Husseini Manji

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Depression, III: treatments
    Husseini Manji
    Maryland Psychiatric Research Center, University of Maryland, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 160:24. 2003
  2. ncbi request reprint Partial dopamine agonists in the treatment of psychosis
    C A Tamminga
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Neural Transm 109:411-20. 2002
  3. ncbi request reprint Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis
    C A Tamminga
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21247, USA
    Curr Drug Targets CNS Neurol Disord 1:141-7. 2002
  4. ncbi request reprint Evaluating glutamatergic transmission in schizophrenia
    Carol A Tamminga
    University of Texas Southwestern Medical School, Dallas, Texas, 75390, USA
    Ann N Y Acad Sci 1003:113-8. 2003
  5. ncbi request reprint Diseases of the mind and brain: depression: a disease of the mind, brain, and body
    Phillip W Gold
    Maryland Psychiatric Reseach Center, University of Maryland, Baltimore, MD 21228, USA
    Am J Psychiatry 159:1826. 2002
  6. pmc Cognitive endophenotypes of psychosis within dimension and diagnosis
    Elena I Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Psychiatry Res 196:38-44. 2012
  7. pmc Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Schizophr Bull 38:927-35. 2012
  8. ncbi request reprint Effects of noncompetitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia
    Henry H Holcomb
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:2275-82. 2005
  9. ncbi request reprint Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 139:19-30. 2005
  10. ncbi request reprint Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 31:221-30. 2006

Detail Information

Publications59

  1. ncbi request reprint Depression, III: treatments
    Husseini Manji
    Maryland Psychiatric Research Center, University of Maryland, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 160:24. 2003
  2. ncbi request reprint Partial dopamine agonists in the treatment of psychosis
    C A Tamminga
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Neural Transm 109:411-20. 2002
    ..Partial dopamine agonists represent the next new class of antipsychotic drugs, effective in treating schizophrenia...
  3. ncbi request reprint Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis
    C A Tamminga
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21247, USA
    Curr Drug Targets CNS Neurol Disord 1:141-7. 2002
    ..One of them, aripiprazole, is nearing approval for marketing. With partial dopamine agonist treatment, advantages should accrue to schizophrenia treatment in the areas of affect control and cognitive performance...
  4. ncbi request reprint Evaluating glutamatergic transmission in schizophrenia
    Carol A Tamminga
    University of Texas Southwestern Medical School, Dallas, Texas, 75390, USA
    Ann N Y Acad Sci 1003:113-8. 2003
    ..What I will report in this paper has been individually reported elsewhere but brought together here in a new synthesis...
  5. ncbi request reprint Diseases of the mind and brain: depression: a disease of the mind, brain, and body
    Phillip W Gold
    Maryland Psychiatric Reseach Center, University of Maryland, Baltimore, MD 21228, USA
    Am J Psychiatry 159:1826. 2002
  6. pmc Cognitive endophenotypes of psychosis within dimension and diagnosis
    Elena I Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Psychiatry Res 196:38-44. 2012
    ..These data support the notion that schizophrenia and psychotic bipolar disorder present a clinical continuum with overlapping cognitive features defining the psychosis phenotype...
  7. pmc Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Schizophr Bull 38:927-35. 2012
    ....
  8. ncbi request reprint Effects of noncompetitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia
    Henry H Holcomb
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:2275-82. 2005
    ..The loss of inhibition and increased glutamate release may cause the distorted thoughts and diminished cognitive abilities elicited by NMDAR blockade...
  9. ncbi request reprint Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 139:19-30. 2005
    ..Differences in the involvement in basal ganglia parallel known differences between the drugs in the emergence of acute EPS upon emergency administration...
  10. ncbi request reprint Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 31:221-30. 2006
    ..The involvement of both frontal and parietal regions is implicated in the pathophysiology of negative symptoms...
  11. ncbi request reprint Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 29:171-8. 2004
    ..Based on these preliminary data, we propose that this pattern may account for the superior therapeutic effect of clozapine and represents a surrogate marker of this action...
  12. pmc Predictive pursuit association with deficits in working memory in psychosis
    Amanda F Moates
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 72:752-7. 2012
    ..Because predictive pursuit might depend on the working memory system, we have hypothesized a relationship between the two in healthy control subjects (HC) and SZ and here examine whether it extends to psychotic bipolar disorder (BDP)...
  13. doi request reprint Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex
    Max A Castillo
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:208-16. 2010
    ..This in turn could affect the binding of Stx 1 to its protein partners and result in abnormal neurotransmitter release and synaptic transmission...
  14. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  15. pmc Brain gray matter phenotypes across the psychosis dimension
    Elena I Ivleva
    Department of Psychiatry, UT Southwestern Medical Center, 6363 Forest Park Road, Suite 6 633, Dallas, TX 75235, USA
    Psychiatry Res 204:13-24. 2012
    ....
