Pranoti Mandrekar

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation
    Sujatha Muralidharan
    1 LRB 221, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605
    J Leukoc Biol 94:1167-84. 2013
  2. ncbi request reprint Signaling mechanisms in alcoholic liver injury: role of transcription factors, kinases and heat shock proteins
    Pranoti Mandrekar
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 213, 364 Plantation Street, Worcester, MA 01605 2324, USA
    World J Gastroenterol 13:4979-85. 2007
  3. pmc The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 183:1320-7. 2009
  4. pmc Signalling pathways in alcohol-induced liver inflammation
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Hepatol 50:1258-66. 2009
  5. pmc Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
    J Leukoc Biol 84:1335-45. 2008
  6. ncbi request reprint Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes
    Pranoti Mandrekar
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Alcohol Clin Exp Res 26:1872-9. 2002
  7. pmc Epigenetic regulation in alcoholic liver disease
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 17:2456-64. 2011
  8. pmc An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 54:2185-97. 2011
  9. doi request reprint The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
  10. pmc Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Gastroenterology 133:1627-36. 2007

Research Grants

  1. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2006
  2. Role of heat shock protein 90 in alcoholic liver disease
    Pranoti Mandrekar; Fiscal Year: 2010

Collaborators

Detail Information

Publications51

  1. pmc Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation
    Sujatha Muralidharan
    1 LRB 221, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605
    J Leukoc Biol 94:1167-84. 2013
    ..Understanding the crosstalk between cellular stress proteins and immune signaling may have translational implications for designing more effective regimens to treat immune disorders. ..
  2. ncbi request reprint Signaling mechanisms in alcoholic liver injury: role of transcription factors, kinases and heat shock proteins
    Pranoti Mandrekar
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 213, 364 Plantation Street, Worcester, MA 01605 2324, USA
    World J Gastroenterol 13:4979-85. 2007
    ....
  3. pmc The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 183:1320-7. 2009
    ..Our data indicate that IRAK-M is a central player in the opposite regulation of LPS signaling by different lengths of alcohol exposure in monocytes...
  4. pmc Signalling pathways in alcohol-induced liver inflammation
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Hepatol 50:1258-66. 2009
    ..In this review we describe the key signalling intermediates leading to alcohol-induced inflammation in alcoholic liver disease...
  5. pmc Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
    J Leukoc Biol 84:1335-45. 2008
    ..These results suggest that alcohol exposure differentially regulates hsp70 and hsp90 via HSF-1 activation. Further, hsp90 regulates TNF-alpha production in macrophages contributing to alcohol-induced inflammation...
  6. ncbi request reprint Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes
    Pranoti Mandrekar
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Alcohol Clin Exp Res 26:1872-9. 2002
    ..Here, we show for the first time that acute alcohol (25 mM) exposure modulates GR activation in monocytes...
  7. pmc Epigenetic regulation in alcoholic liver disease
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 17:2456-64. 2011
    ..Finally, the role of alcohol-mediated oxidative stress in epigenetic regulation in ALD is described. A better understanding of these mechanisms is crucial for designing novel epigenetic based therapies to ameliorate ALD...
  8. pmc An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 54:2185-97. 2011
    ....
  9. doi request reprint The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    Istvan Hritz
    Department of Medicine, University of Massachusetts Medical School, University of Massachusetts, Worcester, MA 01605, USA
    Hepatology 48:1224-31. 2008
    ..However, the induction of IRF7, an IRF3-inducible gene, was found in Kupffer cells of alcohol-fed WT mice. Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner...
  10. pmc Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Gastroenterology 133:1627-36. 2007
    ..Persistent inflammation contributes to progression of liver damage in chronic HCV (cHCV) infection. Repeated exposure to toll-like receptor (TLR) ligands results in tolerance, a protective mechanism aimed at limiting inflammation...
  11. pmc MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 33:1704-10. 2009
    ..Each miRNA controls the expression of multiple targets; miRNAs have been linked to regulation of lipid metabolism and inflammation...
  12. ncbi request reprint Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
    Alcohol Clin Exp Res 29:1018-26. 2005
    ....
  13. pmc Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    Timea Csak
    Department of Medicine, University of Massachusetts, Medical School, Worcester, 01605 2324, USA
    Am J Physiol Gastrointest Liver Physiol 300:G433-41. 2011
    ..In conclusion, our results demonstrate a novel, critical role for LPS recognition complex, including MD-2 and TLR4, through NADPH activation in liver steatosis, and fibrosis in a NASH model in mice...
  14. ncbi request reprint Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 78:1255-64. 2005
    ..These results suggest that although P. acnes triggers TLR2-mediated cell activation, TLR2-independent but MyD88-dependent mechanisms mediate in vivo sensitization by P. acnes for LPS-induced liver injury...
