H Manev

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
  2. pmc Identification of a novel Drosophila gene, beltless, using injectable embryonic and adult RNA interference (RNAi)
    Svetlana Dzitoyeva
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    BMC Genomics 4:33. 2003
  3. ncbi request reprint New antidepressant drugs that do not cross the blood-brain barrier
    H Manev
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, 606912, USA
    Med Hypotheses 58:83-4. 2002
  4. ncbi request reprint DNA hypomethylating agents 5-aza-2'-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNA
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Pharmacol 445:149-50. 2002
  5. ncbi request reprint Fruit flies for anti-pain drug discovery
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Life Sci 76:2403-7. 2005
  6. ncbi request reprint Techniques: fruit flies as models for neuropharmacological research
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Trends Pharmacol Sci 24:41-3. 2003
  7. ncbi request reprint Glia as a putative target for antidepressant treatments
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Affect Disord 75:59-64. 2003
  8. pmc Nomen est Omen: do antidepressants increase p11 or S100A10?
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biomed Discov Collab 1:5. 2006
  9. ncbi request reprint Drosophila model for in vivo pharmacological analgesia research
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, M C912, Chicago, IL 60612, USA
    Eur J Pharmacol 491:207-8. 2004
  10. ncbi request reprint Clock genes: influencing and being influenced by psychoactive drugs
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Trends Pharmacol Sci 27:186-9. 2006

Research Grants

  1. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2009
  2. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2007
  3. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2006
  4. AGING AND NEURONAL 5 LIPOXYGENASE
    Hari Manev; Fiscal Year: 2002
  5. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2010