  16. ncbi request reprint Adverse effects and laboratory parameters of high-dose olanzapine vs. clozapine in treatment-resistant schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21228, USA
    Ann Clin Psychiatry 15:181-6. 2003
    ..High doses of olanzapine during 8 weeks of treatment did not increase lipids and liver enzymes like clozapine did. Olanzapine at 50 mg/day may be associated with more anticholinergic effects and weight gain than clozapine...
  17. ncbi request reprint Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations
    Henry H Holcomb
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 127:207-16. 2004
    ..The schizophrenia group's tendency to process high and low error conditions with similar behavioral resources may reflect a relatively static, non-dynamic cognitive repertoire...
  18. ncbi request reprint Multidose risperidone treatment evaluated in a rodent model of tardive dyskinesia
    Xue Min Gao
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 31:1864-8. 2006
    ..If this animal model predicts TD risk in humans, the TD liability with low-dose risperidone is at a placebo level, whereas higher doses show haloperidol-like TD risk, as predicted from the acute motor effects...
  19. ncbi request reprint The neurobiology of cognition in schizophrenia
    Carol A Tamminga
    Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, USA
    J Clin Psychiatry 67:e11. 2006
    ..Domain treatment of schizophrenia is a new method of treating schizophrenia that involves treating a single domain of dysfunction at a time...
  20. pmc Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?
    Subroto Ghose
    University of Texas Southwestern Medical Center, NE5 110C, Dallas, TX 75390 9127, USA
    Am J Psychiatry 166:812-20. 2009
    ..GCP II is an enzyme that metabolizes N-acetyl-aspartyl-glutamate (NAAG), which is the only known specific endogenous agonist of mGluR3 in the mammalian brain...
  21. pmc The interactive effects of ketamine and nicotine on human cerebral blood flow
    Laura M Rowland
    Department of Psychiatry, Functional Neuroimaging Laboratory, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 208:575-84. 2010
    ..The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF)...
  22. doi request reprint The hippocampal formation in schizophrenia
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, NE5 110F, 2201 Inwood Rd, Dallas, TX 75235, USA
    Am J Psychiatry 167:1178-93. 2010
    ..Tests of this model could result in novel approaches to the treatment of psychosis and declarative memory alterations and in novel animal preparations for basic schizophrenia research...
  23. doi request reprint Hippocampal novelty activations in schizophrenia: disease and medication effects
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States
    Schizophr Res 138:157-63. 2012
    ....
  24. pmc Memory generalization is selectively altered in the psychosis dimension
    Elena I Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Schizophr Res 138:74-80. 2012
    ..These results suggest that the two disorders present a clinical continuum with overlapping hippocampus-mediated memory generalization dysfunction underlying the psychosis phenotype...
  25. pmc AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli
    Vaishnav Krishnan
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 64:691-700. 2008
    ..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability...
  26. doi request reprint Schizophrenia: treatment targets beyond monoamine systems
    Hisham M Ibrahim
    Department of Psychiatry, University of Texas Southwestern, Dallas, 75390 9086, USA
    Annu Rev Pharmacol Toxicol 51:189-209. 2011
    ..Animal models, some with genetic characteristics, can be more easily and directly developed to match an individual component than to match an illness definition as broad as schizophrenia...
  27. pmc Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder
    Elena Ivleva
    Department of Psychiatry, University of Texas Southwestern Medical School, 5352 Harry Hines Boulevard, Dallas, TX 75235, USA
    Schizophr Bull 34:734-42. 2008
  28. doi request reprint Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary
    Elena I Ivleva
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235, USA
    Neurosci Biobehav Rev 34:897-921. 2010
    ..Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed...
  29. ncbi request reprint The science of antipsychotics: mechanistic insight
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    CNS Spectr 8:5-9. 2003
    ..Understanding the differences in mechanisms of action of new antipsychotics will allow physicians to better choose treatment that meets the needs of each individual patient...
  30. ncbi request reprint The anatomy of fear extinction
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110, Dallas, TX 75390 9070, USA
    Am J Psychiatry 163:961. 2006
  31. ncbi request reprint Functional effects of antipsychotic drugs: comparing clozapine with haloperidol
    Adrienne C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 53:601-8. 2003
    ....
  32. ncbi request reprint Similarities and differences among antipsychotics
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Clin Psychiatry 64:7-10. 2003
    ..The treating physician must carefully match the diverse needs of schizophrenic patients with the varied characteristics of the second-generation antipsychotics...
  33. ncbi request reprint Regional expression of RGS4 mRNA in human brain
    Holly A Erdely
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eur J Neurosci 19:3125-8. 2004
    ..In conclusion, RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus...
  34. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
    ..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
  35. doi request reprint Animal models of schizophrenia emphasizing construct validity
    Masaya Yanagi
    Department of Psychiatry, UT Southwestern Medical School, Dallas, Texas, USA
    Prog Mol Biol Transl Sci 105:411-44. 2012
    ..This chapter emphasizes the crucial need for construct validity and of modeling discrete elements of schizophrenia's illness presentation as the way to successful advances...