  15. doi request reprint Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion
    Istvan Hritz
    Department of Medicine, University of Massachusetts, Medical School, Worcester, MA 01605 2324, USA
    Hepatology 48:1342-7. 2008
    ..These results demonstrate that MyD88 in immune cells rather than in liver parenchymal cells plays an important role in inflammatory cell recruitment and liver injury...
  16. ncbi request reprint Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver
    Laszlo Romics
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 40:376-85. 2004
    ..Thus, an imbalance between PPAR-mediated anti-inflammatory and NF-kappaB-mediated proinflammatory signals may contribute to increased inflammation in the fatty liver...
  17. pmc Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells
    Jan Petrasek
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 53:649-60. 2011
    ..Further, parenchymal cell-derived Type I IFNs increase antiinflammatory and suppress proinflammatory cytokines production by LMNC in paracrine manner...
  18. ncbi request reprint Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes
    Oxana Norkina
    University of Massachusetts Medical School, Department of Medicine, LRB 215, 364 Plantation Street, Worcester, MA 01605, USA
    J Leukoc Biol 82:752-62. 2007
    ..Our data suggest that acute alcohol activates Src/STAT3 and Src/MAPK/STAT3, AP-1, and Sp-1 pathways as important mechanisms for IL-10-mediated immunomodulation after acute alcohol use...
  19. doi request reprint Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes
    Oxana Norkina
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Alcohol Clin Exp Res 32:1565-73. 2008
    ..Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes...
  20. ncbi request reprint Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice
    Laszlo Romics
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 40:555-64. 2004
    ..In conclusion, P. acnes priming to selective TLR4-mediated liver injury is associated with up-regulation of TLR4 and MD-2 and is likely to involve IFN-gamma and prevent TLR4 desensitization by P. acnes...
  21. ncbi request reprint Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 170:5615-24. 2003
    ..Our results reveal that HCV core and NS3 proteins activate monocytes and inhibit DC differentiation in the absence of the intact virus and mediate some of the immunoinhibitory effects of HCV via IL-10 induction...
  22. ncbi request reprint Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury
    Arumugam Velayudham
    Liver Center, Department of Medicine, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    J Hepatol 45:813-24. 2006
    ..Toll-like receptors (TLR) recognize pathogens and regulate innate immune activation. Here, we investigated the roles of TLR9 and the common TLR adaptor, MyD88, in liver injury...
  23. ncbi request reprint Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Alcohol Clin Exp Res 27:1023-31. 2003
    ..Here we investigated the effects of HCV infection and alcohol on myeloid dendritic cells (DC) that are critical in antiviral immunity...
  24. ncbi request reprint Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3398-407. 2004
    ..Taken together, alcohol both in vitro and in vivo can impair generation of Th1 immune responses via inhibition of DC differentiation and accessory cell function through mechanisms that involve decreased IL-12 induction...
  25. ncbi request reprint TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes
    Shilpa Oak
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    J Immunol 176:7628-35. 2006
    ..Thus, the complexity of TLR-mediated signals may determine attenuation or augmentation of inflammatory responses by acute alcohol...
  26. pmc Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:1436-44. 2011
    ..In conclusion, our novel data demonstrate that chronic alcohol consumption increases miR-155 in macrophages via NF-κB and the increased miR-155 contributes to alcohol-induced elevation in TNFα production via increased mRNA stability...
  27. ncbi request reprint Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:7686-93. 2007
    ..These findings further implicate an important role for IKKbeta in the acute effects of alcohol in immune cells...
  28. ncbi request reprint Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 30:135-9. 2006
    ..Here, we determine in vivo effects of acute alcohol consumption on inflammatory cytokine production and nuclear regulatory factor kappaB (NF-kappaB) binding in human monocytes...
  29. doi request reprint Human monocytes, macrophages, and dendritic cells: alcohol treatment methods
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 447:113-24. 2008
    ..Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types...
  30. ncbi request reprint Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes
    Yvonne Drechsler
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Immunol 177:2592-600. 2006
    ..Thus, HO-1 activation is a key mediator of the anti-inflammatory effects of acute alcohol on monocytes...
  31. ncbi request reprint Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 29:140S-145S. 2005
    ..These results demonstrate that TLR2 deficiency results in increased liver injury in association with nonalcoholic steatohepatitis and may suggest a protective role for TLR2-mediated signals in liver injury...
  32. pmc Effect of ethanol on inflammatory responses. Implications for pancreatitis
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pancreatology 7:115-23. 2007