Collaborators

Detail Information

Publications75

  1. pmc Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
    ....
  2. pmc Identification of a novel Drosophila gene, beltless, using injectable embryonic and adult RNA interference (RNAi)
    Svetlana Dzitoyeva
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    BMC Genomics 4:33. 2003
    ....
  3. ncbi request reprint New antidepressant drugs that do not cross the blood-brain barrier
    H Manev
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, 606912, USA
    Med Hypotheses 58:83-4. 2002
    ..Moreover, we suggest that new antidepressant drugs could be designed that would not enter into the brain but would stimulate peripheral mediators such as IGF-I...
  4. ncbi request reprint DNA hypomethylating agents 5-aza-2'-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNA
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Pharmacol 445:149-50. 2002
    ..We propose that neuronal 5-lipoxygenase expression can be affected by aging-altered DNA methylation and by hypomethylating drugs, such as the anticonvulsant valproate...
  5. ncbi request reprint Fruit flies for anti-pain drug discovery
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Life Sci 76:2403-7. 2005
    ..Since no serious ethical controversies have been raised regarding experiments in insects, Drosophila may be, for the time being an ethically acceptable animal model for combined genetic and pharmacological analgesia research...
  6. ncbi request reprint Techniques: fruit flies as models for neuropharmacological research
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Trends Pharmacol Sci 24:41-3. 2003
    ..Combined, these methods hold promise for significant neuropharmacological advancement...
  7. ncbi request reprint Glia as a putative target for antidepressant treatments
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Affect Disord 75:59-64. 2003
    ..e., astrocytes. We have recently shown that protracted administration of the antidepressant fluoxetine to adult rats upregulated the astrocytic protein S100beta content and increased neurogenesis in the hippocampus...
  8. pmc Nomen est Omen: do antidepressants increase p11 or S100A10?
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biomed Discov Collab 1:5. 2006
    ..Calling the p11 protein by its other name, S100A10, may prompt more investigators from different fields to participate in this new direction of neurobiological research...
  9. ncbi request reprint Drosophila model for in vivo pharmacological analgesia research
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, M C912, Chicago, IL 60612, USA
    Eur J Pharmacol 491:207-8. 2004
    ..We found a drug-induced dose-dependent increased threshold for heat avoidance and we propose Drosophila as an ethically acceptable animal model for in vivo pharmacological analgesia research...
  10. ncbi request reprint Clock genes: influencing and being influenced by psychoactive drugs
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Trends Pharmacol Sci 27:186-9. 2006
    ..Focusing on clock genes expressed in the brain might lead to the discovery of novel drug-target pathways...
  11. ncbi request reprint 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Med Hypotheses 66:501-3. 2006
    ..e., transgenic mice could be produced by crossing the available 5-LOX-deficient mice with the available transgenic mice models of Alzheimer's disease...
  12. ncbi request reprint Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression
    H Manev
    Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Ann N Y Acad Sci 890:183-90. 1999
    ..The results of our ongoing research are expected to elucidate the role of 5-LO in aging and neurodegeneration and to indicate neuroprotective therapies that would target the 5-LO pathway...
  13. doi request reprint Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, Illinois 60612, USA
    Amyotroph Lateral Scler 10:416-7. 2009
    ..Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic...
  14. pmc Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease
    Hari Manev
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:315-9. 2011
    ....
  15. ncbi request reprint Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro
    H Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street MC912, 60612, Chicago, IL, USA
    Eur J Pharmacol 411:67-70. 2001
    ..Clomipramine and imipramine produced similar action in vitro; desipramine was ineffective...
  16. ncbi request reprint 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate
    H Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Exp Gerontol 35:1201-9. 2000
    ..The mechanism of how NS-398 inhibits this action of kainate should be further investigated...
  17. ncbi request reprint Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?
    H Manev
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Ann N Y Acad Sci 939:45-51. 2001
    ..Additional studies should explore whether 5-LOX may participate in neurogenesis related pathologies and whether it should be considered a target for procedures aimed at altering neurogenesis for therapeutic purposes...
  18. ncbi request reprint 5-Lipoxygenase gene polymorphism and onset of Alzheimer's disease
    H Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Med Hypotheses 54:75-6. 2000
    ....
  19. ncbi request reprint Putative role of neuronal 5-lipoxygenase in an aging brain
    H Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    FASEB J 14:1464-9. 2000
    ..Thus, the 5-LOX pathway could become a promising target of neuroprotective therapies for the aging brain...
  20. ncbi request reprint Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampus
    R Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL60612, USA
