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Genomes and Genes | H ManevSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microgliaA M Mayer
Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
BMC Pharmacol 1:7. 2001....- Identification of a novel Drosophila gene, beltless, using injectable embryonic and adult RNA interference (RNAi)Svetlana Dzitoyeva
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
BMC Genomics 4:33. 2003.... 
New antidepressant drugs that do not cross the blood-brain barrierH Manev
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, 606912, USA
Med Hypotheses 58:83-4. 2002..Moreover, we suggest that new antidepressant drugs could be designed that would not enter into the brain but would stimulate peripheral mediators such as IGF-I...- DNA hypomethylating agents 5-aza-2'-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNAHari Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
Eur J Pharmacol 445:149-50. 2002..We propose that neuronal 5-lipoxygenase expression can be affected by aging-altered DNA methylation and by hypomethylating drugs, such as the anticonvulsant valproate... - Fruit flies for anti-pain drug discoveryHari Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Life Sci 76:2403-7. 2005..Since no serious ethical controversies have been raised regarding experiments in insects, Drosophila may be, for the time being an ethically acceptable animal model for combined genetic and pharmacological analgesia research... - Techniques: fruit flies as models for neuropharmacological researchHari Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Trends Pharmacol Sci 24:41-3. 2003..Combined, these methods hold promise for significant neuropharmacological advancement... - Glia as a putative target for antidepressant treatmentsHari Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
J Affect Disord 75:59-64. 2003..e., astrocytes. We have recently shown that protracted administration of the antidepressant fluoxetine to adult rats upregulated the astrocytic protein S100beta content and increased neurogenesis in the hippocampus... - Nomen est Omen: do antidepressants increase p11 or S100A10?Hari Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Biomed Discov Collab 1:5. 2006..Calling the p11 protein by its other name, S100A10, may prompt more investigators from different fields to participate in this new direction of neurobiological research... - Drosophila model for in vivo pharmacological analgesia researchHari Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, M C912, Chicago, IL 60612, USA
Eur J Pharmacol 491:207-8. 2004..We found a drug-induced dose-dependent increased threshold for heat avoidance and we propose Drosophila as an ethically acceptable animal model for in vivo pharmacological analgesia research... - Clock genes: influencing and being influenced by psychoactive drugsHari Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
Trends Pharmacol Sci 27:186-9. 2006..Focusing on clock genes expressed in the brain might lead to the discovery of novel drug-target pathways... - 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's diseaseHari Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Med Hypotheses 66:501-3. 2006..e., transgenic mice could be produced by crossing the available 5-LOX-deficient mice with the available transgenic mice models of Alzheimer's disease... - Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expressionH Manev
Department of Psychiatry, University of Illinois at Chicago 60612, USA
Ann N Y Acad Sci 890:183-90. 1999..The results of our ongoing research are expected to elucidate the role of 5-LO in aging and neurodegeneration and to indicate neuroprotective therapies that would target the 5-LO pathway... 
Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALSHari Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, Illinois 60612, USA
Amyotroph Lateral Scler 10:416-7. 2009..Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic...
