Patricia Maness

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping
    Jinxia Dai
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e73000. 2013
  2. pmc L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
    Ralf S Schmid
    Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27704, USA
    Curr Opin Neurobiol 18:245-50. 2008
  3. ncbi request reprint Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
    Patricia F Maness
    Department of Biochemistry and Biophysics and Neuroscience Research Center, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Nat Neurosci 10:19-26. 2007
  4. ncbi request reprint Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family
    J S Biscardi
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 271:29049-59. 1996
  5. ncbi request reprint A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
    R S Schmid
    Department of Biochemistry, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 20:4177-88. 2000
  6. ncbi request reprint Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases
    P F Maness
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Perspect Dev Neurobiol 4:169-81. 1996
  7. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
  8. ncbi request reprint Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM)
    C Leann Hinkle
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurobiol 66:1378-95. 2006
  9. pmc Impaired sociability and cognitive function in Nrcam-null mice
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 205:123-31. 2009
  10. ncbi request reprint B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neurons
    Carol A Otey
    Departments of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 71:287-304. 2003

Research Grants

  1. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2000
  2. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2001
  3. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2002
  4. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2003
  5. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2004
  6. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2005
  7. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2006
  8. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2007
  9. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1992
  10. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1991

Collaborators

  • Jeffrey Lieberman
  • Martin Hruska
  • J P O'Bryan
  • Scott Stroup
  • Matthew R Robinson
  • T Scott Stroup
  • Ethan M Lange
  • Joshua Sanes
  • Sheryl S Moy
  • R S Keefe
  • P F Sullivan
  • F Polleux
  • Eva Anton
  • Joshua Weiner
  • Galina P Demyanenko
  • Mona Buhusi
  • Anitha K Panicker
  • Ralf S Schmid
  • Monika C Schlatter
  • Amanda G Wright
  • C Leann Hinkle
  • Jinxia Dai
  • Simone Diestel
  • Melitta Schachner
  • Bentley R Midkiff
  • Priscila F Siesser
  • Karsten Thelen
  • Leann Hinkle Brennaman
  • Neeta Pillai-Nair
  • William C Wetsel
  • Ramona M Rodriguiz
  • Matthew Grove
  • Carol A Otey
  • Ralf Steffen Schmid
  • Rong Yu Liu
  • Matthew B Dalva
  • Leann H Brennaman
  • R S Schmid
  • Karry M Jannie
  • Jasbir Dalal
  • Eli P B Darnell
  • Randy Thresher
  • Tracy S Tran
  • Ashton Powell
  • Lilian Enriquez-Barreto
  • Ann Erickson
  • Ari I Halberstadt
  • Claudia Werner
  • Josh Z Huang
  • Kelly L Gilmore
  • Katherine B Pryzwansky
  • Franz Hofmann
  • Brigitte Schmitz
  • Ralf Schmid
  • Shelby A Martensen
  • Galina Demyanenko
  • Ann Marie Pendergast
  • Marisol E Quiroz
  • Asier Echarri
  • Guoping Feng
  • Martin Playford
  • Patricia A Zipfel
  • Vishram P Kedar
  • Melanie Richter
  • Malika Boukhelifa
  • Amanda M Gates
  • J S Biscardi
  • Vishram Kedar
  • William D Snider
  • W M Pruitt
  • J J Fiordalisi
  • F Denhez
  • C J Der
  • G F Buehler
  • S C Baragona
  • D A Chesnutt
  • D W Fults