    Eur J Pharmacol 420:R1-2. 2001
    ....
  21. pmc Dopamine receptor-mediated regulation of neuronal "clock" gene expression
    M Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Neuroscience 158:537-44. 2009
    ..e. intracellular signaling pathways) and thereby influences neuronal gene expression, neuronal transmission, and brain functioning...
  22. pmc 5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells
    M Imbesi
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroscience 164:1531-7. 2009
    ..In addition, an increase in DNMT3a but not DNMT1 expression accompanies an increase of 5-LOX methylation during in vitro maturation...
  23. ncbi request reprint Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum
    T Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Neuroscience 134:1309-16. 2005
    ..We propose that the effects of psychoactive drugs on clock transcription factors may mediate long-term drug-induced changes, possibly by regulating the expression of a second set of genes (i.e. clock-controlled genes)...
  24. ncbi request reprint Involvement of the pineal gland in diurnal cocaine reward in mice
    Murat Kurtuncu
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Eur J Pharmacol 489:203-5. 2004
    ..Circadian mechanisms regulated by the pineal gland thus appear critically involved in cocaine-induced reward...
  25. doi request reprint Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells
    M Imbesi
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Neuroscience 155:1160-4. 2008
    ..In conclusion, we showed for the first time that a clinically used MT1/MT2 agonist, ramelteon, is capable of activating neuronal ERK1/2...
  26. ncbi request reprint Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice
    T Uz
    The Psychiatric Institute, University of Illinois at Chicago, 60612, USA
    J Pineal Res 30:166-70. 2001
    ..e., both during the day and in the dark at night. Further studies are needed to fully characterize the behavioral significance of AANAT mutation and its possible link to depression...
  27. ncbi request reprint Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent species
    Mustafa Akhisaroglu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Pharmacol Biochem Behav 79:37-42. 2004
    ..g., time of day and subject strain) to study the role of these genes in psychiatric disorders such as addiction and depression...
  28. ncbi request reprint Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference in the central nervous system
    S Dzitoyeva
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Mol Psychiatry 6:665-70. 2001
    ..We propose that our method of RNAi in adult flies can be used to characterize gene functioning in the CNS without the typical interference in development found in most gene mutation studies...
  29. ncbi request reprint 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro
    T Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Eur J Pharmacol 418:15-22. 2001
    ..Their anti-proliferative effect was reversible. We propose that neuronal expression of 5-lipoxygenase is crucial for neurogenesis in vitro, and possibly also in vivo...
  30. doi request reprint Effects of cocaine in 5-lipoxygenase-deficient mice
    M Kurtuncu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA
    J Neural Transm 115:389-95. 2008
    ..Our results demonstrated that a 5-LOX deficiency alters sensitivity to repeated cocaine. It should be investigated whether a human 5-LOX gene polymorphism affects cocaine's actions...
  31. ncbi request reprint Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB)
    Nikola Dimitrijevic
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, MC912, Chicago, Illinois 60612, USA
    Eur J Pharmacol 519:246-52. 2005
    ..These receptors do not have a Drosophila orthologue. Whether Drosophila express a different GHB receptor should be explored...
  32. ncbi request reprint Developmental role of GABAB(1) receptors in Drosophila
    Svetlana Dzitoyeva
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Brain Res Dev Brain Res 158:111-4. 2005
    ..Our results suggest that GABAB receptors are required for normal development and that the Drosophila model could be used to investigate the participating molecular mechanisms...
  33. pmc Minocycline affects cocaine sensitization in mice
    Hu Chen
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Neurosci Lett 452:258-61. 2009
    ..The mechanisms by which minocycline interferes with the development of cocaine sensitization need to be characterized...
  34. ncbi request reprint Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain
    Tolga Uz
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, USA
    Neurosci Res 42:309-16. 2002
    ..Further studies are warranted into the possible functional significance of neuronal expression of AANAT mRNA...
  35. ncbi request reprint Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus
    Mustafa Akhisaroglu
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neuroreport 14:1471-3. 2003
    ..Fluoxetine treatment of old mice further increased hippocampal S100B, suggesting that aging does not interfere with fluoxetine's action on hippocampal S100B...
  36. pmc 5-Lipoxygenase in mouse cerebellar Purkinje cells
    H Chen
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroscience 171:383-9. 2010
    ..We propose that Purkinje cell-localized 5-LOX and FLAP expression may be involved in the cerebellar synthesis of leukotrienes and/or could influence the Dicer-mediated microRNA formation and processes of neuroplasticity...
  37. pmc Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors
    Marta Imbesi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Brain Res 1227:19-25. 2008