Cyclooxygenases and 5-lipoxygenase in Alzheimer's diseaseHari Manev
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Prog Neuropsychopharmacol Biol Psychiatry 35:315-9. 2011....- Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitroH Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street MC912, 60612, Chicago, IL, USA
Eur J Pharmacol 411:67-70. 2001..Clomipramine and imipramine produced similar action in vitro; desipramine was ineffective... - 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainateH Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Exp Gerontol 35:1201-9. 2000..The mechanism of how NS-398 inhibits this action of kainate should be further investigated... - Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?H Manev
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Ann N Y Acad Sci 939:45-51. 2001..Additional studies should explore whether 5-LOX may participate in neurogenesis related pathologies and whether it should be considered a target for procedures aimed at altering neurogenesis for therapeutic purposes... - 5-Lipoxygenase gene polymorphism and onset of Alzheimer's diseaseH Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Med Hypotheses 54:75-6. 2000.... - Putative role of neuronal 5-lipoxygenase in an aging brainH Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
FASEB J 14:1464-9. 2000..Thus, the 5-LOX pathway could become a promising target of neuroprotective therapies for the aging brain... - Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampusR Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL60612, USA
Eur J Pharmacol 420:R1-2. 2001.... - Dopamine receptor-mediated regulation of neuronal "clock" gene expressionM Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
Neuroscience 158:537-44. 2009..e. intracellular signaling pathways) and thereby influences neuronal gene expression, neuronal transmission, and brain functioning... - 5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cellsM Imbesi
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
Neuroscience 164:1531-7. 2009..In addition, an increase in DNMT3a but not DNMT1 expression accompanies an increase of 5-LOX methylation during in vitro maturation... - Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatumT Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Neuroscience 134:1309-16. 2005..We propose that the effects of psychoactive drugs on clock transcription factors may mediate long-term drug-induced changes, possibly by regulating the expression of a second set of genes (i.e. clock-controlled genes)... - Involvement of the pineal gland in diurnal cocaine reward in miceMurat Kurtuncu
Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M/C 912, Chicago, IL 60612, USA
Eur J Pharmacol 489:203-5. 2004..Circadian mechanisms regulated by the pineal gland thus appear critically involved in cocaine-induced reward... - Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cellsM Imbesi
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
Neuroscience 155:1160-4. 2008..In conclusion, we showed for the first time that a clinically used MT1/MT2 agonist, ramelteon, is capable of activating neuronal ERK1/2... - Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant miceT Uz
The Psychiatric Institute, University of Illinois at Chicago, 60612, USA
J Pineal Res 30:166-70. 2001..e., both during the day and in the dark at night. Further studies are needed to fully characterize the behavioral significance of AANAT mutation and its possible link to depression... - Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent speciesMustafa Akhisaroglu
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
Pharmacol Biochem Behav 79:37-42. 2004..g., time of day and subject strain) to study the role of these genes in psychiatric disorders such as addiction and depression... - Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference in the central nervous systemS Dzitoyeva
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
Mol Psychiatry 6:665-70. 2001..We propose that our method of RNAi in adult flies can be used to characterize gene functioning in the CNS without the typical interference in development found in most gene mutation studies... - 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitroT Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Eur J Pharmacol 418:15-22. 2001..Their anti-proliferative effect was reversible. We propose that neuronal expression of 5-lipoxygenase is crucial for neurogenesis in vitro, and possibly also in vivo... - Effects of cocaine in 5-lipoxygenase-deficient miceM Kurtuncu
Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA
J Neural Transm 115:389-95. 2008..Our results demonstrated that a 5-LOX deficiency alters sensitivity to repeated cocaine. It should be investigated whether a human 5-LOX gene polymorphism affects cocaine's actions... - Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB)Nikola Dimitrijevic
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, MC912, Chicago, Illinois 60612, USA
Eur J Pharmacol 519:246-52. 2005..These receptors do not have a Drosophila orthologue. Whether Drosophila express a different GHB receptor should be explored... - Developmental role of GABAB(1) receptors in DrosophilaSvetlana Dzitoyeva
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Brain Res Dev Brain Res 158:111-4. 2005..Our results suggest that GABAB receptors are required for normal development and that the Drosophila model could be used to investigate the participating molecular mechanisms... - Minocycline affects cocaine sensitization in miceHu Chen
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
Neurosci Lett 452:258-61. 2009..The mechanisms by which minocycline interferes with the development of cocaine sensitization need to be characterized... - Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brainTolga Uz
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, USA