Detail Information

Publications28

  1. pmc Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping
    Jinxia Dai
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e73000. 2013
    ....
  2. pmc L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
    Ralf S Schmid
    Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27704, USA
    Curr Opin Neurobiol 18:245-50. 2008
    ..We will also discuss how dysregulation of CAMs may also bear on neuropsychiatric disease and cancer...
  3. ncbi request reprint Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
    Patricia F Maness
    Department of Biochemistry and Biophysics and Neuroscience Research Center, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Nat Neurosci 10:19-26. 2007
    ....
  4. ncbi request reprint Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family
    J S Biscardi
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 271:29049-59. 1996
    ..These properties indicated that Rek has oncogenic potential when overexpressed, but its normal function is likely to be related to cell-cell recognition events governing the differentiation or proliferation of neural cells...
  5. ncbi request reprint A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
    R S Schmid
    Department of Biochemistry, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 20:4177-88. 2000
    ..This study supports a model in which pp60(c-src) regulates dynamin-mediated endocytosis of L1 as an essential step in MAPK-dependent neurite outgrowth on an L1 substrate...
  6. ncbi request reprint Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases
    P F Maness
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Perspect Dev Neurobiol 4:169-81. 1996
    ..In this review we will address novel features of nonreceptor PTKs of the src family which dictate their distinctive molecular interactions with cell adhesion molecules and signaling components...
  7. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
    ..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings...
  8. ncbi request reprint Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM)
    C Leann Hinkle
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurobiol 66:1378-95. 2006
    ..Thus, increased levels of soluble NCAM in schizophrenic brain have the potential to impair neuronal connectivity...
  9. pmc Impaired sociability and cognitive function in Nrcam-null mice
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 205:123-31. 2009
    ..Reversal learning deficits were observed in both male and female Nrcam-null mice. These results provide evidence that NRCAM mediates domains of function relevant to symptoms observed in autism...
  10. ncbi request reprint B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neurons
    Carol A Otey
    Departments of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 71:287-304. 2003
    ..All of these protocols have been written for researchers who have some skill in basic cell culture techniques, but previous experience with cultured neurons is not required...
  11. ncbi request reprint Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I
    Galina P Demyanenko
    Department of Biochemistry and Biophysics CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Brain Res Dev Brain Res 160:1-8. 2005
    ..These results demonstrate a role for cGKI signaling in cortical development related to neuronal migration/positioning that is important for dendritic orientation and connectivity...
  12. ncbi request reprint CHL1 promotes Sema3A-induced growth cone collapse and neurite elaboration through a motif required for recruitment of ERM proteins to the plasma membrane
    Monika C Schlatter
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Neurochem 104:731-44. 2008
    ....
  13. ncbi request reprint The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins
    Karsten Thelen
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 22:4918-31. 2002
    ....
  14. ncbi request reprint NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion molecule
    Rong Yu Liu
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill 27599 7260, USA
    Mol Cell Neurosci 20:2-12. 2002
    ..These results demonstrate a novel substrate-dependent regulation of NGF-induced growth of embryonic sensory axons mediated by RhoA GTPase...
  15. ncbi request reprint Close homolog of L1 is an enhancer of integrin-mediated cell migration
    Mona Buhusi
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill 27599 7260, USA
    J Biol Chem 278:25024-31. 2003
    ..These results support a role for CHL1 in integrin-dependent cell migration that may be physiologically important in regulating cell migration in nerve regeneration and cortical development...
  16. ncbi request reprint Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling
    Ralf S Schmid
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7250, USA
    Neuroreport 15:2791-4. 2004
    ..A signaling pathway is proposed from L1 through Vav2, Rac1, Pak1 and ERK that may be important for L1 mediated neuronal cell migration...
  17. ncbi request reprint The L1 cell adhesion molecule is essential for topographic mapping of retinal axons
    Galina P Demyanenko
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 23:530-8. 2003
    ..Results suggest that retinal axons require the function of L1 in addition to repellent EphA guidance receptors to achieve proper topographic mapping...
  18. ncbi request reprint Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex
    Galina P Demyanenko
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 44:423-37. 2004
    ..The restriction of CHL1 expression and effects of its deletion in posterior neocortical areas suggests that CHL1 may regulate area-specific neuronal connectivity and, by extension, function in the visual and somatosensory cortex...
  19. pmc Developmental regulation of GABAergic interneuron branching and synaptic development in the prefrontal cortex by soluble neural cell adhesion molecule
    Leann Hinkle Brennaman
