Geoffrey Manley

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Altering physiological networks using drugs: steps towards personalized physiology
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, CA, USA
    BMC Med Genomics 6:S7. 2013
  2. pmc Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis
    Mitchell J Cohen
    Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care 14:R10. 2010
  3. pmc Infection in the intensive care unit alters physiological networks
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    BMC Bioinformatics 10:S4. 2009
  4. doi request reprint Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group
    Geoffrey T Manley
    University of California San Francisco, CA 94110, USA
    Arch Phys Med Rehabil 91:1667-72. 2010
  5. ncbi request reprint Pupil examination: validity and clinical utility of an automated pupillometer
    Michele Meeker
    Department of Neurological Surgery at UCSF San Francisco General Hospital, USA
    J Neurosci Nurs 37:34-40. 2005
  6. ncbi request reprint A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients
    Christopher W Barton
    Department of Medicine, University of California, San Francisco, CA 94110, USA
    Acad Emerg Med 12:1-6. 2005
  7. ncbi request reprint Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA, USA San Francisco Injury Center, San Francisco, CA, USA
    Physiol Meas 26:373-86. 2005
  8. ncbi request reprint Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm
    John H Chi
    Department of Neurological Surgery, San Francisco General Hospital, University of California, San Francisco, California, USA
    Neurosurg Focus 19:E7. 2005
  9. doi request reprint Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
  10. ncbi request reprint Motor trephine syndrome: a mechanistic hypothesis
    Shirley I Stiver
    Department of Neurosurgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 101, San Francisco, CA 94110 0899, USA
    Acta Neurochir Suppl 102:273-7. 2008

Research Grants

  1. Vascular Biomechanics in Traumatic Brain Injury
    Geoffrey Manley; Fiscal Year: 2006
  2. Role of Aquaporin-4 Water Channels in Cerebral Edema
    Geoffrey Manley; Fiscal Year: 2009

Detail Information

Publications66

  1. pmc Altering physiological networks using drugs: steps towards personalized physiology
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, CA, USA
    BMC Med Genomics 6:S7. 2013
    ..We constructed correlation networks from physiologic data to demonstrate changes associated with pressor use in the intensive care unit...
  2. pmc Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis
    Mitchell J Cohen
    Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Crit Care 14:R10. 2010
    ..We hypothesized that processing of multivariate data using hierarchical clustering techniques would allow identification of otherwise hidden patient physiologic patterns that would be predictive of outcome...
  3. pmc Infection in the intensive care unit alters physiological networks
    Adam D Grossman
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    BMC Bioinformatics 10:S4. 2009
    ..However, medical sources of clinical physiological data are only now starting to find use in bioinformatics research...
  4. doi request reprint Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group
    Geoffrey T Manley
    University of California San Francisco, CA 94110, USA
    Arch Phys Med Rehabil 91:1667-72. 2010
    ....
  5. ncbi request reprint Pupil examination: validity and clinical utility of an automated pupillometer
    Michele Meeker
    Department of Neurological Surgery at UCSF San Francisco General Hospital, USA
    J Neurosci Nurs 37:34-40. 2005
    ..For these reasons, such a device may be a beneficial addition in the clinical assessment of neurologically impaired patients...
  6. ncbi request reprint A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients
    Christopher W Barton
    Department of Medicine, University of California, San Francisco, CA 94110, USA
    Acad Emerg Med 12:1-6. 2005
    ..The authors hypothesized that a new method that accounts for the cumulative depth and duration of SBIs would provide a more informative measure that better correlates with outcome...
  7. ncbi request reprint Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA, USA San Francisco Injury Center, San Francisco, CA, USA
    Physiol Meas 26:373-86. 2005
    ..High frequency data acquisition may be necessary for more precise evaluation of secondary brain injury in neurocritical care...
  8. ncbi request reprint Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm
    John H Chi
    Department of Neurological Surgery, San Francisco General Hospital, University of California, San Francisco, California, USA
    Neurosurg Focus 19:E7. 2005
    ..Observation should be considered for symptomatic patients at greater than 32 weeks gestation. Surgery should be considered for patients with severe neurological deficits at less than 32 weeks of gestation...