Neurosci Res 42:309-16. 2002..Further studies are warranted into the possible functional significance of neuronal expression of AANAT mRNA... - Both aging and chronic fluoxetine increase S100B content in the mouse hippocampusMustafa Akhisaroglu
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Neuroreport 14:1471-3. 2003..Fluoxetine treatment of old mice further increased hippocampal S100B, suggesting that aging does not interfere with fluoxetine's action on hippocampal S100B... - 5-Lipoxygenase in mouse cerebellar Purkinje cellsH Chen
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neuroscience 171:383-9. 2010..We propose that Purkinje cell-localized 5-LOX and FLAP expression may be involved in the cerebellar synthesis of leukotrienes and/or could influence the Dicer-mediated microRNA formation and processes of neuroplasticity... - Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptorsMarta Imbesi
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Brain Res 1227:19-25. 2008.... - The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic systemTolga Uz
Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
Brain Res Mol Brain Res 136:45-53. 2005..Further research is needed to understand the regional/cellular functional role of melatonin receptors in the regulation of dopaminergic behaviors, using models such as melatonin receptor knockout mice... - Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neuronsMarta Imbesi
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
J Neural Transm 115:1495-9. 2008..Nanomolar melatonin was neuroprotective in MT2-knockout but not WT CGC. We propose that CGC from MT2-knockout mice could serve as a model for studying the influence of melatonin on human CGC, which express MT1 but not MT2 receptors... - The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in miceTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neuropsychopharmacology 28:2117-23. 2003.... - DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cellsZhijing Zhang
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
J Neurochem 88:1424-30. 2004..This is the first report demonstrating that the dynamics of DNA methylation relates to neural 5-lipoxygenase gene expression... - Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferaseTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
Life Sci 70:3069-75. 2002..AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine... - 5-Lipoxygenase as a putative link between cardiovascular and psychiatric disordersRadmila Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Crit Rev Neurobiol 16:181-6. 2004..Future research should characterize the role of the 5-LOX pathway in comorbid cardio-cerebro-vascular and psychiatric disorders and in the therapeutic actions of dietary omega-3 fatty acids... - The pineal gland and anxiogenic-like action of fluoxetine in miceTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Neuroreport 15:691-4. 2004..Fluoxetine was ineffective in pinealectomized C3H or C57BL6 mice. It is possible that the pineal system contributes to the previously observed anxiogenic action of fluoxetine in humans... - An automated assay of the behavioral effects of cocaine injections in adult DrosophilaNikola Dimitrijevic
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
J Neurosci Methods 137:181-4. 2004..In conclusion, we developed a method for accurately measuring the behavioral effects of cocaine in adult fruit flies that can be applied to studies of the mechanisms of behavioral sensitization... - Aminoglycoside antibiotics and autism: a speculative hypothesisR Manev
Department of Psychiatry, The Psychiatric Institute The University of Illinois at Chicago, Chicago, IL 60612, USA
BMC Psychiatry 1:5. 2001..Here, we speculate how aminoglycoside antibiotics might be associated with autism... - RNAi and brain function: was McConnell on the right track?N R Smalheiser
UIC Psychiatric Institute, University of Illinois at Chicago MC912, 1601 W Taylor Street, Chicago, IL 60612, USA
Trends Neurosci 24:216-8. 2001.... - Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampusEmre Yildirim
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neurosci Lett 345:141-3. 2003..Since the extent of 5-LOX expression may alter mouse behavior, we suggest that VPA-altered chromatin remodeling and 5-LOX expression in the brain may be functionally important... - Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cellsMarta Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912 Chicago, IL 60612, USA
Neurosci Lett 439:34-6. 2008..Further research is needed to explore the putative influence of ramelteon on BDNF-associated neuroplasticity... - Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidenceSvetlana Dzitoyeva
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 100:5485-90. 2003..The Drosophila model we have developed can be used for further in vivo functional characterization of GABA(B) receptor subunits and their involvement in the molecular and systemic actions of addictive substances... - 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behaviorTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Restor Neurol Neurosci 20:15-20. 2002..Moreover, the 5LOX pathway has been associated with the neurotoxicity of the prion peptide. 5LOX-deficient mice [5LOX(-); B6129S(Alox5tm1Fun)] and their controls (B6129SF2/J) have not been behaviorally characterized... - Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptorsMarta Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neurosci Lett 447:134-7. 2008..Increased GluR1 phosphorylation and minocycline treatment have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established... - Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2/D3 receptor levels in miceMustafa Akhisaroglu
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M/C 912, Chicago, Illinois 60612, USA
