Ani Manichaikul

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Genet 8:e1002640. 2012
  2. pmc Binary trait mapping in experimental crosses with selective genotyping
    Ani Manichaikul
    Department of Biomedical Engineering, Univeristy of Virginia, Charlottesville, Virginia 22908, USA
    Genetics 182:863-74. 2009
  3. pmc Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain
    Jessica S Rowlan
    Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA
    J Am Heart Assoc 2:e000260. 2013
  4. pmc Analysis of family- and population-based samples in cohort genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Hum Genet 131:275-87. 2012
  5. pmc Robust relationship inference in genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Bioinformatics 26:2867-73. 2010
  6. ncbi request reprint Evaluation of replication of variants associated with genetic risk of otitis media
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 9:e104212. 2014
  7. doi request reprint Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis
    Ani Manichaikul
    Center for Public Health Genomics and Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 32:1991-9. 2012
  8. pmc A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis
    Ani Manichaikul
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Genetics 181:1077-86. 2009
  9. pmc NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection
    Michael D Stadnisky
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Immunogenetics 61:755-64. 2009
  10. doi request reprint Genetic contributors to otitis media: agnostic discovery approaches
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, VA, 22908, USA
    Curr Allergy Asthma Rep 14:411. 2014

Detail Information

Publications15

  1. pmc Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Genet 8:e1002640. 2012
    ....
  2. pmc Binary trait mapping in experimental crosses with selective genotyping
    Ani Manichaikul
    Department of Biomedical Engineering, Univeristy of Virginia, Charlottesville, Virginia 22908, USA
    Genetics 182:863-74. 2009
    ....
  3. pmc Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain
    Jessica S Rowlan
    Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA
    J Am Heart Assoc 2:e000260. 2013
    ....
  4. pmc Analysis of family- and population-based samples in cohort genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Hum Genet 131:275-87. 2012
    ..g., variance-component model for quantitative traits or generalized estimating equations for dichotomous traits) perform best in the context of combined family- and population-based cohort GWAS...
  5. pmc Robust relationship inference in genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Bioinformatics 26:2867-73. 2010
    ..Existing algorithms for relationship inference have a major weakness of estimating allele frequencies at each SNP from the entire sample, under a strong assumption of homogeneous population structure. This assumption is often untenable...
  6. ncbi request reprint Evaluation of replication of variants associated with genetic risk of otitis media
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 9:e104212. 2014
    ..None of the SNP associations replicated in our family-based population (unadjusted Pā€Š=ā€Š0.03-0.93). Replication in an independent sample would confirm that these represent novel OM loci, and that further investigation is warranted. ..
  7. doi request reprint Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis
    Ani Manichaikul
    Center for Public Health Genomics and Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 32:1991-9. 2012
    ....
  8. pmc A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis
    Ani Manichaikul
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Genetics 181:1077-86. 2009
    ..We illustrate the use of our model selection criteria as exploratory tools; simulation studies demonstrate reasonable power to detect QTL. Our liberal criterion is comparable in power to two Bayesian approaches...
  9. pmc NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection
    Michael D Stadnisky
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Immunogenetics 61:755-64. 2009
    ..Importantly, both chromosome 6 and 19 QTLs contribute to virus control independent of H-2(k). Altogether, MHC and non-MHC MCMV-resistance QTL contribute in early resistance to MCMV infection in this genetic system...
  10. doi request reprint Genetic contributors to otitis media: agnostic discovery approaches
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, VA, 22908, USA
    Curr Allergy Asthma Rep 14:411. 2014
    ..Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis. ..
  11. pmc Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, West Complex, 6th Floor, Suite 6111, PO Box 800717, University of Virginia, Charlottesville, VA 22908, USA
    BMC Proc 5:S68. 2011
    ..7 to 1.0. These results suggest that the use of classical linkage and association methods in large families can provide a useful approach to identifying variants that are responsible for diseases and complex traits in families...
  12. pmc A generalized family-based association test for dichotomous traits
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Am J Hum Genet 85:364-76. 2009
    ..For the T1D association at gene UBASH3A, the GDT resulted in a genome-wide significance (p = 4.3 x 10(-6)), much stronger than the published significance (p = 10(-4))...
  13. pmc Metabolic network analysis integrated with transcript verification for sequenced genomes
    Ani Manichaikul
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Nat Methods 6:589-92. 2009
    ..Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering...
  14. pmc A functionally significant polymorphism in ID3 is associated with human coronary pathology
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 9:e90222. 2014
    ..In the current investigation, we characterize the association between the functionally significant polymorphism in ID3, rs11574, with human coronary pathology...
  15. pmc Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 301:H1056-61. 2011
    ..Ath29 is confirmed to be a major atherosclerosis susceptibility locus affecting both early and advanced lesion formation in mice, and Rcn2 is identified as a novel regulator of cytokine expression...