    ....
  38. ncbi request reprint The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
    Tolga Uz
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 136:45-53. 2005
    ..Further research is needed to understand the regional/cellular functional role of melatonin receptors in the regulation of dopaminergic behaviors, using models such as melatonin receptor knockout mice...
  39. doi request reprint Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neurons
    Marta Imbesi
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Neural Transm 115:1495-9. 2008
    ..Nanomolar melatonin was neuroprotective in MT2-knockout but not WT CGC. We propose that CGC from MT2-knockout mice could serve as a model for studying the influence of melatonin on human CGC, which express MT1 but not MT2 receptors...
  40. ncbi request reprint The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 28:2117-23. 2003
    ....
  41. ncbi request reprint DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells
    Zhijing Zhang
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    J Neurochem 88:1424-30. 2004
    ..This is the first report demonstrating that the dynamics of DNA methylation relates to neural 5-lipoxygenase gene expression...
  42. ncbi request reprint Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Life Sci 70:3069-75. 2002
    ..AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine...
  43. ncbi request reprint 5-Lipoxygenase as a putative link between cardiovascular and psychiatric disorders
    Radmila Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Crit Rev Neurobiol 16:181-6. 2004
    ..Future research should characterize the role of the 5-LOX pathway in comorbid cardio-cerebro-vascular and psychiatric disorders and in the therapeutic actions of dietary omega-3 fatty acids...
  44. ncbi request reprint The pineal gland and anxiogenic-like action of fluoxetine in mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neuroreport 15:691-4. 2004
    ..Fluoxetine was ineffective in pinealectomized C3H or C57BL6 mice. It is possible that the pineal system contributes to the previously observed anxiogenic action of fluoxetine in humans...
  45. ncbi request reprint An automated assay of the behavioral effects of cocaine injections in adult Drosophila
    Nikola Dimitrijevic
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Neurosci Methods 137:181-4. 2004
    ..In conclusion, we developed a method for accurately measuring the behavioral effects of cocaine in adult fruit flies that can be applied to studies of the mechanisms of behavioral sensitization...
  46. pmc Aminoglycoside antibiotics and autism: a speculative hypothesis
    R Manev
    Department of Psychiatry, The Psychiatric Institute The University of Illinois at Chicago, Chicago, IL 60612, USA
    BMC Psychiatry 1:5. 2001
    ..Here, we speculate how aminoglycoside antibiotics might be associated with autism...
  47. ncbi request reprint RNAi and brain function: was McConnell on the right track?
    N R Smalheiser
    UIC Psychiatric Institute, University of Illinois at Chicago MC912, 1601 W Taylor Street, Chicago, IL 60612, USA
    Trends Neurosci 24:216-8. 2001
    ....
  48. ncbi request reprint Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus
    Emre Yildirim
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 345:141-3. 2003
    ..Since the extent of 5-LOX expression may alter mouse behavior, we suggest that VPA-altered chromatin remodeling and 5-LOX expression in the brain may be functionally important...
  49. doi request reprint Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912 Chicago, IL 60612, USA
    Neurosci Lett 439:34-6. 2008
    ..Further research is needed to explore the putative influence of ramelteon on BDNF-associated neuroplasticity...
  50. pmc Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence
    Svetlana Dzitoyeva
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:5485-90. 2003
    ..The Drosophila model we have developed can be used for further in vivo functional characterization of GABA(B) receptor subunits and their involvement in the molecular and systemic actions of addictive substances...
  51. ncbi request reprint 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Restor Neurol Neurosci 20:15-20. 2002
    ..Moreover, the 5LOX pathway has been associated with the neurotoxicity of the prion peptide. 5LOX-deficient mice [5LOX(-); B6129S(Alox5tm1Fun)] and their controls (B6129SF2/J) have not been behaviorally characterized...
  52. pmc Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 447:134-7. 2008
    ..Increased GluR1 phosphorylation and minocycline treatment have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established...
  53. ncbi request reprint Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2/D3 receptor levels in mice
    Mustafa Akhisaroglu
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, Illinois 60612, USA
    Pharmacol Biochem Behav 80:371-7. 2005
    ..Therefore, we propose that diurnal mechanisms, which participate in drug-induced long-term changes in the dopamine system, are important for the development of dopaminergic behaviors...
  54. ncbi request reprint 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Brain Res 1147:148-53. 2007
    ....
  55. ncbi request reprint Reliability assessment of an automated forced swim test device using two mouse strains
    Murat Kurtuncu
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Neurosci Methods 149:26-30. 2005
    ..Our results suggest that the tested automated FST system generates reliable data comparable to results obtained by trained observers...
  56. doi request reprint Dosing time-dependent actions of psychostimulants