    Department of Biochemistry and Biophysics, and Silvio Conte Center for Schizophrenia Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Cell Neurosci 37:781-93. 2008
    ..These findings suggested that excess soluble NCAM-EC reduces perisomatic innervation of cortical neurons by perturbing axonal/dendritic branching during cortical development...
  20. ncbi request reprint Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon
    Amanda G Wright
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:13667-79. 2007
    ..These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections...
  21. doi request reprint L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection
    Mona Buhusi
    Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 28:177-88. 2008
    ....
  22. pmc ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory
    Matthew Grove
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, Box 3813, Durham, NC 27710, USA
    Mol Cell Biol 24:10905-22. 2004
    ..These findings support a role for Abi2 in the regulation of cytoskeletal dynamics at adherens junctions and dendritic spines, which is critical for intercellular connectivity, cell morphogenesis, and cognitive functions...
  23. doi request reprint ALCAM regulates mediolateral retinotopic mapping in the superior colliculus
    Mona Buhusi
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Neurosci 29:15630-41. 2009
    ..Together, these results suggest a model in which ALCAM in the SC interacts with L1 on RGC axons to promote medial extension of RGC axon branches important for mediolateral axon targeting in the formation of retinocollicular maps...
  24. pmc L1 cell adhesion molecules as regulators of tumor cell invasiveness
    Priscila F Siesser
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, USA
    Cell Adh Migr 3:275-7. 2009
    ..Despite the promising advances in cancer basic research, a better understanding of the molecular mechanisms dictating L1-mediated signaling is needed for the development of effective therapeutic treatment for cancer patients...
  25. ncbi request reprint Cellular signalling mechanisms of neural cell adhesion molecules
    Anitha K Panicker
    Department of Biochemistry Biophysics, 505 Mary Ellen Jones Bldg, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7260, USA
    Front Biosci 8:d900-11. 2003
    ..Thus a full understanding of the mechanism of NCAM and L1 function will contribute to understanding both normal brain development and pathologies associated with cognitive dysfunction in schizophrenia and mental retardation...
  26. ncbi request reprint Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior
    Neeta Pillai-Nair
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    J Neurosci 25:4659-71. 2005
    ..These results suggested that elevated shedding of NCAM perturbs synaptic connectivity of GABAergic interneurons and produces abnormal behaviors that may be relevant to schizophrenia and other neuropsychiatric disorders...
  27. ncbi request reprint Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1
    Anitha K Panicker
    Department of Biochemistry and Biophysics, 505 Mary Ellen Jones Bldg, CB 7260, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7260, USA
    Exp Cell Res 312:299-307. 2006
    ..These results suggested that downregulation of adhesive complexes of L1 and beta1 integrin at the plasma membrane by clathrin-mediated endocytosis is a potential mechanism for enhancing cell motility...
  28. ncbi request reprint NCAM140 stimulates integrin-dependent cell migration by ectodomain shedding
    Simone Diestel
    Department of Biochemistry, Institute of Physiology, Biochemistry and Animal Health, University of Bonn, Bonn, Germany
    J Neurochem 95:1777-84. 2005
    ..These results suggested that metalloprotease-induced cleavage of NCAM140 from the membrane promotes integrin- and ERK1/2-dependent cell migration to extracellular matrix proteins...

Research Grants25

  1. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2000
    ..A second objective is to determine if REK can function as a homophilic adhesion molecule, as preliminary experiments suggest. It is also hoped that REK kinase activity can be activated by homophilic binding. ..
  2. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2001
    ....
  3. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2002
    ....
  4. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2003
    ....
  5. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2004
    ....
  6. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2005
    ..This investigation can reveal new molecular determinants and novel mechanisms governing cortical area development and provide insight into the pathology associated with mental retardation. ..
  7. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2006
    ..This investigation can reveal new molecular determinants and novel mechanisms governing cortical area development and provide insight into the pathology associated with mental retardation. ..
  8. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2007
    ..This investigation can reveal new molecular determinants and novel mechanisms governing cortical area development and provide insight into the pathology associated with mental retardation. ..
  9. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1992
    ....
  10. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1991
    ....
  11. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1990
    ....
  12. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1999
    ..A second objective is to determine if REK can function as a homophilic adhesion molecule, as preliminary experiments suggest. It is also hoped that REK kinase activity can be activated by homophilic binding. ..
  13. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1993
    ..This research will provide insight into the molecular mechanism of axon outgrowth essential for the development and regeneration of the mammalian nervous system...