Pharmacol Biochem Behav 80:371-7. 2005..Therefore, we propose that diurnal mechanisms, which participate in drug-induced long-term changes in the dopamine system, are important for the development of dopaminergic behaviors... - 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivoMarta Imbesi
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Brain Res 1147:148-53. 2007.... - Reliability assessment of an automated forced swim test device using two mouse strainsMurat Kurtuncu
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
J Neurosci Methods 149:26-30. 2005..Our results suggest that the tested automated FST system generates reliable data comparable to results obtained by trained observers... - Dosing time-dependent actions of psychostimulantsH Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Int Rev Neurobiol 88:25-41. 2009.... - Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient miceSvetlana Dzitoyeva
Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
J Neural Transm 115:823-7. 2008..The BDNF transcript IV decrease was attenuated by caffeic acid in wild-type but not in 5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation... - GABA-B receptors in DrosophilaHari Manev
The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, Illinois, USA
Adv Pharmacol 58:453-64. 2010..Furthermore, recent research suggests that in flies these receptors may play an important developmental role and that they participate in olfaction and in regulation of circadian rhythms... - 5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old miceSvetlana Dzitoyeva
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Neural Plast 2009:209596. 2009..Interpretation of this data must take into account that the tissue samples contained a mixture of various cell types... - Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient miceJohn Larson
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, 60612, USA
Neurosci Lett 393:23-6. 2006..These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes... - Possible role for interactions between 5-lipoxygenase (5-LOX) and AMPA GluR1 receptors in depression and in antidepressant therapyRadmila Manev
Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
Med Hypotheses 69:1076-9. 2007..For example, brain 5-LOX expression is stimulated by stress hormone glucocorticoids, and stress is a known contributing factor in depression... - Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of miceTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Neurosci Lett 436:269-72. 2008..Future research is needed to evaluate the clinical relevance of our findings... - The meaning of mammalian adult neurogenesis and the function of newly added neurons: the "small-world" networkRadmila Manev
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
Med Hypotheses 64:114-7. 2005.... - Enzymatic regional methylation assay for determination of CpG methylation densityZhijing Zhang
The Psychiatric Institute, Department of Psychiatry and Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Anal Chem 76:6829-32. 2004..We envision that for its accuracy, simplicity, low-cost, flexibility, minimum instrumentation requirements, and high-throughput potential our method could greatly benefit research on DNA methylation... - Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivoRosalba Satta
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Eur J Pharmacol 473:149-52. 2003..This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB... - The pattern of melatonin receptor expression in the brain may influence antidepressant treatmentEric Hirsch Rodriguez
Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
Med Hypotheses 69:120-4. 2007.... - Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellumMorena Zusso
Department of Pharmacology and Anesthesiology, University of Padova, Largo E Meneghetti 2, 35131 Padova, Italy
Biochem Pharmacol 76:391-403. 2008..The relevance of these findings for possible SSRI effects on the developing postnatal/infant human cerebellum should be explored... - Clock genes as a link between addiction and obesityHari Manev
Eur J Hum Genet 14:5. 2006 - 5-Lipoxygenase as a putative mechanism of NSAID-related psychiatric adverse eventsRadmila Manev
Drugs 65:577. 2005 - 5-lipoxygenase as a possible biological link between depressive symptoms and atherosclerosisHari Manev
Arch Gen Psychiatry 64:1333. 2007 - Ethanol injections in DrosophilaSvetlana Dzitoyeva
Alcohol Clin Exp Res 29:692; author reply 692. 2005 - The human genome: gene silencingHari Manev
Am J Psychiatry 159:720. 2002 - Photoisomerization of fluvoxamine generates an isomer that has reduced activity on the 5-hydroxytryptamine transporter and does not affect cell proliferationGiorgia Miolo
Department of Pharmaceutical Sciences, Padova University, 35131 Padua, Italy
Eur J Pharmacol 450:223-9. 2002..e., 20 microM) but not the photoproduct was toxic to both immature and mature cultures. We suggest that a mechanism sensitive to fluvoxamine photoisomerization might be involved in the action of antidepressants on cell proliferation... - Depression, inflammation, and cardiovascular disease: is 5-lipoxygenase the missing link?Hari Manev
J Am Coll Cardiol 51:1990-1; author reply 1991. 2008 - Possible genetic predisposition to cardiac effectsHari Manev
Med J Aust 182:198; author reply 199. 2005
Research Grants
- Aging and brain 5-lipoxygenaseHari Manev; Fiscal Year: 2009..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
- Aging and brain 5-lipoxygenaseHari Manev; Fiscal Year: 2007..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
- Proposed Role for Neuronal Serotonin N-acetyltransferaseHari Manev; Fiscal Year: 2006..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
- AGING AND NEURONAL 5 LIPOXYGENASEHari Manev; Fiscal Year: 2002..The results are expected to elucidate the role of 5-LO in aging and neurodegeneration and to indicate neuroprotective therapies that would target the 5-LO pathway. ..
- Aging and brain 5-lipoxygenaseHari Manev; Fiscal Year: 2010..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..