    ..Alcohol use alters inflammatory cell responses. While alcohol has direct effects on pancreatic acinar cells, activation of inflammatory cells is a major component of the pathology of alcoholic pancreatitis...
  33. ncbi request reprint Ethanol-mediated regulation of transcription factors in immunocompetent cells
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Front Biosci 7:a80-9. 2002
    ....
  34. ncbi request reprint Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, University of Massachusetts Medical School LRB215, 364 Plantation Street, Worcester, MA 01604, USA
    Alcohol 33:241-9. 2004
    ....
  35. ncbi request reprint RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease
    Gyongyi Szabo
    University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1753-7. 2005
    ....
  36. pmc VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    Arumugam Velayudham
    Department of Medicine, Liver Center, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Hepatology 49:989-97. 2009
    ..The mechanisms of VSL#3-mediated protection from MCD diet-induced liver fibrosis likely include modulation of collagen expression and impaired TGFbeta signaling...
  37. pmc Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice
    Bharath Nath
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 53:1526-37. 2011
    ..Small interfering RNA inhibition of HIF-1α prevented MCP-1-induced lipid accumulation, suggesting a mechanistic role for HIF-1α in hepatocyte lipid accumulation...
  38. ncbi request reprint Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection
    Angela Dolganiuc
    University of Massachusetts Medical School, Department of Medicine, Worcester, MA 01605, USA
    J Immunol 177:6758-68. 2006
    ..These mechanisms are likely to contribute to HCV viral escape from immune responses...
  39. pmc Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice
    Aditya Ambade
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hepatology 55:1585-95. 2012
    ....
  40. ncbi request reprint Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Alcohol Clin Exp Res 30:76-85. 2006
    ..Alcohol, a substance that is most frequently abused, suppresses innate immune responses to microbial pathogens. The host senses pathogens via Toll-like receptors (TLRs). Recent studies indicate that alcohol affects TLR signaling...
  41. ncbi request reprint RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ
    Jan Hoek
    Department of The University of Massachusetts Medical Center GS and PM, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1735-43. 2005
    ..by Kyle Happel 3) Decreased antigen presentation and anergy induced by alcohol in myeloid dendritic cells by Pranoti Mandrekar 4) Transcriptional regulation of TNF-alpha in human monocytes by chronic ethanol: role of the cellular redox ..
  42. ncbi request reprint Innate immune response and hepatic inflammation
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Semin Liver Dis 27:339-50. 2007
    ..The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis...
  43. ncbi request reprint Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
    Pranoti Mandrekar
    University of Massachusetts Medical School, Department of Medicine, Worcester 01605 2324, USA
    Alcohol Clin Exp Res 26:1609-14. 2002
    ..Here we investigated whether acute alcohol treatment of human monocytes also inhibits NF-kappaB when induced through activation of the interleukin (IL)-1 or tumor necrosis factor (TNF) receptors...
  44. pmc A recent perspective on alcohol, immunity, and host defense
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 33:220-32. 2009
    ..Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system...
  45. ncbi request reprint Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Alcohol Clin Exp Res 28:824-8. 2004
    ..In this study, we investigated the effects of acute, moderate alcohol consumption on antigen presenting cell function of blood monocytes and monocyte-derived myeloid dendritic cells...
  46. ncbi request reprint RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1744-8. 2005
    ....
  47. ncbi request reprint FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development
    Yvonne Drechsler
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Leukoc Biol 72:657-67. 2002
    ..These results suggest that signals mediated via FcgammaRI, -II, and -III have overlapping yet distinct effects on MO, which are likely to be involved in the fine-tuning of the immune responses to various stimuli...
  48. ncbi request reprint Pattern recognition receptors: a contemporary view on liver diseases
    Gyongyi Szabo
    Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 44:287-98. 2006
    ..This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated...
  49. pmc Focus on: alcohol and the liver
    Gyongyi Szabo
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts
    Alcohol Res Health 33:87-96. 2010
    ....
  50. pmc Oxidative stress and inflammation: essential partners in alcoholic liver disease
    Aditya Ambade
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Int J Hepatol 2012:853175. 2012
    ..Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease...
  51. ncbi request reprint Cytokines and alcohol
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:720-30. 2006
    ..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies...

Research Grants3

  1. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2006
    ....
  2. Role of heat shock protein 90 in alcoholic liver disease
    Pranoti Mandrekar; Fiscal Year: 2010
    ..Understanding these pathways will provide novel mechanisms and thus extend our horizons to identify potential new drug targets for alcoholic liver disease. ..