  36. ncbi request reprint Neuroplasticity and schizophrenia
    Douglas O Frost
    Department of Pharmacology and Experimental Therapeutics, Baltimore, Maryland, USA
    Biol Psychiatry 56:540-3. 2004
    ..Although the focus of this workshop was schizophrenia, the phenomena considered are pertinent to other disorders, such as depression and drug abuse...
  37. ncbi request reprint Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia
    Matthew T Avila
    Maryland Psychiatric Research Center, Baltimore 21228, USA
    Am J Psychiatry 159:1490-6. 2002
    ..The authors examined the effects of ketamine on leading saccadic eye movements, a specific component of the smooth-pursuit response shown to be abnormal in schizophrenia patients and their relatives...
  38. pmc Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011
    ..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles...
  39. doi request reprint Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
    ..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
  40. pmc The neuropharmacology of psychosis
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NE5 110F, Dallas, TX 75390 9127, USA
    Schizophr Bull 33:937-46. 2007
    ..We discuss the kinds of data necessary to further support the dimensional aspects of psychosis...
  41. pmc The GABAβ receptor as a target for antidepressant drug action
    Subroto Ghose
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Br J Pharmacol 162:1-17. 2011
    ..Together with the earlier preclinical studies, these new data point to a role for the GABA(B) system in major depression and support the antidepressant potential of GABA(B) receptor antagonists...
  42. ncbi request reprint Neurobiological underpinnings of insight deficits in schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 6363 Forest Park Road, Dallas, TX 75390, USA
    Int Rev Psychiatry 19:437-46. 2007
    ..Using published and preliminary data, we propose a hypothetical model of insight that may help initiate neurobiological investigations in this complex area...
  43. pmc In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1042-6. 2009
    ..03-ppm peaks, assuming identical T(1) and T(2) between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 +/- 0.2 (mean +/- SD; N = 6)...
  44. ncbi request reprint Regional alterations in RGS4 protein in schizophrenia
    Holly A Erdely
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Synapse 59:472-9. 2006
    ..Measurement of protein levels using Western blot demonstrated that RGS4 protein is decreased in the frontal cortex of schizophrenia cases...
  45. ncbi request reprint Frontal cortex function
    Carol A Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:2178. 2004
  46. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  47. ncbi request reprint Preclinical models: status of basic research in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 52:503-28. 2002
    ....
  48. pmc Brief report: Insight into illness and social attributional style in Asperger's syndrome
    Nyaz Didehbani
    Center for BrainHealth, The University of Texas at Dallas, 2200 W Mockingbird Lane, Dallas, TX 75235, USA
    J Autism Dev Disord 42:2754-60. 2012
    ..Results revealed that EB was negatively correlated with insight as assessed with the clinician-administered but not the self-administered measure of insight...
  49. ncbi request reprint Schizophrenia, I
    Carol A Tamminga
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Am J Psychiatry 160:846. 2003
  50. ncbi request reprint The human brain
    Carol A Tamminga
    University of Texas Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Boulevard, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1169. 2004
  51. doi request reprint Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....
  52. ncbi request reprint Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism
    Xizhong Huang
    Schepens Eye Research Institute and Program in Neuroscience, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 44:347-54. 2003
    ..To explore whether lithium, a long-standing mood-stabilizing drug, can be used to induce expression of Bcl-2 and support the survival and regeneration of axons of retinal ganglion cells (RGCs)...
  53. pmc Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment
    Francis J McMahon
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health, Bethesda, MD 20892 3719, USA
    Am J Hum Genet 78:804-14. 2006
    ..Taken together with prior neurobiological findings, these new genetic data make a compelling case for a key role of HTR2A in the mechanism of antidepressant action...
  54. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...
  55. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  56. ncbi request reprint Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort
    Silvia Paddock
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 164:1181-8. 2007
    ..The purpose of the present study was to utilize a second wave of genotype results, for a more powerful analysis, in the complete cohort of patients with available deoxyribonucleic acid (DNA) samples...
  57. ncbi request reprint Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
    ....
  58. ncbi request reprint New insights into BDNF function in depression and anxiety
    Keri Martinowich
    Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 10:1089-93. 2007
    ..Opposing influences of mBDNF and proBDNF on long-term potentiation and long-term depression might contribute to the dichotomy of BDNF actions on behaviors mediated by the brain stress and reward systems...
  59. ncbi request reprint [Possible involvement of protein kinase C in the pathophysiology and treatment of bipolar disorder]
    Haim Einat
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, HHS, Bethesda, USA
    Harefuah 143:420-5, 462. 2004
    ..Therefore, this pathway may be a promising candidate for the development of new, more specific drugs for the disease...