    H Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Int Rev Neurobiol 88:25-41. 2009
    ....
  57. doi request reprint Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice
    Svetlana Dzitoyeva
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neural Transm 115:823-7. 2008
    ..The BDNF transcript IV decrease was attenuated by caffeic acid in wild-type but not in 5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation...
  58. doi request reprint GABA-B receptors in Drosophila
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, Illinois, USA
    Adv Pharmacol 58:453-64. 2010
    ..Furthermore, recent research suggests that in flies these receptors may play an important developmental role and that they participate in olfaction and in regulation of circadian rhythms...
  59. pmc 5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice
    Svetlana Dzitoyeva
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neural Plast 2009:209596. 2009
    ..Interpretation of this data must take into account that the tissue samples contained a mixture of various cell types...
  60. ncbi request reprint Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice
    John Larson
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, 60612, USA
    Neurosci Lett 393:23-6. 2006
    ..These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes...
  61. pmc Possible role for interactions between 5-lipoxygenase (5-LOX) and AMPA GluR1 receptors in depression and in antidepressant therapy
    Radmila Manev
    Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 69:1076-9. 2007
    ..For example, brain 5-LOX expression is stimulated by stress hormone glucocorticoids, and stress is a known contributing factor in depression...
  62. pmc Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 436:269-72. 2008
    ..Future research is needed to evaluate the clinical relevance of our findings...
  63. ncbi request reprint The meaning of mammalian adult neurogenesis and the function of newly added neurons: the "small-world" network
    Radmila Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 64:114-7. 2005
    ....
  64. ncbi request reprint Enzymatic regional methylation assay for determination of CpG methylation density
    Zhijing Zhang
    The Psychiatric Institute, Department of Psychiatry and Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Anal Chem 76:6829-32. 2004
    ..We envision that for its accuracy, simplicity, low-cost, flexibility, minimum instrumentation requirements, and high-throughput potential our method could greatly benefit research on DNA methylation...
  65. ncbi request reprint Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo
    Rosalba Satta
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Eur J Pharmacol 473:149-52. 2003
    ..This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB...
  66. pmc The pattern of melatonin receptor expression in the brain may influence antidepressant treatment
    Eric Hirsch-Rodriguez
    Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 69:120-4. 2007
    ....
  67. doi request reprint Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum
    Morena Zusso
    Department of Pharmacology and Anesthesiology, University of Padova, Largo E Meneghetti 2, 35131 Padova, Italy
    Biochem Pharmacol 76:391-403. 2008
    ..The relevance of these findings for possible SSRI effects on the developing postnatal/infant human cerebellum should be explored...
  68. ncbi request reprint Clock genes as a link between addiction and obesity
    Hari Manev
    Eur J Hum Genet 14:5. 2006
  69. ncbi request reprint 5-Lipoxygenase as a putative mechanism of NSAID-related psychiatric adverse events
    Radmila Manev
    Drugs 65:577. 2005
  70. ncbi request reprint 5-lipoxygenase as a possible biological link between depressive symptoms and atherosclerosis
    Hari Manev
    Arch Gen Psychiatry 64:1333. 2007
  71. ncbi request reprint Ethanol injections in Drosophila
    Svetlana Dzitoyeva
    Alcohol Clin Exp Res 29:692; author reply 692. 2005
  72. ncbi request reprint The human genome: gene silencing
    Hari Manev
    Am J Psychiatry 159:720. 2002
  73. ncbi request reprint Photoisomerization of fluvoxamine generates an isomer that has reduced activity on the 5-hydroxytryptamine transporter and does not affect cell proliferation
    Giorgia Miolo
    Department of Pharmaceutical Sciences, Padova University, 35131 Padua, Italy
    Eur J Pharmacol 450:223-9. 2002
    ..e., 20 microM) but not the photoproduct was toxic to both immature and mature cultures. We suggest that a mechanism sensitive to fluvoxamine photoisomerization might be involved in the action of antidepressants on cell proliferation...
  74. ncbi request reprint Depression, inflammation, and cardiovascular disease: is 5-lipoxygenase the missing link?
    Hari Manev
    J Am Coll Cardiol 51:1990-1; author reply 1991. 2008
  75. ncbi request reprint Possible genetic predisposition to cardiac effects
    Hari Manev
    Med J Aust 182:198; author reply 199. 2005

Research Grants15

  1. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2009
    ..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
  2. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2007
    ..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
  3. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2006
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  4. AGING AND NEURONAL 5 LIPOXYGENASE
    Hari Manev; Fiscal Year: 2002
    ..The results are expected to elucidate the role of 5-LO in aging and neurodegeneration and to indicate neuroprotective therapies that would target the 5-LO pathway. ..
  5. Aging and brain 5-lipoxygenase
    Hari Manev; Fiscal Year: 2010
    ..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..