  9. doi request reprint Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
    ..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients...
  10. ncbi request reprint Motor trephine syndrome: a mechanistic hypothesis
    Shirley I Stiver
    Department of Neurosurgery, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 101, San Francisco, CA 94110 0899, USA
    Acta Neurochir Suppl 102:273-7. 2008
    ..The goal of this study was to define causal factors associated with this syndrome...
  11. ncbi request reprint Brain tissue oxygen monitoring in intracerebral hemorrhage
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA, 94110, USA
    Neurocrit Care 3:260-70. 2005
    ..We report complementary preliminary studies in a large animal model and in patients that demonstrate the feasibility of PbrO2 monitoring after ICH...
  12. doi request reprint Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury
    Shirley I Stiver
    Departments of Neurosurgery, University of California San Francisco, California, USA
    J Neurosurg 110:1242-6. 2009
    ..Aggressive intracranial monitoring and treatment of a Duret hemorrhage arising secondary to cerebral herniation may enable a good recovery in selected patients after severe TBI...
  13. ncbi request reprint Controlled cortical impact in swine: pathophysiology and biomechanics
    Geoffrey T Manley
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    J Neurotrauma 23:128-39. 2006
    ..Physiological parameters after injury are readily monitored in a setting mimicking conditions of an intensive care unit, establishing a more clinically relevant experimental model for future investigations...
  14. doi request reprint Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury
    Shirley I Stiver
    Department of Neurosurgery, School of Medicine, University of California, San Francisco, California 94110 0899, USA
    J Neurosurg 109:245-54. 2008
    ..The authors set out to study motor function systematically in this patient population to define the incidence, contributing factors, and outcome of patients with motor trephine syndrome...
  15. ncbi request reprint Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation
    Geoffrey T Manley
    School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
    Adv Exp Med Biol 530:311-7. 2003
    ..To investigate the effects of small-volume resuscitation with a hemoglobin based oxygen carrier on brain tissue oxygen tension (PbrO2) in hemorrhaged swine...
  16. doi request reprint Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports
    Daniel C Lu
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94107, USA
    Surg Neurol 69:226-9. 2008
    ..Here, we describe 2 cases of CSW in TBI patients with elevated BNP levels. This phenomenon has not been previously described...
  17. ncbi request reprint Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two cases
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, San Francisco General Hospital, University of California, 94143 0112, USA
    J Trauma 56:201-4. 2004
  18. ncbi request reprint Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report
    Devin K Binder
    Department of Neurological Surgery, M779 Moffitt Hospital, Box 0112, University of California San Francisco, San Francisco, CA 94143 0112, USA
    Neurosurgery 54:999-1002; discussion 1002-3. 2004
    ..Here, we demonstrate a case in which clinical, radiological, and electrophysiological findings were used together to define this syndrome...
  19. doi request reprint Prehospital management of traumatic brain injury
    Shirley I Stiver
    Department of Neurosurgery, School of Medicine, University of California San Francisco, California 94110 0899, USA
    Neurosurg Focus 25:E5. 2008
    ..The quality of prehospital care is a major determinant of long-term outcome for patients with traumatic brain injury...
  20. ncbi request reprint Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201
    M Margaret Knudson
    San Francisco Injury Center, University of California, USA
    J Trauma 54:242-52. 2003
    ..We further hypothesized that changes in tissue oxygen tension measurements in the deltoid muscle would reflect the changes seen in the liver and could thus be used as a monitor of splanchnic resuscitation...
  21. doi request reprint Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head trauma
    Alisa D Gean
    Department of Radiology, University of California, San Francisco, San Francisco, Calif, USA
    Radiology 257:212-8. 2010
    ..To study the incidence, pathogenesis, imaging characteristics, and clinical importance of a unique subtype of epidural hematoma (EDH) associated with blunt head trauma...
