Bratton
J Neurotrauma 24:S45-54. 2007 - Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoringSusan L Bratton
J Neurotrauma 24:S37-44. 2007 - Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxisSusan L Bratton
J Neurotrauma 24:S32-6. 2007 - Increased seizure threshold in mice lacking aquaporin-4 water channelsDevin K Binder
Department of Neurological Surgery, University of California, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143, USA
Neuroreport 15:259-62. 2004..These results suggest that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity...
Research Grants
- Vascular Biomechanics in Traumatic Brain InjuryGeoffrey Manley; Fiscal Year: 2006..abstract_text> ..
- Role of Aquaporin-4 Water Channels in Cerebral EdemaGeoffrey Manley; Fiscal Year: 2009..If AQP4 is proven to be important, as anticipated, then modulation of AQP4 function could provide a novel therapeutic strategy for the treatment of cerebral edema. ..