  22. ncbi request reprint Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study
    John H Chi
    Department of Surgery, The University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California 94143, USA
    J Trauma 61:1134-41. 2006
    ....
  23. doi request reprint Post-operative expansion of hemorrhagic contusions after unilateral decompressive hemicraniectomy in severe traumatic brain injury
    Alexander C Flint
    Department of Neurology, Neurovascular and Neurocritical Care Service, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
    J Neurotrauma 25:503-12. 2008
    ..Severity of initial CT findings may predict the risk of contusion expansion following hemicraniectomy, thereby identifying a subgroup of patients who might benefit from therapies aimed at augmenting the coagulation system...
  24. ncbi request reprint Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, CA 94110, USA
    AJNR Am J Neuroradiol 26:1095-100. 2005
    ..The purpose of this study was to determine if there is a relationship between CT perfusion (CTP) imaging parameters and P(br)O(2)...
  25. pmc Interobserver variability in the assessment of CT imaging features of traumatic brain injury
    Kimberly A Chun
    Department of Radiology, Neuroradiology Section, University of California San Francisco, San Francisco, California 94143 0628, USA
    J Neurotrauma 27:325-30. 2010
    ..In conclusion, there is good interobserver reproducibility between neuroradiologists and neurosurgeons in the interpretation of CT imaging features of TBI and calculation of Marshall and Rotterdam scores...
  26. pmc Novel variants in human Aquaporin-4 reduce cellular water permeability
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA 94110, USA
    Hum Mol Genet 17:2379-89. 2008
    ..Our experiments provide insight into the function of the AQP4 protein. These nsSNPs may have clinical implications for patients with cerebral edema and related disorders...
  27. doi request reprint Dose-response relationship of mannitol and intracranial pressure: a metaanalysis
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, CA 94110, USA
    J Neurosurg 108:80-7. 2008
    ..The goal of this metaanalysis was to aggregate and analyze data from studies in which authors have described the dose-response relationship between mannitol and ICP...
  28. ncbi request reprint Aquaporins: role in cerebral edema and brain water balance
    Zsolt Zador
    Department of Neurological Surgery, Brain and Spinal Injury Center, University of California, San Francisco, CA 94110, USA
    Prog Brain Res 161:185-94. 2007
    ..These advances will require the development of AQP inhibitors and activators to establish the benefit modulating the function of these water channels...
  29. doi request reprint Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury
    Anne Vik
    Department of Neurosurgery, St Olav University Hospital, and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurosurg 109:678-84. 2008
    ..The objective of this study was to determine whether the calculated "ICP dose"-the ICP AUC-is related to mortality rate, outcome, and Marshall CT classification...
  30. ncbi request reprint New approaches to physiological informatics in neurocritical care
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco, USA
    Neurocrit Care 7:45-52. 2007
    ..We propose that advances in monitoring must be accompanied by advances in methods of high-frequency, multivariate data analysis that integrate the multiple processes occurring in critically ill patients...
  31. doi request reprint The role of lung function in brain tissue oxygenation following traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, California, USA
    J Neurosurg 108:59-65. 2008
    ..The purpose of this study was to investigate the influence of lung function on PbtO2 with an oxygen challenge (increase in fraction of inspired oxygen [FiO2] concentration to 1.0)...
  32. ncbi request reprint Infrared pupillometry during uncal herniation
    Geoffrey T Manley
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Anesthesiol 14:223-8. 2002
    ....
  33. ncbi request reprint Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial
    David H Livingston
    Department of Surgery, New Jersey Trauma Center, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 59:1298-304; discussion 1304. 2005
    ..The purpose of this study was to further investigate the effect of age on outcome at 1 year in all patients surviving isolated TBI...
  34. ncbi request reprint Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine
    Seong K Lee
    San Francisco Injury Center, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
    Acad Emerg Med 9:969-76. 2002
    ....
  35. ncbi request reprint Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation
    Susan L Bratton
    J Neurotrauma 24:S7-13. 2007
  36. ncbi request reprint Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds
    Susan L Bratton
    J Neurotrauma 24:S65-70. 2007
  37. ncbi request reprint The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    Anne C Mosenthal
    Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
    J Trauma 56:1042-8. 2004
    ..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization...
  38. ncbi request reprint Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study
    Marcus L Ware
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 57:727-36; discussion 727-36. 2005
    ..This preliminary study assessed the safety and efficacy of small-volume injections of 23.4% sodium chloride solution for the treatment of intracranial hypertension in patients with traumatic brain injury who became tolerant to mannitol...
  39. doi request reprint Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury
    Guy Rosenthal
    Department of Neurosurgery, University of California, San Francisco, USA
    Crit Care Med 36:1917-24. 2008
    ..The objective of this study was to evaluate whether P(bt)O2 more closely reflects variables related to cerebral oxygen diffusion or reflects cerebral oxygen delivery and metabolism...
  40. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...
  41. doi request reprint Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system
    MARCO D SORANI
    Program in Biological and Medical Informatics, University of California, San Francisco UCSF, San Francisco, California, USA
    J Neurotrauma 25:291-8. 2008
    ..In a large, retrospective study of high-frequency ICP data, we have quantitatively shown that mannitol's effect on ICP is dose-dependent and that higher doses provide a more durable reduction in ICP...
  42. pmc Aquaporin-4-deficient mice have increased extracellular space without tortuosity change
    Xiaoming Yao
    Department of Neurosurgery and Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 28:5460-4. 2008
    ..These findings provide direct evidence for involvement of AQP4 in modulation of the ECS volume fraction and provide a basis for future modeling of water and ion transport in the CNS...
  43. ncbi request reprint The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage
    Justin S Smith
    Department of Neurological Surgery, UCSF Brain and Spinal Injury Center, San Francisco General Hospital and University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    J Trauma 63:75-82. 2007
    ..The purpose of this study was to investigate whether routine follow-up computed tomography (CT) for patients with head injury, in the absence of clinical indications, alters patient management...
  44. ncbi request reprint Volumetric proton spectroscopic imaging of mild traumatic brain injury
    Varanavasi Govindaraju
    Northern California Institute for Research and Education, MR Spectroscopy Unit, Veterans Affairs Medical Center, San Francisco, California, USA
    AJNR Am J Neuroradiol 25:730-7. 2004
    ..In this study, MTBI-associated metabolic changes were assessed over the entire brain by using volumetric proton MR spectroscopic imaging (MRSI) and the findings related to injury and outcome assessments...
  45. ncbi request reprint Guidelines for the management of severe traumatic brain injury. XV. Steroids
    Susan L Bratton
    J Neurotrauma 24:S91-5. 2007
  46. ncbi request reprint Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy
    Susan L Bratton
    J Neurotrauma 24:S14-20. 2007
  47. ncbi request reprint Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice
    Orin Bloch
    Department of Medicine, Cardiovascular Research Institute, San Francisco, California 94143 0521, USA
    J Cereb Blood Flow Metab 26:1527-37. 2006
    ..Our results indicate a significant role for AQP4-mediated transparenchymal CSF absorption in hydrocephalus and provide a rational basis for evaluation of AQP4 induction as a nonsurgical therapy for hydrocephalus...
  48. ncbi request reprint Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, San Francisco, 94110, USA
    Glia 53:631-6. 2006
    ..5 +/- 0.1 and 6.6 +/- 0.7 s, respectively). These results implicate AQP4 in the expression and termination of seizure activity and support the hypothesis that AQP4 is coupled to potassium homeostasis in vivo...
  49. ncbi request reprint K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator
    Prashant Padmawar
    Department of Medicine, Cardiovascular Research Institute, 1246 Health Sciences East Tower, University of California, San Francisco, California 94143, USA
    Nat Methods 2:825-7. 2005
    ..4 +/- 0.5 mm/min, and K(+) release and reuptake half-times (t(1/2)) of 12 +/- 2 and 32 +/- 4 s, respectively. Aquaporin-4 (AQP4) deletion slowed K(+) reuptake about twofold, suggesting AQP4-dependent K(+) uptake by astroglia...
  50. ncbi request reprint Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess
    Orin Bloch
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Neurochem 95:254-62. 2005
    ..Our findings demonstrate a protective effect of AQP4 on brain swelling in bacterial abscess, suggesting that AQP4 induction may reduce vasogenic edema associated with cerebral infection...
  51. ncbi request reprint Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice
    E I Solenov
    Departments of Medicine and Physiology, 1246 Health Sciences East Tower, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Neurosci Methods 113:85-90. 2002
    ..These results establish a simple imaging method to map changes in water content of spinal cord slices, and provide evidence that aquaporins facilitate osmotic water transport in functionally relevant areas of the spinal cord...
  52. ncbi request reprint Significance of source and size in the mechanical response of human cerebral blood vessels
    Kenneth L Monson
    Department of Mechanical Engineering, University of California, San Francisco, Berkeley, CA 94720, USA
    J Biomech 38:737-44. 2005
    ..These effects are, however, secondary to differences identified between arteries and veins in the previous study...
  53. ncbi request reprint Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1
    Kotaro Oshio
    Department of Neurosurgery, University of California, San Francisco, California 94110, USA
    FASEB J 19:76-8. 2005
    ..The reduced ICP and CSF production in AQP1 null mice provides direct functional evidence for the involvement of AQP1 in CSF dynamics, suggesting AQP1 inhibition as a novel option for therapy of elevated ICP...
  54. ncbi request reprint Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema
    Marios C Papadopoulos
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA, 94143 0521, USA
    FASEB J 18:1291-3. 2004
    ..Thus, AQP4-mediated transcellular water movement is crucial for fluid clearance in vasogenic brain edema, suggesting AQP4 activation and/or up-regulation as a novel therapeutic option in vasogenic brain edema...
  55. ncbi request reprint Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia
    Susan L Bratton
    J Neurotrauma 24:S21-5. 2007
  56. ncbi request reprint Guidelines for the management of severe traumatic brain injury. IV. Infection prophylaxis
    Susan L Bratton
    J Neurotrauma 24:S26-31. 2007
  57. ncbi request reprint Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation
    Susan L Bratton
    J Neurotrauma 24:S87-90. 2007
  58. ncbi request reprint Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis
    Susan L Bratton
    J Neurotrauma 24:S83-6. 2007
  59. ncbi request reprint Guidelines for the management of severe traumatic brain injury. XII. Nutrition
    Susan L Bratton
    J Neurotrauma 24:S77-82. 2007
  60. ncbi request reprint Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives
    Susan L Bratton
    J Neurotrauma 24:S71-6. 2007
  61. ncbi request reprint Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds
    Susan L Bratton
    J Neurotrauma 24:S59-64. 2007
  62. ncbi request reprint Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds
    Susan L Bratton
    J Neurotrauma 24:S55-8. 2007
  63. ncbi request reprint Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology
    Susan L Bratton
    J Neurotrauma 24:S45-54. 2007
  64. ncbi request reprint Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring
    Susan L Bratton
    J Neurotrauma 24:S37-44. 2007
  65. ncbi request reprint Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxis
    Susan L Bratton
    J Neurotrauma 24:S32-6. 2007
  66. ncbi request reprint Increased seizure threshold in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143, USA
    Neuroreport 15:259-62. 2004
    ..These results suggest that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity...

Research Grants6

  1. Vascular Biomechanics in Traumatic Brain Injury
    Geoffrey Manley; Fiscal Year: 2006
    ..abstract_text> ..
  2. Role of Aquaporin-4 Water Channels in Cerebral Edema
    Geoffrey Manley; Fiscal Year: 2009
    ..If AQP4 is proven to be important, as anticipated, then modulation of AQP4 function could provide a novel therapeutic strategy for the treatment of cerebral edema. ..